scholarly journals FORMULATION AND EVALUATION OF MASLINIC ACID LOADED TRANSDERMAL PATCHES

2021 ◽  
pp. 89-98
Author(s):  
NEHA CHOUDHORY ◽  
TARANJIT KAUR ◽  
AJEET PAL SINGH ◽  
AMAR PAL SINGH
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
Vapour Permeability ◽  
Maslinic Acid ◽  
Casting Technique ◽  
Transdermal Patches

Objective: To develop and evaluate Transdermal patch of Maslinic acid for Transdermal drug delivery. The current study is to develop Transdermal drug delivery system. Methods: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for preparation of Transdermal patch. Results: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for the preparation of the system was found satisfactory. Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation technique with the incorporation of penetration enhancer such as dimethylsulfoxide and dibutyl phthalate as plasticizer In vitro studies concluded that HPMC E5 patches has better release than that of EC patches, which may be attributed to high water vapour permeability of HPMC patches and hydrophobic nature of EC. An attempt was made to incorporate HPMC E5 and EC to the monolithic system for better release and prolong the duration of release. Formulation F7 containing an equal ratio of HPMC E5: EC (5:5) showed maximum and sustained release of 86.816±0.264 within 24 h. Kinetic models were used to confirm the release mechanism of the formulations. Maslinic acid release from the patches F1 to F7 followed non Fickian diffusion rate controlled mechanism.

scholarly journals COMPARATIVE EVALUATION OF SELECTED POLYMERS AND PLASTICIZER ON TRANSDERMAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Bhawana Sethi ◽  
Rupa Mazumder
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Propylene Glycol ◽  
Drug Delivery System ◽  
Transdermal Drug Delivery ◽  
Release Kinetics ◽  
Content Uniformity ◽  
Transdermal Drug Delivery System ◽  
Transdermal Patches

Objective: The present work was aimed at preparation of transdermal patches by a solvent casting method using a varying concentration of polymers i.e. methocel (K15 and K100), ethocel (4 and 10), gelatin, chitosan, eudragit (RL and RS) grade using plasticizer (glycerin and propylene glycol).Methods: The ratio of drug to polymers and plasticizer was varied and the effect of formulation variables was studied. Prepared transdermal patches were evaluated for physicochemical properties, in-vitro permeation studies, content uniformity, primary skin irritation studies and FT-IR studies.Results: The formulated transdermal patch by using Methocel K 100 M showed good physical properties. The average weight of patches prepared using glycerin as a plasticizer were ranged from 42.33-67.00 mg and propylene glycol as a plasticizer were ranged from 40.67-67.67 mg. The percentage moisture absorption varies from 1.76 to 10.73 for patches formulated using glycerin and 2.28 to 7.97 for propylene glycol patches. The percentage moisture loss from patches prepared using glycerin was ranged from 2.75 to 11.54 and 2.87 to 12.02 from propylene glycol. The water vapour transmission rate from patches prepared using glycerin was ranged from 0.25 to 0.92 and 0.41 to 1.76. The formulated patch showed the acceptable quantity of medicament ranged from (100.20-101.05%). This result met the test content uniformity as per BP (85% to 115%). According to that, the drug was consistent throughout the patches. The formulation PGD is considered as the best formulation, since it shows a maximum in vitro drug release as 43.75 % at 24 h. The drug release kinetics studied showed that the majority of formulations was following zero order.Conclusion: In conclusion, controlled release transdermal drug delivery system patches of aliskiren can be prepared using polymer combinations, with a different plasticizer. The release rate of drug depends upon the polymer. However, release kinetics followed zero order.

scholarly journals Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis

2019 ◽  
Author(s):  
Fanguo Kong ◽  
Bin Jia ◽  
Peng Cui ◽  
Duojun Wang
Keyword(s):  
Drug Delivery ◽  
Normal Level ◽  
Transdermal Drug Delivery ◽  
Plasma Calcium ◽  
The Novel ◽  
Transdermal Patch ◽  
Rat Skin ◽  
Transdermal Drug Delivery System ◽  
Treatment Of Osteoporosis ◽  
Pure Drug

The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.

scholarly journals FORMULATION AND DEVELOPMENT OF TRANSDERMAL DRUG DELIVERY SYSTEM OF ETHINYLESTRADIOL AND TESTOSTERONE: IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Shikha Baghel Chauhan ◽  
Tanveer Naved ◽  
Nayyar Parvez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Skin Permeation ◽  
Physical Parameters ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
In Vitro Skin Permeation

Objective: The combination therapy of ethinylestradiol and testosterone in post-menopausal females has shown improved sexual response and libido. The present studies were designed to develop a suitable matrix-type transdermal drug delivery system (TDDS) of ethinylestradiol and testosterone using the polymer chitosan.Methods: Five formulations (ET1 to ET5) were developed by varying the concentration of polymer and keeping the drug load constant. Physical parameters and drug excipient interaction studies were evaluated in all the formulations. In vitro skin permeation profiles of ethinylestradiol and testosterone from various formulations were simultaneously characterized in a thermostatically controlled modified Franz Diffusion cell using HPLC. Based on the physical parameters and in vitro skin permeation profile formulation ET3 containing 30 mg/ml of chitosan was found to be the best and chosen for further studies. Optimized formulation was subjected to in vivo pharmacokinetic analysis in rats using ELISA.Results: Stability profile of patch formulation ET3 depicted stability up to 3 mo. One week skin irritation evaluation in rats indicated that formulation ET3 was nonirritating. Combination transdermal patch across rat skin showed a maximum release of 92.936 and 95.03 % in 60 h with a flux of 2.088 and 21.398 µg/cm2h for ethinylestradiol and testosterone respectively.Conclusion: The net result of this study is the formulation of a stable, non-irritating transdermal patch of ethinylestradiol and testosterone, with good bioavailability and can be used as Estrogen Replacement Therapy (ERT) in postmenopausal women.

scholarly journals "FORMULATION AND EVALUATION OF MORONIC ACID LOADED TRANSDERMAL PATCHES"

2021 ◽  
pp. 81-88
Author(s):  
RITU RANI ◽  
TARANJIT KAUR ◽  
AJEET PAL SINGH ◽  
AMAR PAL SINGH
Keyword(s):  
Dibutyl Phthalate ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Film Casting ◽  
Casting Technique ◽  
Hydrophobic Polymers ◽  
Transdermal Patches ◽  
Evaporation Technique ◽  
Rate Controlled ◽  
Acid Release

Objective: To prepare Transdermal patches of Moronic acid along with various polymers for controlled release action. Methods: Suitable method such as Solvent Casting Technique of Film Casting Technique are used for the preparation of Transdermal patch. Results: The prepared Transdermal patches were transparent, smooth, uniform and flexible. The method adopted for the preparation of the system was found satisfactory. Conclusion: Various formulations were developed by using hydrophilic and hydrophobic polymers like HPMC E5 and EC respectively in single and combinations by solvent evaporation technique with the incorporation of penetration enhancer such as dimethylsulfoxide and dibutyl phthalate as plasticizer. Formulation F7 containing an equal ratio of HPMC E5: EC (5:5) showed maximum and sustained release of 86.814±0.262 within 24 h. Kinetic models were used to confirm the release mechanism of the formulations. Moronic acid release from the patches F1 to F7 followed non Fickian diffusion rate controlled mechanism.

Evaluation of Transdermal Patches of Valproic Acid

2020 ◽  
Vol 8 (3) ◽  
pp. 238-245
Author(s):  
Sudhir Singh ◽  
Anand Singh ◽  
Anil Bhandari ◽  
Satish Kumar Sharma ◽  
Sumer Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Valproic Acid ◽  
Transdermal Drug Delivery ◽  
Dosage Form ◽  
Controlled Drug Delivery ◽  
Systemic Circulation ◽  
Transdermal Drug Delivery System ◽  
New Approach ◽  
Manic Disorder ◽  
Transdermal Patches

Conventional System of Medication that requires multi dose therapy are having many problems. The controlled drug delivery is a newer approach is to deliver drug into systemic circulation. As Valproic Acid is a drug to control the manic disorder so it is necessary to maintain the concentration of drug in systemic circulation continuously. So a new approach known as transdermal drug delivery system is adopted to avoid the various drawbacks of oral and other conventional dosage form.  

Formulation and evaluation of Clopidogrel bisulfate loaded transdermal patches for anti-platelet activity

2018 ◽  
Vol 9 (1) ◽  
pp. 25
Author(s):  
Subramanian S ◽  
Senith SK
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
In Vitro Drug Release ◽  
Clopidogrel Bisulfate ◽  
Transdermal Patches

Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally clopidogrel bisulfate has a short elimination half-life (7-8 h), low oral bioavailability (50 %) undergoes extensive first pass metabolism (85 %) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result. The purpose of this research was formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate using various polymers such as HPMC and EC by solvent casting technique for improvement of bioavailability of drug and reducing toxic effects. The developed transdermal patches may increase the therapeutic efficacy and reduce toxic effect of clopidogrel bisulfate. The prepared transdermal drug delivery system of clopidogrel bisulfate using different polymers such as HPMC and EC had shown good & promising results for all the evaluated parameters. Based on the in vitro drug release, drug content, weight variation, tensile strength, thickness and folding endurance results formulation F2 was concluded as an optimized formulation which shows its higher percentage of drug release. Keyword: Clopidogrel bisulfate; Transdermal patch; TDDS; Solvent evaporation; In vitro drug release

scholarly journals FORMULATION AND EVALUATION OF CLOPIDOGREL BISULFATE TRANSDERMAL PATCHES

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
P. Srikanth Reddy ◽  
V. Alagarsamy ◽  
G. Ravi ◽  
P. Subhash Chandra Bose ◽  
D. Saritha
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Transdermal Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
Matrix Type ◽  
Clopidogrel Bisulfate ◽  
Transdermal Patches ◽  
Folding Endurance

Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. The main objective of the present work was to develop a suitable matrix type transdermal drug delivery system of Clopidogrel bisulphate using different polymers HPMC E15, Eudragit L100 and to compare the drug release through physical method and chemical method. Matrix type transdermal patches containing Clopidogrel Bisulfate were prepared by solvent evaporation technique. The prepared transdermal patches were evaluated for Thickness, folding endurance, tensile strength and in vitro studies. The prepared transdermal drug delivery system of Clopidogrel bisulphate using different polymers such as HPMC E15 and Eudragit L 100 had shown good promising results for all the evaluated parameters. Based on the In-vitro drug release, drug content and folding endurance results formulation F4 was concluded as an optimized formulation which shows its higher percentage of drug release. Keywords: Transdermal drug delivery, Clopidogrel bisulphate, HPMC E15, Eudragit L100

scholarly journals An Emerging Transdermal Drug Delivery System: Fabrication and Characterization of Natural and Biodegradable Polymeric Microneedles Transdermal Patch

2021 ◽  
pp. 46-54
Author(s):  
Deepesh Lall ◽  
MOHD. Javed Naim ◽  
Shruti Rathore
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Physical Stability ◽  
Circulation System ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
Transport Pathway

Promising drug agents are limited by their inability to reach in systematic circulation system when applied on skin, because of the excellent barrier of biological membranes, such as the stratum corneum (SC) of the skin. It is the outermost layer of the skin, SC, the principal barrier to all the topical application applied on skin. Various strategies were employed by many research group and pharmaceutical companies worldwide, for the formulation of microneedles. Therefore, microneedles (MN’s), used to puncture skin, it created the transient aqueous transport pathway and enhanced the trandermal permeability. Microneedles (MN’s) fabricated with natural and biodegradable polymer, such as carboxymethyl cellulose (CMC), and dextran. Inverse replication of micro milled master mould reproduced, solid out of natural polymeric microneedles, were subsequently assembled into transdermal patch and physiochemical characterized for dissolution index, mechanical strength constructed physical strong and uniform shape and size and inert profile. Although, dissolvable PVP and PVA based microneedle showed physical stability and MN’s, their different analyzed parameter is of promise for the fabrication matrix device of natural biodegradable polymeric microneedle transdermal drug delivery system.

scholarly journals CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 8 (5-s) ◽  
pp. 62-66 ◽  
Author(s):  
Anupriya Kapoor ◽  
Shashi Kiran Mishra ◽  
Dharmesh Kumar Verma ◽  
Prashant Pandey
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Oral Route ◽  
Penetration Enhancer ◽  
Penetration Enhancers ◽  
Transdermal Drug Delivery System ◽  
Transdermal Patches

In present scenario more than 70% of the drugs that are taken by oral route are found to be less effective as desired, to overcome this constraint Transdermal drug delivery system has emerged as an innovative area of research, this system helps in delivering the drugs and macromolecules through skin into systemic circulation. At present, the worldwide market of Transdermal patch has reached 2 billion pounds. Many drugs like Estrogen, Progestrone, Nitroglycerine, Clonodine etc. are fabricated in form of Transdermal patches due to its ability to deliver the drug in non-invasive manner and also to overcome the problems associated with oral route. Although the Transdermal patches deliver the drug at predetermined rate1, the partitioning of drug from the system to the skin and then penetration through different layers of skin can be altered by adding penetration enhancers that can be physical or chemical in nature. This article deals with the role of different chemicals that can be used as penetration enhancer. Keywords: Penetration enhancer, Layer of skin, Fatty alcohol and glycol

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