scholarly journals A COMPREHENSIVE CHEMICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL

2021 ◽  
pp. 47-53
Author(s):  
INSAN SUNAN KURNIAWANSYAH ◽  
IYAN SOPYAN ◽  
TAOFIK RUSDIANA ◽  
FIRDA SILVIA PRAMASHELA ◽  
ANAS SUBARNAS
Keyword(s):  
Ophthalmic Solution ◽  
Chemical Characterization ◽  
Chemical Bonds ◽  
In Situ Gel ◽  
Chemical Evaluation ◽  
Polymer Interactions ◽  
Gel Preparation ◽  
The Ideal

In situ ophthalmic gel is a gel preparation that is initially in the form of ophthalmic solution that dripped into the eye and then the solution turns into a gel after contact with the surface of the eye. In situ gel will undergo phase change to gel due to pH, electrolyte and temperature conditions. So that the preparation of ophthalmic in situ gel is required characterization to make sure that the prepared preparations meet the standards and are safe when used. Chemical evaluation includes pH, concentration, chemical bonds, crystallization and drug and polymer interactions. The purpose of this review is to discuss the evaluation methods used in preparations, and to see whether the pH of in situ ophthalmic gel formulation that provided can met the ideal pH requirements of the eye, so that the ophthalmic in situ gel preparation would not causing irritation and liquid tear production.

scholarly journals APPLICATION AND CHARACTERIZATION OF IN SITU GEL

2018 ◽  
Vol 10 (6) ◽  
pp. 34 ◽  
Author(s):  
Insan Sunan Kurniawansyah ◽  
Iyan Sopyan ◽  
Nasrul Wathoni ◽  
Dasty Latifa Fillah ◽  
Rahadianti Umi Praditya
Keyword(s):  
Polymer Gel ◽  
In Situ Gel ◽  
Visual Appearance ◽  
Ocular Irritation ◽  
Chemical Evaluation ◽  
Draize Test ◽  
Delivery Routes

Applications of in situ gel have been used for a variety of drug delivery routes, such as oral, ocular, rectal, vaginal and injection. Characterization of in situ gel was determined to ensure that the prepared preparation met the standard and it safe. This review describes every aspects of this novel application and characterization of in situ gel preparations, which present the readers an exhaustive detail and might contribute to research and development. In the chemical evaluation in situ gel determined the diffusion of the active substance of a compound by measuring its concentration. In physical evaluation of isotonic calculated by osmotic pressure, drug release was determined by melting point of the substance polymer, gel strength as measured by rheometer, homogenecity test determined by under the light, and stability test with environmental conditions setting. In microbiology evaluation determine if the preparations was contaminated or not, also be effective and safe. Ocular irritation studies-Draize Test us an animal mice or rabbit and determination of visual appearance, clarity, and pH is required. In situ gels offer the primary requirement of a successful controlled release product that is increasing patient compliance.

scholarly journals Novel Approach for Design and Characterization Of Muco Adhesive Buccal Ganciclovir In Situ Gel

2020 ◽  
Vol 8 (3) ◽  
pp. 19-33
Author(s):  
CH.N.V.S Masthan Rao ◽  
R.B. Desireddy ◽  
D. Vasavilatha ◽  
G.L.S. Mounika ◽  
G. Ramya Sadhana ◽  
...  
Keyword(s):  
In Situ Gel ◽  
Novel Approach

scholarly journals PHYSICAL CHARACTERIZATION OF IN SITU OPHTHALMIC GEL: A CONCISE REVIEW

2022 ◽  
pp. 18-21
Author(s):  
INSAN SUNAN KURNIAWANSYAH ◽  
IYAN SOPYAN ◽  
GENI REFSI
Keyword(s):  
Therapeutic Effect ◽  
Contact Time ◽  
Drug Preparation ◽  
Journal Review ◽  
In Situ Gel ◽  
Concise Review ◽  
Gel Formulations ◽  
Active Substances

In situ ophthalmic gel is a type of eye drug preparation that has a higher bioavailability value and has a longer contact time with maximum therapeutic effect and with minimal side effects compared to conventional eye preparations. The preparation of ophthalmic in situ gel is required characterization to make sure that the prepared preparations meet the standards and are safe when used. This journal review aims to look at the methods used in characterizing physical properties in in situ ophthalmic gel formulations with different active substances such as rheology studies, organoleptic tests, pH, clarity, and gelling capacity. In order to get the best formulation of in situ ophthalmic gel preparations so as to provide maximum therapeutic effect.

Chemical characterization of soda-lime glass samples by in situ current normalised PIGE and conventional INAA methods for forensic applications

2019 ◽  
Vol 323 (3) ◽  
pp. 1451-1457 ◽  
Author(s):  
V. Sharma ◽  
R. Acharya ◽  
S. K. Samanta ◽  
M. Goswami ◽  
H. K. Bagla ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Soda Lime ◽  
Soda Lime Glass

The Effectiveness of Chloramphenicol In-Situ Opthalmic Gel with Base Poloxamer 407 and HPMC Against Staphylococcus Aureus Atcc 29213 And Pseudomonas Aeruginosa Atcc 27853

2019 ◽  
Vol 9 (01) ◽  
pp. 76-82 ◽  
Author(s):  
Insan Sunan Kurniawansyah ◽  
Norisca Aliza Putriana ◽  
Agung Fitri Kusuma ◽  
Tan Mei Lee
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Design Method ◽  
Storage Conditions ◽  
Poloxamer 407 ◽  
Simple Liquid ◽  
High Concentration ◽  
In Situ Gel ◽  
Gel Preparation

Introduction: In-situ gel is a simple liquid transparent polymer solution under storage conditions, but turns into a viscoelastic gel after entering the eye due to the phase transition properties of the polymer that increase the residence time in ocular organ and bioavailability, enabling the delivery of reproducible doses and improving patient compliance. The aim of the present study was to formulate and evaluate the antibacterial effectivity of chloramphenicol in-situ ophthalmic gel with base poloxamer 407 and HPMC base against Staphylococcus aureus and Pseudomonas aeruginosa. Material and Methods: The optimization of ophthalmic gel preparation by the factorial design method has been carried out in order to know the best formula of all the formulas employed with 0.5% chloramphenicol active substance, wherein each formula was obtained from high concentration and low concentration of each base. Results: The measurement of the antibacterial effectivity against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 27853 by oneway ANOVA analysis showed that formula with base poloxamer 407 5% (F1) gave the best result. F1 has a dilute consistency, clear and stable during 28 days storage time when effectiveness test performed. Conclusions: Chloramphenicol in-situ gel with base poloxamer 407 and HPMC were effective against Staphylococcus aureus ATCC 29213 with intermediate to sensitive category, and Pseudomonas aeruginosa ATCC 27853 with sensitive category in accordance to the requirements of the Clinical and Laboratory Standards Institute (CLSI).

Physical and Chemical Characterization of Ni+MoO2 Composite Electrocoatings

2015 ◽  
Vol 228 ◽  
pp. 58-62
Author(s):  
B. Łosiewicz ◽  
Grzegorz Dercz ◽  
Magdalena Popczyk
Keyword(s):  
Chemical Characterization ◽  
Electrodeposition Technique ◽  
Plating Bath ◽  
Physical And Chemical Characterization ◽  
Magnetic Stirring ◽  
Physical And Chemical ◽  
Crystalline Component ◽  
Deposition Conditions

This work deals with the development of new electrochemical ways to improve the cathode activity towards hydrogen evolution reaction. Anin situcomposite electrodeposition technique has been proposed to obtain the porous Ni+MoO2coatings by simultaneous co-deposition of Ni and MoO2onto a Cu substrate from a nickel plating bath containing 10 g dm-3of MoO2powder suspended by magnetic stirring. Electrodeposition was conducted at 30°C at the deposition current density ofjd= 50-250 mA cm-2. SEM, EDS, and XRD measurements, were applied for physical and chemical characterization of the obtained coatings. It was found that by controlling the deposition conditions it was possible to obtain porous Ni+MoO2coatings containing from 10 to 15 at.% of MoO2. The XRD results confirmed their diphase structure with a polycrystalline Ni matrix into which a crystalline component in the form of MoO2particles was built-in.

An in situ correlative STEM-EDS and HRTEM based nanoscale chemical characterization of solid-liquid interfaces in an aluminium alloy

2016 ◽  
Vol 264 (1) ◽  
pp. 64-70 ◽  
Author(s):  
S. ESWARA ◽  
C. MITTERBAUER ◽  
T. WIRTZ ◽  
S. KUJAWA ◽  
J.M. HOWE
Keyword(s):  
Aluminium Alloy ◽  
Chemical Characterization ◽  
Liquid Interfaces ◽  
Solid Liquid
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