scholarly journals STUDY OF HEPATOPROTECTIVE ACTIVITY OF STINGLESS BEE PROPOLIS AGAINTS TOXICITY OF DRUGS

2021 ◽  
pp. 86-92
Author(s):  
MAHANI ◽  
GREGORIUS A O B ◽  
ENDAH WULANDARI ◽  
AHMAD SULAEMAN ◽  
HARDINSYAH ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Therapy ◽  
Nutritional Status ◽  
Normal Values ◽  
Hepatoprotective Activity ◽  
Stingless Bee ◽  
Literature Study ◽  
Drug Induction ◽  
Toxicity Of Drugs ◽  
Antioxidant Mechanisms

Objective: The aim of this study is to determine the effect of stingless bee propolis supplementation as a hepatoprotector on the prevention of DILI and the effect of healing and restoring nutrition for DILI patients due to drug induction. Methods: The literature review starts from problem identification, library data collection, reading, taking notes, analyzing, and processing the data obtained and then compiling it into a systematic review Results: The results of a literature study conducted show that propolis has a good hepatoprotective ability against drugs that cause DILI cases such as the anti-tuberculosis, antibiotic and antipyretic groups as indicated by the SGPT, SGOT, BT, GSH, and SOD values that are close to normal values. In addition, propolis supplementation can accelerate the healing and restoration of the nutritional status of DILI patients. All active compounds contained in propolis such as phytochemicals and lipopolysaccharides work to protect the liver from the toxic effects of DILI through antioxidant mechanisms. Conclusion: Overall, the data from this literature study show that the hepatoprotective activity of propolis has the potential to complement drug therapy to reduce hepatotoxic effects and can conclusively beneficial to accelerate the restoration of nutritional status for DILI patients.

Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review

2020 ◽  
Author(s):  
Judd Sher ◽  
Kate Kirkham-Ali ◽  
Denny Luo ◽  
Catherine Miller ◽  
Dileep Sharma
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Drug Therapy ◽  
Dental Implant ◽  
Case Series ◽  
Cochrane Central Register ◽  
Bisphosphonate Treatment ◽  
Implant Placement ◽  
Increased Risk ◽  
History Of

The present systematic review evaluates the safety of placing dental implants in patients with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and OpenGrey databases were used to search for clinical studies (English only) to July 16, 2019. Study quality was assessed regarding randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases using a modified Newcastle-Ottawa scale and the Joanna Briggs Institute critical appraisal checklist for case series. A broad search strategy resulted in the identification of 7542 studies. There were 28 studies reporting on bisphosphonates (5 cohort, 6 case control, and 17 case series) and one study reporting on denosumab (case series) that met the inclusion criteria and were included in the qualitative synthesis. The quality assessment revealed an overall moderate quality of evidence among the studies. Results demonstrated that patients with a history of bisphosphonate treatment for osteoporosis are not at increased risk of implant failure in terms of osseointegration. However, all patients with a history of bisphosphonate treatment, whether taken orally for osteoporosis or intravenously for malignancy, appear to be at risk of ‘implant surgery-triggered’ MRONJ. In contrast, the risk of MRONJ in patients treated with denosumab for osteoporosis was found to be negligible. In conclusion, general and specialist dentists should exercise caution when planning dental implant therapy in patients with a history of bisphosphonate and denosumab drug therapy. Importantly, all patients with a history of bisphosphonates are at risk of MRONJ, necessitating this to be included in the informed consent obtained prior to implant placement. The James Cook University College of Medicine and Dentistry Honours program and the Australian Dental Research Foundation Colin Cormie Grant were the primary sources of funding for this systematic review.

The effect of additional drug therapy as metaphylaxis in patients with cystinuria: a systematic review

2020 ◽  
Vol 72 (4) ◽  
Author(s):  
Indra M. Melessen ◽  
Michaël M. Henderickx ◽  
Maria M. Merkx ◽  
Faridi S. van Etten-Jamaludin ◽  
Jaap J. Homan van der Heide ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Therapy

scholarly journals Prediction of all-cause mortality with malnutrition assessed by controlling nutritional status score in patients with heart failure: a systematic review and meta-analysis

2021 ◽  
pp. 1-8
Author(s):  
Huiyang Li ◽  
Peng Zhou ◽  
Yikai Zhao ◽  
Huaichun Ni ◽  
Xinping Luo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Nutritional Status ◽  
Meta Analysis ◽  
Predictive Values ◽  
Increased Risk ◽  
Patients With Heart Failure ◽  
All Cause Mortality ◽  
Conut Score

Abstract Objective: The aim of this meta-analysis was to investigate the association between malnutrition assessed by the controlling nutritional status (CONUT) score and all-cause mortality in patients with heart failure. Design: Systematic review and meta-analysis. Settings: A comprehensively literature search of PubMed and Embase databases was performed until 30 November 2020. Studies reporting the utility of CONUT score in prediction of all-cause mortality among patients with heart failure were eligible. Patients with a CONUT score ≥2 are grouped as malnourished. Predictive values of the CONUT score were summarized by pooling the multivariable-adjusted risk ratios (RR) with 95 % CI for the malnourished v. normal nutritional status or per point CONUT score increase. Participants: Ten studies involving 5196 patients with heart failure. Results: Malnourished patients with heart failure conferred a higher risk of all-cause mortality (RR 1·92; 95 % CI 1·58, 2·34) compared with the normal nutritional status. Subgroup analysis showed the malnourished patients with heart failure had an increased risk of in-hospital mortality (RR 1·78; 95 % CI 1·29, 2·46) and follow-up mortality (RR 2·01; 95 % CI 1·58, 2·57). Moreover, per point increase in CONUT score significantly increased 16% risk of all-cause mortality during the follow-up. Conclusions: Malnutrition defined by the CONUT score is an independent predictor of all-cause mortality in patients with heart failure. Assessment of nutritional status using CONUT score would be helpful for improving risk stratification of heart failure.

Effect of drug therapy on the lipid profiles of patient with inflammatory bowel disease: A systematic review and meta-analysis

2021 ◽  
Vol 331 ◽  
pp. e36-e37
Author(s):  
J.A.M. Sleutjes ◽  
E. Boersma ◽  
C.J. Van Der Woude ◽  
A.C. De Vries ◽  
J. E. Roeters Van Lennep
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Drug Therapy ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Lipid Profiles ◽  
Inflammatory Bowel

Systematic Review of Combination Drug Therapy for Non-neurogenic Male Lower Urinary Tract Symptoms

2013 ◽  
Vol 64 (2) ◽  
pp. 228-243 ◽  
Author(s):  
Claudius Füllhase ◽  
Christopher Chapple ◽  
Jean-Nicolas Cornu ◽  
Cosimo De Nunzio ◽  
Christian Gratzke ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Drug Therapy ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Combination Drug Therapy ◽  
Combination Drug ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review

2021 ◽  
Author(s):  
Stacey Peters ◽  
Bryony A. Thompson ◽  
Mark Perrin ◽  
Paul James ◽  
Dominica Zentner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Therapy ◽  
Dilated Cardiomyopathy ◽  
Sodium Channel ◽  
Early Recognition ◽  
Treatment Success ◽  
Atrial Arrhythmias ◽  
Blocking Drug ◽  
Cardiac Sodium Channel ◽  
Channel Blocking

Background: Variants in the SCN5A gene, that encodes the cardiac sodium channel, Nav1.5, are associated with a highly arrhythmogenic form of dilated cardiomyopathy (DCM). Our aim was to review the phenotypes, natural history, functional effects, and treatment outcomes of DCM-associated rare SCN5A variants. Methods: A systematic review of reported DCM-associated rare SCN5A variants was undertaken using PubMed and Embase. Results: Eighteen SCN5A rare variants in 29 families with DCM (173 affected individuals) were identified. Eleven variants had undergone experimental evaluation, with 7 of these resulting in increased sustained current flow during the action potential (eg, increased window current) and at resting membrane potentials (eg, creation of a new gating pore current). These variants were located in transmembrane voltage-sensing domains and had a consistent phenotype characterized by frequent multifocal narrow and broad complex ventricular premature beats (VPB; 72% of affected relatives), ventricular arrhythmias (33%), atrial arrhythmias (32%), sudden cardiac death (13%), and DCM (56%). This VPB-predominant phenotype was not seen with 1 variant that increased late sodium current, or with variants that reduced peak current density or had mixed effects. In the latter groups, affected individuals mainly showed sinus node dysfunction, conduction defects, and atrial arrhythmias, with infrequent VPB and VA. DCM did not occur in the absence of arrhythmias for any variant. Twelve studies (23 total patients) reported treatment success in the VPB-predominant cardiomyopathy using sodium channel-blocking drug therapy. Conclusions: SCN5A variants can present with a diverse spectrum of primary arrhythmic features. A majority of DCM-associated variants cause a multifocal VPB-predominant cardiomyopathy that is reversible with sodium channel blocking drug therapy. Early recognition of the distinctive phenotype and prompt genetic testing to identify variant carriers are needed. Our findings have implications for interpretation and management of SCN5A variants found in DCM patients with and without arrhythmias.

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