scholarly journals NEUROPROTECTIVE EFFECT OF CITRULLUS LANATUS SEED EXTRACTS ON CEREBRAL ISCHEMIC REPERFUSION INJURY INDUCED COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS

2019 ◽  
pp. 38-44
Author(s):  
Girija Pashikanti ◽  
MAKULA AJITHA ◽  
GOVERDHAN PUCHCHAKAYALA
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Memory Performance ◽  
Albino Rats ◽  
Early Event ◽  
Neuroprotective Effects ◽  
Aqueous Fraction ◽  
And Oxidative Stress

Objective: Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease (AD). The present study was designed to investigate the neuroprotective effects of citrullus lanatus on bilateral common carotid artery occlusion (BCCAO) induced cognitive impairment and oxidative stress in Wistar albino rats. Methods: Cognitive impairment and oxidative stress were induced by BCCAO for 30 min, followed by 7 d reperfusion of male wistar rats. Morris water maze and rectangular maze performance tests and locomotor activity were used to assess memory performance tasks. To study the activity, rats weighing 250-300g were pre-treated with successive extracts of n-hexane fraction (HF), ethyl acetate fraction (EAF), ethanol fraction (EF) and aqueous fraction (AF) of 400 mg/kg, 200 mg/kg, p. o of each for 10 d and the treatment was continued for another 7 d after cerebral ischemia. Various biochemical parameters like lipid peroxidation, Catalase, DPPH and AchE were also estimated in the brain after the treatment. Results: There was significantly increased oxidative stress and cholinesterase activity with cognitive decline in the hippocampus in rats of BCCAO group as compared to sham-operated (p<0.05). The animals treated with Donepezil, HF and EF prevented the biochemical changes significantly (p<0.001) and there was significant (p<0.001) improvement in cognitive parameters compared to BCCAO treated rats. Conclusion: Thus present study indicates the neuroprotective effect of citrulus lanatus seed extract (HF and EF) against BCCAO induced cognitive impairment and associative oxidative damage.

scholarly journals Neuroprotective Effects ofCentella asiaticaagainst Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Anil Kumar ◽  
Samrita Dogra ◽  
Atish Prakash
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Oxidative Damage ◽  
Memory Impairment ◽  
Memory Performance ◽  
Centella Asiatica ◽  
Acetylcholinesterase Activity ◽  
Early Event ◽  
Neuroprotective Effects ◽  
Male Wistar Rats

Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects ofCentella asiaticaagainst colchicine-induced memory impairment and oxidative damage in rats. Colchicine (15 μg/5 μL) was administered intracerebroventricularly in the lateral ventricle of male wistar rats. Morris water maze and plus-maze performance tests were used to assess memory performance tasks. Various biochemical parameters such as lipid peroxidation, nitrite, reduced glutathione, glutathione-S-transferase, superoxide dismutase, acetylcholinesterase were also assessed. ICV colchicine resulted marked memory impairment and oxidative damage. Chronic treatment withCentella asiaticaextract (150 and 300 mg/kg, p.o.) for a period of 25 days, beginning 4 days prior to colchicine administration, significantly attenuated colchicine-induced memory impairment and oxidative damage. Besides,Centella asiaticasignificantly reversed colchicines administered increase in acetylcholinesterase activity. Thus, present study indicates protective effect ofCentella asiaticaagainst colchicine-induced cognitive impairment and associated oxidative damage.

scholarly journals NEUROPROTECTIVE EFFECT OF WATERMELON (CITRULLUS LANATUS) PULP JUICE ON SCOPOLAMINE-INDUCED MEMORY DEFICITS IN SWISS ALBINO MICE: THE ROLE OF ACETYLCHOLINESTERASE AND OXIDATIVE STRESS

2021 ◽  
Vol 12 (3) ◽  
pp. 52-56
Author(s):  
Divya N ◽  
Amudha P ◽  
Viveka K Priya
Keyword(s):  
Oxidative Stress ◽  
Ache Activity ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Memory Deficits ◽  
Memory Deficit ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

The effect of Watermelon (Citrullus lanatus) Pulp Juice (WPJ) on scopolamine (SCOP) induced memory deficits is due to the involvement of oxidative stress and AChE activity. The juice was obtained by crushing the pulp in blender and three different concentrations of 100%, 50% and 25% was administration to prevent memory deficit by evaluating changes of AChE activity and oxidative stress indicators (SOD, CAT, LPO and GPx) induced by scopolamine. These results provide evidence that WPJ is an alternative to protect SCOP induced memory deficits in mice by involvement of oxidative stress and AChE activity.

Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain

2010 ◽  
Vol 13 (4) ◽  
pp. 821-826 ◽  
Author(s):  
Amin Ataie ◽  
Masoumeh Sabetkasaei ◽  
Abbas Haghparast ◽  
Akbar Hajizadeh Moghaddam ◽  
Ramin Ataee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Rat Brain ◽  
Intracerebroventricular Injection ◽  
Neuroprotective Effects ◽  
And Oxidative Stress

scholarly journals Evaluation of Neuroprotective and In-vitro Anti-oxidant Activity Isolated Hexane and Ethyl Acetate Fraction from Methanolic Extract of Biophytum reinwardtii

2020 ◽  
Vol 13 (2) ◽  
pp. 110-122
Author(s):  
Bandaru Nagaraju ◽  
A. Ramu ◽  
S. Vidhyadhara
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Methanolic Extract ◽  
Neuroprotective Effect ◽  
Ethyl Acetate Fraction ◽  
Acetylcholinesterase Activity ◽  
Male Rats ◽  
Neuroprotective Effects ◽  
And Oxidative Stress

Nature is the best source of complementary and alternative medicine. The plant Biophytum reinwardtii has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, fraction of methanolic extract of Biophytum reinwardtii was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetyl cholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of HEMBR on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with HEMBR (i.e., 50 and 100 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 7 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test and, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), reduced glutathione (GSH) and acetylcholinesterase (AChE) activity in rat brain tissue homogenates. The present study demonstrates that HEMBR showed the neuroprotective effect by improving cognitive functions and reduces oxidative stress by increasing the level of brain antioxidant enzymes as well as decreasing acetylcholinesterase activity. Therefore, this plant extract faction can be used for enhancing learning, memory, antioxidant potentiality and anti-acetylcholinesterase activity in neurodegenerative disorders like AD.

scholarly journals Neuroprotective effect of resveratrol against scopolamine-induced cognitive impairment and oxidative stress in rats

2013 ◽  
Vol 65 (4) ◽  
pp. 1381-1386 ◽  
Author(s):  
Bunadri Pushpalatha ◽  
Neerati Venumadhav ◽  
Merugu Swathi ◽  
Butchi Raju
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Neuroprotective Effect ◽  
And Oxidative Stress

scholarly journals NXP032 Ameliorates Aging-Induced Oxidative Stress and Cognitive Impairment in Mice through Activation of Nrf2 Signaling

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 130
Author(s):  
Jae-Min Lee ◽  
Joo Hee Lee ◽  
Min Kyung Song ◽  
Youn-Jung Kim
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Vitamin C ◽  
Neuronal Damage ◽  
Chemical Properties ◽  
Brain Regions ◽  
Dna Aptamer ◽  
Antioxidant Vitamin ◽  
Neuroprotective Effects ◽  
And Oxidative Stress

Aging is a neurodegenerative disease that leads to cognitive impairment, and an increase in oxidative stress as a major cause is an important factor. It has been reported that aging-related cognitive impairment is associated with increased oxidative damage in several brain regions during aging. As a powerful antioxidant, vitamin C plays an important role in preventing oxidative stress, but due to its unstable chemical properties, it is easily oxidized and thus the activity of antioxidants is reduced. In order to overcome this easily oxidized vulnerability, we developed NXP032 (vitamin C/DNA aptamer complex) that can enhance the antioxidant efficacy of vitamin C using an aptamer. We developed NXP032 (vitamin C/DNA Aptamin C320 complex) that can enhance the antioxidant efficacy of vitamin C using an aptamer. In the present study, we evaluated the neuroprotective effects of NXP032 on aging-induced cognitive decline, oxidative stress, and neuronal damage in 17-month-old female mice. NXP032 was orally administered at 200 mg/kg of ascorbic acid and 4 mg/kg of DNA aptamer daily for eight weeks. Before the sacrifice, a cognitive behavioral test was performed. Administration of NXP032 alleviated cognitive impairment, neuronal damage, microglia activity, and oxidative stress due to aging. We found that although aging decreases the Nrf2-ARE pathway, NXP032 administration activates the Nrf2-ARE pathway to increase the expression of SOD-1 and GSTO1/2. The results suggest that the new aptamer complex NXP032 may be a therapeutic intervention to alleviate aging-induced cognitive impairment and oxidative stress.

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