Minoxidil and I (eye), just a coincidence or is it fate?

Purpose: To report a case of multiple superior quadrant intraretinal haemorrhages in post-COVID-19 patient. Case description: A 58-year-old male with a history of coronary artery disease and hypertension, presented with multiple superior quadrant intraretinal haemorrhages in the superonasal quadrant of the left eye 1 month after hospitalization for COVID-19. The right eye was normal. During his 10-day stay, he was treated with hydroxychloroquine, lopinavir + ritonavir, ceftriaxone, and his pre-existing antiplatelet therapy. During hospitalization, a complete medical work up showed an anomalous increase in D-dimer. He did not require intensive care support. Conclusions: In this report, we focused on the origin of retinal bleeding in a post COVID-19 patient, likely due to a focal occlusion of a vessel. Considering the nature of SARS-CoV-2 infection, we hypothesize that retinal haemorrhages were caused by a combination of factors including the patient’s antiplatelet therapy and the thrombotic microvascular injury caused by the virus.

Download Full-text

Comparing the therapeutic efficacy of topical minoxidil and finasteride with topical minoxidil and oral finasteride in androgenetic alopecia: a randomized trial

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20183163 ◽

2018 ◽

Vol 4 (3) ◽

pp. 386 ◽

Cited By ~ 1

Author(s):

Priyam Bhaskar Rai ◽

Pragya Khushwaha ◽

Nitish Jain ◽

Swati Gupta

Keyword(s):

Androgenic Alopecia ◽

Hair Density ◽

Treatment Groups ◽

Topical Minoxidil ◽

History Of ◽

Group A ◽

Good Improvement ◽

Group B ◽

Time Of Presentation

Background: There is an increased interest in the development and use of topical finasteride for treating androgenic alopecia (AGA) due to growing evidence of side effects from oral finasteride. In this study we aimed to compare the treatment outcomes of topical 5% minoxidil with 0.1% finasteride and topical 5% minoxidil with oral 1 mg finasteride.Methods: 50 patients of stage III and IV of Hamilton-Norwood scale were randomly assigned to either Group A receiving topical 5% minoxidil and oral finasteride 1 mg and Group B receiving topical 5% minoxidil and topical 0.1% finasteride. After taking uninterrupted treatment for 12 months, patients were assessed for hair regrowth and maintenance using global photography and trichoscopy and compared with baseline parameters. Patients in both the groups were assessed for any adverse effects as well.Results: At baseline, patients in both the treatment groups were similar with respect to their age at the time of presentation, family history of hair loss and Hamilton Norwood scale. In group A, three discontinued treatment and of the rest 65% maintained a good hair density and reduced hairfall. In group B, five discontinued treatment, of the rest 83% patients demonstrated good improvement in hair density (p<0.05).Conclusions: The results of this study strongly support the use of topical finasteride in combination with topical 5% minoxidil for AGA and this may obviate the need of taking long term oral finasteride.

Download Full-text

Neonate born with ischemic limb to a COVID-19 positive mother: management and review of literature

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2020-0086 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Shahana Perveen ◽

Karmaine A. Millington ◽

Suchitra Acharya ◽

Amit Grag ◽

Vita Boyar

Keyword(s):

Differential Diagnosis ◽

Compartment Syndrome ◽

Upper Extremity ◽

Preterm Neonate ◽

Review Of Literature ◽

Case Presentation ◽

Ischemic Limb ◽

History Of ◽

Hand Amputation ◽

Work Up

AbstractObjectivesTo describe challenges in diagnosis and treatment of congenital neonatal gangrene lesions associated with history of maternal coronavirus disease 2019 (COVID-19) infection.Case presentationA preterm neonate was born with upper extremity necrotic lesions and a history of active maternal COVID-19 infection. The etiology of his injury was challenging to deduce, despite extensive hypercoagulability work-up and biopsy of the lesion. Management, including partial forearm salvage and hand amputation is described.ConclusionsNeonatal gangrene has various etiologies, including compartment syndrome and intrauterine thromboembolic phenomena. Maternal COVID-19 can cause intrauterine thrombotic events and need to be considered in a differential diagnosis.

Download Full-text

Metastatic adrenal pheochromocytoma to the thoracic spine

Coluna/Columna ◽

10.1590/s1808-18512010000300017 ◽

2010 ◽

Vol 9 (3) ◽

pp. 343-346 ◽

Cited By ~ 4

Author(s):

Michael T. Scalfani ◽

Paul M. Arnold ◽

Karen K. Anderson

Keyword(s):

Differential Diagnosis ◽

Surgical Intervention ◽

Hepatic Metastases ◽

Posterior Fixation ◽

Original Diagnosis ◽

Average Survival ◽

Progression Of Disease ◽

Adrenal Pheochromocytoma ◽

History Of ◽

Work Up

To report on a case of pheochromocytoma metastases to the spine occurring more than 20 years after initial diagnosis. A 34-year-old female with a history of metastatic pheochromocytoma diagnosed at age 12 presented with weakness, heart palpitations, and circumferential back pain of five months duration. The patient had undergone multiple laparatomies for abdominal and hepatic metastases. Work-up revealed a destructive lesion at T9. After two weeks of preoperative phenoxybenzamine to control her hypertension, she underwent decompression, posterior fixation and fusion. Surgical intervention was followed by radiation therapy, zoledronic acid, and only one cycle of chemotherapy due to intolerance of side effects. The patient survived 25 years after original diagnosis, which far exceeds the average survival of less than 15 years. The patient died 26 months postoperatively due to progression of disease. Pheochromocytoma with spine metastases occurring more than 20 years after diagnosis is very uncommon, and should be considered in the differential diagnosis of a patient with a history of pheochromocytoma.

Download Full-text

Parasitic hypereosinophilia in childhood: a diagnostic challenge

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2018.034 ◽

2018 ◽

Vol 10 (1) ◽

pp. 2018034

Author(s):

Roberto Antonucci ◽

Nadia Vacca ◽

Giulia Boz ◽

Cristian Locci ◽

Rosanna Mannazzu ◽

...

Keyword(s):

Eosinophil Count ◽

Hypereosinophilic Syndrome ◽

Igg Antibodies ◽

Diagnostic Challenge ◽

Etiological Diagnosis ◽

Maximum Value ◽

History Of ◽

Diagnostic Work ◽

Patient’S History ◽

Work Up

Severe hypereosinophilia (HE) in children is rare, and its etiological diagnosis is challenging. We describe a case of a 30-month-old boy, living in a rural area, who was admitted to our Clinic with a 7-day history of fever and severe hypereosinophilia. A comprehensive diagnostic work-up could not identify the cause of this condition. On day 6, the rapidly increasing eosinophil count (maximum value of 56,000/mm3), the risk of developing hypereosinophilic syndrome, and the patient’s history prompted us to undertake an empiric treatment with albendazole.The eosinophil count progressively decreased following treatment. On day 13, clinical condition and hematological data were satisfactory, therefore the treatment was discontinued and the patient was discharged. Three months later, anti-nematode IgG antibodies were detected in patient serum, thus establishing the etiological diagnosis. In conclusion, an empiric anthelmintic treatment seems to be justified when parasitic hypereosinophilia is strongly suspected, and other causes have been excluded.

Download Full-text

APASL Single Topic Conference DELTA HEPATITIS, 27-28 June 2019, Baku, Azerbaijan

EURASIAN JOURNAL OF CLINICAL SCIENCES ◽

10.28942/ejcs.v2i2.62 ◽

2019 ◽

Vol 2 (2) ◽

pp. 1-46

Author(s):

Gulnara Aghayeva

Keyword(s):

Hepatitis B ◽

Current Treatment ◽

Hbv Infection ◽

Good Chance ◽

Hepatitis Delta ◽

New Horizons ◽

History Of ◽

Pharmaceutical Agents ◽

Work Up ◽

First Time

As Delta problem moved from the shadow up on the stage, becoming one of the most crucial disease in Hepatology area, our STC 2019 is dedicated to hepat itis D, for the first time in the history of APASL STC topics. As hepatitis Delta occurs only with HBV infection, we will discuss hepatitis B, its epidemiology, work - up, current treatment and new horizons in the developing pharmaceutical agents. The scient ific program will include the topics presented by the best speakers and the experts in Delta and B hepatitis. This conference is a good chance to meet and interact with leading clinical professionals and researches and to obtain latest information for hepa tologists.

Download Full-text

Middle Ear Adenoma presenting as a Petrous Mass Lesion Lesion

UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY ◽

10.36611/upjohns/19.9 ◽

2019 ◽

Vol VOLUME 7 (VOLUME 7 NUMBER 2 NOV 2018) ◽

pp. 40-42

Author(s):

Pearly PK

Keyword(s):

Middle Ear ◽

Benign Tumor ◽

Unilateral Hearing Loss ◽

Mri Findings ◽

Short Segment ◽

Facial Movements ◽

History Of ◽

Middle Ear Adenoma ◽

Work Up ◽

Ct And Mri

Introduction: Inspite of modern radiological work up, surgeons can still be surprised by intraoperative findings or by pathologists report. Materials and methods: We present the case history of a 51 year old male who came to our institute with complaints of unilateral hearing loss, involuntary facial movements and retroauricular pain for a period of 1 year. He underwent Fisch approach with short segment mobilization of facial nerve. Results: Though pre-operative CT and MRI findings were suggestive of a petroclival mass he had middle ear adenoma. Key Words: Middle ear, Middle Ear Adenoma, Middle Ear benign tumor, Adenoma

Download Full-text

Androgenic alopecia in post-menopausal female: a clinical presentation

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201824 ◽

2020 ◽

Vol 9 (5) ◽

pp. 2157

Author(s):

Kirty Nahar ◽

Usha Bohra ◽

Vivek Arya

Keyword(s):

Hair Loss ◽

Histopathological Examination ◽

Clinical Signs ◽

Signs And Symptoms ◽

Abdominal Hysterectomy ◽

Androgenic Alopecia ◽

Clinical Signs And Symptoms ◽

Significant Regression ◽

Post Menopausal ◽

Work Up

Androgenic alopecia is a patterned hair loss occurring due to systemic androgens and genetic factors. It is the most common cause of hair loss in both genders. The appearance of this condition is the cause of significant stress and psychological problems, making appropriate management important. A 68-year-old postmenopausal female presented with complaints of increased hair loss from scalp, excessive hair growth at undesired sites and hirsutism not corrected with medications. On thorough investigations, CT scan whole abdomen and endocrinological workup, a clinical diagnosis of alopecia and hirsutism due to hyperandrogenemia secondary to ovarian tumor made. Abdominal hysterectomy with B/L salpingo-oophorectomy was done. Histopathological examination revealed an encapsulated tumor in right ovary-sex cord stromal tumor consistent with Leydig cell tumor in right ovary, no evidence of malignancy. Left ovary was normal. Patient showed significant regression of clinical signs and symptoms on follow up after 1 month. All women with severe hirsutism or androgenic alopecia needs further work up to locate the source of androgen over production.

Download Full-text

Familial Cerebral Cavernous Malformation Mimicking Cerebral Amyloid Angiopathy

Neurology Clinical Practice ◽

10.1212/cpj.0000000000001055 ◽

2021 ◽

pp. 10.1212/CPJ.0000000000001055

Author(s):

Mohamed Ridha ◽

Yasmin Aziz ◽

Joseph Broderick

Keyword(s):

Cerebral Amyloid Angiopathy ◽

Cavernous Malformation ◽

Pathogenic Mutation ◽

Cerebral Cavernous Malformation ◽

Amyloid Angiopathy ◽

History Of ◽

Cerebral Amyloid ◽

Cerebral Microhemorrhages ◽

Familial Cerebral Cavernous Malformation ◽

Work Up

A 67-year-old man was referred from ophthalmology for possible cerebral amyloid angiopathy (CAA) discovered during work-up of possible optic neuropathy. MRI (figure 1) demonstrated innumerable periventricular, brainstem, and cortical cerebral microhemorrhages (CMH). Scattered, non-specific white matter hyperintensities was seen on T2-weighted imaging without surrounding hypointense rim. He had no hypertension, and the distribution was uncharacteristic for CAA. Despite absent family history of stroke or seizure, testing for familial cerebral cavernous malformation (FCCM) identified a pathogenic mutation of KRIT1 (c.382G>T).

Download Full-text