scholarly journals Hydrophilic Phytochelators in Iron Overload Condition

2019 ◽  
Author(s):  
Zohreh Sajadi Hezaveh ◽  
Farzad Shidfar
Keyword(s):  
Adverse Effects ◽  
Iron Overload ◽  
Caffeic Acid ◽  
Iron Absorption ◽  
Kojic Acid ◽  
Inflammatory Activity ◽  
Iron Chelators ◽  
Natural Iron ◽  
Chelating Ability ◽  
Anti Inflammatory

Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible natural iron chelators including quercetin, rutin, bailcalin, silymarin, resveratrol, mimosine, tropolone, curcumine, catechin, kojic acid, and caffeic acid were investigated. Furthermore, the mechanisms through which they chelate iron were discussed. Results: The mentioned antioxidants eliminated excessive iron, decreased iron absorption, exerted antioxidant and anti-inflammatory activity without causing adverse effects and other metal deficiencies in iron overload condition. Conclusion: The combination of synthetic chelators with these antioxidants or their replacement with natural chelators could be possible treatments for iron overload.

scholarly journals Natural Iron Chelators as Potential Therapeutic Agents for the Treatment of Iron Overload Diseases

2021 ◽  
Author(s):  
Naheed Waseem A. Sheikh ◽  
Satish B. Kosalge ◽  
Tusharbindu R. Desai ◽  
Anil P. Dewani ◽  
Deepak S. Mohale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Iron Overload ◽  
Chelating Agents ◽  
Cell Injury ◽  
Wide Spectrum ◽  
Cellular Damage ◽  
Iron Chelators ◽  
Natural Iron ◽  
Iron Chelating Agents

Iron overload disease is a group of heterogeneous disease, which is caused either due to hereditary or acquired condition. Excess of iron participate in redox reactions that catalyzes the generation of reactive oxygen species (ROS) and increases oxidative stress, which causes cellular damage and encourage the cell injury and cell death. The electronic databases of Scopus, PubMed and Google Scholar have been intensively searched for the research as well as review articles published with the full text available and with the key words such as natural iron chelating agent, synthetic iron chelating agents, iron overload disease, oxidative stress and antioxidant which were appearing in the title, abstract or keywords. In light of the literature review presented in this artial, based on meta-analyses, we suggest that iron chelating agents were used for the management of iron overload disease. These agents were having wide spectrum of activity, they were not only used for the management of iron overload disease but also used as anticancer and antioxidant in various oxidative stress mediated diseases. Last from many years Desferoxamine (DFO) was used as standard iron chelator but currently two new synthetic iron chelators such as Deferiprone (DFP) and Deferasirox (DFS) are available clinically. These clinically available synthetic iron chelators were having serious side effects and certain limitations. Phytochemicals such as flavonoids and polyphenols compounds were having iron chelating as well as antioxidant property with no or minimal side effects. Hence, this review provides an updates on natural iron chelation therapy for the safe and efficacious management of iron overload diseases.

Anti-inflammatory activity of caffeic acid derivatives isolated from the roots of Salvia miltiorrhiza Bunge

2017 ◽  
Vol 41 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Hyun Gyu Choi ◽  
Phuong Thao Tran ◽  
Jeong-Hyung Lee ◽  
Byung Sun Min ◽  
Jeong Ah Kim
Keyword(s):  
Caffeic Acid ◽  
Salvia Miltiorrhiza ◽  
Inflammatory Activity ◽  
Salvia Miltiorrhiza Bunge ◽  
Caffeic Acid Derivatives ◽  
Anti Inflammatory

scholarly journals Evaluation of anti-inflammatory activity of Jasminum sessiliflorum extracts

2019 ◽  
Vol 10 (3) ◽  
pp. 2515-2518
Author(s):  
Ruby Philip ◽  
Kathiresan Krishnasamy ◽  
Elessy Abraham
Keyword(s):  
Medicinal Plants ◽  
Adverse Effects ◽  
Ethyl Acetate ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Reference Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Ethyl Acetate Extracts

Medicinal plants are important resources for the development of novel anti-inflammatory agents. Synthetic anti-inflammatory drugs have several adverse effects. Medicinal plants have numerous that are safer well as better substitutes for the prevention and management of various diseases and disorders. The and ethyl acetate extracts of Jasminum were evaluated for their potential as anti-inflammatory agents in by inducing paw edema in rats using . The anti-inflammatory activity of the reference drug was compared with the extracts of Jasminum . The extracts on screening indicated the presence of such as , , , alkaloids, and . The study established significant anti-inflammatory nature of the Jasminum extracts in a manner which is dose-dependent. The results indicate that both the extracts of Jasminum possess anti-inflammatory activity of significance and can be used in the development for novel anti-inflammatory moieties.

scholarly journals Pharmaceutical Advantages of GenoTX-407, A Combination of Extracts from Scutellaria baicalensis Root and Magnolia officinalis Bark

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1111
Author(s):  
Eun-Jung Yoon ◽  
Mi Young Lee ◽  
Byoung Il Choi ◽  
Kyong Jin Lim ◽  
Seung Young Hong ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Adverse Effects ◽  
Hela Cells ◽  
Scutellaria Baicalensis ◽  
Inflammatory Activity ◽  
Disk Diffusion ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Anti Inflammatory ◽  
Magnolia Officinalis

Background: Extracts of Scutellaria baicalensis root (SBR) and Magnolia officinalis barks (MOB) possess significant antioxidant, anti-inflammatory, and antimicrobial properties; however, these also exert adverse effects such as cytotoxicity. To overcome the adverse effects, we formulated a combination of the extracts, named GenoTX-407, with SBR and MOB extracts mixed in 5:1 ratio. The antioxidant, antimicrobial, and anti-inflammatory activities of SBR and MOB extracts and GenoTX-407 were evaluated. Methods: To optimize the extraction conditions of SBR and MOB, different ethanol concentrations and extraction times and treatments of the extracts with different solvents for varying time periods were tested. Anti-inflammatory activity was assessed via NO scavenging assay and analysis of anti-inflammatory activity-related gene expression in RAW 264.7 cells. Agar disk diffusion and microdilution assays were used to determine the antimicrobial activity. Antioxidant activity was evaluated through DPPH assay and analyses of peroxidation and antioxidant-related protein expression in HeLa cells. Results: Extraction with 0% ethanol for 2 h and 1.5% phosphoric acid for 0.5 h yielded maximum SBR extracts. For MOB, 50% ethanol extraction for 2 h followed by further extraction in hexane for 0.5 h yielded the highest extracts. SBR (46.1 ± 0.9 %) and MOB (48.9 ± 1.0 %) extracts effectively inhibited NO production, and dose-dependently reduced the expression of TNF-α, iNOS, NF-κB, COX2, and IL-6. MOB and GenoTX-407 inhibited the growth of Escherichia coli, Staphylococcus aureus, Candida albicans, and Propionibacterium acnes, as evidenced in disk diffusion and microdilution assays. SBR (EC50, 107.7 µg/mL and 38.3 µg/mL), MOB (62.41 µg/mL and 72.45 µg/mL), and GenoTX-407 (7.7 µg/mL and 26.4 µg/mL) exhibited excellent antioxidant potency and could scavenge free radicals of DPPH and lipid peroxidation; additionally, SOD, CAT, HO-1, and Nrf2 expression was increased in HeLa cells. SBR showed more potent antioxidant activity than MOB. Contrastingly, MOB exhibited more potent anti-inflammatory and antimicrobial activities than SBR. Interestingly, GenoTX-407 was the most efficient in all the assays, compared with SBR and MOB. Conclusion: This study demonstrated that GenoTX-407, the combination of SBR and MOB, is a potential drug candidate exerting antioxidant and anti-inflammatory effects via the Nrf2/HO-1 and NF-κB signaling pathways.

scholarly journals GASTROPROTECTIVE NSAIDs

2018 ◽  
Vol 8 (5) ◽  
pp. 141-145
Author(s):  
Mohammad Shahnaz ◽  
Parminder Kaur ◽  
DN Prasad
Keyword(s):  
Carboxylic Acid ◽  
Adverse Effects ◽  
Side Effect ◽  
Digestive System ◽  
Natural Antioxidants ◽  
Inflammatory Activity ◽  
Natural Origin ◽  
Anti Inflammatory ◽  
Gi Inflammation ◽  
Chronic Use

NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic acid derivatives) with some antioxidants can be synthesized by esterification with various antioxidants of natural origin. The conjugates that show the retention or potentiating of anti-inflammatory activity with reduced ulcerogenic side effect could be potential gastroprotective co-drugs of NSAIDs. Keyboards: NSAIDs, Gastroprotective, ROS, Natural antioxidants, Conjugates, Ulcerogenic

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