Regional lymph node metastases in breast cancer

2013 ◽  
pp. 32-41
Author(s):  
Sarah DeSnyder
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Node Metastases

Additional Prone 18F-FDG PET/CT Acquisition to Improve the Visualization of the Primary Tumor and Regional Lymph Node Metastases in Stage II/III Breast Cancer

2016 ◽  
Vol 41 (4) ◽  
pp. e181-e186 ◽  
Author(s):  
Suzana Cipriano Teixeira ◽  
Bas B. Koolen ◽  
Wouter V. Vogel ◽  
Jelle Wesseling ◽  
Marcel P. M. Stokkel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Regional Lymph Node ◽  
Pet Ct ◽  
Node Metastases ◽  
18F Fdg ◽  
Fdg Pet Ct

DNA ploidy and helix pomatia lectin binding as predictors of regional lymph node metastases and prognostic factors in breast cancer

1993 ◽  
Vol 26 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Masakuni Noguchi ◽  
Michael Thomas ◽  
Hirohisa Kitagawa ◽  
Kazuo Kinishita ◽  
Shinich Kinami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Dna Ploidy ◽  
Regional Lymph Node ◽  
Lectin Binding ◽  
Helix Pomatia ◽  
Node Metastases ◽  
Helix Pomatia Lectin

A multivariate study of the relationship between regional lymph node metastases and prognosis in patients with operable breast cancer

1991 ◽  
Vol 21 (6) ◽  
pp. 613-620 ◽  
Author(s):  
Masakuni Noguchi ◽  
Takao Taniya ◽  
Naohiro Koyasaki ◽  
Nagayoshi Ohta ◽  
Itsuo Miyazaki
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Operable Breast Cancer ◽  
Multivariate Study ◽  
Node Metastases ◽  
The Relationship

Comparative Analysis of Coagulation System Proteins Distribution in Breast Cancer Primary Lesions and Lymph Node Metastases.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3137-3137
Author(s):  
Marek Wojtukiewicz ◽  
Ewa Sierko ◽  
Zbigniew Sawicki ◽  
Lech Zimnoch ◽  
Walter Kisiel
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Cells ◽  
Tissue Factor ◽  
Lymph Node Metastases ◽  
Primary Tumor ◽  
Regional Lymph Node ◽  
Coagulation System ◽  
Metastatic Lesions ◽  
Node Metastases

Abstract Breast cancer is the most frequent cause of morbidity and mortality due to cancer in women. Thromboembolic episodes are relatively common complication during the course of the disease. It was widely documented, that components of blood coagulation play a role in tumor progression and metastasis formation. Presence of hemostatic proteins was observed in primary lesions of different malignant tumors. However, information on expression and role of coagulation system components in regional lymph node metastases is scanty. The purpose of the study was to assess and compare the distribution of selected coagulation proteins - in primary versus metastatic lesions of breast cancer. Specimens of primary tumor of different degree of malignancy and metastatic lesions localized in regional lymph nodes were obtained during surgical treatment of previously untreated twenty five breast cancer patients and fixed in formalin. Immunohistochemical procedure was employed using monoclonal and polyclonal antibodies against tissue factor (TF), tissue factor pathway inhibitor (TFPI), factor IX, factor X, fibrinogen and fibrin. A strong expression of TF was demonstrated in cancer cells of both primary tumors and lymph node metastases. Coagulation factors IX and X were also present in primary and metastatic breast cancer lesions. However, the expression of the proteins was weaker in regional lymph node metastases than in primary tumor. Strong staining for fibrinogen was detected in the stroma of primary breast cancer, particularly at the area adjacent to the cancer foci. Stroma of metastatic lesions was characterized by much weaker staining for fibrinogen. Strong expression of fibrin and TFPI was demonstrated in cancer cells of primary tumor while much weaker expression of the antigens was visualized in cancer cells localized in lymph node metastatic lesions. Furthermore, the presence of all examined proteins was observed in small blood vessel walls and in macrophages infiltrating both primary tumor tissue as well as metastatic lesions. The results of the study indicate extravascular activation of blood coagulation in loco in breast cancer, both in the primary tumor and in the regional lymph node metastatic lesions. The presence of coagulation system proteins in cancer tissue (primary tumor and metastatic foci) suggests that they may play a role in the biology of breast cancer growth as well as they may modulate breast cancer metastatic dissemination.

scholarly journals Nodal Positive Breast Cancer and Its Regional Lymph Node Involvement

2021 ◽  
Author(s):  
Heidrun Maennle ◽  
Matthias Frank ◽  
Felix Momm ◽  
Jan Willem Siebers
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Lymph Node Status ◽  
Nodal Stage ◽  
Node Metastases ◽  
Level I ◽  
Positive Breast Cancer

Abstract Purpose: In breast cancer, the lymph node status is of prognostic importance and a decisive factor in therapy planning. This study shows the distribution of lymph nodes metastases of node-positive breast cancer patients. Risk factors for lymph node metastases are described.Methods: 2095 patients with primary breast cancer were analyzed. Analysis included descriptive analysis (median, standard deviation, ranges) and statistical analysis (Chi², discriminant analysis).Results: The nodal stage was positive in 39.4% of all patients and negative in 60.6%. If the nodal stage was positive, only 1 lymph node was involved in 36% of the patients; more than 1 lymph node was involved in 64% of the patients. With an increasing number of lymph node metastases in level I, the probability of an involvement in level III also increases (F 437.845, p = .000). Other indicators are evidence of hemangiosis (F 247.728, p = .000) or lymphangiosis (F 167.368, P = .000). Despite <10 affected lymph nodes, 3.4% of the patients had nodal stage N3 due to level III involvement.Conclusion: Even with only a small number of lymph node metastases in level I higher lymphatic stations are often affected. The data cannot lead to a decision regarding an operation or radiation indication, but they can better substantiate the risk for certain therapy decisions.

Elevated ras oncogene expression correlates with lymph node metastases in breast cancer patients.

1986 ◽  
Vol 4 (9) ◽  
pp. 1321-1325 ◽  
Author(s):  
J Lundy ◽  
R Grimson ◽  
Y Mishriki ◽  
S Chao ◽  
S Oravez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Estrogen Receptor Status ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Primary Tumors ◽  
Ras P21 ◽  
Node Metastases

The protein product of the ras cellular oncogene(s) (p21) was assayed in primary breast carcinomas from two groups of patients who had different axillary lymph node status. Using an immunohistochemical assay, the intensity and percent of neoplastic cells demonstrating ras p21 antigen staining were significantly higher in the primary tumors from patients with lymph nodes positive (LN+) for malignancy (20 patients) compared with the lymph node negative (LNO) group (21 patients). The expression of p21 also correlated with tumor size. Age and estrogen receptor status did not influence p21 staining. The antigen expression of p21 was similar in intensity and distribution in the primary tumor and regional lymph node metastases. Enhanced expression of p21 in primary breast cancers that metastasize to regional nodes indicates that ras p21 may be a determinant of the malignant potential of breast cancer cells and may represent a new class of more biologically relevant tumor markers.

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