scholarly journals A Review on Gastro-Retentive Floating Microspheres

2021 ◽  
Vol 11 (1-s) ◽  
pp. 131-138
Author(s):  
Anuradha A. Birajdar ◽  
Madhuri T. Deshmukh ◽  
Rajkumar V. Shete
Keyword(s):  
Gastric Juice ◽  
Retention Time ◽  
Gastric Fluid ◽  
Inappropriate Drug ◽  
Gastric Retention ◽  
Gastric Emptying Rate ◽  
Drug Candidates ◽  
Floating System ◽  
Gastric Retention Time ◽  
Gastro Retentive

The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application. Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods

A REVIEW ON MICRO-BALLOONS

2018 ◽  
pp. 1-2
Author(s):  
Gupta B ◽  
Mishra R ◽  
Mishra I
Keyword(s):  
Gastric Emptying ◽  
Retention Time ◽  
Drug Targeting ◽  
Extended Period ◽  
Prolonged Release ◽  
Gastric Retention ◽  
Low Density ◽  
Methods Of Evaluation ◽  
Gastric Retention Time

Oral prolonged release systems are manufactured to release the drug in-vivo with privies to enhance bioavailability, diminish untoward effectsand enhance effectiveness of drugs. Microballoons or hollow microspheres are anticipated to persist buoyant in a permanent way upon the gastricingredients. The various formulations comprise unfilled microspheres, powders, capsules, tablets and laminated films. Micro-balloons aredistinctly attaining attention due to their immense significance in the drug targeting to the stomach. These floating micro-balloons have theconvenience that they stay buoyant and circulate uniformly over the gastric ingredients to refrain the variations of gastric emptying and releasethe drug for extended period of time. Multiparticulate particles of low density can efficiently prolong the gastric retention time of drugs. Thisarticle provides an insight of fabrication and methods of evaluation of micro-balloons.

scholarly journals Microballoons: A Gastro Retentive Drug Delivery System

2019 ◽  
Vol 9 (4-s) ◽  
pp. 625-630
Author(s):  
Ankita Srivastava ◽  
Ruchi Shukla ◽  
Kusum Sharma ◽  
Hitesh Jain ◽  
D. B. Meshram
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Fluid ◽  
Oral Route ◽  
Gastric Retention ◽  
Preparation Temperature ◽  
Novel Technology ◽  
Floating Drug Delivery ◽  
Gastro Retentive

Oral route is most preferable and widely used route for the administration of drug. Microballoons becomes novel technology in pharmaceutical field in the floating drug delivery for achieving the gastric retention. Microballoons are also called as hollowspheres which are porous smooth in nature and thus show good floating properties in gastric fluid. Microballoons release the drug in controlled manner at the targeted site. Microballoons are spherical empty vesicles without core and that can remain buoyant in gastric region for prolong period of time without irritation in gastrointestinal tract. Multiparticulate particles having a low density system that can efficiently prolong the gastric retention time of the drugs, thus enhanced bioavailability and thus improve the dosing frequency. These are less soluble at higher pH environment. As microballoons delivery systems provide longer retention in gastric pH and enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microballoons depend on the preparation, temperature and the surface smoothness determine the floatability and the release rate of microballoons. Keywords: Microballoons, Gastro retentive drug delivery system, Hollowspheres, Controlled release

scholarly journals A REVIEW ON FLOATING MICROSPHERES

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
T. S. SHINDE ◽  
A. N. BARHATE
Keyword(s):  
Retention Time ◽  
In Vitro Dissolution ◽  
Current Status ◽  
Special Focus ◽  
Gastric Retention ◽  
Oral Formulations ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Gastric Retention Time

The purpose of writing this review on floating microspheres is to compile the recent literature with special focus on the principle mechanism of floatation to achieve gastric retention. Recent advances indicate that floating microspheres are especially suitable for achieving sustained or delayed release oral formulations with flexibility of blending to attain different release patterns, low risk of dose dumping as well as reproducible and short gastric retention time. One of the approaches toward this goal is to develop the floating microspheres so as to increase the gastric retention time. In this review, the current status of floating microspheres including hollow microspheres (micro balloons) and their characterization, advantages, disadvantages, mechanism and method of preparation for gastric retention of drug are discussed. This review also summarizes the in-vitro dissolution study to evaluate the performance and applications of floating microspheres. Keywords: Floating microspheres, Floating Drug Delivery System, Gastro Retention, Bioavailability, Hydro dynamically Balanced Systems.

Floating Microspheres - to Prolong the Gastric Retention Time in Stomach

2012 ◽  
Vol 9 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Priyanka Bhadouriya ◽  
Manish Kumar ◽  
Kamla Pathak
Keyword(s):  
Retention Time ◽  
Gastric Retention ◽  
Gastric Retention Time

Drug-Excipient Interaction during Formulation Development, in vitro andin vivo Evaluation of Gastroretentive Drug Delivery System for Nizatidine

2013 ◽  
Vol 6 (4) ◽  
pp. 2281-2293
Author(s):  
Kishan V ◽  
Ramireddy Amarnath Reddy ◽  
Ramesh Bomma
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Retention Time ◽  
Prolonged Release ◽  
Matrix Tablet ◽  
Gastric Retention ◽  
Human Volunteers ◽  
Controlled Release Tablets ◽  
Gastric Retention Time

The present investigation dealswith the development and evaluation of floating tablets of nizatidine to prolong the gastric residence time, increase local delivery of drug to the H2-receptor of the parietal cell wall to reduce stomach acid secretion. The drug-excipient compatibility studies were conducted by using FTIR, DSC and visual observations. Citric acid inclusion in formulations resulted in incompatibility and the composition was modified to eliminate the problem of incompatibility. Floating matrix tablets of nizatidine were developed by direct compression method using hydroxypropyl methylcellulose (HPMC K4M) and polyox WSR 1105 alone as release retardants and sodium bicarbonate as a gas-generating agent. Alleleven formulations exhibited satisfactory physicochemical characteristics andin vitro buoyancy. Formulations F6 and F10 exhibited controlled and prolonged drug release for 10 h with zero order release. Formulation (F10) was selected as optimized formulation based on physicochemical properties and in vitro drug release and was used inradiographic studies by incorporating BaSO4. The radiographic studies were conducted in comparison with plain controlled release tablets. These studies revealed that gastric retention time of floating and plain controlled release tablets in fasting state were 2 ± 0.86 h and ≤ 0.5 h respectively in human volunteers. Gastric retention time of floating and plain controlled release tablets in fed state were 5.33 ± 0.57 h and 1.66 ± 0.28 h respectively in human volunteers. In conclusion, optimal floating matrix tablet for nizatidine with desired in vitro buoyancy, in vivo gastric retention time and prolonged release could be prepare

Assessment of gastric retention time through a magnetic indigestible particle: Preliminary results

2007 ◽  
Vol 1300 ◽  
pp. 275-278 ◽  
Author(s):  
T. Córdova-Fraga ◽  
E. Hernández ◽  
R. Huerta ◽  
M. Vargas ◽  
A. Bradshaw ◽  
...  
Keyword(s):  
Retention Time ◽  
Gastric Retention ◽  
Preliminary Results ◽  
Gastric Retention Time

Evaluation of the effect of food and specific gravity of tablets on gastric retention time

1987 ◽  
Vol 35 (3) ◽  
pp. 187-191 ◽  
Author(s):  
S. Sangekar ◽  
W.A. Vadino ◽  
I. Chaudry ◽  
A. Parr ◽  
R. Beihn ◽  
...  
Keyword(s):  
Specific Gravity ◽  
Retention Time ◽  
Gastric Retention ◽  
Effect Of Food ◽  
Gastric Retention Time

Novel Swellable/Expandable Gastroretentive Floating Films of Gliclazide Folded in Capsule Shell for the Effective Management of Diabetes Mellitus: Formulation Development, Optimization and In vitro Evaluation

2020 ◽  
Vol 15 ◽  
Author(s):  
Diksha Sharma ◽  
Deepak Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Drug Absorption ◽  
Gastric Fluid ◽  
Stability Study ◽  
Gastric Retention ◽  
Effective Management ◽  
In Vitro Evaluation ◽  
Capsule Shell ◽  
Study Results

Background: Gliclazide (GLZ) belongs to the second-generation of sulphonylureas, is a drug of choice for the management of type II DM. It belongs to BCS Class II. The major site of drug absorption for GLZ is the stomach; it displayed variation in the drug absorption rate and bioavailability due to the shorter gastric retention time. Floating mechanism performance gets affected when the gastric fluid level not sufficiently higher, which ultimately obstructs the floating behavior, which is the major limitation of reported formulations. This limitation can get over by folded the film into the capsule shell that dissolved in gastric fluid and film swell/expands to dimensions higher than pylorus sphincter (12mm), thus prevents its evacuation. Objective: To explore the floating mechanism in the designing of films along with a tendency to expand by swelling and unfolding by utilizing a mixture of hydrophilic and hydrophobic polymer to achieve the controlled drug delivery and prolonged gastric retention of drug. Methods: The gastroretentive floating films were formulated by the solvent casting technique using 32 full factorial design and subjected to in vitro evaluation parameters, drug-excipient compatibility, X-ray diffraction and accelerated stability study. Results: The pre-formulation study established the purity and identification of drug. FTIR study confirmed no drug excipient interaction. F3, F6, and F9 were optimized based on in vitro floating characteristics, swelling/expanding ability, and unfolding time study. All developed formulations were unfolded within 14-22 min after capsule disintegration. The F3 was selected as final formulation as its ability to control the release of drug for 24 hrs followed by Zero-order kinetics having super case 2 transport. XRD confirmed the amorphousness of drug within formulation. The stability study results revealed that formulation was quite stable at extreme storage condition. Conclusion: The developed novel formulation has a good potential for the effective management and treatment of Diabetes Mellitus.

scholarly journals A Comprehensive Review on Floating Drug Delivery System (FDDS)

2020 ◽  
Vol 10 (6) ◽  
pp. 174-182
Author(s):  
Aishwarya Rajendra Bhosale ◽  
Jitendra V Shinde ◽  
Rajashree S. Chavan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Gastric Emptying Rate ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.

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