COMPARISON OF MALASSEZIA SPP. PROPORTIONS IN INFLAMMATORY AND NON-INFLAMMATORY FACIAL ACNE VULGARIS LESIONS

2020 ◽  
pp. 7-11
Author(s):  
AGASSI SUSENO SUTARJO ◽  
IRMA BERNADETTE S. SITOHANG ◽  
MARDIASTUTI H. WAHID ◽  
SANDRA WIDATY
Keyword(s):  
Species Identification ◽  
Potassium Hydroxide ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Skin Microbiome ◽  
Inflammatory Lesions ◽  
Predominant Species ◽  
Malassezia Spp ◽  
Spore Load ◽  
Facial Acne

Objective: The skin microbiome plays a role in the pathogenesis of acne vulgaris (AV). Among other species, Malassezia spp. can be found in the pilosebaceous follicle. However, its role on the pathogenesis of AV has not yet been described. The objective of this study was to identify the presence and the distribution of Malassezia spp. in facial AV lesions and also to compare the distribution of Malassezia spp. between inflammatory and non-inflammatory lesions. Methods: One hundred and twenty subjects were allocated into two groups: inflammatory lesions and non-inflammatory lesions. Samples were taken from hair follicles and examined by microscopy using 20% potassium hydroxide and Parker ink and cultured for species identification. Results: There was no difference in the spore load between the two groups (p=0.142). Malassezia spp. were isolated from 64.2% of subjects and consisted of M. dermatis (43%), M. sympodialis (18%), M. slooffiae (16%), M. japonica (5%), M. furfur (5%), M. pachydermatis (3%), and M. restricta (1%). There was a higher Malassezia spp. proportion in non-inflammatory lesions (p=0.019). The predominant species in inflammatory AV lesions was M. dermatis (45,8%), followed by M. sympodialis (17.1%), and M. slooffiae (11.4%). Conclusion: Malassezia spp. were found in facial acne lesions. M. dermatis was the predominant species found in facial AV, followed by M. sympodialis, and M. slooffiae. A higher proportion of Malassezia spp. was found in non-inflammatory lesions.

scholarly journals Facial Acne Vulgaris Exacerbation During COVID-19 Pandemic Due to Wearing Face Surgical Masks

2021 ◽  
Author(s):  
Shahin Hamzelou ◽  
Samaneh Torabi Kachousangi Pharm
Keyword(s):  
Acne Vulgaris ◽  
Hair Follicles ◽  
Protective Equipment ◽  
Common Complication ◽  
Local Pressure ◽  
Skin Reactions ◽  
Surgical Masks ◽  
The Face ◽  
Dermatologic Disease ◽  
Facial Acne

Acne vulgaris is a very common dermatologic disease. Here, we reported at least two cases of facial acne vulgaris exacerbation during the pandemic of coronavirus disease 2019 (COVID-19). Also, during the other respiratory disaster due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)in Singapore, skin reactions and complications of the personal protective equipment (PPE) were assessed. Acne was the most common complication of N95 masks. In China, where the COVID-19 has begun, the exacerbation of previous facial dermatoses was asked and the most exacerbated dermatoses after rosacea was acne. Two justifications for the exacerbation of acne have been proposed: first, the humid tropical microclimate created by the mask on the facial s kin, which can induce acne and the second is local pressure of the mask on the face, which may cause pressure-induced obstruction of the infundibulum of hair follicles. Dermatologists should expect exacerbations of acne in many patients during the respiratory epidemic and educate their patients.

scholarly journals Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 567
Author(s):  
Ivona Tomić ◽  
Sandra Miočić ◽  
Ivan Pepić ◽  
Dubravka Šimić ◽  
Jelena Filipović-Grčić
Keyword(s):  
Azelaic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Adverse Event Rate ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
First Choice ◽  
In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

scholarly journals Lack of association in acne and salivary testosterone

2018 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
David Fresnais ◽  
Edvin Ingberg ◽  
Elvar Theodorsson ◽  
Jakob O Ström
Keyword(s):  
Acne Vulgaris ◽  
Daily Basis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Weak Correlation ◽  
Salivary Testosterone ◽  
Weak Association ◽  
The Individual ◽  
Actual Relation ◽  
Facial Acne ◽  
Monotonic Relation

The pathogenesis of acne vulgaris has only been partially elucidated. Various hormones, especially androgens, are likely to play a role, but results of studies are still inconclusive. The objective of the current study was to investigate whether day to day variation in salivary testosterone correlates with acne in males. Saliva samples were collected for 120 consecutive days from each of the 40 males. Salivary testosterone concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Facial acne lesions were assessed on a daily basis by photography by the participating males. Potential confounders’ (sexual intercourse, masturbation, physical exercise and disease) were also registered every day by the participants. A significant but weak association between salivary testosterone and acne was found (n = 4602, r = 0.031, P = 0.034). Elevated testosterone concentrations were associated with an increase in acne, but when testosterone concentrations were above twice the individual average, acne lesions paradoxically decreased. The current results indicate that daily fluctuations in salivary testosterone levels in males are associated with acne patterns, but the weak correlation suggests that the effect is too small to be of clinical significance. The analysis in the current study was complicated by a large number of days on which the participants had no acne, as well as the seemingly non-monotonic relation between testosterone and acne. This may indicate that the actual relation is stronger than concluded here.

scholarly journals ID3024 Polymeric nanoparticles display bactericidal effect and selective fermentation for the treatment of acne vulgaris

2017 ◽  
Vol 4 (S) ◽  
pp. 34
Author(s):  
Ming-Fa Hsieh
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Polymeric Nanoparticles ◽  
Acne Vulgaris ◽  
Short Chain Fatty Acids ◽  
Bactericidal Effect ◽  
Skin Microbiome ◽  
Poly Ethylene Glycol ◽  
Effective Doses ◽  
Poly Ethylene

The use of antibiotics in the treatment of acne in specific group (pregnant women) of patients can lead to serious complications. We have previously demonstrated that the nanoparticles made of block copolymers of poly (ethylene glycol) and poly(e-caprolactone) can inhibit the growth of Propionibacterium acnes (P. acnes), a bacterium highly associated with the progress of acne vulgaris in the human skin [Polymers 2016; 8, 321]. To reduce the amount of antibiotics used in the treatment of skin acne, we have further demonstrated that a bacterium in the human skin microbiome can utilize PEG-based polymers to produce various short-chain fatty acids (SCFAs) which suppressed the growth of P. acnes. PEG-based polymers were chosen as selective fermentation initiators which specifically induced the fermentation of the skin commensal bacterium but not P. acnes. Interestingly, PEG-based polymers can efficiently suppress the growth of P. acnes. An acne ex vivo explant was established by using acne biopsies collected from patients with acne vulgaris at the early and middle stages. The levels of pro-inflammatory interleukin (IL)-8 cytokine in early- and middle-staged acnes were significantly higher than those in healthy skins. Incubation of acne ex vivo explants with sucrose remarkably reduced the level of IL-8 and the number of P. acnes. Results from mouse studies revealed that PEG-based polymer functions as antibiotic adjuvants which can considerably reduce the effective doses of clindamycin, a clinically-used acne antibiotic

scholarly journals Skin Microbiome and Acne Vulgaris: Staphylococcus, a New Actor in Acne

2017 ◽  
Vol 1 ◽  
pp. s54
Author(s):  
B Dreno ◽  
R Martin ◽  
A Khammari ◽  
D Moyal ◽  
J B Henley ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Skin Microbiome

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