scholarly journals Pneumococcal Septicemia after COVID-19 in Teenager: Clinical Case

2021 ◽  
Vol 18 (4) ◽  
pp. 292-297
Author(s):  
Viktor V. Krasnov ◽  
Danila A. Pimenov ◽  
Valery I. Sedov ◽  
Vera N. Kotova ◽  
Lilia R. Pavlovich
Keyword(s):  
Infectious Diseases ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Infectious Process ◽  
Blood Assay ◽  
Negative Effect ◽  
Inflammatory Syndrome ◽  
The Impact ◽  
Pcr Test

There is a hypothesis among the scientists that COVID-19 and SARS-CoV-2 have negative effect on the immune system. Many reports on multisystem inflammatory syndrome (MIS) development after COVID-19 are published worldwide. Whereas, the impact of this infection on prevalence and course of any other infectious diseases has not been studied. The aim of the study is to draw attention to the estimation of other infectious diseases course after COVID-19 by analyzing the clinical case of pneumococcal septicemia in 17 years old boy who has undergone COVID-19. We obtained data about COVID-19 during the analysis of the child's medical history. The course of infectious process was similar to the course of multisystem inflammatory syndrome in children (MIS-C), compared by clinical manifestations. The results of ELISA blood assay have proved it: we revealed IgG to SARS-CoV-2. However, PCR test revealed S. pneumoniae DNA in blood, so MIS-C diagnosis was excluded. The role of SARS-CoV-2 in other diseases in postcovid period can not be excluded, and it requires further studies. Development of screening and rehabilitation principles is recommended despite the severity of COVID-19 in children.

scholarly journals SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestations and the role of infliximab treatment

2021 ◽  
Author(s):  
Nahed Abdel-Haq ◽  
Basim I. Asmar ◽  
Maria P. Deza Leon ◽  
Eric J. McGrath ◽  
Harbir S. Arora ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Infliximab Treatment ◽  
Inflammatory Syndrome

scholarly journals Impact of the trace element status on the course of ankylosing spondylitis in the Orenburg Region patients

2019 ◽  
Vol 13 (4) ◽  
pp. 66-74
Author(s):  
U. A. Yakubova ◽  
O. V. Bugrova ◽  
S. I. Krasikov ◽  
N. P. Setko ◽  
R. I. Saifutdirov
Keyword(s):  
Ankylosing Spondylitis ◽  
Inflammatory Diseases ◽  
Clinical Manifestations ◽  
Atomic Absorption Spectrophotometry ◽  
Zn Deficiency ◽  
Orenburg Region ◽  
And Zn Deficiency ◽  
Trace Element Status ◽  
The Impact

The role of trace elements (TEs) and their imbalance in the physiology of bone tissue and in the development of inflammatory diseases of the joints and spine has been discussed in recent years; however, there is no evidence for the TE status of patients with ankylosing spondylitis (AS) and its possible impact on the course of the disease.Objective: to investigate the impact of the TE status of patients with AS on the course, clinical manifestations, and activity of the disease.Patients and methods. Examinations were made in 58 patients (39 men and 19 women), residents of the Orenburg Region, with a reliable diagnosis of AS, the duration of which was 16 [11; 26] years. The patients’ mean age was 38 [31; 48] years. HLA-B27 antigen was detected in 91.4% of cases. In addition to the generally accepted examination, atomic absorption spectrophotometry was used to determine the hair levels of 9 TEs: Cu, Zn, Fe, Mn, Cr, Co, Ni, Pb, and Cd in all the patients.Results and discussion. The AS patients living in the Orenburg Region showed TE imbalance manifested by Cu and Zn deficiency and Ni, Cr, and Mn accumulation in the hair. Multidirectional correlations were found between the values of these TEs and the presence of extra-axial (peripheral arthritis, dactylitis) and extra-skeletal (uveitis) manifestations of AS, its activity, and severity of functional disorders.Conclusion. The preliminary results may suggest that the emerging imbalance of TEs can affect the course of AS, maintaining and increasing its activity.

scholarly journals Circulating Leukocytes and Oxidative Stress in Cardiovascular Diseases: A State of the Art

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Speranza Rubattu ◽  
Maurizio Forte ◽  
Salvatore Raffa
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Stress Level ◽  
Mononuclear Cells ◽  
Pathological Condition ◽  
Clinical Manifestations ◽  
Therapeutic Interventions ◽  
Oxidative Stress Level ◽  
The Impact

Increased oxidative stress from both mitochondrial and cytosolic sources contributes to the development and the progression of cardiovascular diseases (CVDs), and it is a target of therapeutic interventions. The numerous efforts made over the last decades in order to develop tools able to monitor the oxidative stress level in patients affected by CVDs rely on the need to gain information on the disease state. However, this goal has not been satisfactorily accomplished until now. Among others, the isolation of circulating leukocytes to measure their oxidant level offers a valid, noninvasive challenge that has been tested in few pathological contexts, including hypertension, atherosclerosis and its clinical manifestations, and heart failure. Since leukocytes circulate in the blood stream, it is expected that they might reflect quite closely both systemic and cardiovascular oxidative stress and provide useful information on the pathological condition. The results of the studies discussed in the present review article are promising. They highlight the importance of measuring oxidative stress level in circulating mononuclear cells in different CVDs with a consistent correlation between degree of oxidative stress and severity of CVD and of its complications. Importantly, they also point to a double role of leukocytes, both as a marker of disease condition and as a direct contributor to disease progression. Finally, they show that the oxidative stress level of leukocytes reflects the impact of therapeutic interventions. It is likely that the isolation of leukocytes and the measurement of oxidative stress, once adequately developed, may represent an eligible tool for both research and clinical purposes to monitor the role of oxidative stress on the promotion and progression of CVDs, as well as the impact of therapies.

Moving music for moving source texts

2018 ◽  
Vol 1 (2) ◽  
pp. 319-340 ◽  
Author(s):  
Beatriz Naranjo Sánchez
Keyword(s):  
Literary Texts ◽  
Emotional Engagement ◽  
Translation Quality ◽  
Creative Behaviour ◽  
Negative Effect ◽  
Potential Benefits ◽  
The Impact ◽  
Sad Music ◽  
Positive Effect

Abstract Based on previous findings about the role of music as an emotional stimulus, as well as the potential benefits of music-driven emotional engagement in written production and creative behaviour, the present study investigates the impact of emotional background music on translation quality and creativity. A translation experiment in two different conditions (music vs. silence) was conducted in a controlled environment. Participants translated two literary texts of opposing emotional contents (happy vs. sad) while they listened to an emotionally-matching soundtrack. Statistical analysis of within- and between-group comparisons only revealed conclusive results for the sad condition, showing a positive effect of sad music on translation creativity and a negative effect on accuracy.

scholarly journals Internal R&D and Acquisition Performance of Chinese Pharmaceutical Firms: Moderation Effect of Acquisition Motive and Corporate Ownership

Processes ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 292 ◽  
Author(s):  
Qi Yue ◽  
Xing Hua ◽  
Jianyuan Li
Keyword(s):  
Path Dependence ◽  
Corporate Ownership ◽  
Acquisition Performance ◽  
Moderation Effect ◽  
Pharmaceutical Firms ◽  
Key Factor ◽  
Negative Effect ◽  
The Impact ◽  
The Relationship

Although corporate capability has been recognized as a key factor affecting corporate acquisition performance, the role of R&D capability in acquisition performance has not been fully explained. The aim of this paper was to research the impact of internal R&D on acquisition performance according to a sample of 215 acquisitions of Chinese listed pharmaceutical companies from 2012 to 2016. First, it was found that R&D has a significant negative effect on acquisition performance. Furthermore, it was confirmed that the acquisition motive and the ownership of the acquiring firm have a moderating effect on the relationship between R&D and acquisition performance. Compared to non-technical acquisitions, the negative effect of internal R&D on acquisition performance was reduced for technical acquisitions. Compared with non-state-owned-enterprise acquisition, the negative effect of internal R&D on the acquisition performance of state-owned enterprises was weakened. Our study enriches the research of the path dependence theory on the acquisition performance of enterprises and also the interpretation of acquisition performance on the basis of internal and external innovation and the institutional theory.

scholarly journals THE CLINICAL CASE OF DETECTION OF TICKS GENUS DEMODEX OF ATYPICAL LOCALIZATION

2017 ◽  
Vol 23 (5) ◽  
pp. 275-278
Author(s):  
Svetlana V. Kuleshova ◽  
A. A Altaeva ◽  
N. Kh Aysina ◽  
A. A. Tarasov ◽  
E. V Dvoretskaya ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Atypical Localization

The role of the tick Demodex in pathogenesis of different diseases of skin until now suffer from ambiguous evaluation. The article presents examples of detection of the tick Demodex in diverse material with and without clinical manifestations. The clinical case is presented concerning detection of the tick in secretion from nipple of mammary gland. The issue of various approaches to diagnostic both in our country and abroad is brought up.

scholarly journals The Effects of Corporate Bonds on Employment: Early Evidence from Greece

2020 ◽  
Vol 12 (2) ◽  
pp. 235-253
Author(s):  
Sotirios Karagiannis ◽  
Dimitrios Thomakos
Keyword(s):  
Corporate Bonds ◽  
Banking System ◽  
External Financing ◽  
Listed Firms ◽  
Negative Effect ◽  
The Impact ◽  
First Time ◽  
Investment Choices ◽  
Positive Effect

This study investigates the impact of corporate bonds issued by Greek listed firms on employment. Even though external financing and the effects on employment has been studied in the literature, we extend the existing literature by focusing for the first time on the specific role of corporate bonds on employment. We have collected all the relevant papers on this line of the literature and concisely report them in a table format and then use them in analyzing our results. Our empirical analysis is based on a panel dataset from 2001 to 2014 and we examine the effect of corporate bonds in the pre and post period of the Greek economic crisis, in which the banking system is vulnerable and unable to provide financing to the firms. The results suggest that corporate bonds have a positive effect on employment in the pre-crisis sample, denoting that firms hire employees and proceed to investment choices. On the contrary, during the recession, corporate bonds have a negative effect on employment. Firms reduce their costs and try to control their debt obligations by issuing corporate bonds.

The impact of values on consumer adoption of takāful with mediating role of religiosity and moderating role of confusion

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Amer Sarfraz ◽  
Asif Khurshid Mian
Keyword(s):  
Urban Areas ◽  
Consumer Adoption ◽  
Content Type ◽  
Rural And Urban Areas ◽  
Mediating Role ◽  
Rural And Urban ◽  
Negative Effect ◽  
The Impact ◽  
Moderating Role

Purpose This study aims to address a leading challenge of confusion about the concept of takāful confronted by existing and potential consumers of the insurance industry. There are multiple sources of confusion, including the lack of consensus among religious scholars to implement a standardized business model of takāful, the lack of knowledge or awareness and the lack of skilled or trained personnel, which prevent existing and potential consumers from adopting takāful products or services. The fundamental concept of takāful is introduced mainly to fulfill the religious, social and economic needs of Muslims. Thus, the choice of takāful activates the religious, cultural, family and traditional values of individuals. Hence, the primary purpose of this study is to determine the impact of tradition value and stimulation value on consumer adoption of takāful services. Further, the scope of this study is extended to establish the mediating role of religiosity and moderating role of confusion on the association between traditional value and consumer adoption of takāful services. Design/methodology/approach This study follows quantitative research methods and a cross-sectional approach for data collection. Thus, the sample is collected from 768 respondents belongs to rural and urban areas by using a close-ended questionnaire. The mediation and moderation analysis are performed by using Andrew F. Hayes process Models-4 and −5. Findings The result reveals that religiosity mediates and confusion moderates the relationship of traditional value and consumer adoption of takāful. However, the traditional value shows a negative effect on consumer adoption of takāful. Moreover, the confusion negatively moderates the association between traditional value and consumer adoption of takāful. Finally, the stimulation value also reflects a negative effect on consumer adoption of takāful services. Originality/value The findings of this study shed novel insights into the existing literature of takāful and basic human values. The outcomes of stimulation values contradict with the findings of Wang et al. (2008). The result of mediation analysis reveals that religiosity plays a vital role in activating the goals of traditional value, which motivates consumers to adopt takāful services. The present study is useful for takāful operators to understand the value priorities of prospect clients belong to rural and urban areas.

scholarly journals MANAGING KNOWLEDGE-RELATED BARRIERS TO TECHNOLOGICAL INNOVATION THROUGH EXPLOITATIVE AND EXPLORATIVE ORGANISATIONAL STRATEGIES

2019 ◽  
Vol 23 (04) ◽  
pp. 1950035 ◽  
Author(s):  
NUTTANEEYA (ANN) TORUGSA ◽  
WAYNE O’DONOHUE
Keyword(s):  
Firm Performance ◽  
Technological Innovation ◽  
Hierarchical Regression ◽  
Business Success ◽  
Negative Effects ◽  
Negative Interaction ◽  
Negative Effect ◽  
The Impact ◽  
Workplace Creativity

This study uses data from a sample of 31,948 European innovating firms to examine the impact that knowledge-related barriers to technological innovation have on the link between the level of such innovation and firm performance, and, to investigate the role of “exploitative” and “explorative” organisational strategies in moderating such impact. Exploitative strategies are measured by the level of organisational innovations, and exploratory strategies are measured by the level of methods for fostering workplace creativity. Using moderated hierarchical regression, the results reveal a negative effect of the interaction between technological innovation and related knowledge constraints on firm performance. They also reveal that the negative interaction effect becomes positive at high levels of organisational innovations and creativity-fostering methods. The study findings thus indicate the need for managers of technologically innovative firms to implement both exploitative and explorative organisational strategies. Doing so could help minimise the negative effects of knowledge-related barriers to technological innovation, and in turn promote innovation-based competitiveness and business success.

scholarly journals The Impact of High Glucose or Insulin Exposure on S100B Protein Levels, Oxidative and Nitrosative Stress and DNA Damage in Neuron-Like Cells

2021 ◽  
Vol 22 (11) ◽  
pp. 5526
Author(s):  
Adriana Kubis-Kubiak ◽  
Benita Wiatrak ◽  
Agnieszka Piwowar
Keyword(s):  
High Glucose ◽  
Nitrosative Stress ◽  
Statistical Significance ◽  
S100 Protein ◽  
Clinical Manifestations ◽  
Amyloid Β ◽  
S100b Protein ◽  
The Impact ◽  
S100b Secretion

Alzheimer’s disease (AD) is attracting considerable interest due to its increasing number of cases as a consequence of the aging of the global population. The mainstream concept of AD neuropathology based on pathological changes of amyloid β metabolism and the formation of neurofibrillary tangles is under criticism due to the failure of Aβ-targeting drug trials. Recent findings have shown that AD is a highly complex disease involving a broad range of clinical manifestations as well as cellular and biochemical disturbances. The past decade has seen a renewed importance of metabolic disturbances in disease-relevant early pathology with challenging areas in establishing the role of local micro-fluctuations in glucose concentrations and the impact of insulin on neuronal function. The role of the S100 protein family in this interplay remains unclear and is the aim of this research. Intracellularly the S100B protein has a protective effect on neurons against the toxic effects of glutamate and stimulates neurites outgrowth and neuronal survival. At high concentrations, it can induce apoptosis. The aim of our study was to extend current knowledge of the possible impact of hyper-glycemia and -insulinemia directly on neuronal S100B secretion and comparison to oxidative stress markers such as ROS, NO and DBSs levels. In this paper, we have shown that S100B secretion decreases in neurons cultured in a high-glucose or high-insulin medium, while levels in cell lysates are increased with statistical significance. Our findings demonstrate the strong toxic impact of energetic disturbances on neuronal metabolism and the potential neuroprotective role of S100B protein.

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