scholarly journals Qualitative Analysis of Hydroxyurea

2020 ◽  
Vol 4 (1) ◽  
pp. 18-21
Author(s):  
Stéfanno Souza Santos ◽  
Isis Gomes Dos Santos ◽  
Cinara Vanconcelos Da Silva ◽  
Edith C L Cazedey
Keyword(s):  
Mobile Phase ◽  
Uv Spectroscopy ◽  
Clinical Importance ◽  
Uv Spectra ◽  
Essential Medicines ◽  
Green Analytical Chemistry ◽  
Cell Disease ◽  
Chemical Waste ◽  
Main Concept ◽  
Ir And Uv Spectroscopy

Hydroxyurea (HU) is a cytostatic agent with antineoplastic activity and it has great clinical efficacy in the treatment of sickle cell disease. HU is part of the National Relation of Essential Medicines of Brazil and despite of its clinical importance, only the Portuguese, American and European Pharmacopoeias present monographs for this medicine. This study aimed to develop qualitative methods for identification and verification of purity of HU. For the HU identification, IR and UV spectroscopy were used, as well as TLC. The IR and UV spectra showed compatibility and the maximum absorption at 213 nm. For TLC, various pure or polarity gradient solvents were tested with results satisfactory for a mobile phase containing acetone and ethyl acetate (99:1, v/v). The replacement of the mobile phase generated less chemical waste, while minimizing the risks to the health of the operator, in accordance with the main concept of green analytical chemistry.

scholarly journals Preparation, Diagnosis, Biological Activity, and Theoretical Studies of Some Mixed Drug Complexes

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Bayader F. Abbas ◽  
Barakat A. F. Kamel ◽  
Wessal M. Khamais
Keyword(s):  
Theoretical Study ◽  
Biological Activities ◽  
Uv Spectroscopy ◽  
Transition Metal Ions ◽  
Uv Spectra ◽  
Molar Conductance ◽  
Spectral Techniques ◽  
Homo Lumo ◽  
Ir And Uv Spectroscopy

This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II). These complexes have been characterized by magnetic susceptibility, molar conductance, TG analyses, and spectral techniques such as FTIR and UV spectra. The theoretical study of the ligands and their complexes using semiempirical (PM6) method was used to measure IR and UV spectroscopy, HOMO-LUMO categories of the ligands. These synthesized complexes are also studied for their biological activities. The studies made on these complexes proposed a six octahedral geometry.

A Green Liquid Chromatographic Method For The Simultaneous Determination of Chlorpheniramine Maleate, Pseudoephedrine Hydrochloride and Propyphenazone

2019 ◽  
Vol 15 (6) ◽  
pp. 635-641
Author(s):  
Nadia M. Mostafa ◽  
Ghada M. Elsayed ◽  
Nagiba Y. Hassan ◽  
Dina A. El Mously
Keyword(s):  
Simultaneous Determination ◽  
Mobile Phase ◽  
Dosage Form ◽  
Chromatographic Method ◽  
Green Analytical Chemistry ◽  
Chlorpheniramine Maleate ◽  
Accuracy And Precision ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Background:The concept of green analytical chemistry prevails due to the growing environmental pollution.Objective:Our attempts are to develop simple and eco-friendly method which is non-harmful to the environment by producing minimal waste. In this context, a green liquid chromatographic method was applied for the simultaneous determination of chlorpheniramine maleate, pseudoephedrine hydrochloride and propyphenazone in their combined dosage form.Methods:Separation was carried out using X select HSS RP C18 analytical column (250 × 4.6 mm, 5μm) using methanol - 0.02 M phosphate buffer pH 3 - triethylamine (60:40: 0.1, by volume) as a mobile phase. The separated peaks were detected at 215 nm at a flow rate 1.0 mL/min.Results:Quantification was done over the concentration ranges of 1-25 µg/mL for chlorpheniramine maleate, 5-35 µg/mL for pseudoephedrine hydrochloride and 10-120 µg/mL for propyphenazone. The suggested method was validated with regard to linearity, accuracy and precision according to the International Conference on Harmonization guidelines with good results.Conclusion:It could be used as a safer alternative for routine analysis of the mentioned drugs in quality control laboratories.

Separation and Determination of Some Aromatic Sulfones by Reversed-Phase High-Performance Liquid Chromatography

1994 ◽  
Vol 59 (3) ◽  
pp. 569-574 ◽  
Author(s):  
Josef Královský ◽  
Marta Kalhousová ◽  
Petr Šlosar
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Mobile Phase ◽  
High Performance ◽  
Reversed Phase ◽  
Uv Spectra ◽  
Optimum Conditions ◽  
Linear Calibration ◽  
Technical Grade

The reversed-phase high-performance liquid chromatography of some selected, industrially important aromatic sulfones has been investigated. The chromatographic behaviour of three groups of aromatic sulfones has been studied. The optimum conditions of separation and UV spectra of the sulfones and some of their hydroxy and benzyloxy derivatives are presented. The dependences of capacity factors vs methanol content in mobile phase are mentioned. The results obtained have been applied to the quantitative analysis of different technical-grade samples and isomer mixtures. For all the separation methods mentioned the concentration ranges of linear calibration curves have been determined.

scholarly journals 7-Bromo-[1,2,5]selenadiazolo[3,4-d]pyridazin-4(5H)-one

Molbank ◽  
10.3390/m1229 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1229
Author(s):  
Timofey N. Chmovzh ◽  
Oleg A. Rakitin
Keyword(s):  
Mass Spectrometry ◽  
Heterocyclic System ◽  
High Resolution Mass Spectrometry ◽  
Uv Spectroscopy ◽  
Hydrolysis Product ◽  
Selenium Dioxide ◽  
Biologically Active ◽  
Photovoltaic Materials ◽  
Organic Photovoltaic Materials ◽  
Ir And Uv Spectroscopy

New heterocyclic systems containing 1,2,5-chalcogenadiazoles are of great interest for the creation of organic photovoltaic materials and biologically active compounds. In this communication, 3,6-dibromopyridazine-4,5-diamine was investigated in reaction with selenium dioxide in order to obtain 4,7-dibromo-[1,2,5]selenadiazolo[3,4-d]pyridazine. We found that 7-bromo-[1,2,5]selenadiazolo[3,4-d]pyridazin-4(5H)-one, the first representative of the new heterocyclic system, was isolated as a hydrolysis product of the corresponding 4,7-dibromoderivative. The structure of the newly synthesized compound was established by means of elemental analysis, high-resolution mass spectrometry, 1H, 13C NMR, IR and UV spectroscopy, and mass spectrometry.

Cyclic Constraints on Conformational Flexibility in γ-Peptides: Conformation Specific IR and UV Spectroscopy

2013 ◽  
Vol 117 (47) ◽  
pp. 12350-12362 ◽  
Author(s):  
Patrick S. Walsh ◽  
Ryoji Kusaka ◽  
Evan G. Buchanan ◽  
William H. James ◽  
Brian F. Fisher ◽  
...  
Keyword(s):  
Uv Spectroscopy ◽  
Conformational Flexibility ◽  
Ir And Uv Spectroscopy

Quantitative determination of the vinylthio groups in divinyl sulphide copolymers by IR and UV spectroscopy

1981 ◽  
Vol 23 (7) ◽  
pp. 1845-1847
Author(s):  
L.V. Morozova ◽  
E.I. Brodskaya ◽  
D.-S.D. Taryashinova ◽  
S.V. Amosova ◽  
B.A. Trofimov
Keyword(s):  
Quantitative Determination ◽  
Uv Spectroscopy ◽  
Ir And Uv Spectroscopy

scholarly journals Diastereo-specific conformational properties of neutral, protonated and radical cation forms of (1R,2S)-cis- and (1R,2R)-trans-amino-indanol by gas phase spectroscopy

2015 ◽  
Vol 17 (39) ◽  
pp. 25809-25821 ◽  
Author(s):  
Aude Bouchet ◽  
Johanna Klyne ◽  
Giovanni Piani ◽  
Otto Dopfer ◽  
Anne Zehnacker
Keyword(s):  
Electronic Structure ◽  
Gas Phase ◽  
Radical Cation ◽  
Amino Alcohol ◽  
Uv Spectroscopy ◽  
Conformational Properties ◽  
Gas Phase Spectroscopy ◽  
Ir And Uv Spectroscopy

The effects of ionisation and protonation on the geometric and electronic structure of a prototypical aromatic amino-alcohol with two chiral centres are revealed by IR and UV spectroscopy.

scholarly journals Ultraviolet Spectroscopy Used to Fingerprint Five Wild-Grown Edible Mushrooms (Boletaceae) Collected from Yunnan, China

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yan Li ◽  
Ji Zhang ◽  
Tao Li ◽  
Tianwei Yang ◽  
Yuanzhong Wang ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Discriminant Analysis ◽  
Hierarchical Cluster Analysis ◽  
Visual Discrimination ◽  
Uv Spectroscopy ◽  
Hierarchical Cluster ◽  
Uv Spectra ◽  
Edible Mushrooms ◽  
Ultraviolet Spectroscopy

Nowadays, wild-grown edible mushrooms which are natural, nutritious, and healthy get more and more popular by large consumers. In this paper, UV spectra of different Boletaceae mushrooms with the aid of partial least squares discriminant analysis (PLS-DA) and hierarchical cluster analysis (HCA) were shown to be a practical and rapid method for discrimination purpose. The specimens of Boletus edulis, Boletus ferrugineus, Boletus tomentipes, Leccinum rugosiceps, and Xerocomus sp. were described based on the UV spectra. From the results, all the specimens were characterized by strong absorption at the wavelengths of 274 and 284 nm and showed the shoulder at 296 nm. However, changes could be seen in the peak heights at the same wavelength for different samples. After analyzing by chemometrics, visual discrimination among samples was presented and the relationships among them were also obtained. This study showed that UV spectroscopy combined with chemometrics methods could be used successfully as a simple and effective approach for characterization of these five wild-grown edible mushrooms at species and genus levels. Meanwhile, this rapid and simple methodology could also provide reference for the discrimination of edible mushrooms.

scholarly journals Exploring Abundance and Isotope Anomalies in CP Stars with the HST/GHRS: High Resolution UV Spectroscopy of χ Lupi

1993 ◽  
Vol 138 ◽  
pp. 42-59 ◽  
Author(s):  
David S. Leckrone ◽  
Glenn M. Wahlgren ◽  
Sveneric G. Johansson ◽  
Saul J. Adelman
Keyword(s):  
High Resolution ◽  
Uv Spectroscopy ◽  
Uv Spectra ◽  
Heavy Elements

AbstractWe are using the HST/GHRS in a long-term program to obtain UV spectra of unprecedented resolution and precision for bright, ultra-sharp-lined Bp (HgMn) stars and comparable normal stars. To date we have doubled the number of heavy elements for which abundances may be estimated in χ Lupi, and have obtained the first observations of Hg III lines with which to test diffusion scenarios for its extreme Hg isotope anomaly.

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