Post Treatment Effect of Grewia asiatica against Radiation-Induced Biochemical Alterations in Swiss Albino Mice

2008 ◽  
Vol 27 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Rashmi Sisodia ◽  
Smita Singh ◽  
K. V. Sharma ◽  
Muktika Ahaskar
Keyword(s):  
Treatment Effect ◽  
Post Treatment ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice ◽  
Post Treatment Effect

Dose-dependent suppression of haloperidol-induced catalepsy by potentized Agaricus muscarius

1996 ◽  
Vol 85 (03) ◽  
pp. 141-144 ◽  
Author(s):  
Souvik Ghosh ◽  
S.P. Sinha Babu ◽  
N.C. Sukul
Keyword(s):  
Treatment Effect ◽  
Post Treatment ◽  
Active Principle ◽  
Mechanical Agitation ◽  
Swiss Albino Mice ◽  
Before And After ◽  
Albino Mice ◽  
Pre Treatment ◽  
Dose Dependent ◽  
Post Treatment Effect

Abstract Agaricus muscarius 30c, a potentized homoeopathic drug prepared by successive dilution with 90% alcohol followed by sonication, suppressed haloperidol-induced catalepsy in Swiss albino mice significantly. This anticataleptic effect was dose-dependent being greatest with the undiluted Agaricus 30c and least if diluted 1:20,000. Higher dilutions like 1:40,000 and 1:50,000 did not produce an anticataleptic effect. The effect reappeared when the 1:50,000 dilution was sonicated. The anticataleptic effect of potentized Agaricus was observed with the drug administered both before and after haloperidol. However, the pre-treatment effect was more pronounced than the post-treatment effect.It is thought that potentized Agaricus contains an active principle that can be attenuated by dilution and multiplied by mechanical agitation or sonication.

scholarly journals RADIOPROTECTION OF ALOE VERA AGAINST BIOCHEMICAL ALTERATIONS IN SWISS ALBINO MICE

2018 ◽  
Vol 10 (3) ◽  
pp. 55
Author(s):  
Priyanka Dadupanthi
Keyword(s):  
Radiation Treatment ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aloe Vera ◽  
Radiation Energy ◽  
Tissue Water ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

Objective: In this study, radioprotection against radiation-induced hepatic damage in Swiss Albino Mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals.Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5,10 and 20 after irradiation to evaluate the radio modulator effect in terms of LPO and GSH.Results: Radiation treatment showed a decrease in GSH content and an increase of LPO in control set animals, however, the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO but values remained below normal.Conclusion: The result of present study suggests that Aloe vera has a radioprotective effect due to their antioxidant and radical scavenging activity.

scholarly journals Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

2010 ◽  
Vol 10 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Preeti Verma ◽  
Priyanka Sharma ◽  
Jyoti Parmar ◽  
Priyanka Sharma ◽  
Annapurna Agrawal ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Ginseng Extract ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

Effectiveness of transdiagnostic seminars to support patients with common mental disorders: a multi-service practice research network study

2021 ◽  
pp. 1-13
Author(s):  
Chris Gaskell ◽  
Ryan Askey-Jones ◽  
Martin Groom ◽  
Jaime Delgadillo
Keyword(s):  
Treatment Effect ◽  
High Intensity ◽  
Post Treatment ◽  
Waiting List ◽  
Effect Sizes ◽  
Research Network ◽  
Randomised Control Trial ◽  
Practice Research ◽  
Matched Sample ◽  
Post Treatment Effect

Abstract Background: This was a multi-site evaluation of psycho-educational transdiagnostic seminars (TDS) as a pre-treatment intervention to enhance the effectiveness and utilisation of high-intensity cognitive behavioural therapy (CBT). Aims: To evaluate the effectiveness of TDS combined with high-intensity CBT (TDS+CBT) versus a matched sample receiving CBT only. Second, to determine the consistency of results across participating services which employed CBT+TDS. Finally, to determine the acceptability of TDS across patients with different psychological disorders. Method: 106 patients across three services voluntarily attended TDS while on a waiting list for CBT (TDS+CBT). Individual and pooled service pre–post treatment effect sizes were calculated using measures of depression, anxiety and functional impairment. Effectiveness and completion rates for TDS+CBT were compared with a propensity score matched sample from an archival dataset of cases who received high-intensity CBT only. Results: Pre–post treatment effect sizes for TDS+CBT were comparable to the matched sample. Recovery rates were greater for the group receiving TDS; however, this was not statistically significant. Greater improvements were observed during the waiting-list period for patients who had received TDS for depression (d = 0.49 compared with d = 0.07) and anxiety (d = 0.36 compared with d = 0.04). Conclusions: Overall, this new evidence found a trend for TDS improving symptoms while awaiting CBT across three separate IAPT services. The effectiveness of TDS now warrants further exploration through an appropriately sized randomised control trial.

Investigation of post-treatment effect on morphology and pervaporation performance of PEG added PAN hollow fiber membranes

Desalination ◽  
2008 ◽  
Vol 234 (1-3) ◽  
pp. 232-243 ◽  
Author(s):  
Hui-An Tsai ◽  
Liang-Chih Ma ◽  
Fan Yuan ◽  
Kueir-Rarn Lee ◽  
Juin-Yih Lai
Keyword(s):  
Treatment Effect ◽  
Hollow Fiber ◽  
Post Treatment ◽  
Hollow Fiber Membranes ◽  
Fiber Membranes ◽  
Post Treatment Effect

Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride

2010 ◽  
Vol 29 (5) ◽  
pp. 409-418 ◽  
Author(s):  
E. Kasi Viswanadh ◽  
B. Nageshwar Rao ◽  
BS Satish Rao
Keyword(s):  
Cadmium Chloride ◽  
Mangifera Indica ◽  
Optimal Dose ◽  
Protective Role ◽  
Reduction Factor ◽  
Post Treatment ◽  
Glutathione S Transferase ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Antigenotoxic Effect

Cadmium is an environmental metal toxin implicated in human diseases. Mangiferin (MGN), a naturally occurring glucosylxanthone, is present in Mangifera indica. In this study, the protective role of MGN against cadmium chloride (CdCl2)-induced genotoxicity was studied in Swiss albino mice. Mice were administered with single intra-peritoneal (i.p.) optimal dose of MGN (2.5 mg/kg b.wt.) before treatment with various concentrations of CdCl2 (7, 8, 9, 10 and 11 mg/kg b.wt.). The LD 50(30) was found to be 8.5 mg/kg b.wt. for DDW + CdCl2 group, while it was increased to 9.77 mg/kg after MGN treatment resulting in increase in the LD50(30) value by 1.26 mg, with a dose reduction factor (DRF) of 1.14. Treatment of mice to various doses of CdCl2 resulted in a dose-dependent increase in the frequency of micronucleated polychromatic (MnPCE) and normochromatic erythrocytes (MnNCE), with corresponding decrease in the polychromatic / normochromatic erythrocyte ratio (PCE/NCE ratio) at various post-treatment times. MGN (2.5 mg/kg b.wt.) pretreatment significantly (p < .001) reduced the frequency of MnPCE, MnNCE and increased PCE/NCE ratio when compared with the DDW + CdCl2 group at all post-treatment times indicating its antigenotoxic effect. Further, pretreatment of MGN declined the lipid peroxidation (LPx) content in liver, whereas significant increase was observed in hepatic Glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activity. Our study revealed that MGN has potent antigenotoxic effect against CdCl2-induced toxicity in mice, which may be due to the scavenging of free radicals and increased antioxidant status.

scholarly journals EFFECT OF OPUNTIA ELATIOR ON CHOLESTEROL LEVEL ALTERATIONS INDUCED BY GAMMA RADIATION IN SWISS ALBINO MICE

2019 ◽  
pp. 578-581
Author(s):  
KAVITA POONIAM ◽  
JAIMALA SHARMA
Keyword(s):  
Side Effects ◽  
Gamma Radiation ◽  
Cholesterol Level ◽  
Plant Extract ◽  
Treated Group ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice

Objectives: Radiotherapy is deleterious to patient health by making the patient more susceptible to other diseases and often causes death by weakening the immune system and also affects cholesterol level. Based on these studies, it was moved toward the selection of Opuntia elatior as a herbal remedy for serum cholesterol level induced by gamma radiation. Methods: The modulatory effect of O. elatior stem extract was studied in Swiss albino mice at dose, i.e., 6 Gy of gamma radiation in the presence (experimental) or absence (control) of O. elatior extract (OEE) (10 mg/kg body weight) to observe in blood cholesterol level alterations. The animals were scarified and their blood was collected at days 1, 15, and 30 post-irradiation from heart puncture. Cholesterol level was estimated by the modified method of Roeschlau et al., 1974, using kit. Results: The cholesterol level was found almost constant in the control group (without any treatment) and increased in gamma radiation-treated group and decreased in only plant extract-treated group, whereas radiation-induced increased level of cholesterol was reduced by plant extract treatment in experimental animals (in plant extract with radiation-treated group), a normal level was achieved by day 30 post-treatment. Hence, O. elatior is beneficial to control radiation-induced blood cholesterol level. Conclusion: Radiation-induced side effects get lowered by herbal treatment and herbal products do not have their own side effects on body on their physical and chemical processes; thus, OEE is useful to manage blood cholesterol level as an edible part, it is easy to use as treatment and in my results OEE also support to maintain cholesterol level in serum of mice.

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