Spray Dried Micronized Particles and Electrostatic Separation

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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A Comparison of Spray Dried and Agglomerated Maltodextrins of Various Dextrose Equivalence as Binders in Top Drive Acetaminophen Granulations Using Cold Water as the Binding Solution

10.26226/morressier.57d6b2bed462b8028d88d6ec ◽

2016 ◽

Author(s):

Susan Freers

Keyword(s):

Cold Water ◽

Spray Dried

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Structural characterization of spray-dried microgranules by spin-echo small-angle neutron scattering

Powder Technology ◽

10.1016/j.powtec.2020.10.035 ◽

2021 ◽

Vol 378 ◽

pp. 680-684

Author(s):

Priyanka Biswas ◽

Debasis Sen ◽

Wim Bouwman

Keyword(s):

Neutron Scattering ◽

Structural Characterization ◽

Small Angle ◽

Small Angle Neutron Scattering ◽

Spin Echo ◽

Spray Dried

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The automated determination of alkyl aryl sulfonates in spray-dried detergents by ultraviolet absorption

Journal of the American Oil Chemists Society ◽

10.1007/bf02638870 ◽

1970 ◽

Vol 47 (6) ◽

pp. 200-202 ◽

Cited By ~ 1

Author(s):

E. H. Brandli ◽

R. M. Kelley

Keyword(s):

Ultraviolet Absorption ◽

Alkyl Aryl ◽

Automated Determination ◽

Spray Dried

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Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration

Pharmaceutics ◽

10.3390/pharmaceutics13050608 ◽

2021 ◽

Vol 13 (5) ◽

pp. 608

Author(s):

Csilla Bartos ◽

Patrícia Varga ◽

Piroska Szabó-Révész ◽

Rita Ambrus

Keyword(s):

Drug Delivery ◽

Spray Drying ◽

Process Parameters ◽

Sodium Tripolyphosphate ◽

Structural Characteristics ◽

Nasal Administration ◽

Drug Bioavailability ◽

Intranasal Application ◽

Spray Dried

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy. Thanks to the bonding of chitosan to the nasal mucosa and its permeability-enhancing effect, it is an excellent choice to formulate microspheres for the increase of drug bioavailability. The aim of our work includes the preparation of spray-dried cross-linked and non-cross-linked chitosan-based drug delivery systems for intranasal application, the optimization of spray-drying process parameters (inlet air temperature, pump rate), and the composition of samples. Cross-linked products were prepared by using different amounts of sodium tripolyphosphate. On top of these, the micrometric properties, the structural characteristics, the in vitro drug release, and the in vitro permeability of the products were studied. Spray-drying resulted in micronized chitosan particles (2–4 μm) regardless of the process parameters. The meloxicam (MEL)-containing microspheres showed nearly spherical habit, while MEL was present in a molecularly dispersed state. The highest dissolved (>90%) and permeated (~45 µg/cm2) MEL amount was detected from the non-cross-linked sample. Our results indicate that spray-dried MEL-containing chitosan microparticles may be recommended for the development of a novel drug delivery system to decrease acute pain or enhance analgesia by intranasal application.

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Spray-Dried Plasma Improves Body Weight, Intestinal Barrier Function, and Tibia Strength during Experimental Constant Heat Stress Conditions

Animals ◽

10.3390/ani11082213 ◽

2021 ◽

Vol 11 (8) ◽

pp. 2213

Author(s):

Jared Ruff ◽

Thaina L. Barros ◽

Joy Campbell ◽

Ricardo González-Esquerra ◽

Christine N. Vuong ◽

...

Keyword(s):

Heat Stress ◽

Intestinal Barrier ◽

Fluorescein Isothiocyanate ◽

Serum Levels ◽

Negative Control ◽

Intestinal Barrier Function ◽

Negative Consequences ◽

Fluorescein Isothiocyanate Dextran ◽

Prolonged Heat ◽

Spray Dried

The aim of this study was to see how spray-dried plasma (SDP) supplementation affected broiler chicken performance, intestinal permeability, and bone strength during persistent heat stress. One-day-old chicks (n = 480) were randomly assigned into twelve environmental corrals; four thermoneutral (TN-negative control, maintained at 24 °C from d 21–42); four heat stress (HS, exposed to 35 °C from d 21–42); and four heat stress treated with 2% SDP in the feed until d 28 followed by 1% SDP until d 42 (HS-SDP). The performance and serum levels of fluorescein isothiocyanate-dextran (FITC-d) were evaluated at d 21, 28, 35, and 42. The tibias strength was evaluated on d 21 and 42. The increment in chicken temperature (p < 0.05) was observed two h following the increase in environmental temperature in both HS groups and was associated with decreased performance parameters compared with the TN group. At d 42 of age, the chickens exposed to HS had an impaired gut permeability and decreased tibia strength compared to the TN group (p < 0.05). However, partially feeding SDP mitigated these adverse effects significantly. These findings imply that using SDP strategically during stressful times, such as prolonged heat stress, may help mitigate its negative consequences.

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