scholarly journals COVID-19: additive manufacturing response in the UK

2020 ◽  
Vol 4 (3) ◽  
pp. 167-174
Author(s):  
Elen J Parry ◽  
Craig E Banks
Keyword(s):  
Additive Manufacturing ◽  
Severe Acute Respiratory Syndrome ◽  
Medical Equipment ◽  
Lessons Learned ◽  
Protective Equipment ◽  
Safety Regulations ◽  
Novel Coronavirus ◽  
The Uk ◽  
Am Processes ◽  
Regulatory Landscape

Severe acute respiratory syndrome coronavirus 2, a novel coronavirus, caused global disruption specifically in linear supply chains. Increased demand for already disrupted services led to a global shortage of medical equipment and personal protective equipment. Use of additive manufacturing (AM) processes by the manufacturing community has shown great innovation, agility and flexibility to fill supply chain gaps and meet shortfalls. In the context of contingency reaction to a global healthcare emergency, decisions have had to be made quickly, in some cases bypassing device safety regulations. This concentrated and spontaneous use of AM has highlighted the challenges and risks of such innovation, which we discuss in relation to the UK’s current regulatory landscape. We have discussed lessons learned and the potential future impact upon wider use of AM in healthcare.

Challenges post-COVID-19: planning strategies to resume elective dentistry and allied surgical specialities

2020 ◽  
Vol 26 (6) ◽  
pp. 1-4
Author(s):  
Melissa Loh ◽  
Karthikeyan Iyengar ◽  
William YC Loh
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Surgical Management ◽  
Personal Protective Equipment ◽  
Dental Treatment ◽  
Protective Equipment ◽  
Limited Availability ◽  
Viral Spread ◽  
Elective Treatment ◽  
Planning Strategies ◽  
The Uk

The effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on the NHS in the UK has been profound and unprecedented. Many surgical specialities, including dentistry, throughout the country have not been exempt from this effect. As there are many aerosol-generating procedures and aerosol-generating exposures in surgical specialities, there has been a substantial cancellation of elective treatment. This has been in part because of the limited availability of personal protective equipment for surgeons as this is being use elsewhere by clinicians to aid the reduction of viral spread in the community. As the UK is preparing to emerge from the ‘lockdown’ during the pandemic, restarting elective surgical and dental treatment is an expected challenge. This article looks at the possible roadmap to recovery of elective surgical management and dentistry, taking into consideration possible predicted further peaks and troughs of COVID-19 infections.

scholarly journals Genomic epidemiology of the first epidemic wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Palestine

2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Nouar Qutob ◽  
Zaidoun Salah ◽  
Damien Richard ◽  
Hisham Darwish ◽  
Husam Sallam ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
The Novel ◽  
Public Health Burden ◽  
Genomic Epidemiology ◽  
Health Burden ◽  
The World ◽  
Significant Public Health ◽  
Novel Coronavirus ◽  
The Uk ◽  
Epidemic Wave

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus responsible for the COVID-19 pandemic, continues to cause a significant public-health burden and disruption globally. Genomic epidemiology approaches point to most countries in the world having experienced many independent introductions of SARS-CoV-2 during the early stages of the pandemic. However, this situation may change with local lockdown policies and restrictions on travel, leading to the emergence of more geographically structured viral populations and lineages transmitting locally. Here, we report the first SARS-CoV-2 genomes from Palestine sampled from early March 2020, when the first cases were observed, through to August of 2020. SARS-CoV-2 genomes from Palestine fall across the diversity of the global phylogeny, consistent with at least nine independent introductions into the region. We identify one locally predominant lineage in circulation represented by 50 Palestinian SARS-CoV-2, grouping with genomes generated from Israel and the UK. We estimate the age of introduction of this lineage to 05/02/2020 (16/01/2020–19/02/2020), suggesting SARS-CoV-2 was already in circulation in Palestine predating its first detection in Bethlehem in early March. Our work highlights the value of ongoing genomic surveillance and monitoring to reconstruct the epidemiology of COVID-19 at both local and global scales.

scholarly journals Developing the COVID-19 intensive care medical equipment distribution platform: outcomes and lessons learned

2021 ◽  
Vol 10 (2) ◽  
pp. e001383
Author(s):  
Emmanuel Adeoluwa Akinluyi ◽  
David Stell ◽  
Nayanee Perera ◽  
Christopher Sibley-Allen
Keyword(s):  
Intensive Care ◽  
Medical Equipment ◽  
Early Stage ◽  
Lessons Learned ◽  
System Capacity ◽  
Full Potential ◽  
Implementation Approach ◽  
Innovation Projects ◽  
The Uk ◽  
Clinical Engineers

During the first wave of the coronavirus pandemic, the UK government took the decision to centralise the procurement, allocation and distribution of mission-critical intensive care unit (ICU) medical equipment. Establishing new supply chains in the context of global shortages presented significant challenges. This report describes the development of an innovative platform developed rapidly and voluntarily by clinical engineers, to mobilise the UK’s shared medical equipment inventory, in order to match ICU capacity to dynamically evolving clinical demand. The ‘Coronavirus ICU Medical Equipment Distribution’ platform was developed to optimise ICU equipment allocation, distribution, collection, redeployment and traceability across the National Health Service. Although feedback on the platform has largely been very positive, the platform was built for a scenario that did not fully materialise in the UK and this affected the implementation approach. As such, it was not used to its full potential. Nonetheless, the platform and the insights derived and disseminated in its development have been extremely valuable. It provides a prototype for not only optimising system capacity in future pandemic scenarios but also a means for maximally exploiting the large amount of new equipment in the UK health system, as a result of the coronavirus pandemic. This early stage innovation has demonstrated that a system-wide pooled information resource can benefit the operations of individual organisations. It has also generated numerous lessons to be borne in mind in innovation projects.

The genomic epidemiology of SARS-CoV-2 in Palestine

2020 ◽  
Author(s):  
Nouar Qutob ◽  
Zaidoun Salah ◽  
Damien Richard ◽  
Hisham Darwish ◽  
Husam Sallam ◽  
...  
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
The Novel ◽  
Public Health Burden ◽  
Genomic Epidemiology ◽  
Health Burden ◽  
The World ◽  
Significant Public Health ◽  
Novel Coronavirus ◽  
The Uk

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus responsible for the COVID-19 pandemic, continues to cause significant public health burden and disruption globally. Genomic epidemiology approaches point to most countries in the world having experienced many independent introductions of SARS-CoV-2 during the early stages of the pandemic. However, this situation may change with local lockdown policies and restrictions on travel leading to the emergence of more geographically structured viral populations and lineages transmitting locally. Here, we report the first SARS-CoV-2 genomes from Palestine sampled from early March, when the first cases were observed, through to August of 2020. SARS-CoV-2 genomes from Palestine fall across the diversity of the global phylogeny, consistent with at least nine independent introductions into the region. We identify one locally predominant lineage in circulation represented by 50 Palestinian SARS-CoV-2, grouping with isolated viral samples from patients in Israel and the UK. We estimate the age of introduction of this lineage to 05/02/2020 (16/01/2020 - 19/02/2020), suggesting SARS-CoV-2 was already in circulation in Palestine predating its first detection in Bethlehem in early March. Our work highlights the value of ongoing genomic surveillance and monitoring to reconstruct the epidemiology of COVID-19 at both local and global scales.

scholarly journals Clinical characteristics of COVID-19 and personal protective equipment for trauma surgeons

2020 ◽  
pp. 81-83
Keyword(s):  
Infectious Disease ◽  
Phylogenetic Analysis ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Rna Viruses ◽  
Protective Equipment ◽  
Whole Genome ◽  
Positive Sense ◽  
Novel Coronavirus ◽  
Trauma Surgeons

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new virus from the coronavirus family (1) regarded as enveloped, positive-sense, single-stranded ribonucleic acid (RNA) viruses with helical symmetric nucleocapsid (2). According to the whole genome sequencing and phylogenetic analysis of coronavirus strains, a distinct clade of betacoronavirus is shown to be associated with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (3). This novel clade is called the 2019 novel coronavirus (2019-nCoV) and due to more similarity to the SARS virus is also called severe acute respiratory syndrome coronavirus 2. The disease is known as COVID-19.

scholarly journals SARS Coronavirus 2, Severe Acute Respiratory Syndrome, and Middle East Respiratory Syndrome in Children: A Review on Epidemiology, Clinical Presentation, and Diagnosis

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Seyed Ahmad Tabatabaii ◽  
Pegah Soltani ◽  
Ghamartaj Khanbabaee ◽  
Deepak Sharma ◽  
Rohollah Valizadeh ◽  
...  
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Lessons Learned ◽  
Middle East Respiratory Syndrome ◽  
Clinical Feature ◽  
Sars Coronavirus ◽  
Control And Prevention ◽  
Novel Coronavirus

Context: Coronavirus Disease 2019 (COVID-19) pandemic has caused irreparable damage to society. The pediatric population may be asymptomatic but has positive viral nucleic acid test results and plays an important role in spreading the infection in populations. However, there is a substantial information gap on the epidemiology, pathology, and clinical presentations of COVID-19 in pediatric patients. Evidence Acquisition: English research articles published before April 18, 2020, were reviewed to understand the clinical characteristics of SARS coronavirus 2, Severe Acute Respiratory Syndrome, and Middle East Respiratory Syndrome in children. The WHO (https://www.who. int/) and CDC (Centers for Disease Control and Prevention, https://www.cdc.gov/) websites were also reviewed to find eligible studies, besides articles extracted from PubMed, Scopus, and Google Scholar. Results: In comparison with SARS and MERS, COVID-19 seems to have wider clinical symptoms and routes of transmission. Multisystem inflammatory syndrome is a unique clinical feature of this novel virus. The low prevalence of COVID-19 in children may be due to lower contacts or incomplete identification rather than resistance to the virus. Conclusions: As this virus is novel, we believe that lessons learned from SARS and MERS outbreaks are very valuable in handling the current pandemic. The aim of this paper was to provide the updated summary of clinical manifestation, diagnostic, molecular, and genetic aspects of the novel coronavirus in comparison with SARS and MERS coronaviruses in children.

Institutional developments, standards and river quality: a UK history and some lessons for industrialising countries

1996 ◽  
Vol 33 (3) ◽  
pp. 211-222 ◽  
Author(s):  
D. W. M. Johnstone ◽  
N. J. Horan
Keyword(s):  
Middle Ages ◽  
Aquatic Environment ◽  
Industrial Revolution ◽  
Integrated Management ◽  
Sewage Treatment ◽  
Lessons Learned ◽  
Process Manufacturing ◽  
Treatment And Disposal ◽  
The Uk ◽  
Developed World

From the middle ages until the early part of the nineteenth century the streets of European cities were foul with excrement and filth to the extent that aristocrats often held a clove-studded orange to their nostrils in order to tolerate the atmosphere. The introduction in about 1800 of water-carriage systems of sewage disposal merely transferred the filth from the streets to the rivers. The problem was intensified in Britain by the coming of the Industrial Revolution and establishment of factories on the banks of the rivers where water was freely available for power, process manufacturing and the disposal of effluents. As a consequence the quality of most rivers deteriorated to the extent that they were unable to support fish life and in many cases were little more than open sewers. This was followed by a period of slow recovery, such that today most of these rivers have been cleaned with many having good fish stocks and some even supporting salmon. This recovery has not been easy nor has it been cheap. It has been based on the application of good engineering supported by the passing and enforcement of necessary legislation and the development of suitable institutional capacity to finance, design, construct, maintain and operate the required sewerage and sewage treatment systems. Such institutional and technical systems not only include the disposal of domestic sewage but also provisions for the treatment and disposal of industrial wastewaters and for the integrated management of river systems. Over the years a number of institutional arrangements and models have been tried, some successful other less so. Although there is no universally applicable approach to improving the aquatic environment, many of the experiences encountered by the so-called developed world can be learned by developing nations currently attempting to rectify their own aquatic pollution problems. Some of these lessons have already been discussed by the authors including some dangers of copying standards from the developed world. The objective of this paper is to trace the steps taken over many years in the UK to develop methods and systems to protect and preserve the aquatic environment and from the lessons learned to highlight what is considered to be an appropriate and sustainable approach for industrialising nations. Such an approach involves setting of realistic and attainable standards, providing appropriate and affordable treatment to meet these standards, establishment of the necessary regulatory framework to ensure enforcement of the standards and provision of the necessary financial capabilities to guarantee successful and continued operation of treatment facilities.

Novel Coronavirus Disease (COVID-19): A Narrative Review Based on Current Status

2020 ◽  
Vol 18 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Relevant Literature ◽  
World Health ◽  
Current Status ◽  
Future Research ◽  
Treatment And Prevention ◽  
First Case ◽  
Novel Coronavirus

Abstract:: A novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared and expanded globally by the end of year in 2019 from Wuhan, China, causing severe acute respiratory syndrome. During its initial stage, the disease was called the novel coronavirus (2019-nCoV). It was named COVID-19 by the World Health Organization (WHO) on 11 February 2020. The WHO declared worldwide the SARS-CoV-2 virus a pandemic on March 2020. On 30 January 2020 the first case of Corona Virus Disease 2019 (COVID-19) was reported in India. Now in current situation the virus is floating in almost every part of the province and rest of the globe. -: On the basis of novel published evidences, we efficiently summarized the reported work with reference to COVID-19 epidemiology, pathogen, clinical symptoms, treatment and prevention. Using several worldwide electronic scientific databases such as Pubmed, Medline, Embase, Science direct, Scopus, etc were utilized for extensive investigation of relevant literature. -: This review is written in the hope of encouraging the people successfully with the key learning points from the underway efforts to perceive and manage SARS-CoV-2, suggesting sailent points for expanding future research.

scholarly journals Visitor Restriction Policy on Pediatric Wards During Novel Coronavirus (COVID-19) Outbreak: A Survey Study Across North America

2020 ◽  
Author(s):  
Taito Kitano ◽  
Pierre-Philippe Piché-Renaud ◽  
Helen E Groves ◽  
Laurie Streitenberger ◽  
Renee Freeman ◽  
...  
Keyword(s):  
North America ◽  
Personal Protective Equipment ◽  
Survey Study ◽  
Protective Equipment ◽  
The Novel ◽  
Restriction Policy ◽  
Novel Coronavirus

Abstract Visitor restriction policies in pediatric wards during the novel coronavirus (COVID-19) outbreak are variable. Among 36 hospitals that responded to our survey, 97% allowed at least 1 visitor, with 67% restricting to 1 caregiver. Sixty-nine percent required the visitor to wear personal protective equipment and only 19% allowed non-household visitors.

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