scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF 5-FLUROURASIL AND ECONAZOLE GEL USING RICE BRAN WAX

2017 ◽  
Vol 7 (4) ◽  
Author(s):  
Rajeev Malviya ◽  
MD Khirsagar ◽  
AV Chandewar
Keyword(s):  
Rice Bran ◽  
Formulation Development ◽  
Rice Bran Wax

Formulation Development and Evaluation of Sustained Release Matrix Tablets of Guaiphenesin

2016 ◽  
Vol 9 (3) ◽  
pp. 3312-3316
Author(s):  
Ganesh D. Basarkar ◽  
Ketan H. Shah ◽  
Madhuri B. Sonawane
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Rice Bran ◽  
Half Life ◽  
Water Soluble ◽  
Matrix Tablet ◽  
Formulation Development ◽  
Sustained Release Formulation ◽  
Rice Bran Wax ◽  
Melt Granulation

In this study we sought to formulate and evaluate sustained release matrix tablet of guaiphenesin by melt granulation technology. The sustained release tablets were prepared by melt granulation technique using rice bran wax as a drug retardant and dibasic calcium phosphate (DCP) as a channelling agent. Guaiphenesin is an expectorant and has a short plasma half-life of one hour. Because of high frequency of administration and short biological half-life, guaiphenesin was considered as model drug. Sustained release formulation that would maintain plasma levels for 12 hours is sufficient for twice daily dosing of guaiphenesin. The compatibility of drug and wax was examined by differential scanning calorimetry (DSC). The effect of waxes at different (drug: wax) concentrations on the release profile of drug from matrix formulation were studied. Drug release was studied at pH 1.2 for 2 hour and pH 6.8 for 10 hours. A significant retardation in the drug release was observed by increasing the wax concentration. The drug release study revealed that wax concentration of 30% to be optimum. Dissolution study showed 99% drug release within 12 hrs. Kinetic modelling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport. These results suggest that the rice bran wax has good release retardant property for highly water-soluble drug such as guaiphenesin.

Oxidative Stability of Rice Bran Wax Oleogels and an Oleogel Cream Cheese Product

2018 ◽  
Vol 95 (10) ◽  
pp. 1267-1275 ◽  
Author(s):  
Clifford Park ◽  
Hanna L. Bemer ◽  
Farnaz Maleky
Keyword(s):  
Oxidative Stability ◽  
Rice Bran ◽  
Cream Cheese ◽  
Rice Bran Wax

Replacement of pork fat in frankfurter-type sausages by soybean oil oleogels structured with rice bran wax

Meat Science ◽  
2018 ◽  
Vol 145 ◽  
pp. 352-362 ◽  
Author(s):  
Taylor L. Wolfer ◽  
Nuria C. Acevedo ◽  
Kenneth J. Prusa ◽  
Joseph G. Sebranek ◽  
Rodrigo Tarté
Keyword(s):  
Soybean Oil ◽  
Rice Bran ◽  
Rice Bran Wax ◽  
Pork Fat

Evaluation of Beeswax, Candelilla Wax, Rice Bran Wax, and Sunflower Wax as Alternative Stabilizers for Peanut Butter

2019 ◽  
Vol 96 (11) ◽  
pp. 1235-1248 ◽  
Author(s):  
Jill K. Winkler‐Moser ◽  
Julie Anderson ◽  
Jeffrey A. Byars ◽  
Mukti Singh ◽  
Hong‐Sik Hwang
Keyword(s):  
Rice Bran ◽  
Peanut Butter ◽  
Rice Bran Wax ◽  
Candelilla Wax ◽  
Sunflower Wax

scholarly journals The Effect of Cooling Rate on the Microstructure and Macroscopic Properties of Rice Bran Wax Oleogels

2021 ◽  
Vol 70 (1) ◽  
pp. 135-143
Author(s):  
Yunping Yao ◽  
Hang Zhou ◽  
Wentao Liu ◽  
Changmo Li ◽  
Shuo Wang
Keyword(s):  
Cooling Rate ◽  
Rice Bran ◽  
Rice Bran Wax ◽  
Macroscopic Properties

scholarly journals ANTIEPILEPTIC RECTAL HYDROGEL LOADED WITH CARBAMAZEPINE – RICE BRAN WAX MICROSPHERES

2017 ◽  
Vol 10 (3) ◽  
pp. 264 ◽  
Author(s):  
Sreeja C Nair ◽  
Krishnapriya M ◽  
Karthika Ramesh
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Rice Bran ◽  
Ex Vivo ◽  
Rectal Mucosa ◽  
Natural Polymers ◽  
Rice Bran Wax ◽  
Release Pattern ◽  
Wide Range

ABSTRACTObjectives: The objective behind the study is to develop a mucoadhesive rectal hydrogel from carbamazepine (CBZ) – rice bran wax (RBW)microspheres for the purpose of controlled release for the treatment of epilepsy.Methods: The study was conducted to formulate controlled release rectal hydrogel loaded with CBZ – RBW microspheres in two different natural polymers,RBW and collagen which are prepared by modified cooling induced solidification method and gel preparation along with their evaluation studies.Results: A thorough analysis of the optimized gel revealed that all the evaluation parameters evaluated are within the acceptable limits. Further, theoptimized microsphere formulation (M5) was used to formulate it as rectal hydrogel using polymer collagen and was characterized. The mucoadhesiontime of 25% w/w collagen hydrogel (H4) was 565 minutes, allowing the loaded microspheres to be attached on rectal mucosa. In vitro drug releasefrom the mucoadhesive hydrogel formulations showed controlled drug release pattern with a maximum drug release of 96.45±0.35% for optimizedH4 formulation after 12 hr, followed zero order release pattern with diffusion mediated Higuchi model. Ex vivo permeation studies using bovine rectalmucosa revealed that H4 formulation showed greater permeability compared to control. Histopathological findings revealed that H4 formulation issafer for rectal administration without any signs of rectal irritancy. The stability studies of optimized formulation (H4) proved that hydrogel remainedstable over a wide range of temperature condition.Conclusion: Hence, the developed rectal hydrogel formulation seems to be a viable alternative to conventional drug delivery system for the effectivemanagement of epilepsy.Keywords: Carbamazepine, Rice bran wax, Rectal hydrogel, Sustainability.

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