scholarly journals GASTROPROTECTIVE NSAIDs

2018 ◽  
Vol 8 (5) ◽  
pp. 141-145
Author(s):  
Mohammad Shahnaz ◽  
Parminder Kaur ◽  
DN Prasad
Keyword(s):  
Carboxylic Acid ◽  
Adverse Effects ◽  
Side Effect ◽  
Digestive System ◽  
Natural Antioxidants ◽  
Inflammatory Activity ◽  
Natural Origin ◽  
Anti Inflammatory ◽  
Gi Inflammation ◽  
Chronic Use

NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic acid derivatives) with some antioxidants can be synthesized by esterification with various antioxidants of natural origin. The conjugates that show the retention or potentiating of anti-inflammatory activity with reduced ulcerogenic side effect could be potential gastroprotective co-drugs of NSAIDs. Keyboards: NSAIDs, Gastroprotective, ROS, Natural antioxidants, Conjugates, Ulcerogenic

scholarly journals A New Bithiophene from the Root of Echinops grijsii

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Fang-Pin Chang ◽  
Chien-Chih Chen ◽  
Hui-Chi Huang ◽  
Sheng-Yang Wang ◽  
Jih-Jung Chen ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cell Line ◽  
Natural Source ◽  
Inflammatory Activity ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Anti Inflammatory ◽  
First Time ◽  
Raw 264.7 Cell Line

A new bithiophene, 5-(4-hydroxy-3-methoxy-1-butyny)-2,2′-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (2), α-terthienyl (3), 5-(3,4-dihydroxybut-1-ynyl)-2,2′-bithiophene (4), 5-acetyl-2,2′-bithiophene (5), 5-formyl-2,2′-bithiophene (6), methyl 2,2′-bithiophene-5-carboxylate (7), 5-(but-3-en-1-ynyl)-2,2′-bithiophene (8), 5-(4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (12), 5-(3-hydroxymethyl-3-isovaleroyloxyprop-1-ynyl)-2,2′-bithiophene (13), 5-(4-hydroxy-1-butynyl)-2,2′-bithiophene (14), 5-(4-acetoxy-1-butynl)-2,2′-bithiophene (15), 2,2′-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grijisii Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.

scholarly journals Hydrophilic Phytochelators in Iron Overload Condition

2019 ◽  
Author(s):  
Zohreh Sajadi Hezaveh ◽  
Farzad Shidfar
Keyword(s):  
Adverse Effects ◽  
Iron Overload ◽  
Caffeic Acid ◽  
Iron Absorption ◽  
Kojic Acid ◽  
Inflammatory Activity ◽  
Iron Chelators ◽  
Natural Iron ◽  
Chelating Ability ◽  
Anti Inflammatory

Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible natural iron chelators including quercetin, rutin, bailcalin, silymarin, resveratrol, mimosine, tropolone, curcumine, catechin, kojic acid, and caffeic acid were investigated. Furthermore, the mechanisms through which they chelate iron were discussed. Results: The mentioned antioxidants eliminated excessive iron, decreased iron absorption, exerted antioxidant and anti-inflammatory activity without causing adverse effects and other metal deficiencies in iron overload condition. Conclusion: The combination of synthetic chelators with these antioxidants or their replacement with natural chelators could be possible treatments for iron overload.

scholarly journals Evaluation of anti-inflammatory activity of Jasminum sessiliflorum extracts

2019 ◽  
Vol 10 (3) ◽  
pp. 2515-2518
Author(s):  
Ruby Philip ◽  
Kathiresan Krishnasamy ◽  
Elessy Abraham
Keyword(s):  
Medicinal Plants ◽  
Adverse Effects ◽  
Ethyl Acetate ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Reference Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Ethyl Acetate Extracts

Medicinal plants are important resources for the development of novel anti-inflammatory agents. Synthetic anti-inflammatory drugs have several adverse effects. Medicinal plants have numerous that are safer well as better substitutes for the prevention and management of various diseases and disorders. The and ethyl acetate extracts of Jasminum were evaluated for their potential as anti-inflammatory agents in by inducing paw edema in rats using . The anti-inflammatory activity of the reference drug was compared with the extracts of Jasminum . The extracts on screening indicated the presence of such as , , , alkaloids, and . The study established significant anti-inflammatory nature of the Jasminum extracts in a manner which is dose-dependent. The results indicate that both the extracts of Jasminum possess anti-inflammatory activity of significance and can be used in the development for novel anti-inflammatory moieties.

Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives of Potential Anti-inflammatory Activity

2006 ◽  
Vol 339 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Safwat M. Rabea ◽  
Nawal A. El-Koussi ◽  
Hoda Y. Hassan ◽  
Tarek Aboul-Fadl
Keyword(s):  
Carboxylic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Derivatives Of

scholarly journals Endoscopic and Pathologic Resolution of Chronic Nonsteroidal Anti-Inflammatory Drug-Induced Diaphragm-Like Colonic Strictures and Ulceration

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Behdod Poushanchi ◽  
Hiren Vallabh ◽  
Justin Kupec
Keyword(s):  
Adverse Effects ◽  
Case Reports ◽  
Nsaid Therapy ◽  
Unique Case ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chronic Use ◽  
Colonic Strictures

The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has steadily increased and, as a result, adverse effects have become more common. Isolated case reports have documented diaphragm-like colonic strictures and ulceration as the result of NSAID use. We report a unique case of this rare side effect with documented endoscopic and histologic healing of multiple proximal diaphragm-like colonic strictures and ulceration months after simple discontinuation of NSAID therapy.

Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva

2012 ◽  
Vol 144 (1) ◽  
pp. 175-181 ◽  
Author(s):  
Md. Nurul Islam ◽  
Ran Joo Choi ◽  
Seong Eun Jin ◽  
Yeong Shik Kim ◽  
Bo Ra Ahn ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Inflammatory Activity ◽  
Angelica Decursiva ◽  
Anti Inflammatory

scholarly journals Synthesis, Characterization and Evaluation of In Vivo Anti-Inflammatory Activity of N-Substituted-1,3,4-Oxadiazole Derivatives

2020 ◽  
pp. 234-239
Author(s):  
Manisha Dhondising Rajput ◽  
C. S. Magdum. ◽  
S. K. Mohite ◽  
S. R. Kane
Keyword(s):  
Carboxylic Acid ◽  
1H Nmr ◽  
Clinical Studies ◽  
Chemical Structure ◽  
Ethyl Benzoate ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Oxadiazole Derivatives ◽  
Anti Inflammatory

The new series oxadiazole derivatives were prepared by reacting aromatic carboxylic acids.In the present work 10 different 5-substituted-1,3,4-oxadiazole -2-amine derivatives (3a -i) were synthesized. Substituted carboxylic acid is converted into substituted ethyl benzoate by esterification. Different ethyl benzoate is converted into different aroyl hydrazide by treating with hydrazine hydrate.The different aroyl hydrazide is converted 5-substituted-1,3,4-oxadiazole-2-amine derivatives by treating with cyanogen bromide.Confirmation of the chemical structure of the synthesized compounds was substantiated by TLC,IR,1H NMR, and MS spectroscopy.In present study,a series of 1,3,4-oxadiazole derivatives(3a- i)were evaluated for in vivo anti-inflammatory activity by carrageenan induced paw edema method. The results of anti-inflammatory evaluation revealed that compounds 3c, 3e and3i exhibited significant anti-inflammatory activity at a dose of 25 mg kg-1 compared to indomethacin used as the reference standard.The anti-inflammatory activity investigation highlights that the synthesized compound 3e could be considered for further clinical studies.

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