scholarly journals Principal component articial neural network calibration models for the simultaneous spectrophotometric estimation of mefenamic acid and paracetamol in tablets

2006 ◽  
Vol 71 (11) ◽  
pp. 1207-1218
Author(s):  
Dondeti Satyanarayana ◽  
Kamarajan Kannan ◽  
Rajappan Manavalan
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Mefenamic Acid ◽  
Principal Component Regression ◽  
Principal Component ◽  
Simultaneous Estimation ◽  
Uv Spectrophotometry ◽  
Novel Approach ◽  
Marquardt Algorithm ◽  
Calibration Models

Simultaneous estimation of all drug components in a multicomponent analgesic dosage form with artificial neural networks calibration models using UV spectrophotometry is reported as a simple alternative to using separate models for each component. A novel approach for calibration using a compound spectral dataset derived from three spectra of each component is described. The spectra of mefenamic acid and paracetamol were recorded as several concentrations within their linear range and used to compute a calibration mixture between the wavelengths 220 to 340 nm. Neural networks trained by a Levenberg-Marquardt algorithm were used for building and optimizing the calibration models using MATALAB? Neural Network Toolbox and were compared with the principal component regression model. The calibration models were thoroughly evaluated at several concentration levels using 104 spectra obtained for 52 synthetic binary mixtures prepared using orthogonal designs. The optimized model showed sufficient robustness even when the calibration sets were constructed from a different set of pure spectra of the components. The simultaneous prediction of both components by a single neural network with the suggested calibration approach was successful. The model could accurately estimate the drugs, with satisfactory precision and accuracy, in tablet dosage with no interference from excipients as indicated by the results of a recovery study.

scholarly journals The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Guzide Pekcan Ertokus
Keyword(s):  
Urine Sample ◽  
Human Urine ◽  
Principal Component Regression ◽  
Principal Component ◽  
Healthy Person ◽  
Drug Analysis ◽  
Uv Spectrophotometry ◽  
Least Squares Regression ◽  
Chemometric Methods

The spectrophotometric-chemometric analysis of levodopa and carbidopa that are used for Parkinson’s disease was analyzed without any prior reservation. Parkinson’s drugs in the urine sample of a healthy person (never used drugs in his life) were analyzed at the same time spectrophotometrically. The chemometric methods used were partial least squares regression (PLS) and principal component regression (PCR). PLS and PCR were successfully applied as chemometric determination of levodopa and carbidopa in human urine samples. A concentration set including binary mixtures of levodopa and carbidopa in 15 different combinations was randomly prepared in acetate buffer (pH 3.5).). UV spectrophotometry is a relatively inexpensive, reliable, and less time-consuming method. Minitab program was used for absorbance and concentration values. The normalization values for each active substance were good (r2>0.9997). Additionally, experimental data were validated statistically. The results of the analyses of the results revealed high recoveries and low standard deviations. Hence, the results encouraged us to apply the method to drug analysis. The proposed methods are highly sensitive and precise, and therefore they were implemented for the determination of the active substances in the urine sample of a healthy person in triumph.

Security of E-Health Systems Using Face Recognition Based on Convolutional Neural Network

2020 ◽  
Vol 2 (2) ◽  
pp. 37-41
Author(s):  
Zhixian Chen ◽  
Jialin Tang ◽  
Xueyuan Gong ◽  
Qinglang Su
Keyword(s):  
Neural Network ◽  
Face Recognition ◽  
Convolutional Neural Network ◽  
Principal Component ◽  
Activation Function ◽  
Support Vector ◽  
Data Set ◽  
Novel Approach ◽  
Rectified Linear Unit ◽  
The Face

In order to improve the low accuracy of the face recognition methods in the case of e-health, this paper proposed a novel face recognition approach, which is based on convolutional neural network (CNN). In detail, through resolving the convolutional kernel, rectified linear unit (ReLU) activation function, dropout, and batch normalization, this novel approach reduces the number of parameters of the CNN model, improves the non-linearity of the CNN model, and alleviates overfitting of the CNN model. In these ways, the accuracy of face recognition is increased. In the experiments, the proposed approach is compared with principal component analysis (PCA) and support vector machine (SVM) on ORL, Cohn-Kanade, and extended Yale-B face recognition data set, and it proves that this approach is promising.

scholarly journals A Novel Evaluation Model for Urban Smart Growth Based on Principal Component Regression and Radial Basis Function Neural Network

2019 ◽  
Vol 11 (21) ◽  
pp. 6125
Author(s):  
Lianyan Li ◽  
Xiaobin Ren
Keyword(s):  
Neural Network ◽  
Radial Basis Function ◽  
Basis Function ◽  
Rbf Neural Network ◽  
Evaluation Model ◽  
Smart Growth ◽  
Principal Component Regression ◽  
Principal Component ◽  
Self Organizing Map ◽  
Radial Basis

Smart growth is widely adopted by urban planners as an innovative approach, which can guide a city to develop into an environmentally friendly modern city. Therefore, determining the degree of smart growth is quite significant. In this paper, sustainable degree (SD) is proposed to evaluate the level of urban smart growth, which is established by principal component regression (PCR) and the radial basis function (RBF) neural network. In the case study of Yumen and Otago, the SD values of Yumen and Otago are 0.04482 and 0.04591, respectively, and both plans are moderately successful. Yumen should give more attention to environmental development while Otago should concentrate on economic development. In order to make a reliable future plan, a self-organizing map (SOM) is conducted to classify all indicators and the RBF neural network-trained indicators are separate under different classifications to output new plans. Finally, the reliability of the plan is confirmed by cellular automata (CA). Through simulation of the trend of urban development, it is found that the development speed of Yumen and Otago would increase slowly in the long term. This paper provides a powerful reference for cities pursuing smart growth.

scholarly journals Modeling a Thermochemical Reactor of a Solar Refrigerator by BaCl2-NH3 Sorption Using Artificial Neural Networks and Mathematical Symmetry Groups

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Onesimo Meza-Cruz ◽  
Isaac Pilatowsky ◽  
Agustín Pérez-Ramírez ◽  
Carlos Rivera-Blanco ◽  
Youness El Hamzaoui ◽  
...  
Keyword(s):  
Neural Network ◽  
Experimental Data ◽  
Neural Networks ◽  
Heating Temperature ◽  
Barium Chloride ◽  
Symmetry Groups ◽  
Solar Cooling ◽  
Network Training ◽  
The Neural Network ◽  
Marquardt Algorithm

The aim of this work is to present a model for heat transfer, desorbed refrigerant, and pressure of an intermittent solar cooling system’s thermochemical reactor based on backpropagation neural networks and mathematical symmetry groups. In order to achieve this, a reactor was designed and built based on the reaction of BaCl2-NH3. Experimental data from this reactor were collected, where barium chloride was used as a solid absorbent and ammonia as a refrigerant. The neural network was trained using the Levenberg–Marquardt algorithm. The correlation coefficient between experimental data and data simulated by the neural network was r = 0.9957. In the neural network’s sensitivity analysis, it was found that the inputs, reactor’s heating temperature and sorption time, influence neural network’s learning by 35% and 20%, respectively. It was also found that, by applying permutations to experimental data and using multibase mathematical symmetry groups, the neural network training algorithm converges faster.

scholarly journals Principal Component Analysis Based Dynamic Fuzzy Neural Network for Internal Corrosion Rate Prediction of Gas Pipelines

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiaoxu Chen ◽  
Linyuan Wang ◽  
Zhiyu Huang
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Principal Component Analysis ◽  
Artificial Neural Networks ◽  
Corrosion Rate ◽  
Fuzzy Neural Network ◽  
Principal Component ◽  
Component Analysis ◽  
Internal Corrosion ◽  
Fuzzy Neural

Aiming at the characteristics of the nonlinear changes in the internal corrosion rate in gas pipelines, and artificial neural networks easily fall into a local optimum. This paper proposes a model that combines a principal component analysis (PCA) algorithm and a dynamic fuzzy neural network (D-FNN) to address the problems above. The principal component analysis algorithm is used for dimensional reduction and feature extraction, and a dynamic fuzzy neural network model is utilized to perform the prediction. The study implementing the PCA-D-FNN is further accomplished with the corrosion data from a real pipeline, and the results are compared among the artificial neural networks, fuzzy neural networks, and D-FNN models. The results verify the effectiveness of the model and algorithm for inner corrosion rate prediction.

Empirical mean curve decomposition with multiwavelet transformation for eye movements recognition using electrooculogram signals

2020 ◽  
Vol 234 (8) ◽  
pp. 794-811
Author(s):  
Harikrishna Mulam ◽  
Malini Mudigonda
Keyword(s):  
Neural Network ◽  
Eye Movements ◽  
False Positive Rate ◽  
False Negative ◽  
False Negative Rate ◽  
Principal Component ◽  
The Neural Network ◽  
Marquardt Algorithm ◽  
Positive Rate ◽  
Sensitivity Specificity

Many research works are in progress in classification of the eye movements using the electrooculography signals and employing them to control the human–computer interface systems. This article introduces a new model for recognizing various eye movements using electrooculography signals with the help of empirical mean curve decomposition and multiwavelet transformation. Furthermore, this article also adopts a principal component analysis algorithm to reduce the dimension of electrooculography signals. Accordingly, the dimensionally reduced decomposed signal is provided to the neural network classifier for classifying the electrooculography signals, along with this, the weight of the neural network is fine-tuned with the assistance of the Levenberg–Marquardt algorithm. Finally, the proposed method is compared with the existing methods and it is observed that the proposed methodology gives the better performance in correspondence with accuracy, sensitivity, specificity, precision, false positive rate, false negative rate, negative predictive value, false discovery rate, F1 score, and Mathews correlation coefficient.

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