scholarly journals Whether immunostimulants are effective in susceptible children suffering from recurrent respiratory tract infections: a modeling analysis based on literature aggregate data

2021 ◽  
Author(s):  
Weilong Zhang ◽  
Jihan Huang ◽  
Hongxia Liu ◽  
Xin Wen ◽  
Qingshan Zheng ◽  
...  
Keyword(s):  
Tract Infection ◽  
Adverse Events ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Respiratory Tract Infections ◽  
Meta Analysis ◽  
Cumulative Number ◽  
Recurrent Respiratory Tract Infection ◽  
Prevention And Treatment ◽  
Tract Infections

Background: Immunostimulants are gradually being used in the prevention and treatment of recurrent respiratory tract infection (RRTIs) in susceptible children, but its drug effects have not been quantified. The purpose of this paper is to confirm the efficacy of immunostimulants in the prevention and treatment of RRTIs in susceptible children. Methods: Model-based meta-analysis (MBMA) was used to describe the time-course of placebo and immunostimulants in the prevention of RRTIs in children. The cumulative number of acute respiratory tract infections (ARTIs) was used as the indicator of efficacy. The single-arm meta-analysis was used to analyze the incidence of drug related adverse events. Results: A total of 14 articles with 2,400 pediatric subjects were finally included for analysis. The results showed that the cumulative number of ARTIs increased linearly with time, and the incidence of ARTIS in the placebo group was 0.65 (95% CI: 0.55 to 0.75) per month. OM-85 BV and pidotimod significantly reduced the incidence of ARTIs by 0.21 (95% CI: 0.16 to 0.26) and 0.19 (95% CI: 0.17 to 0.21) compared with placebo per month, respectively. The incidence of drug-related adverse events of pidotimod and OM-85 BV was comparable with that of placebo. Conclusions: Pidotimod and OM-85 BV can effectively reduce the incidence of ARTIs in susceptible children, and there is no significant increase in the incidence of drug-related adverse events. This study provides quantitative support for the application of immunostimulants for the prevention of recurrent respiratory tract infection in children.

scholarly journals Recurrent Respiratory Tract Infection in an infant: Early Diagnosis by Clinical and Radiological Pearls

2021 ◽  
Vol 41 (1) ◽  
pp. 111-114
Author(s):  
Shatanik Sarkar ◽  
Chaitali Patra ◽  
Shibani Pal ◽  
Arkapriya Pramanik
Keyword(s):  
Tract Infection ◽  
Early Diagnosis ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Clinical Examination ◽  
Respiratory Tract Infections ◽  
Recurrent Respiratory Tract Infection ◽  
Organ Systems ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

Recurrent respiratory tract infections, a cause of concern for both parents and paediatricians, can have various etiologies entitled to different organ systems. Diagnosing the exact cause warrants both clinical acumen and timely investigations. Here, we are reporting an infant with recurrent respiratory tract infections, where adequate clinical examination prompted us to diagnose the extra-respiratory cause with simple investigations.

scholarly journals Pharmacokinetics of EDP-420 after Ascending Single Oral Doses in Healthy Adult Volunteers

2009 ◽  
Vol 53 (5) ◽  
pp. 1786-1792 ◽  
Author(s):  
Li-Juan Jiang ◽  
Michelle Wang ◽  
Yat Sun Or
Keyword(s):  
Tract Infection ◽  
Adverse Events ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Half Life ◽  
Respiratory Tract Infections ◽  
Healthy Adult ◽  
Tract Infections

ABSTRACT EDP-420 (EP-013420, S-013420) is a first-in-class bicyclolide (bridged bicyclic macrolide) currently in clinical development for the treatment of respiratory tract infections. It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e.g., Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila), and multidrug-resistant streptococci. The safety, tolerability, and pharmacokinetics of an orally administered EDP-420 suspension in 40 healthy adult subjects were assessed in a randomized, double-blind, placebo-controlled, ascending single-dose study. Eligible subjects were sequentially randomized into one of five study groups (i.e., 100-, 200-, 400-, 800-, or 1,200-mg dosing groups) consisting of eight subjects (six active and two placebo) each. EDP-420 was well tolerated. There were no serious adverse events reported, nor were there any dose-limiting clinical or laboratory adverse events reported. EDP-420 was rapidly absorbed after a single oral dose. The mean plasma terminal half-life ranged from 15.6 to 20.1 h with low clearance. At the 400-mg dose, the area under the curve was 14.4 μg·h/ml, which well exceeded the required area under the concentration-time curve to cover common respiratory tract infection pathogens based on preclinical pharmacokinetic/pharmacodynamic modeling. The long half-life and high systemic exposure of EDP-420 support once-daily dosing and may allow for shorter treatment durations compared to other macrolide antibiotics. Based on its human pharmacokinetic profiles, taken together with its in vitro/in vivo activity against common respiratory pathogens, EDP-420 warrants efficacy trials for the treatment of respiratory tract infections.

scholarly journals Effect of vitamin D supplementation to prevent acute respiratory tract infection : an evidence-based case report

2020 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Oki Yonatan Oentiono ◽  
Nurul Ratna Mutu Manikam
Keyword(s):  
Vitamin D ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Respiratory Tract Infections ◽  
Meta Analysis ◽  
Acute Respiratory Tract Infection ◽  
Vitamin D Supplementation ◽  
Low Levels ◽  
Tract Infections

Background: One of the frequent health problems that regularly occurs in Indonesia, as a tropical country is an acute respiratory tract infection, including influenza. Since immunological benefit of vitamin D already proven, hypothetically, vitamin D can be used as protective agent to prevent influenza or other respiratory tract infections. Objective: This evidence-based case report was focused on the evaluation of protective ability of vitamin D supplementation to prevent influenza or other acute respiratory tract infections.Methods: Literature searching was conducted on PubMed data base and Cochrane Library using the related keyword combinations.Results: Two randomized-clinical trials (RCTs) and a meta-analysis study were fulfilled the eligibility criteria. Vitamin D supplementation did not reduce the incidence of influenza but reduce the incidence of non-influenza infection. High-dose vitamin D supplementation had no effect on the reduction of acute respiratory tract infection incidence. The meta-analysis concluded that vitamin D supplementation reduced the risk for acute respiratory tract infection and the stronger effects occurred on low-levels of vitamin D serum.Conclusion: Vitamin D supplementation may prevent acute respiratory tract infections, especially in subjects with low-levels of vitamin D serum.

scholarly journals Manejo perioperatorio de niños con infección respiratoria superior

2019 ◽  
Vol 67 (2) ◽  
pp. 341-347
Author(s):  
Norma Constanza Corrales-Zúñiga ◽  
Nelly Patricia Martínez-Muñoz ◽  
Sara Isabel Realpe-Cisneros ◽  
Carlos Eberth Pacichana-Agudelo ◽  
Leandro Guillermo Realpe-Cisneros ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infection ◽  
Cochrane Library ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections

Introducción. Es frecuente que muchos niños sometidos a procedimientos con anestesia general tengan historia de infección viral respiratoria superior reciente o activa.Objetivo. Realizar una revisión narrativa acerca de las pautas de manejo anestésico para los niños con infección reciente o activa de la vía aérea superior.Materiales y métodos. Se realizó una búsqueda estructurada de la literatura en las bases de datos ProQuest, EBSCO, ScienceDirect, PubMed, LILACS, Embase, Trip Database, SciELO y Cochrane Library con los términos Anesthesia AND Respiratory Tract Infections AND Complications; Anesthesia AND Upper respiratory tract infection AND Complications; Anesthesia, General AND Respiratory Tract Infections AND Complications; Anesthesia, General AND Upper respiratory tract infection AND Complications; Anesthesia AND Laryngospasm OR Bronchospasm. La búsqueda se hizo en inglés con sus equivalentes en español.Resultados. Se encontraron 56 artículos con información relevante para el desarrollo de la presente revisión.Conclusiones. Una menor manipulación de la vía aérea tiende a disminuir la frecuencia de aparición y severidad de eventos adversos respiratorios perioperatorios. No existe evidencia suficiente para recomendar la optimización medicamentosa en pacientes con infección respiratoria superior.

Effectiveness of Oral Rinse with Chlorhexidine in Preventing Nosocomial Respiratory Tract Infections among Intensive Care Unit Patients

2009 ◽  
Vol 30 (10) ◽  
pp. 952-958 ◽  
Author(s):  
Fernando Bellissimo-Rodrigues ◽  
Wanessa Teixeira Bellissimo-Rodrigues ◽  
Jaciara Machado Viana ◽  
Gil Cezar Alkmim Teixeira ◽  
Edson Nicolini ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Length Of Stay ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Respiratory Tract Infections ◽  
Icu Patients ◽  
Oral Application ◽  
Tract Infections

Objective.To evaluate the effectiveness of the oral application of a 0.12% solution of Chlorhexidine for prevention of respiratory tract infections among intensive care unit (ICU) patients.Design.The study design was a double-blind, randomized, placebo-controlled trial.Setting.The study was performed in an ICU in a tertiary care hospital at a public university.Patients.Study participants comprised 194 patients admitted to the ICU with a prospective length of stay greater than 48 hours, randomized into 2 groups: those who received Chlorhexidine (n = 98) and those who received a placebo (n = 96).Intervention.Oral rinses with Chlorhexidine or a placebo were performed 3 times a day throughout the duration of the patient's stay in the ICU. Clinical data were collected prospectively.Results.Both groups displayed similar baseline clinical features. The overall incidence of respiratory tract infections (RR, 1.0 [95% confidence interval [CI], 0.63-1.60]) and the rates of ventilator-associated pneumonia per 1,000 ventilator-days were similar in both experimental and control groups (22.6 vs 22.3; P = .95). Respiratory tract infection-free survival time (7.8 vs 6.9 days; P = .61), duration of mechanical ventilation (11.1 vs 11.0 days; P = .61), and length of stay (9.7 vs 10.4 days; P = .67) did not differ between the Chlorhexidine and placebo groups. However, patients in the Chlorhexidine group exhibited a larger interval between ICU admission and onset of the first respiratory tract infection (11.3 vs 7.6 days; P = .05). The chances of surviving the ICU stay were similar (RR, 1.08 [95% CI, 0.72-1.63]).Conclusion.Oral application of a 0.12% solution of Chlorhexidine does not prevent respiratory tract infections among ICU patients, although it may retard their onset.

scholarly journals Anemia as a Risk Factor for Acute Lower Respiratory Tract Infection in Children Below Five Years of Age

2018 ◽  
Vol 1 (1) ◽  
pp. 5-8
Author(s):  
Henish Shakya ◽  
Saurav Singh ◽  
Ashish Lakhey
Keyword(s):  
Risk Factor ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
P Value ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

Introduction: Lower respiratory tract infection is a major cause of death in children in a developing country and anemia is found to be one of the commonest associated cofactors. This study was aimed to determine association of anemia in children with lower respiratory tract infections.Materials and Methods: The retrospective study was done over a one-year period for children under 5 years of age, admitted in Pediatric Ward of a tertiary Hospital in Lalitpur. The study included 100 diagnosed cases of lower respiratory tract infections as per WHO criteria and 100 age and sex matched patients who did not have respiratory complaints as controls, excluding prematurity, chronic diseases, malnutrition and severe systemic illness. Appropriate clinical history, examination routine investigations like hemoglobin, peripheral smear, and Chest X-ray were included.Results: The age distribution maximum children were in the age group of 3 months to 23 months with significant association with prevalence of both pneumonia (p value 0.005) and anemia (p value 0.002). Anemia was found to be a significant risk factor for LRTI (p value < 0.001) with odds ratio of 2.68 and 95% CI (1.51 – 4.75).Conclusions: Anemia was significantly found to be associated with lower respiratory tract infections and these children were found to be 2.68 times more susceptible to lower respiratory tract infections. Early diagnosis and prevention of anemia is thus important to reduce the incidence of lower respiratory tract infections in children.Nepalese Medical Journal. vol.1, No. 1, 2018, page: 5-8

scholarly journals THE EFFECT OF ENVIRONMENTAL FACTOR AND USE OF PERSONAL PROTECTIVE EQUIPMENT ON THE SYMPTOMS OF ACUTE RESPIRATORY TRACT INFECTIONS IN FURNITURE INDUSTRY WORKERS

2020 ◽  
Vol 2 (1) ◽  
pp. 42-49
Author(s):  
Merry Sunaryo
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Environmental Factor ◽  
Respiratory Tract Infections ◽  
Acute Respiratory Tract Infection ◽  
Dust Exposure ◽  
Wood Dust ◽  
Furniture Industry ◽  
Tract Infections

Dust is one type of potential hazardzs in the workplace that can affect the health of the workers. The occupation that are always exposed to dust is furniture industry workers so that they have higher risk of getting acute respiratory tract infection (ARI) disorder which can interfere with breathing. The wood dust is formed from some of the sawn wood and sanding that will lead to an acute respiratory tract infection. The study aimed to determine the effect of environmental factor and the use of Personal Protective Equipment (PPE) against the symptoms of acute respiratory infections in the furniture industry workers. The research method used was quantitative method with observational and cross-sectional research types and it was analysed by using logistic regression test. The population in this study was the workers of the furniture industry at Semarang street, Surabaya City, with a total of 57 people, of which 37 furniture workers as a sample. The results show that most of the workers has symptoms of acute respiratory tract infection. It could be influenced by the environmental factor such as dust exposure that produced wood dust in each manufacturing processes. Additionally, the use of PPE also affected the occurrence of acute respiratory tract infections symptoms in the workers. In conslusion, many factors can influence the occurrence of acute respiratory tract infection symptoms in the furniture industry workers. Therefore, it is necessary to minimize the dust exposure in workers by wearing PPE such as respirators.

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