scholarly journals Importance of haemovigilance and reports on transfusion reaction in blood component therapy

2012 ◽  
Vol 65 (1-2) ◽  
pp. 50-53 ◽  
Author(s):  
Jasmina Grujic ◽  
Zdravko Gulan ◽  
Zorana Budakov
Keyword(s):  
Blood Transfusion ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Safe Procedure ◽  
Transfusion Reaction ◽  
Blood Components ◽  
Blood Component Therapy ◽  
Fresh Frozen ◽  
Novi Sad ◽  
Transfusion Reactions

Introduction. Application of blood and blood components throughout decades is very successful and mostly safe procedure in patients? therapy. However, it may lead to unfavourable effects, such as transfusion reactions. Material and Methods. In the period from 2000 to 2009, 180 transfusion reactions were reported at the Department of Clinical Transfusion of the Service for Blood Transfusion of Vojvodina in Novi Sad. The aetiology of transfusion reactions was determined by examining pretransfusion and post-transfusion sample of patient?s blood and by examining the unit of blood component that induced reaction. Results. Out of 180 reported transfusion reactions, 98 (54.4%) were febrile non-haemolytic transfusion reactions, 69 (38.3%) allergic reactions and 2 (1.11%) haemolytic reactions. Blood components that caused most of transfusion reactions were erythrocytes (62.4%), fresh frozen plasma (11.2%) and platelets (14.4%). All patients underwent multiple transfusions. Discussion. The fact that only 0.13% transfusion reactions were reported, compared with data from literature (2-15%), points to the lack of regular reporting of transfusion reactions, as well as the fact that there is only one report of delayed transfusion reaction. Conclusions. To improve and make blood transfusion safer it is necessary to respect all pre-transfusion procedures, constant follow up of blood transfusion must be done and patients with diagnosed non-haemolytic transfusion reaction should be given leukocyte reduced blood components.

The physiology of blood in anaesthetic practice

2017 ◽  
Author(s):  
Hanane El Kenz ◽  
Philippe Van der Linden
Keyword(s):  
Blood Transfusion ◽  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Blood Components ◽  
Pathogen Inactivation ◽  
Septic Complications ◽  
Packed Red Blood Cells ◽  
Blood Component Therapy ◽  
Fresh Frozen

Following the discovery of the ABO blood groups by Landsteiner in 1901, Albert Hustin described the first transfusion of a whole blood unit in 1914. The modern transfusion era really begins in 1916 with the discovery of sodium citrate as an anticoagulant by the same physician, allowing blood conservation in dedicated packs. Since that time, many advances have been made especially over the past two decades in the storage, the conservation, and the laboratory testing of blood components and in transfusion medicine practice. Transfusion of whole blood has been replaced by blood component therapy, which consists of the administration of packed red blood cells, fresh frozen plasma, or platelets. Although blood transfusion is safer than ever, the risk of complications will never reach zero. The risk of infectious transfusion-transmitted diseases has been markedly reduced by the implementation of extensive infectious disease testing, donor selection, and pathogen-inactivation procedures. In countries with a high human development index, the leading causes of allogeneic blood transfusion-related deaths actually resulted from immunological and septic complications. The first section of this chapter describes the structure, function, and immunological aspects of the different blood components that are routinely transfused today. The second section details the composition of the different blood components, their indications, the pre-transfusion compatibility tests, and the main adverse effects associated with their transfusion.

scholarly journals Distribusi Komponen Darah Thrombocyte Contentrate (TC)

2021 ◽  
Vol 2 (2) ◽  
pp. 75-81
Author(s):  
Gina Almirah ◽  
Nurpuji Mumpuni ◽  
Fransisca Romana Sri Supadmi
Keyword(s):  
Blood Transfusion ◽  
Maternity Hospital ◽  
Fresh Frozen Plasma ◽  
Buffy Coat ◽  
Red Cross ◽  
Blood Component ◽  
Distribution Data ◽  
Blood Components ◽  
Blood Transfusion Service ◽  
Fresh Frozen

Blood transfusions become an important component in the management of patients with injuries to cases of accidents, surgical conditions, violence, pregnancy complications, anemia, hemodialysis, and other medical conditions. The blood transferred can be complete blood and blood components such as Packed Red Cells (PRC), Thrombocyte Concentrate (TC), Anti hemophilia Factor (AHF)/Cryoprecipitate, Fresh Frozen Plasma (FFP), Buffy Coat (BC), Liquid Plasma (LP). This research aims to determine the distribution of blood component Thrombocyte Concentrate (TC) in Indonesian Red Cross Blood Transfusion Service Pontianak City. The design of this research is a quantitative study with a descriptive design, the approach of time used is retrospective by collecting and processing all the distribution data of blood component Thrombocyte Concentrate (TC) in Indonesian Red Cross Blood Transfusion Service Pontianak City in 2019. Processing and analyzing data in this study using the Statistical Product and Service Solutions (SPSS) application. Data analysis results of the number of Thrombocyte Concentrate requests 5,427 bags in 12 months, with an average (Mean) of 452.25 and a data spread (Std. Deviation) of 224.620 is greater than the dosage amount and the distribution of Thrombocyte Concentrate 3,444 bags in 12 months, with an average (Mean) 287 and a data spread (Std. Deviation) 79.681. The most demand and distribution is Dr. Soedarso country general hospital, while the fewest are the Nabasa maternity hospital. The distribution of Thrombocyte Concentrate blood components in Indonesian Red Cross Blood Transfusion Service Pontianak City still needs improvement for both inventory and distribution to be fulfilled the number of Thrombocyte Concentrate requests.

Factors Affecting Transfusion of Fresh Frozen Plasma, Platelets, and Red Blood Cells During Elective Coronary Artery Bypass Graft Surgery

2003 ◽  
Vol 127 (4) ◽  
pp. 415-423
Author(s):  
Randal Covin ◽  
Maureen O'Brien ◽  
Gary Grunwald ◽  
Bradley Brimhall ◽  
Gulshan Sethi ◽  
...  
Keyword(s):  
Blood Cells ◽  
Prediction Models ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Artery Bypass Graft ◽  
Blood Components ◽  
Fresh Frozen ◽  
Frozen Plasma

Abstract Context.—The ability to predict the use of blood components during surgery will improve the blood bank's ability to provide efficient service. Objective.—Develop prediction models using preoperative risk factors to assess blood component usage during elective coronary artery bypass graft surgery (CABG). Design.—Eighty-three preoperative, multidimensional risk variables were evaluated for patients undergoing elective CABG-only surgery. Main Outcome Measures.—The study endpoints included transfusion of fresh frozen plasma (FFP), platelets, and red blood cells (RBC). Multivariate logistic regression models were built to assess the predictors related to each of these endpoints. Setting.—Department of Veterans Affairs (VA) health care system. Patients.—Records for 3034 patients undergoing elective CABG-only procedures; 1033 patients received a blood component transfusion during CABG. Results.—Previous heart surgery and decreased ejection fraction were significant predictors of transfusion for all blood components. Platelet count was predictive of platelet transfusion and FFP utilization. Baseline hemoglobin was a predictive factor for more than 2 units of RBC. Some significant hospital variation was noted beyond that predicted by patient risk factors alone. Conclusions.—Prediction models based on preoperative variables may facilitate blood component management for patients undergoing elective CABG. Algorithms are available to predict transfusion resources to assist blood banks in improving responsiveness to clinical needs. Predictors for use of each blood component may be identified prior to elective CABG for VA patients.

scholarly journals DIFFERENCES IN CHANGES OF HEMOGLOBIN BETWEEN 6-12 HOURS AND 12-14 HOURS AFTER TRANSFUSION

2018 ◽  
Vol 24 (2) ◽  
pp. 108
Author(s):  
Rosita Linda ◽  
Devita Ninda
Keyword(s):  
Blood Transfusion ◽  
Secondary Data ◽  
Hemoglobin Concentration ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Blood Products ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Hemoglobin Measurement ◽  
Baseline Hemoglobin

Each year more than 41,000 blood donations are needed every day and 30 million blood components are transfused. Blood products that can be transfused include Packed Red Cells (PRC), Whole Blood (WB), Thrombocyte Concentrate (TC), Fresh Frozen Plasma (FFP). Monitoring Hemoglobin (Hb) after transfusion is essential for assessing the success of a transfusion. The time factor after transfusion for Hemoglobin (Hb) examination needs to be established, analyze to judge the success of a blood transfusion which is performed. The aim of this study was to analyze the differences in changes of hemoglobin between 6-12 hours, and 12-24 hours after-transfusion. This study was retrospective observational using secondary data. The subjects were patients who received PRC, and WBC transfusion. At 6-12, and 12-24 hours after-transfusion, hemoglobin, RBC, and hematocrit were measured. Then the data were analyzed by unpaired t-test. The collected data included the results of the Hb pre-transfusion, 6-12, and 12-24 hours after-transfusion. The subjects of this study were 98 people. The administration of transfusion increased by 10-30% in hemoglobin concentration at 6-12 hours after-transfusion. While at 12-24 hours after-transfusion, hemoglobin after-transfusion increased 15-37% from the baseline. Hemoglobin values were not different at any of the defined after-transfusion times (p = 0.76 (p>0.05)). Hemoglobin values were not different at 6-12 hours, and 12-24 hours after-transfusion.    Keywords: Hemoglobin, measurement, after-transfusion 

scholarly journals Organizational measures for the prevention of complications of blood transfusion

2012 ◽  
Vol 93 (2) ◽  
pp. 383-384
Author(s):  
N I Stepanova ◽  
N A Polyanin
Keyword(s):  
Blood Transfusion ◽  
Essential Element ◽  
Fresh Frozen Plasma ◽  
Blood Components ◽  
Medical Department ◽  
Transfusion Therapy ◽  
Surgical Interventions ◽  
Fresh Frozen ◽  
Passport Data ◽  
Instructions For Use

Organization of the blood transfusion therapy in a hospital is an essential element in delivering medical care to the wounded, injured and sick. In each medical department of the hospital a physician responsible for the organization of transfusion therapy is appointed by the order of the chief. The provision of donor blood and its components for the elective surgical interventions is carried out on the basis of preliminary requests of the attending physicians. It is unacceptable to conduct elective surgical interventions without the required number of screened blood components. In order to conduct blood transfusions when providing emergency care there should be a supply of fresh frozen plasma and frozen erythrocytes in the hospital in the amount of a monthly requirement. All blood transfusion must have a clear clinical rationale and should be performed in strict accordance with current instructions for use of blood components. The completed measures for determination of blood component’s compatibility with the blood of the recipient, the name, amount, passport data of each transfusion environment have to be reflected in the blood transfusion protocol.

scholarly journals Blood Component Therapy

2018 ◽  
Vol 9 (2) ◽  
pp. 142-147
Author(s):  
Shanaz Karim ◽  
Ehteshamul Hoque ◽  
Md Mazharul Hoque ◽  
Syeda Masooma Rahman ◽  
Kashfia Islam
Keyword(s):  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Packed Red Blood Cells ◽  
Medical College ◽  
Blood Component Therapy ◽  
Fresh Frozen ◽  
Cellular Components

Transfusion medicine has undergone advancements since its initiation in the early 20th century. One of these was the discovery that blood can be divided into individual components and delivered separately. Today, blood transfusions nearly always consist of the ad-ministration of 1 or more components of blood. Whole blood transfusion is now limited to situations involving massive resuscitation (trauma ) The most familiar cellular components include packed red blood cells (PRBC), washed PRBC, leukoreduced PRBC and pooled or aphaeresis platelets. Plasma products such as FFP or cryoprecipitate, ant hemophilic factor (CRYO). The transfusion of red blood cells (RBCs), platelets, fresh-frozen plasma (FFP), and cryoprecipitate has the potential of improving clinical outcomes in perioperative and peripartum settings. These benefits include improved tissue oxygenation and decreased bleeding. However, transfusions are not without risks or costs. With the advent of blood component therapy, each unit of whole blood collected serves the specific needs of several, rather than a single patient.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 142-147

III.—New Developments in Large-scale Plasma Fractionation

1972 ◽  
Vol 71 (S1) ◽  
pp. s15-s34
Author(s):  
J. G. Watt ◽  
J. K. Smith ◽  
W. Grant ◽  
C. Turnbull
Keyword(s):  
Side Effects ◽  
Blood Transfusion ◽  
Large Scale ◽  
American Association ◽  
Blood Component ◽  
Blood Components ◽  
Donor Blood ◽  
New Developments ◽  
Blood Banks ◽  
Blood Component Therapy

‘Selective transfusion of appropriate blood components is preferable to the routine use of whole blood.’ (American Association of Blood Banks. Physicians' Handbook of Blood Component Therapy, 1969).The rational use of donor blood in the environment of modern blood transfusion revolves around a series of developments in the field of component therapy. The fractionation of plasma, i.e. the separation of plasma into a series of subdivisions each containing one or other of the constituent proteins in varying degrees of purity and concentration, was one of the first of these developments to become established.Early fractionation of plasma was applied in various ways to the purification of animal antisera; initially to antipneumococcal serum for therapeutic use. These sera frequently provoked reactions in patients until Sabin showed that absorption with Fullers earth could abolish these side-effects by removing complexed molecules.

scholarly journals Frequency and Nature of Transfusion Related Adverse Reactions in Patients Admitted in A Tertiary Care Hospital

2021 ◽  
Vol 33 (1) ◽  
pp. 27-33
Author(s):  
Naylla Islam ◽  
- Amiruzzaman ◽  
Mohammad Ehasun Uddin Khan ◽  
Ashim Chakrabarty ◽  
Md Arifuzzaman ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Fresh Frozen Plasma ◽  
Care Hospital ◽  
Transfusion Reaction ◽  
Blood Products ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Duration Of Storage ◽  
Fresh Frozen ◽  
Transfusion Reactions

Background:Transfusion of blood and blood products if employed safely, with intensive care can save manyvaluable lives. But a number of transfusion reactions may develop that are sometimesmore serious and life threatening.So this study was done to find out the most frequent and life threatening reactions that develop during transfusion. Methods: A Cross sectional descriptive observational study was performed at a tertiary care centre. Patients of 18 years and older irrespective of sexes who received blood and blood products due to different reasons between April 2020 to September 2020 were included in this study. A total of 96 patients were included in the study. Results:In thisstudy 11(11.5%) out of 96 patients had transfusion reactions of different types .Febrile non haemolytic reaction was the highest with 8 patients (8.33%),followed by Allergic reaction in 2 patients(2.08%) and Acute haemolytic transfusion reaction in 1 patient (1.04%).Among them 7(63.6%) reactions occurred with whole blood , 2(18.2%) reactions occurred with red cell concentrate and 1 reaction occurred with Apheresis platelet (9.1%) and fresh frozen plasma(9.1%).Statistically significant association was found between duration of storage of blood and transfusion reaction. Conclusion: Febrile non haemolytic reaction was the commonest type of transfusion reaction found in this study and there was also statistically significant association between duration of storage of blood and transfusion reaction. Bangladesh J Medicine July 2022; 33(1) : 27-33

scholarly journals Transfusion reaction and hemovigilance: An imperative discussion in Brazilian hemotherapy services

10.3823/2526 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
João Paulo dos Santos ◽  
Angela Alzamora ◽  
Mariana Dutra Teles ◽  
Veruska Lucena ◽  
Tatiana Almeida Omura de Paula ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Transfusion Reaction ◽  
Blood Components ◽  
Important Data ◽  
History Of ◽  
Transfusion Reactions

Transfusion of blood components is considered safer, but it took years to reach this level. One of the most effective ways to make blood transfusion a safer practice is hemovigilance, which provides important data, including the history of feared transfusion reactions. In recent years in Brazil, there has been an improvement in the reporting of transfusion reactions, however due to the great diversity of hematology services, there are still transfusion reactions. The aims of this study were described the main types of transfusion reactions, as well as to evaluate the underreporting importance of transfusion occurrences of hemotherapy services in Brazil.

The Role of Thromboelastography in Directing Blood Product Usage in Infant Open Heart Surgery

2009 ◽  
Vol 4 (5) ◽  
pp. 282-290 ◽  
Author(s):  
Eric N. Mendeloff ◽  
George F. Glenn ◽  
Paul Tavakolian ◽  
Eugene Lin ◽  
Allison Leonard ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Blood Product ◽  
Open Heart Surgery ◽  
Fresh Frozen Plasma ◽  
Blood Component ◽  
Open Heart ◽  
Product Usage ◽  
Blood Component Therapy ◽  
Fresh Frozen

Objective Thromboelastography (TEG) measures the dynamics of clot formation in whole blood and provides data that can guide specific blood component therapy. This study analyzed whether the implementation of TEG affected blood product utilization and overall hemostasis in infants (6 months and younger) undergoing open heart surgery. Methods TEG values measured include R (time to fibrin formation), angle (fibrinogen formation), and MA (platelet function). Blood product usage, TEG values, and operative parameters were collected during surgery on 112 consecutive infants (66 acyanotic) undergoing open heart surgery within the first 6 months of life. Controls consisted of chart data on 70 consecutive patients (57 acyanotic) undergoing the same surgical procedures before implementation of TEG (pre-TEG). Results Using TEG, the pattern of blood product utilization changed. Compared with the pre-TEG era, TEG era patients demonstrated a significant increase in fresh frozen plasma usage intraoperatively (4.74 vs. 1.83 mL/kg; P < 0.001) and reduced postoperative use of platelets (1.69 vs. 3.74 mL/kg; P = 0.006) and cryoprecipitate (0.89 vs. 1.95 mL/kg; P = 0.149). Chest tube drainage was significantly reduced at 1, 2, and 24 hours in the TEG group. TEG angle and MA measurements suggest that fibrinogen and platelets of cyanotic patients are more sensitive to hemodilution than the acyanotic patients. Conclusions TEG allows for proactive, goal-directed blood component therapy with improved postoperative hemostasis in infants undergoing cardiopulmonary bypass.

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