scholarly journals Injectable Microcarriers as Human Mesenchymal Stem Cell Support and their Application for Cartilage and Degenerated Intervertebral Disc Repair

2015 ◽  
Vol 29 ◽  
pp. 70-81 ◽  
Author(s):  
A Bertolo ◽  
◽  
S Häfner ◽  
AR Taddei ◽  
M Baur ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Intervertebral Disc ◽  
Human Mesenchymal Stem Cell ◽  
Stem Cell Support ◽  
Disc Repair ◽  
Intervertebral Disc Repair ◽  
Cell Support

scholarly journals Timing of mesenchymal stem cell delivery impacts the fate and therapeutic potential in intervertebral disc repair

2017 ◽  
Vol 35 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Robert Maidhof ◽  
Asfi Rafiuddin ◽  
Farzana Chowdhury ◽  
Timothy Jacobsen ◽  
Nadeen O. Chahine
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Intervertebral Disc ◽  
Therapeutic Potential ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
Disc Repair ◽  
Intervertebral Disc Repair

scholarly journals Human mesenchymal stem cell co-culture modulates the immunological properties of human intervertebral disc tissue fragments in vitro

2010 ◽  
Vol 20 (4) ◽  
pp. 592-603 ◽  
Author(s):  
Alessandro Bertolo ◽  
Thomas Thiede ◽  
Niklaus Aebli ◽  
Martin Baur ◽  
Stephen J. Ferguson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Intervertebral Disc ◽  
Human Mesenchymal Stem Cell ◽  
Immunological Properties ◽  
Disc Tissue

scholarly journals Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a

Cell Cycle ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 256-270
Author(s):  
Tao Wen ◽  
Hongshen Wang ◽  
Yongjin Li ◽  
Yongpeng Lin ◽  
Shuai Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Extracellular Vesicles ◽  
Intervertebral Disc Degeneration

scholarly journals The CXCL12 Crossroads in Cancer Stem Cells and Their Niche

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 469
Author(s):  
Juan Carlos López-Gil ◽  
Laura Martin-Hijano ◽  
Patrick C. Hermann ◽  
Bruno Sainz
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tumor Microenvironment ◽  
Cancer Stem Cells ◽  
Crucial Role ◽  
Diverse Group ◽  
Hematopoietic Stem ◽  
Stem Cell Support ◽  
Cell Support ◽  
Tumor Entities

Cancer stem cells (CSCs) are defined as a subpopulation of “stem”-like cells within the tumor with unique characteristics that allow them to maintain tumor growth, escape standard anti-tumor therapies and drive subsequent repopulation of the tumor. This is the result of their intrinsic “stem”-like features and the strong driving influence of the CSC niche, a subcompartment within the tumor microenvironment that includes a diverse group of cells focused on maintaining and supporting the CSC. CXCL12 is a chemokine that plays a crucial role in hematopoietic stem cell support and has been extensively reported to be involved in several cancer-related processes. In this review, we will provide the latest evidence about the interactions between CSC niche-derived CXCL12 and its receptors—CXCR4 and CXCR7—present on CSC populations across different tumor entities. The interactions facilitated by CXCL12/CXCR4/CXCR7 axes seem to be strongly linked to CSC “stem”-like features, tumor progression, and metastasis promotion. Altogether, this suggests a role for CXCL12 and its receptors in the maintenance of CSCs and the components of their niche. Moreover, we will also provide an update of the therapeutic options being currently tested to disrupt the CXCL12 axes in order to target, directly or indirectly, the CSC subpopulation.

Sign in / Sign up

Export Citation Format

Share Document