scholarly journals Paclitaxel Coated Balloon Fibroplasty: A more effective treatment of chronic symptomatic lead-related venous obstruction?

2020 ◽  
Author(s):  
Omar Yacob ◽  
Vijaywant Brar ◽  
Arooje Towheed ◽  
Cyrus Hadadi ◽  
Susan O'Donoghue ◽  
...  
Keyword(s):  
High Pressure ◽  
Effective Treatment ◽  
Arteriovenous Fistula ◽  
Thrombus Formation ◽  
Permanent Pacemaker ◽  
Pacemaker Lead ◽  
Common Complication ◽  
Venous Obstruction ◽  
Cardiac Device ◽  
Device Placement

Subclavian venous obstruction is a common complication after cardiac device placement. Patients typically remain asymptomatic but at times may present with acute symptoms due to thrombus formation immediately after device placement or years later, due to chronic obstruction, with pain and swelling. Various techniques have been attempted to resolve symptoms in patients with chronic lead-related subclavian obstruction but are associated with a high recurrence of restenosis. Drug coated balloons (DCB) have been used subsequently after pre-dilation with high-pressure balloons, of the stenosed region, in patients with arteriovenous fistula obstruction, and have shown promising results. We discuss the utilization of DCB in our patient with chronic subclavian obstruction due to a permanent pacemaker lead.

scholarly journals Identification of Critical Genes and lncRNAs in Osteolysis after Total Hip Arthroplasty and Osteoarthritis by RNA Sequencing

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Guang Yang ◽  
Kai Tang ◽  
Li Qiao ◽  
Yixin Li ◽  
Shui Sun
Keyword(s):  
Total Hip Arthroplasty ◽  
Effective Treatment ◽  
Rna Sequencing ◽  
Hip Arthroplasty ◽  
Specific Interaction ◽  
Cost Effective ◽  
Common Complication ◽  
Total Hip ◽  
Cost Effective Treatment ◽  
Coexpression Networks

Total hip arthroplasty (THA) is a cost-effective treatment for osteoarthritis (OA), and osteolysis is a common complication of THA. This study was aimed at exploring the relevant molecular biomarkers for osteolysis after THA. We performed RNA sequence to identify and characterize expressed mRNAs and lncRNAs in OA and osteolysis. Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) in OA and osteolysis were acquired, as well as shared DEmRNAs/DElncRNAs in OA and osteolysis and osteolysis-specific DEmRNAs/DElncRNAs. Then, shared and osteolysis-specific DElncRNA-DEmRNA coexpression networks were constructed to further investigate the function of DElncRNAs and DEmRNAs in OA and osteolysis. In total, 343 DEmRNAs and 25 DElncRNAs in OA, 908 DEmRNAs and 107 DElncRNAs in osteolysis, and 406 DEmRNAs and 46 DElncRNAs between OA and osteolysis were acquired. A total of 136 shared DEmRNAs and 9 shared DElncRNAs in OA and osteolysis and 736 osteolysis-specific DEmRNAs and 103 osteolysis-specific DElncRNAs were acquired. Then, 128 shared DElncRNA-DEmRNA coexpression pairs and 522 osteolysis-specific DElncRNA-DEmRNA coexpression pairs were identified. The present study highlighted the roles of four interaction pairs, including two shared lncRNA-mRNA interaction pairs in OA and osteolysis (AC111000.4 and AC016831.6), which may function in the immune process of OA and osteolysis by regulating CD8A and CD8B, respectively, and two osteolysis-specific interaction pairs (AC090607.4-FOXO3 and TAL1-ABALON), which may play an important role in osteoclastogenesis.

scholarly journals Efficacy of high-pressure balloon for the treatment of arteriovenous fistula stenosis: a meta-analysis

2021 ◽  
Author(s):  
Yu Li ◽  
Wenhao Cui ◽  
Jukun Wang ◽  
Chao Zhang ◽  
Tao Luo
Keyword(s):  
High Pressure ◽  
Arteriovenous Fistula ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Technical Success Rate ◽  
Stenosis Rate ◽  
Significant Difference ◽  
Arteriovenous Fistula Stenosis ◽  
Using Data ◽  
The Cochrane Library

AbstractObjectiveThe objective of the present study was to compare the effectiveness of high-pressure balloon (HPB) versus conventional balloon angioplasty (BA) in treating arteriovenous fistula (AVF) stenosis.Materials and MethodsA meta-analysis was conducted using data acquired from PubMed, EMBASE, the Cochrane Library, SinoMed, CNKI, WanFang and VIP databases from the time the databases were established to November 2020. All analyses included in the studies comprised the subgroups of HPB and BA. The patency of AVF was compared between the two groups at 3 months, 6 months and 12 months after operation.ResultsNine studies comprising 475 patients were included in the meta-analysis. The pooled results revealed that stenosis rate of AVFs treated with HPB was significantly lower than that of AVFs treated with conventional balloon at 3 months (OR= 0.37, 95% CI 0.21 to 0.67, p<0.001) and 6 months after operation (OR= 0.33, 95% CI 0.15 to 0.75, p=0.008). In addition, the technical success rate of HPB groups was high (OR= 0.14, 95% CI 0.05 to 0.35, p<0.001). However, no significant difference was observed between the experimental and control groups at 12 months after operation (OR= 0.61, 95% CI 0.29 to 1.25, p=0.18). No significant publication bias was observed in the analyses.ConclusionHPB is a potential primary option for the treatment of AVF stenosis, with a lower 3- and 6-month stenosis rate than BA. However, the long-term effect of HPB was not satisfactory; therefore, further research should be conducted to elucidate the relationship between the two groups.

Placement issues of hemodialysis catheters with pre-existing central lines and catheters

2018 ◽  
Vol 19 (4) ◽  
pp. 366-369 ◽  
Author(s):  
Afsha Aurshina ◽  
Anil Hingorani ◽  
Ahmad Alsheekh ◽  
Pavel Kibrik ◽  
Natalie Marks ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Jugular Vein ◽  
Central Line ◽  
Implantable Cardioverter Defibrillators ◽  
Venous Obstruction ◽  
Central Lines ◽  
Hemodialysis Catheter ◽  
Chest X Ray ◽  
Accepted Practice ◽  
Cardioverter Defibrillators

Objective: It has been a widely accepted practice that a previous placed pacemaker, automatic implantable cardioverter defibrillators, or central line can be a contraindication to placing a hemodialysis catheter in the ipsilateral jugular vein. Fear of dislodging pacing wires, tunneling close to the battery site or causing venous obstruction has been a concern for surgeons and interventionalists alike. We suggest that this phobia may be unfounded. Methods: A retrospective review was conducted of patients in whom hemodialysis catheters were placed over a period of 10 years. For each hemodialysis catheter that was placed, perioperative chest X-ray performed was used to evaluate for pre-existing pacemakers and central lines. The position and laterality of placement of the hemodialysis catheter along with presence of arteriovenous fistula with functional capacity for access were noted. Results: A total of 600 hemodialysis catheters were placed in patients over the period of 10 years. The mean age of the patients was 73.6 ± 12 years with a median age of 76 years. We found 20 pacemakers or automatic implantable cardioverter defibrillators and 19 central lines on the same side of the neck as the hemodialysis catheter that was placed in the ipsilateral jugular vein. No patient exhibited malfunction or dislodgment of the central line, the pacemaker, or automatic implantable cardioverter defibrillator or evidence of upper extremity venous obstruction based upon signs symptoms or duplex exams. Conclusion: Based on our experience, we suggest that placement of hemodialysis catheter in the internal jugular vein ipsilateral to the pre-existing catheter/leads is safe and spares the contralateral limb for arteriovenous fistula creation.

scholarly journals High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Bo Lu ◽  
Hui Yuan ◽  
Xiaojie Zhai ◽  
Xiaoyu Li ◽  
Jinling Qin ◽  
...  
Keyword(s):  
High Pressure ◽  
Cognitive Dysfunction ◽  
Microglial Activation ◽  
Postoperative Cognitive Dysfunction ◽  
Abdominal Pressure ◽  
Common Complication ◽  
Operative Field ◽  
Aged Patients ◽  
Aged Mice ◽  
Postoperative Cognitive Impairment

Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While the contribution of pneumoperitoneum to the systemic inflammation has been well documented, the effect of pneumoperitoneal pressure on neuroinflammation and postoperative cognitive function remains unclear. In this study, we showed that high-pressure pneumoperitoneum promoted the postoperative neuroinflammation and microglial activation in the hippocampus and aggravated the postoperative cognitive impairment in aged mice. These results support the requirement to implement interventions with lower intra-abdominal pressure, which allows for adequate exposure of the operative field rather than a routine pressure.

A case of permanent pacemaker lead infection

2008 ◽  
Vol 5 (10) ◽  
pp. 649-652 ◽  
Author(s):  
Caterina Simon ◽  
Fabio Capuano ◽  
Antonino Roscitano ◽  
Riccardo Sinatra
Keyword(s):  
Permanent Pacemaker ◽  
Pacemaker Lead ◽  
Lead Infection

Hemoclips of a Band Released After Recovery of a Stenosed Shunt

2014 ◽  
Vol 19 (3) ◽  
pp. 143-144
Author(s):  
Unal Mutlu ◽  
Ninos Ayez ◽  
Bram Fioole ◽  
George P. Akkersdijk ◽  
Hans M. Boots ◽  
...  
Keyword(s):  
High Pressure ◽  
Arteriovenous Fistula ◽  
Satisfactory Result ◽  
Percutaneous Transluminal Angioplasty ◽  
Transluminal Angioplasty ◽  
Upper Arm ◽  
Left Hand ◽  
Different Diameters ◽  
Percutaneous Transluminal ◽  
Reduced Flow

Abstract A man aged 30 years with a brachiocephalic arteriovenous fistula in the left upper arm developed clinical complaints of a cold left hand due to a flow of 3,500 mL/min. A successful banding procedure was performed. Nineteen months later, a stenosis at the banding site resulted in reduced flow and insufficient dialysis. Several percutaneous transluminal angioplasty procedures with different diameters were performed. A satisfactory result was achieved using a 6-mm high-pressure balloon.

Pathogenesis of thrombosis

Hematology ◽  
2009 ◽  
Vol 2009 (1) ◽  
pp. 255-258 ◽  
Author(s):  
Bruce Furie
Keyword(s):  
High Pressure ◽  
Host Defense ◽  
Intravital Microscopy ◽  
Defense Mechanism ◽  
Tissue Injury ◽  
Thrombus Formation ◽  
Animal Experiments ◽  
Circulatory System ◽  
Live Animal ◽  
Host Defense Mechanism

Abstract The hemostatic process is a host defense mechanism to preserve the integrity of the closed high pressure circulatory system. This process must remain inactive but poised to minimize extravasation of blood from the vasculature following tissue injury. Given the complexity of the hemostatic mechanism, paradigms developed from biochemical and cell biological approaches have been revisited by studying thrombus formation in a live animal by intravital microscopy. Many of these paradigms have proven accurate, but others need to be reconsidered given the results of whole animal experiments.

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