scholarly journals Some aspects of the transport system of iron metabolism depending on the degree of iron overload syndrome in children with chronic hepatitis B

2019 ◽  
Vol 18 (1) ◽  
pp. 17-21 ◽  
Author(s):  
F. I. Inoyatova ◽  
Kh. M. Kadyrkhodjaeva ◽  
G. Z. Inogamova ◽  
A. Kh. Akhmedova ◽  
N. K. Valieva ◽  
...  
2021 ◽  
Vol 13 (2) ◽  
pp. 108-114
Author(s):  
F. I. Inoyatova ◽  
Kh. M. Kadyrkhodzhayeva ◽  
G. Z. Inogamova ◽  
N. A. Ikramova ◽  
F. G. Abdullayeva ◽  
...  

Purpose: to establish the frequency and clinical significance of mutant variations of the HFE gene polymorphism in chronic hepatitis B (CHB) in children with iron overload syndrome (IOS).Materials and methods: 60 children with chronic hepatitis B with iron overload syndrome (IOS) were examined. When distributing children into groups, we took into account the criteria we developed for assessing the degree of life expectancy in children with CHB: CST>0.5 – mild degree of life expectancy (43,3% of children), CST˃0.5 – mild degree of life expectancy (43,3% of children), CST˂0,5 – moderate severity of life expectancy (31,7% of children) and CST˂0,2 – severe degree of SPL (25,0%). Virological verification of HBV was performed by ELISA and PCR. Using PCR Real Time and molecular genetic analysis, HFE gene C282Y, H63D, S65C mutations were detected from amplified DNA using the PRONTO Hemochromatosis reagent kit (Israel). The transferrin saturation coefficient (CST) was calculated using the formula CST = sTfR / log10.Ft. Results:Results: The study of the hemochromatosis gene HFE showed that the overwhelming majority (84,0%) of children with CHB with IOS were carriers of heterozygous, phenotypically different, mutant types. And only 16,0% of sick children were homozites of the wild (normal) HFE gene. Analysis of the phenotypic polymorphism of the hemochromatosis gene HFE revealed the presence of three point heterozygous mutations: H63D, S65C and combined variations in H63D / S65C, the latter of which is associated with severe forms of CHB and severe IOS.Conclusion. Children with CHB with IOS are characterized by a high incidence of heterozygous mutations in the HFE gene, the phenotypic manifestations of which were S65C, H63D, H63D / S65C. The comparability of the heterozygous combined mutation H63D / S65C with severe forms of CHB and a severe degree of IOS gives grounds to consider this phenotype of the HFE gene as a factor in the progression of the disease.


Medicine ◽  
2017 ◽  
Vol 96 (52) ◽  
pp. e9566
Author(s):  
Dong-Mei Zou ◽  
Dong-Dong Rong ◽  
Hong Zhao ◽  
Li Su ◽  
Wan-Ling Sun

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Tze Tong Tey ◽  
Richard Yiu ◽  
Wei Qiang Leow

Symptomatic iron overload and hyperferritinemia are rarely mentioned as complications of chronic hepatitis B infection. We report a case of a 70-year-old woman who presented with symptoms of iron overload including aches in the calves, fatigue, poor appetite, and low mood. Laboratory results showed a serum ferritin of 2449 μg/L and transferrin saturation of 74%. Her symptoms completely resolved with hepatitis B antiviral treatment. Serum ferritin and transferrin saturation also normalized. Symptomatic iron overload is a rare yet clinically important complication that can result from chronic hepatitis B infection.


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