scholarly journals Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

2009 ◽  
Vol 78 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Edson Lucas Santos ◽  
Kely de Picoli Souza ◽  
Elton Dias da Silva ◽  
Elice Carneiro Batista ◽  
Paulo J. Forcina Martins ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Life Span ◽  
Ace Inhibitor ◽  
Body Weight Gain ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Effects of long-term treatment with antipsychotics on serum leptin levels

2001 ◽  
Vol 179 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Andrés Herrán ◽  
María Teresa García-Unzueta ◽  
José Antonio Amado ◽  
María Teresa De La Maza ◽  
Concepción Álvarez ◽  
...  
Keyword(s):  
Weight Gain ◽  
Healthy Subjects ◽  
Body Weight Gain ◽  
Chronic Schizophrenia ◽  
Term Treatment ◽  
Antipsychotic Treatment ◽  
Serum Leptin ◽  
Long Term Treatment ◽  
Current Weight

BackgroundAbnormal regulation of the adipocyte-derived hormone leptin could play a role in body weight gain induced by antipsychotics.AimsTo study the effects of long-term antipsychotic treatment on leptin levels in patients with schizophrenia.MethodSerum leptin levels were determined in 59 out-patients with chronic schizophrenia and in the same number of healthy subjects controlled by gender, age and body mass index.ResultsLeptin levels did not differ between patients and controls. Leptin levels in patients with schizophrenia correlated with weight gain, even after controlling for current weight, but did not show any association with clinical variables. Antipsychotic class tended to exert different effects over leptin levels (among atypicals, olanzapine induced a greater increase).ConclusionsElevation of leptin levels induced by chronic antipsychotic treatment can be attributed to weight gain, but other mechanisms could be involved.

Weight Gain During Long-Term Treatment of Obsessive-Compulsive Disorder

2004 ◽  
Vol 65 (10) ◽  
pp. 1365-1371 ◽  
Author(s):  
Giuseppe Maina ◽  
Umberto Albert ◽  
Virginio Salvi ◽  
Filippo Bogetto
Keyword(s):  
Weight Gain ◽  
Obsessive Compulsive Disorder ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Treatment

scholarly journals Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects

1984 ◽  
Vol 52 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Marcin Krotkiewski
Keyword(s):  
Body Weight ◽  
Dietary Habits ◽  
Guar Gum ◽  
Term Treatment ◽  
Total Serum ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Long Term Treatment ◽  
Obese Subjects

1. The effect of a palatable granulated guar-gum preparation (10 g twice daily) was studied in obese subjects. The acute effect of a single dose of guar gum to reduce the peak postprandial whole blood glucose levels (about 10%) was verified. Following long-term treatment, a further reduction was seen in the obese subjects with the highest postprandial glucose levels. Since the postprandial plasma insulin levels were essentially unchanged, this finding suggested an increased responsiveness to insulin. Total serum cholesterol levels were significantly reduced following long-term treatment but serum α-cholesterol levels, representing the high-density-lipoprotein fraction, was unchanged.2. Body-weight was significantly reduced during guar-gum treatment even though the patients were asked to maintain their normal dietary habits. Daily hunger ratings recorded for up to 10 weeks showed that guar gum reduced hunger significantly better than commercially available bran taken in the same way.3. Thus, guar gum seemed to influence carbohydrate and lipid metabolism in a beneficial way in obese subjects. The reduction in hunger would offer an additional benefit to these patients.

Sign in / Sign up

Export Citation Format

Share Document