scholarly journals PALEOGRAPHY AND ORTHOGRAPHY OF HANKENSTEIN CODEX

2019 ◽  
Vol 8 (5) ◽  
Author(s):  
Anna P. Khmelevskaya ◽  
Oleg F. Zholobov ◽  
Georgiy A. Molkov
Keyword(s):  
Present State ◽  
Main Text ◽  
Liturgical Texts ◽  
Satisfactory Analysis ◽  
Functional Features ◽  
First Time

Hankenstein Code (Vienna Octoix) is the collection of liturgical texts dating by the XII-XIII centuries or by the beginning of the XIIIth century. Since 1804, the general descriptions of the collection appear in the works by I.A. Ganke von Gankenstein, J. Dobrovsky, S. Smal-Stotsky, A. Sobolevsky, Yu. Shevelev, G. Birkfellner. Nowadays, there is no satisfactory analysis of the Code text at all levels, including graphic one. In order to study the spelling and the paleographic features of the manuscript, the main text, the inscriptions and the drawings on the fields, ornaments, the material for writing, the present state of the manuscript and its parts were described. We found that the text was written by two scribes, characterized the manner of writing each of them, determined the differences in the graphics and spelling (different use of the letters я, 1, 8 and o). A large number of external letters was noted and 7 basic traits of the title were described, 3 types of superscripts and 6 types of inline signs were fixed, their graphic and functional features were described. For the first time corrections and the entries were described on the margins of the manuscript. The examples found in the text of the letters э, е and и, в and оу proved the hypothesis of the southwestern origin of the monument.

scholarly journals MiRNA Expression in Neuroendocrine Neoplasms of Frequent Localizations

2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin
Keyword(s):  
Mirna Expression ◽  
Malignant Tumors ◽  
Neuroendocrine Neoplasms ◽  
Specific Expression ◽  
Clinical Biomarkers ◽  
Different Types ◽  
Functional Features ◽  
First Time ◽  
Potential Biomarkers

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.

scholarly journals Gut microbiome activity contributes to individual variation in glycemic response in adults

2019 ◽  
Author(s):  
Hal Tily ◽  
Ally Perlina ◽  
Eric Patridge ◽  
Stephanie Gline ◽  
Matvey Genkin ◽  
...  
Keyword(s):  
Individual Variation ◽  
Gut Microbiome ◽  
Metabolic Diseases ◽  
Nutritional Composition ◽  
Gradient Boosting ◽  
Glycemic Response ◽  
Activity Data ◽  
Gradient Boosting Machine ◽  
Functional Features ◽  
First Time

AbstractLimiting post-meal glycemic response is an important factor in reducing the risk of chronic metabolic diseases, and contributes to significant health benefits in people with elevated levels of blood sugar. In this study, we collected gut microbiome activity (i.e., metatranscriptomic) data and measured the glycemic responses of 550 adults who consumed more than 30,000 meals from omnivore or vegetarian/gluten-free diets. We demonstrate that gut microbiome activity makes a statistically significant contribution to individual variation in glycemic response, in addition to anthropometric factors and the nutritional composition of foods. We describe predictive models (multilevel mixed-effects regression and gradient boosting machine) of variation in glycemic response among individuals ingesting the same foods. We introduce functional features aggregated from microbial activity data as candidates for association with mechanisms of glycemic control. In summary, we demonstrate for the first time that metatranscriptomic activity of the gut microbiome is correlated with glycemic response among adults.

Modular arrangements of sequence motifs determine the functional diversity of KDM proteins

2020 ◽  
Author(s):  
Zerong Wang ◽  
Dongyang Liu ◽  
Baofang Xu ◽  
Ruixia Tian ◽  
Yongchun Zuo
Keyword(s):  
Vital Role ◽  
Sequence Motifs ◽  
Chromatin Dynamics ◽  
Regulatory Motifs ◽  
Demethylase Activity ◽  
Functional Features ◽  
Catalytic Motif ◽  
Functional Mechanisms ◽  
Deep Exploration ◽  
First Time

Abstract Histone lysine demethylases (KDMs) play a vital role in regulating chromatin dynamics and transcription. KDM proteins are given modular activities by its sequence motifs with obvious roles division, which endow the complex and diverse functions. In our review, according to functional features, we classify sequence motifs into four classes: catalytic motifs, targeting motifs, regulatory motifs and potential motifs. JmjC, as the main catalytic motif, combines to Fe2+ and α-ketoglutarate by residues H-D/E-H and S-N-N/Y-K-N/Y-T/S. Targeting motifs make catalytic motifs recognize specific methylated lysines, such as PHD that helps KDM5 to demethylate H3K4me3. Regulatory motifs consist of a functional network. For example, NLS, Ser-rich, TPR and JmjN motifs regulate the nuclear localization. And interactions through the CW-type-C4H2C2-SWIRM are necessary to the demethylase activity of KDM1B. Additionally, many conservative domains that have potential functions but no deep exploration are reviewed for the first time. These conservative domains are usually amino acid-rich regions, which have great research value. The arrangements of four types of sequence motifs generate that KDM proteins diversify toward modular activities and biological functions. Finally, we draw a blueprint of functional mechanisms to discuss the modular activity of KDMs.

p97 and close encounters of every kind: a brief review

2004 ◽  
Vol 32 (5) ◽  
pp. 715-720 ◽  
Author(s):  
I. Dreveny ◽  
V.E. Pye ◽  
F. Beuron ◽  
L.C. Briggs ◽  
R.L. Isaacson ◽  
...  
Keyword(s):  
Structural Elucidation ◽  
Interacting Proteins ◽  
Future Studies ◽  
Aaa Atpase ◽  
Close Encounters ◽  
Functional Features ◽  
Cellular Pathways ◽  
First Time

The AAA (ATPase associated with various cellular activities) ATPase, p97, is a hexameric protein of chaperone-like function, which has been reported to interact with a number of proteins of seemingly unrelated functions. For the first time, we report a classification of these proteins and aim to elucidate any common structural or functional features they may share. The interactors are grouped into those containing ubiquitin regulatory X domains, which presumably bind to p97 in the same way as the p47 adaptor, and into non-ubiquitin regulatory X domain proteins of different functional subgroups that may employ a different mode of interaction (assuming they also bind directly to p97 and are not experimental artifacts). Future studies will show whether interacting proteins direct p97 to different cellular pathways or a common one and structural elucidation of these interactions will be crucial in understanding these underlying functions.

scholarly journals XIII.—Hegel and the Metaphysics of the Fluxional Calculus

1869 ◽  
Vol 25 (2) ◽  
pp. 491-511 ◽  
Author(s):  
W. Robertson Smith
Keyword(s):  
Present State ◽  
Cambridge Philosophical Society ◽  
Newton's Law ◽  
Newton’S Law ◽  
Kepler's Laws ◽  
First Time ◽  
Kepler’S Laws

It is now many years since Dr Whewell drew the attention of the Cambridge Philosophical Society to the courageous, if somewhat Quixotic, attempts of Hegel to cast discredit on Newton's law of gravitation, and on the mathematical demonstrations of Kepler's laws given in the “Principia.” At the time when Whewell wrote, it would probably have been difficult to find in Britain any one ready to maintain the cause of Hegel in this matter, or even to hint that the astounding arguments of the Naturphilosophie flowed from any deeper source than self-complacent ignorance.The present state of matters is different. The philosophy of Hegel is now for the first time beginning to have a direct and powerful influence on British speculation. Men are beginning to study Hegel; and an author whose works confessedly demand the labour of years, if they are to be fully understood, can hardly be studied at all except by devoted disciples. A man whose determination to master Hegel's philosophy survives the repelling impression which the obscurity and arrogance of the philosopher are sure to produce at first, is very likely to be carried away by the calm assumption of omniscience which runs through Hegel's writings. It is not, therefore, surprising that Dr Stirling extends his admiration to Hegel's physical positions; and if he does not venture to say that Hegel's proof of Kepler's laws is right, at least feels sure that it would repay the attention of mathematicians.

Liturgy and Byzantinization in Jerusalem

2018 ◽  
Author(s):  
Daniel Galadza
Keyword(s):  
English Translations ◽  
Imperial Capital ◽  
Liturgical Texts ◽  
Sacred Topography ◽  
First Time ◽  
The Church

The church of Jerusalem, the ‘mother of the churches of God’, influenced all Christendom before it underwent multiple captivities between the eighth and thirteenth centuries: first, political subjugation to Arab Islamic forces, then displacement of Greek-praying Christians by crusaders, and, finally, ritual assimilation to fellow Orthodox Byzantines in Constantinople. All three contributed to the phenomenon of the Byzantinization of Jerusalem’s liturgy, but only the last explains how the latter was completely lost and replaced by the liturgy of the imperial capital, Constantinople. The basis of this study is the rediscovered manuscripts of Jerusalem’s liturgical calendar and lectionary. When examined in context, they reveal that the devastating events of the Arab conquest in 638 and the destruction of the Holy Sepulchre in 1009 did not have as detrimental an effect on liturgy as previously held. They confirm that the process of Byzantinization was gradual and locally implemented rather than an imposed element of Byzantine imperial policy or ideology from the church of Constantinople. Originally the city’s worship consisted of reading Scripture and singing hymns at places connected with the life of Christ, so that the link between holy sites and liturgy became a hallmark of Jerusalem’s worship; but the changing sacred topography caused changes in the local liturgical tradition. This book is the first monograph dedicated to the question of the Byzantinization of Jerusalem’s liturgy; it provides for the first time English translations of many liturgical texts and hymns and offers a glimpse of Jerusalem’s lost liturgical and theological tradition.

The Danish Paradox: Intolerance in the Land of Perpetual Compromise

2009 ◽  
Author(s):  
Thorfinn Stainforth
Keyword(s):  
20Th Century ◽  
Present State ◽  
Full Text ◽  
Industrial Society ◽  
Wide Spread ◽  
Apparent Contradiction ◽  
Political Spectrum ◽  
Post Industrial ◽  
First Time

What explains the apparent contradiction between Denmark's reputation as a liberal, tolerant society, and the recent rise in wide-spread xenophobia there? The root causes of the present wave of xenophobia are fundamentally similar to the rest of Europe: they grow primarily out of the tensions inherent in the transition from an industrial to post-industrial society. However, its unusual virulence across an apparently inclusive mainstream political spectrum, and departure from the established norms in the country, is an outgrowth of the present challenge to the egalitarian, anti-modern ethos that has steered Denmark toward its present state. Modern Danish nationalism, heavily influenced by the ideas of N.F.S. Grundtvig, has emphasized anti-elitism, decentralization, and egalitarianism. However, for the first time since at least the 1920s these political cornerstones are being seriously challenged and re-examined. Immigration has become one of the symbols of, and primary battlefield in, the challenge to the socil consensus that has existed throughout most of the 20th century.   Full text available at: https://doi.org/10.22215/rera.v5i1.204

An update on the spider genus Loxosceles (Araneae: Sicariidae) in the Afrotropical region, with description of seven new species

Zootaxa ◽  
2017 ◽  
Vol 4341 (4) ◽  
pp. 475 ◽  
Author(s):  
L. N. LOTZ
Keyword(s):  
South Africa ◽  
New Species ◽  
Present State ◽  
Taxonomic Key ◽  
Afrotropical Region ◽  
The Status ◽  
First Time

In this paper the present state of knowledge of the genus Loxosceles Heineken & Lowe, 1832 from the Afrotropical region is discussed. The distribution of nine of the 16 described Afrotropical species of Loxosceles is updated and the status of the types of L. bergeri Strand, 1906b and L. pilosa Purcell, 1908 are discussed. A further four new species from South Africa: L. cederbergensis sp. nov.; L. dejagerae sp. nov.; L. haddadi sp. nov.; L. makapanensis sp. nov.; and three from Namibia: L. griffinae sp. nov.; L. irishi sp. nov.; and L. maraisi sp. nov., are described. The female of L. smithi Simon, 1897 is described for the first time. A new taxonomic key to all the Afrotropical species is given. 

scholarly journals Życie i działanie św. Pawła Apostoła w świetle liturgii Kościoła

2009 ◽  
Vol 62 (2) ◽  
pp. 131
Author(s):  
Paweł Maciaszek
Keyword(s):  
Holy Spirit ◽  
Good News ◽  
Spiritual Values ◽  
God's People ◽  
Liturgical Texts ◽  
The Holy Spirit ◽  
The Hours ◽  
Pain And Suffering ◽  
First Time ◽  
The Church

In the liturgical calendar St. Paul is mentioned twice – for the first time on the day of his conversion (25 January), and then during the celebration – in common with St. Peter the Apostle – when the congregation contemplates his life and martyr’s death (29 June). In this article, through the analysis of liturgical texts about St. Paul – biblical readings and forms of the Holy Mass, and Liturgy of the Hours – the spiritual richness and depth of mysteries of salvation are transmitted to the Church community by this Apostle of the Nations. The Apostle of Tarsus, through his life and deeds, showed us the power of the Holy Spirit operating in mankind, who makes us God’s children and lets us live not according to worldly but according to spiritual values. By giving His gifts to people, He contributes to the development of the Church. The Apostle is also the example of acceptance of the Gospel, which is revealed through preaching the Good News to all peoples. He shows that one can endure pain and suffering for sake of the Gospel. And sacrificing our life, giving it for the act of salvation leads to friendship with Christ and brotherly love. The liturgical texts which are designed to be prayed on St. Paul’s days deeper the certainty that God’s people have that Jesus was resurrected and is alive, and wishes to lead each man on the way to salvation.

scholarly journals CHRISTIAN DUALISM OF CONFESSION AND GLORIFICATION AS THE BASIS OF MUSICAL DRAMATURGY AND STYLISTIC FEATURES OF LITURGY OF ST. JOANNA ZLATOUST BY M. SKORYK

2019 ◽  
pp. 16-31
Author(s):  
Н. Ю. Тарасова ◽  
П. В. Камуз
Keyword(s):  
Choral Music ◽  
System Analysis ◽  
Canonical Structure ◽  
Musical Style ◽  
Semantic Level ◽  
Divine Will ◽  
Liturgical Texts ◽  
Canonical Texts ◽  
First Time

The aim of the article is detenction of dramaturgic role inherent toOrthodox liturgical canonical texts and motets of dualism of christianconfession and glorification on dramaturgic and stylistic levels of Liturgyof St. I. Zlatoust by M. Skoryk. The canonical structure of Liturgy ofSt. I. Zlatoust at the level of liturgical texts and motets is investigated; thefeatures of composer's interpretation of characteristic structuralcompositional, harmony mode, texture, thematic methods of transmissionof sense of liturgical texts and canonical motets are examined. Themethods of the research are based on the use of musically-culturological,comparatively-historical, theoretical-analytical, textological methods.Scientific novelty. For the first time the system analysis of LiturgySt. Joanna Zlatoust 1) in the context of authorial choral style of M. Skorik;2) in unity of neobargee, neoromantic and neofolklore stylistic principlesof composer’s thinking; 3) in the aspect of cooperation of harmonic, tonemode, form-building means of expression of music of the ХХ century;4) at symbolically-semantic level of work is carried out. Conclusions.Sacred choral music became a major landmark in creative heritage ofМ. Skoryk. Embodiment by the composer of sacral senses of Liturgy differs free character sent to opening of typical for Orthodox of dualismconfession and glorification, through experiencing of such fundamentalreligious states, as 1) is personality-dramatic confession, 2) is transcendentcontemplativeness, 3) is catharsis state, 4) is subjectively-lyric acceptanceof Divine will, 5) is glad glorification. Thus, in the process of analysis theoriginality of authorial interpretation of genre of Liturgy was educed at thelevel of composition, in correlation with the canonical following of textsand motets, at the level of musical style; connection of musical languageof Liturgy by М. Skoryk is argued with neofolklore principles, tone modeand harmonic receptions of music of the ХХ century.

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