scholarly journals Nodular lesion in the tongue: A rare case of low grade myofibroblastic sarcoma

2020 ◽  
Vol 26 (2) ◽  
pp. 35-36
Author(s):  
Jefferson Tenório ◽  
Frederico Medeiros ◽  
Machado Orsini ◽  
Santos dos
Keyword(s):  
Smooth Muscle Actin ◽  
Malignant Neoplasm ◽  
Immunohistochemical Analysis ◽  
Nodular Lesion ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Lateral Border ◽  
Myofibroblastic Sarcoma ◽  
Spindle Cell Lesion ◽  
S 100

Low grade myofibroblastic sarcoma is an atypical myofibroblastic malignant neoplasm that rarely affects the oral cavity and presents a challenging histological diagnosis. Here we report the case of a 38-year-old woman who had a nodular and symptomatic lesion on the lateral border of the tongue. After the biopsy, the histopathological analysis revealed a spindle cell lesion with fascicular and storiform pattern. We performed immunohistochemical analysis that showed intense labeling for vimentin, smooth muscle actin and moderate labeling for calponin and S-100. We emphasize the rarity of low grade myofibroblastic sarcoma such as a nodular lesion on the tongue and the need for accurate diagnosis.

scholarly journals Canine Cutaneous Clear Cell Adnexal Carcinoma: Histopathology, Immunohistochemistry, and Biologic Behavior of 26 Cases

2005 ◽  
Vol 17 (5) ◽  
pp. 403-411 ◽  
Author(s):  
F. Y. Schulman ◽  
T. P. Lipscomb ◽  
T. J. Atkin
Keyword(s):  
Clear Cell ◽  
Regional Lymph Node ◽  
Smooth Muscle Actin ◽  
Periodic Acid ◽  
Dermal Papilla ◽  
Low Grade ◽  
Periodic Acid Schiff ◽  
Regional Lymph Nodes ◽  
S 100 ◽  
Clear Cytoplasm

Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff—positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as “clear-cell hidradenocarcinoma” and “follicular stem cell carcinoma.” The authors propose the designation “cutaneous clear cell adnexal carcinoma.”

scholarly journals Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Amerigo Giudice ◽  
Francesco Bennardo ◽  
Caterina Buffone ◽  
Ylenia Brancaccio ◽  
Francesca Maria Plutino ◽  
...  
Keyword(s):  
English Language ◽  
Immunohistochemical Analysis ◽  
Surgical Excision ◽  
Clinical Aspects ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Presumptive Diagnosis ◽  
Female Ratio ◽  
S 100 ◽  
Male To Female

Angioleiomyoma (AL) is an uncommon benign soft tissue neoplasia arising from the tunica media of the smooth muscle cells. AL appears as a solitary and slow-growing mass and seldom is observed in oral tissues. We reported a rare case of AL involving the cheek of a 17-year-old young woman. A review of the English-language literature was performed entering the keywords “angioleiomyoma” and “oral” in the search fields of PubMed. 70 results were identified. Excluded were cases that were not in the oral cavity or not compatible with the AL diagnosis or report lacking immunohistochemical analysis. According to the exclusion criteria, we selected 30 studies that included 63 cases of AL. The results of the review showed an average age of 42.97 years with a prevalence between the fourth and fifth decade of life with a male-to-female ratio of 1.95 : 1. The most affected sites were palate, buccal mucosa of the cheek, lip, tongue, and gingiva. Surgical excision was the treatment of choice, and diagnosis was possible through histopathological and immunohistochemical analysis. SMA, vimentin, CD34, desmin, and S-100 were the most common markers to guide the histopathological diagnosis of oral AL. In conclusion, oral AL is a rare entity, especially in adolescence as in the reported case of AL of the cheek in a 17-year-old woman. The clinical aspects of AL did not allow clinicians to make a correct presumptive diagnosis. A scrupulous histopathological analysis and immunohistochemical examinations are fundamental to differentiate AL from other lesions.

scholarly journals Low-grade myofibroblastic sarcoma of retroperitoneum: a rare case

2019 ◽  
Vol 6 (2) ◽  
pp. 633
Author(s):  
Suresh K. Choudhary ◽  
Shalu Gupta ◽  
Somendra Bansal ◽  
Narender Kumar
Keyword(s):  
Splenic Flexure ◽  
Soft Tissues ◽  
Imaging Modality ◽  
Smooth Muscle Actin ◽  
Abdominal Cavity ◽  
Neck Region ◽  
Low Grade ◽  
Tissue Mass ◽  
Myofibroblastic Sarcoma

Low-grade myofibroblastic sarcoma (LGMFS) is an uncommon tumor which develops mainly in the bone or soft tissues of the head and neck region, trunk, or extremities and extremely rarely found in the abdominal cavity. The rarity of the disease and its low-grade features make an accurate diagnosis difficult in most cases. We recently encountered a giant LGMFS which had developed in retroperitoneum and surgically resected with gratifying results. An 18 years old female presented with complaint of left sided abdominal pain since 8 months and left sided abdominal lump since 5 months. Imaging examinations revealed retroperitoneal soft tissue mass, and surgical treatment was scheduled. During operation, a tumor about 20x18x15cm in diameter with its anterior aspect covered with the pancreas, mesocolon and splenic flexure of colon with densely adhered to splenic vessels and left renal vessels was found. The tumor had firm adhesions to the surrounding tissues, and it was excised with concomitant distal pancreato-splenectomy, left nephrectomy and resection of splenic flexure of colon with colo-colic anastomosis. Histopathologically, fusiform cells were arranged in a complicated or storiform pattern, and immunohistochemical staining revealed that the tumor was positive for vimentin and focally positive for α-smooth muscle actin (SMA), negative for desmin, CD34, CD117, EMA, DOG-1 and S-100. Diagnosis of LGMFS was made. During 6 months follow up patient is asymptomatic and ultrasound abdomen is normal. In case of LGMFS, favorable prognosis can be attained by complete resection of the primary lesion and regular follow up of patient by physical examination and imaging modality.

scholarly journals Low-Grade Myofibroblastic Sarcoma of the Oral Cavity: A Report of Three Cases Illustrating an Emerging Disease in Children

2021 ◽  
Vol 8 (1) ◽  
pp. 1-9
Author(s):  
Primali Rukmal Jayasooriya ◽  
Chamara Athukorala ◽  
Manjula Attygalla ◽  
Balapuwaduge Ranjit Rigobert Nihal Mendis ◽  
Tommaso Lombardi
Keyword(s):  
Oral Cavity ◽  
Smooth Muscle Actin ◽  
Emerging Disease ◽  
Low Grade ◽  
Beta Catenin ◽  
Moderate Degree ◽  
Ki 67 ◽  
Myofibroblastic Sarcoma ◽  
First Case ◽  
Current Series

Low-grade myofibroblastic sarcoma (LGMS) is a mesenchymal tumor of myofibroblasts that occurs more frequently in adults. A series of three cases is presented to illustrate that LGMS may also occur within the oral cavity in children and adolescents. The first case (Case 1) occurred intra-osseously in the mandible, while the remaining two presented as gingival swellings and were purely restricted to soft tissue (cases 2 and 3). The intra-osseous lesion arose in a 7-year-old girl, whereas the gingival lesions were observed in a 12-year-old girl (Case 2) and a 13-year-old boy (Case 3). Histopathologically, all cases were composed of spindle shaped cells arranged into long fascicles showing mild to moderate degree of nuclear atypia. Ki-67 (MIB-1) proliferation activity was relatively low, amounting to 3–5% in all cases. Immunohistochemically, all cases showed smooth muscle actin (SMA) positivity in spindle cells, while desmin, beta catenin, cytokeratin, and CD34 were negative, resulting in a diagnosis of LGMS. In conclusion, current series of three cases of LGMSs that occurred in the oral cavity in a child and two adolescent patients is presented to highlight an emerging disease that requires additional data for further characterization.

scholarly journals Rare Variant of Adult Rhabdomyosarcoma Presenting as a Palatal Swelling

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Hafiz Aamer Iqbal ◽  
Rabia Anjum ◽  
Nadia Naseem
Keyword(s):  
Rare Variant ◽  
Smooth Muscle Actin ◽  
Tertiary Care ◽  
Maxillofacial Surgery ◽  
Malignant Neoplasm ◽  
Immunohistochemical Analysis ◽  
Oral And Maxillofacial Surgery ◽  
Care Hospital ◽  
Creative Commons ◽  
Adult Rhabdomyosarcoma

A 26-year-old male was referred to the Department of Oral and Maxillofacial Surgery of a tertiary care hospital in Lahore with chief complaint of painless swelling on the right palate of 40 days duration. Clinical differential diagnosis included squamous cell carcinoma, Ewing sarcoma, fibrosarcoma, neuroblastoma and rhabdomyosarcoma. Computed tomography scan revealed hypodense mass with necrotic changes. Histological examination of the excised tumor revealed malignant neoplasm arranged in fascicles and bundles comprising of spindle cells with pleomorphic, hyperchromatic nuclei and increased atypical mitosis. Immunohistochemical analysis showed negative staining with Cytokeratin, S100, CD34, Stat6, h-Caldesmon and EMA while the tumour cells were positive for desmin, myogenin, smooth muscle actin, CD-99 and MyoD1 thus confirming the diagnosis of spindle cell rhabdomyosarcoma. doi: https://doi.org/10.12669/pjms.37.3.3305 How to cite this:Iqbal HA, Anjum R, Naseem N. Rare Variant of Adult Rhabdomyosarcoma Presenting as a Palatal Swelling. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3305 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Histopathological Analysis of Neoplastic and Non Neoplastic Lesions of Salivary Gland – A Retrospective Study in a Tertiary Care Hospital

2021 ◽  
Vol 8 (05) ◽  
pp. 236-240
Author(s):  
Sheela K.M ◽  
Priya V.S. ◽  
Lali K. Rajan ◽  
Ashida M. Krishnan
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Care Hospital ◽  
Neoplastic Lesions

BACKGROUND Salivary gland lesions constitute less than 1 % of tumours and about 4 % of all epithelial neoplasms of head and neck region. These comprise of a wide variety of benign, malignant and non-neoplastic lesions which exhibits a difference in histological behaviour. There are no reliable criteria to differentiate on clinical grounds the benign from malignant ones. So morphological evaluation is necessary. We aim to study the frequency of various salivary gland lesions in sialoadenectomy specimens and categorise them into neoplastic and nonneoplastic lesions. METHODS It is a record based retrospective 5-year study carried out in the Government Medical College, Thiruvananthapuram, Kerala, from January 2014 to December 2018. RESULTS In this study a total of 329 histopathologically proven cases of salivary gland lesions were included. Neoplastic lesions and non-neoplastic lesions constituted 78.42 % and 21.58 % respectively. Pleomorphic adenoma was the most common neoplasm (50.54 %) trailed by Warthin’s tumour (9.73 %). Most common malignant neoplasm encountered in our study was mucoepidermoid carcinoma (9.73 %) among which low grade tumours showed predominance. We observed significantly higher incidence of benign and malignant lesions in the 5 th to 6th decade while non neoplastic lesions were seen more in the 4th to 5th decade. Average age of the patients with salivary gland tumours was 46.12  SD 15.57. Majority of cases of salivary gland lesions in our study were from parotid gland (75.68 %) followed by submandibular gland 24.01 %. CONCLUSIONS Pleomorphic adenoma was the most common benign tumour in our study and mucoepidermoid carcinoma the most common malignant tumour. Neoplastic lesions showed a predominance over non neoplastic lesions. Histopathological examination is the mainstay for diagnosis and clinical management. KEYWORDS Histopathology, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

Primary Peritoneal Malignant Mixed Mesodermal (Müllerian) Tumor

2009 ◽  
Vol 95 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Mahmoud R Hussein ◽  
Saad Rezk Abudlwahed Hussein ◽  
Ahmad Rezk Abd-Elwahed
Keyword(s):  
Abdominal Mass ◽  
Malignant Neoplasm ◽  
Immunohistochemical Analysis ◽  
Molecular Alterations ◽  
Gynecological Examination ◽  
Positive Reactivity ◽  
S 100 ◽  
Poorly Differentiated ◽  
Exact Origin ◽  
Abdominal Fullness

Aims and background Malignant mixed mesodermal tumor (MMMT) is a biphasic neoplasm (carcinosarcoma) composed of both epithelial and mesenchymal elements. Extragenital MMMT, including primary peritoneal MMMT, is an extremely rare tumor with features consistent with its origin from the secondary Müllerian system. The neoplastic elements of extragenital MMMT presumably arise directly from the mesothelium or submesothelial stroma and hence parallel the biphasic pattern of the genital (uterine or ovarian) counterpart. Methods and study design Here we report on the clinical, pathological, and immunohistochemical features of a case of peritoneal MMMT in a 65-year-old woman. The patient presented with abdominal fullness and pain. Gynecological examination revealed a huge pelvic abdominal mass. On histology, the tumor consisted of poorly differentiated carcinomatous and sarcomatous (rhabdomyosarcoma) components. Further immunohistochemical analysis revealed positive reactivity for both epithelial (cytokeratin and epithelial membrane antigen) and mesenchymal (vimentin, S-100, and desmin) markers. The patient refused treatment and died of the disease three months later. Results and conclusions Based on the present case and on previous studies, primary peritoneal MMMT seems to be a rare but highly malignant neoplasm with an aggressive behavior and poor prognosis. Its exact origin, histogenesis and molecular alterations are poorly understood.

Development of an Atypical Teratoid Rhabdoid Tumor in a Meningioma

2017 ◽  
Vol 25 (6) ◽  
pp. 567-572 ◽  
Author(s):  
Boleslaw Lach ◽  
Michelle Kameda-Smith ◽  
Sheila Singh ◽  
Olufemi Ajani
Keyword(s):  
Epithelial Membrane Antigen ◽  
Smooth Muscle Actin ◽  
Rhabdoid Tumor ◽  
Low Grade ◽  
Recurrent Tumor ◽  
Atypical Teratoid Rhabdoid Tumor ◽  
Muscle Actin ◽  
Anaplastic Meningioma ◽  
S 100 ◽  
Atypical Teratoid

We describe an atypical teratoid rhabdoid tumor (AT/RT) with a component of low-grade and anaplastic rhabdoid meningioma in a 7-year-old child. The AT/RT was uniformly negative for INI1 and displayed immunoreactivity for vimentin, P53, CD99, cytokeratins with AE1/AE3 antibodies, epithelial membrane antigen, β-catenin, smooth muscle actin, E-cadherin, and S-100 protein. AT/RT was continuous, with small foci of recognizable low-grade and anaplastic meningioma. The low-grade meningioma was INI1 positive with scattered INI1-negative nuclei, whereas the remaining tumor components were INI1 negative. A recurrent tumor 6 months after partial resection contained only INI1-negative AT/RT. This case supports the hypothesis that rare examples of AT/RT may emerge from a preexisting “parent” neoplasm as a result of a second hit mutation.

Aggressive angiomyxoma of the female genital tract: a clinicopathologic and immunohistochemical study of 12 cases

2005 ◽  
Vol 15 (1) ◽  
pp. 140-145 ◽  
Author(s):  
C. A. Amezcua ◽  
S. J. Begley ◽  
N. Mata ◽  
J. C. Felix ◽  
C. A. Ballard
Keyword(s):  
Genital Tract ◽  
Smooth Muscle Actin ◽  
Tumor Resection ◽  
Female Genital Tract ◽  
Immunohistochemical Analysis ◽  
Definitive Treatment ◽  
Aggressive Angiomyxoma ◽  
Clinicopathological Findings ◽  
S 100 ◽  
Female Genital

Aggressive angiomyxoma (AAM) is a distinctive neoplasm seen in the female genital tract. We present the clinicopathological findings of 12 female patients with AAM. Immunohistochemical analysis for vimentin, desmin, smooth-muscle actin (SMA), muscle-specific actin (MSA), S-100, CD44, estrogen receptor (ER), and progesterone receptor (PR) was performed. Mean patient age was 39 years (range 20–77 years). Eight tumors arose in the vulva, two in the suburethral area, and two in the perirectal area. Three were pedunculated (two vulvar and one suburethral). Perineal tumors were locally excised, with limited removal of adjacent tissue or tissue surrounding the pedicle base of pedunculated tumors. Perirectal tumors were removed by wide excision. Tumors ranged 2.8–40.0 cm in size. Eleven patients were followed-up (mean 19 months). Recurrence occurred in one patient 48 months after tumor resection from perirectum and abdomen. Immunohistochemistry showed tumor positivity for vimentin (11/11), desmin (8/11), CD44 (8/11), ER (10/12), PR (11/12), and SMA (3/11). MSA and S-100 were negative. In summary, AAM in the perineum especially pedunculated tumors may possibly require only local excision for definitive treatment. Furthermore, the majority of AAM have CD44 expression.

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