Clinical case of multisystem inflammatory syndrome development in a child with new coronavirus infection

Objective: The article deals with a clinical case of new coronavirus infection in a 1 5-year-old child who was receiving treatment in an infectious diseases hospital of City Children's Clinical Hospital №3 during the period from 1 0 October to 1 December 2020.Materials and methods. The diagnosis was confirmed through nasal swabs examination for the presence of SARS-CoV-2 RNA using PCR and SARS-CoV-2 IgM detection through ELISA.Results. The main feature of the infection course in the present patient was multisystem inflammatory syndrome development with long-term fever, maculopapular rash and multisystemic lesions including bilateral pneumonia, acute carditis and polyserositis.

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Multisystem inflammatory syndrome in children - a clinical example in pediatrics

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2021-25(2)-12 ◽

2021 ◽

Vol 25 (2) ◽

pp. 258-260

Author(s):

V. M. Dudnyk ◽

V. Н. Furman ◽

I. I. Andrikevych ◽

N. O. Buglova ◽

O. V. Кutsak ◽

...

Keyword(s):

Serological Test ◽

World Health ◽

Rt Pcr ◽

The Us ◽

Control And Prevention ◽

Coronavirus Infection ◽

Polymerase Chain ◽

Health Organization ◽

Inflammatory Syndrome

Annotation. Peculiarities of clinical course and differential diagnosis of multisystem inflammatory syndrome (MIS-C) in children with coronavirus infection are described. The main features of this disease are long-term fever, multiorgan dysfunction, laboratory signs of inflammation and positive tests for SARS-CoV-2 (polymerase chain reaction using reverse transcription (RT-PCR), antigen test or positive serological test). The criteria of the World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) are used to confirm the MIS-C diagnosis.

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A clinical case of chickenpox complicated by meningoencephalitis and cerebral edema in combination with a novel coronavirus infection (COVID-19) in a 5-year-old child

CHILDREN INFECTIONS ◽

10.22627/2072-8107-2021-20-2-64-67 ◽

2021 ◽

Vol 20 (2) ◽

pp. 64-67

Author(s):

M. N. Kuzmina ◽

E. G. Klimovitskaya ◽

S. N. Eshmolov ◽

I. G. Sitnikov ◽

E. V. Elyakova

Keyword(s):

Infectious Diseases ◽

Cerebral Edema ◽

Blood Test ◽

Clinical Case ◽

Neurological Symptoms ◽

Immune Reactivity ◽

Mucous Membranes ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Inflammatory Changes

The new coronavirus infection COVID-1 9 in children generally proceeds favorably, but in combination with other acute infectious diseases and in persons with background pathology and impaired immune reactivity may pose a particular threat.The article presents a clinical case of chickenpox, complicated by meningoencephalitis and cerebral edema, in combination with COVID-1 9 in a 5-year-old child. Chickenpox was not quite typical: against the background of febrile temperature, there was a scanty spot-papular rash with single vesicles that appeared later, the absence of elements on the mucous membranes and the development of neurological symptoms in the first day of the disease. CОVID-1 9 was characterized by a wave-like course with fever up to 39,1 °C, tonsillitis phenomena and inflammatory changes in the blood test.

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Bilateral polysegmentary pneumonia caused by SARS-CoV-2 in a transplanted liver recipient

Clinical Practice ◽

10.17816/clinpract35121 ◽

2020 ◽

Vol 11 (2) ◽

pp. 101-106

Author(s):

Roman V. Ishenko ◽

Sergei V. Golovincki ◽

Artur R. Akhmedianov ◽

Sergei E. Voskanyan ◽

Ilya Yu. Kolyshev

Keyword(s):

Infectious Disease ◽

Clinical Case ◽

Organ Transplant ◽

Immunosuppressive Drugs ◽

Right Lobe ◽

Coronavirus Infection ◽

Disease Hospital ◽

The Right ◽

Liver Recipient

Background. In December 2019, the humanity met a previously unknown infectious disease (COVID-19) caused by a new coronavirus called SARS-CoV-2. An important role in the treatment of COVID-19 belongs to anti-inflammatory and immunosuppressive drugs. In this regard, the cases of the disease in patients undergoing long-term immunosuppressive therapy, for example, organ transplant recipients, are of particular interest. We present our clinical observation of COVID-19 in a liver recipient patient, which, apparently, is the first in the Russian Federation. Clinical case description A 54-year-old man, 10 years ago at the A.I. Burnazyan Center underwent transplantation of the right lobe of the liver after resection of hepatocellular carcinoma, T2N0M0, and due to liver cirrhosis as a result of НСV hepatitis. At the time of hospitalization, he had been constantly receiving immunosuppressive monotherapy with everolimus. The patient was transferred to an infectious disease hospital due to a positive PCR test for SARS-CoV-2 RNA. No signs of respiratory failure were found upon admission. Subsequently, a mild course of COVID-19 was observed, without signs of an acute inflammatory reaction, with normal CRP values and a slight increase of ferritin. 7 days after the treatment, the patient was discharged for outpatient observation. Conclusion. This clinical case is of interest not only by the success of the treatment of the new coronavirus infection COVID-19 in an immunocompromised patient a recipient of a liver transplant, but also by the fact that the disease manifested itself primarily as a transient increase in hepatic aminotransferases, which can be attributed to the gastrointestinal manifestations of COVID-19.

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Minimum requirements for rescuit beds and respiratory equipment in institutions refined for treatment of the new coronavirus infection COVID-19. Article

Alexander Saltanov Intensive Care Herald ◽

10.21320/1818-474x-2020-2-34-40 ◽

2020 ◽

pp. 34-40

Author(s):

B. V Silaev ◽

V. I Vechorko ◽

D. N Protsenko ◽

O. V Averkov ◽

E. Yu Khalikova

Keyword(s):

Intensive Care Unit ◽

Mechanical Ventilation ◽

Intensive Care ◽

Infectious Diseases ◽

Clinical Hospital ◽

Hospital Beds ◽

Minimum Requirements ◽

Bed Capacity ◽

Coronavirus Infection

City Clinical Hospital No. 15 named after O.M. Filatov, in the context of re-profiling into an infectious diseases hospital, the need for beds in the intensive care unit amounted to at least 12 % of the total number of hospital beds. Provision of apparatus for mechanical ventilation of lungs (mechanical ventilation) should be at least 80 % of the total number of beds in the intensive care unit. In addition, it is necessary to provide for the possibility of expanding the bed capacity to 30 % of the number of regular beds.

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Features of tuberculosis diagnosis in the COVID-19

Journal Infectology ◽

10.22625/2072-6732-2021-13-1-117-123 ◽

2021 ◽

Vol 13 (1) ◽

pp. 117-123

Author(s):

O. L. Ekaterincheva ◽

A. M. Malkova ◽

V. E. Karev ◽

I. V. Kudryavtsev ◽

Yu. S. Zinchenko ◽

...

Keyword(s):

Infectious Diseases ◽

Incidence Rate ◽

Clinical Case ◽

Clinical Course ◽

Diagnosis And Treatment ◽

Published Data ◽

The World ◽

History Of ◽

Tuberculosis Diagnosis ◽

Coronavirus Infection

2020 began with the most significant pandemic COVID-19 in the history of this century. The epidemiology indicators are growing every day. The spread of COVID-19 may affect an increase in the incidence of tuberculosis, despite a decrease in the incidence rate that is associated with objective difficulties in detecting tuberculosis against the background of COVID-19 and severe complications after the new coronavirus infection. Tuberculosis is one of the infectious diseases, and the problem of its spread continues to be relevant throughout the World. The effect of the SARS-CoV-2 virus can cause certain difficulties in the diagnosis and treatment of tuberculosis infection. The possibility of concomitant these infectious diseases can affect the clinical course of tuberculosis, an influence on mortality of the disease, but at the same time, there is a decrease in the number of cases that is not objective. The authors analyzed the currently published data on detecting tuberculosis in the conditions of the COVID-19 problem and presented difficulties in the diagnosis of COVID-19 and TB concomitant diseases with a description in the clinical case.

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MANIFESTATIONS OF ACUTE APPENDICITIS IN A CHILD WITH MULTISYSTEMIC INFLAMMATORY SYNDROME ASSOCIATED WITH SARS-COV-2: A CLINICAL CASE

Neonatology surgery and perinatal medicine ◽

10.24061/2413-4260.xi.4.42.2021.15 ◽

2021 ◽

Vol 11 (4(42)) ◽

pp. 102-106

Author(s):

O. Panchenko ◽

H. Pavlyshyn ◽

M. Halych ◽

V. Bodnarchuk

Keyword(s):

Abdominal Pain ◽

Acute Appendicitis ◽

Inflammatory Disease ◽

Clinical Case ◽

Gastrointestinal Symptoms ◽

Transmission Mechanism ◽

Oral Transmission ◽

Coronavirus Infection ◽

Loss Of Appetite ◽

Inflammatory Syndrome

The pandemic of the coronavirus disease caused by SARS-CoV-2, continues. The airborne way stays the main one in transmission of coronavirus infection. However, the fecal-oral transmission mechanism plays a significant role. Gastrointestinal symptoms of SARS-CoV-2 infection include loss of appetite, diarrhea, vomiting, and abdominal pain, which can often mask other conditions and require diagnostic search and differential diagnosis.The presence of multisystem inflammatory syndrome, according to the international classification, indicates a critical course of infection caused by SaRS-CoV-2, and can develop in children a few weeks after infection. The acute symptoms from the digestive tract side are one of the criteria of the multisystem inflammatory syndrome.The article presents a clinical case of acute appendicitis in a child with multisystem inflammatory disease associated with SARS-COV-2 infection, evaluates the dynamics of the main manifestations following the treatment, and analyzes the literature on such cases, emphasizing the features and difficulties of diagnostic search.

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CLINICAL, LABORATORY-INSTRUMENTAL CHARACTERISTICS, COURSE AND THERAPY OF PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-19

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2020-99-6-73-83 ◽

2020 ◽

Vol 99 (6) ◽

pp. 73-83

Author(s):

Yu.Yu. Novikova ◽

◽

D.Yu. Ovsyannikov ◽

A.A. Glazyrina ◽

O.I. Zhdanova ◽

...

Keyword(s):

Clinical Laboratory ◽

Intensive Therapy ◽

Gastrointestinal Symptoms ◽

Arterial Hypotension ◽

Therapy Outcomes ◽

Clinical Hospital ◽

Severe Manifestation ◽

Symptom Complex ◽

Coronavirus Infection ◽

Inflammatory Syndrome

The most severe manifestation of the new coronavirus infection COVID-19 in children is the multisystem inflammatory syndrome in children (MIS-C). A systematic review of foreign publications as of July 25, 2020 contains an analysis of the disease course in 662 children with this syndrome and is used for comparison with the data obtained. Objective of the research: to characterize clinical manifestation, results of laboratory and instrumental studies, therapy, outcomes and consequences of the COVID-19- associated MIS-C, based on the observation of patients hospitalized to Morozov Children's City Clinical Hospital and Children’s clinical hospital of infectious diseases № 6 from May 1 to September 15, 2020. Materials and methods: the pilot study included 32 children aged 9 months – 15 years with COVID-19-associated MIS-C, verified based on WHO criteria (2020), including symptoms of Kawasaki disease (KD), arterial hypotension/shock, laboratory and instrumental signs of heart damage, signs of coagulopathy, gastrointestinal symptoms, increased inflammation markers, COVID-19 markers. Results: the median age of patients was 6 years, boys predominated among the patients (66%), all patients had antibodies to SARS-CoV-2 (31 children of the IgG class); MIS-C manifested itself as a combination of KD symptom complex (75% of patients) with arterial hypotension/shock (28%), neurological (50%), respiratory (41%), gastrointestinal (59%) symptoms; macrophage activation syndrome (MAS) was verified in 16% of patients. Therapy included intravenous immunoglobulin (75%), systemic glucocorticosteroids (88%), anticoagulants (91%), vasoactive/vasopressor support (31%). In 38% of cases treatment was performed in intensive care unit; one child died. According to echocardiography, 16% of patients had coronariitis, ectasia, and coronary arteries aneurysms. Conclusion: COVID-19-associated MIS-C is characterized by a severe course, cross-features with KD, shock syndrome with KD, MAS which requires intensive therapy and can cause acquired pathology of the cardiovascular system in children.

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Long-term follow up of the course of Covid-19 infection in a patient with allergic rhinitis and conjunctivitis

Immunopathology Allergology Infectology ◽

10.14427/jipai.2020.4.12 ◽

2020 ◽

pp. 12-20

Author(s):

E Matsko

Keyword(s):

Allergic Rhinitis ◽

Clinical Case ◽

Long Term Follow Up ◽

Coronavirus Infection ◽

Long Term Observation

The article presents the data on the etiology and pathogenesis of Covid-19. The clinical charact---eristics of various organs and systems lesions are described. A clinical case of the coronavirus infection course in a doctor with allergic rhinitis and conjunctivitis during long-term observation is presented.

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Pneumococcal Septicemia after COVID-19 in Teenager: Clinical Case

Педиатрическая фармакология ◽

10.15690/pf.v18i4.2295 ◽

2021 ◽

Vol 18 (4) ◽

pp. 292-297

Author(s):

Viktor V. Krasnov ◽

Danila A. Pimenov ◽

Valery I. Sedov ◽

Vera N. Kotova ◽

Lilia R. Pavlovich

Keyword(s):

Infectious Diseases ◽

Clinical Case ◽

Clinical Manifestations ◽

Infectious Process ◽

Blood Assay ◽

Negative Effect ◽

Inflammatory Syndrome ◽

The Impact ◽

Pcr Test

There is a hypothesis among the scientists that COVID-19 and SARS-CoV-2 have negative effect on the immune system. Many reports on multisystem inflammatory syndrome (MIS) development after COVID-19 are published worldwide. Whereas, the impact of this infection on prevalence and course of any other infectious diseases has not been studied. The aim of the study is to draw attention to the estimation of other infectious diseases course after COVID-19 by analyzing the clinical case of pneumococcal septicemia in 17 years old boy who has undergone COVID-19. We obtained data about COVID-19 during the analysis of the child's medical history. The course of infectious process was similar to the course of multisystem inflammatory syndrome in children (MIS-C), compared by clinical manifestations. The results of ELISA blood assay have proved it: we revealed IgG to SARS-CoV-2. However, PCR test revealed S. pneumoniae DNA in blood, so MIS-C diagnosis was excluded. The role of SARS-CoV-2 in other diseases in postcovid period can not be excluded, and it requires further studies. Development of screening and rehabilitation principles is recommended despite the severity of COVID-19 in children.

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