Asthma severity identification from pulmonary acoustic signal for computerized decision support system

2020 ◽  
pp. 1-18
Author(s):  
Fizza Ghulam Nabi ◽  
Kenneth Sundaraj ◽  
Chee Kiang Lam
Keyword(s):  
Statistical Significance ◽  
Asthma Severity ◽  
Tidal Breathing ◽  
Computerized Decision Support ◽  
Severity Level ◽  
Asthmatic Patients ◽  
Breath Sounds ◽  
Lower Lung ◽  
Different Characteristics ◽  
Frequency Features

Abstract Objective: Breath sound has information about underlying pathology and condition of subjects. The purpose of this study is to examine asthmatic acuteness levels (Mild, Moderate, Severe) using frequency features extracted from wheeze sounds. Further, analysis has been extended to observe behavior of wheeze sounds in different datasets. Method: Segmented and validated wheeze sounds was collected from 55 asthmatic patients from the trachea and lower lung base (LLB) during tidal breathing maneuvers. Segmented wheeze sounds have been grouped in to nine datasets based on auscultation location, breath phases and a combination of phase and location. Frequency based features F25, F50, F75, F90, F99 and mean frequency (MF) has been calculated from normalized power spectrum. Subsequently, multivariate analysis has been performed for analysis. Result: Generally frequency features observe statistical significance (p < 0.05) for the majority of datasets to differentiate severity level ? = 0.432-0.939, F(12, 196-1534) = 2.731-11.196, p < 0.05, ????2 = 0.061-0.568. It was observed that selected features performed better (higher effect size) for trachea related samples ? = 0.432-0.620, F(12, 196-498) = 6.575-11.196, p < 0.05, ????2 = 0.386-0.568. Conclusion: The results demonstrate that severity levels of asthmatic patients with tidal breathing can be identified through computerized wheeze sound analysis. In general, auscultation location and breath phases produce wheeze sounds with different characteristics. Keywords: Asthma, Breath Sounds, Wheeze Detection, Airway Obstruction, Severity Level Continuous...

scholarly journals Asthma Control According to the Community Pharmacists: Evidence and Potential Implications from an Italian Cross-Sectional Study

2020 ◽  
Author(s):  
Marco Caminati ◽  
Luca Cegolon ◽  
Marco Bacchini ◽  
Nadia Segala ◽  
Annarita Dama ◽  
...  
Keyword(s):  
Asthma Control ◽  
Multinomial Logistic Regression ◽  
Treatment Compliance ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Community Pharmacies ◽  
Sectional Study ◽  
Cross Sectional ◽  
Severity Level ◽  
Asthmatic Patients

Abstract Background. Asthma control and monitoring still represents a challenge worldwide. Although the international guidelines suggest the interplay with primary care as an effective strategy, the community pharmacies’are rarely involved in asthma management.The present cross-sectional study aimed at providing a picture of the relationship between asthma severity and control according to the community pharmacies’ perspective of the health district of Verona (North-Eastern Italy).Methods. A call for participation was launched through the Pharmacists’ Association of Verona.Patients referring to the participating pharmacies with an anti-asthmatic drug medical prescription and an asthma exemption code were asked to completethe Asthma Control Testand a brief questionnaire collecting information on their age, sex, smoking status, aerobic physical exercise and usual asthma therapy, which also defined the severity level of asthma.A multinomial logistic regression model was fitted to investigate the risk of uncontrolled as well as poorly controlled vs. controlled asthma (base). Results were expressed as relative risk ratios (RRR) with 95% confidence interval (95%CI).Results.57 community pharmacies accepted to participate and 584 asthmatic patients (54% females; mean-age: 51 ± 19 years) were recruited. According to the ACT score 50.5% patients hada controlled asthma, 22.3% a poorly controlled and 27.2% uncontrolled. A variable proportion patients with uncontrolled asthma was observed at every level of severity, although more frequently in mild persistent form of disease. Most patients (92%) reported regular compliance with therapy. At multinomial regression analysis, patients under regular asthma treatment course (RRR=0.33; 95%CI: 0.15; 0.77) were less likely to have an ACT<16 compared to those not taking medications regularly.Conclusions.Overall, our findings highlighted an unsatisfactory asthma control from the pharmacists’ perspective, independently of the asthma severity level. The relevance of community pharmacies as a first line interface suggest their involvement inan effective asthma management plan, from disease control and treatment compliance assessment to referral of asthmatic patients to medical consultancies.

scholarly journals Asthma severity in relation to allergenic risk factors in childhood

2005 ◽  
Vol 133 (Suppl. 2) ◽  
pp. 101-104
Author(s):  
Snezana Zivanovic ◽  
Radmila Mileusnic-Milenovic ◽  
Maja Slavkovic-Jovanovic ◽  
Marija Conic
Keyword(s):  
Statistical Significance ◽  
Persistent Asthma ◽  
Asthma Severity ◽  
Specific Ige ◽  
Atopic Asthma ◽  
Dermatophagoides Farinae ◽  
Asthmatic Patients ◽  
Ige Mediated ◽  
Inhalant Allergens ◽  
Airborne Allergens

The majority of asthmatic patients are atopic - that is to say, they exhibit IgE-mediated sensitivity to common inhalant allergens. Exposure and sensitisation to allergens from the housedust mite has been established as an important risk factor in asthma in most parts of the world. The aim of our study was to assess total IgE and specific IgE on airborne allergens (Dermatophagoides pteronyssinus - DP, Dermatophagoides farinae - DF, mould, and grass pollen) in relation to asthma severity. The study involved 64 children with atopic asthma. Statistical significance was present between groups of intermittent and moderately persistent asthma for IgE and specific IgE on DP and moulds. In mild and moderate asthma, statistically significant differences were present for all parameters except for DF.

Active Eosinophilic Esophagitis is Associated with Increased Asthma Severity and Lower Lung Function in Children with Comorbid Asthma

2021 ◽  
Vol 147 (2) ◽  
pp. AB92
Author(s):  
Karyn Parsons ◽  
Katharine Guarnieri ◽  
Dawit Tadesse ◽  
Md Monir Hossain ◽  
Vincent Mukkada ◽  
...  
Keyword(s):  
Lung Function ◽  
Eosinophilic Esophagitis ◽  
Asthma Severity ◽  
Lower Lung

scholarly journals Relationship of Oxidant and Antioxidant Markers to Asthma Severity in Egyptian Asthmatic Children

2017 ◽  
Vol 5 (5) ◽  
pp. 645-650 ◽  
Author(s):  
Inas R. EL-Alameey ◽  
Gihan A. Fathy ◽  
Mones M. Abu Shady ◽  
Alaa Ali ◽  
Hanan A. Fathy ◽  
...  
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Strong Predictor ◽  
Predictive Biomarker ◽  
Asthma Severity ◽  
Healthy Children ◽  
Serum Concentrations ◽  
Asthmatic Children ◽  
Paraoxonase Activity ◽  
Asthmatic Patients ◽  
Anti Oxidant

BACKGROUND: Asthma is a chronic airway disease which is characterized by oxidant antioxidant imbalance with the generation of oxidative stress related mediators.AIM: The study aimed to evaluate the role of asymmetric dimethylarginine, and malondialdehyde as oxidant markers and serum paraoxonase activity as an antioxidant marker in asthma, and to determine their relationship to the asthma severity and lung function among asthmatic children in Egypt.PATIENTS AND METHODS: This case control study was conducted on sixty patients with asthma compared with sixty apparently healthy children of matched age and sex.RESULTS: Serum concentrations of oxidant markers as asymmetric dimethylarginine and malondialdehyde were significantly increased in asthmatic patients while anti-oxidant marker as paraoxonase activity was significantly decreased compared to healthy controls (P < 0.05). ANOVA test revealed highly significant elevation of the serum concentrations of oxidant markers while anti-oxidant marker was significantly decreased in severe asthmatic patients (P < 0.001) compared to the patients with moderate and mild asthma respectively. Serum malondialdehyde concentration was a strong predictor of asthma severity by multiple regression analysis (P < 0.05).CONCLUSION: The study revealed an imbalance between oxidative and antioxidant defence systems in asthmatic children. Serum concentration of malondialdehyde was the most predictive biomarker having a significant association with asthma severity.

scholarly journals Comparison Of Lung Function Tests Between Healthy And Asthmatic Individuals

BioSight ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 6-10
Author(s):  
Hira Liaquat ◽  
Tabinda Najeeb ◽  
Rahima Aftab ◽  
Tayyaba Kazmi ◽  
Padma Rathore ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Case Control Study ◽  
Pulmonary Function Tests ◽  
Case Control ◽  
Asthmatic Patients ◽  
Function Tests ◽  
Lower Lung ◽  
Medical University ◽  
Control Study ◽  
Asthmatic Case

Background: Comparison of pulmonary function tests (PFTs) were achieved between asthmatic case and Controls. Materials & Methods: Case-control study conducted at Baqai Medical University (50 cases and 50 control). PFTs in both the participants were estimated by spirometry; FEC, FEV1 and their ratios were estimated. Results: According to the findings all spirometric values were lower in asthmatic patients as compared to healthy subjects. Moreover the asthamatic subjects had lower lung values when compared with healthy subjects. Conclusion: The current study evaluated spirometric values in asthmatic patients in Gadap area. This study's findings can be applied to the treatment of asthma in people of all ages.

scholarly journals The Role of Airways 17β-Estradiol as a Biomarker of Severity in Postmenopausal Asthma: A Pilot Study

2020 ◽  
Vol 9 (7) ◽  
pp. 2037
Author(s):  
Giulia Scioscia ◽  
Giovanna Elisiana Carpagnano ◽  
Donato Lacedonia ◽  
Piera Soccio ◽  
Carla Maria Irene Quarato ◽  
...  
Keyword(s):  
Asthma Severity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Adult Women ◽  
Serum Concentrations ◽  
Asthmatic Patients ◽  
Menopausal Women ◽  
17Β Estradiol ◽  
Severity Of The Disease ◽  
Positive Correlations

Background: Asthma severity differs according to gender; in adult women, there is higher prevalence and severity of asthma than in men, and it coincides with changes in sex hormones. Recently, a new phonotype of asthma has been identified that appears after menopause, and it may be associated with decreased estrogen levels. Our goal was to study the 17β-estradiol (E2) concentrations in the blood and airways of women affected by asthma onset after menopause, evaluating its possible role in the severity of the disease. Methods: We enrolled 33 consecutive women with a diagnosis of postmenopausal asthma, recruited from the outpatient pulmonary clinic: 18 with severe (SA) and 15 with mild-to-moderate (MMA) asthma. We also included 30 age-matched healthy menopausal women as controls (HS). All subjects enrolled underwent blood and sputum collection (IS), and E2 concentrations were determined in plasma and sputum supernatant samples using an enzyme-linked immunosorbent assay (ELISA) kit. Results: Significantly higher serum concentrations of E2 were found in postmenopausal SA compared to MMA and HS, respectively (33 ± 5.5 vs. 24 ± 6.63 vs. 7.79 ± 1.54 pg/mL, p < 0.05). Similar results were found in the IS: significantly higher levels of E2 were detected in patients with postmenopausal SA compared with MMA and HS, respectively (0.34 ± 0.17 vs. 0.26 ± 0.13 vs. 0.07 ± 0.06 pg/mL, p < 0.05). We found positive correlations between IS E2 concentrations and sputum neutrophil levels in SA group (ρ = 0.52, p < 0.05). Conclusions: Our findings showed the possibility to measure E2 in the airways, and it has increased in postmenopausal asthmatic patients, especially in those with SA. Airways E2 levels may serve as a suitable biomarker of postmenopausal SA to help to phenotype SA patients with neutrophil inflammation.

Asthma: An Important Disease to Otolaryngologists — Part II: Asthma Management Strategy

1996 ◽  
Vol 75 (3) ◽  
pp. 136-142
Author(s):  
Bruce R. Gordon
Keyword(s):  
Asthma Management ◽  
Asthma Severity ◽  
Chronic Inflammatory Disease ◽  
Beta Agonist ◽  
Asthmatic Patients ◽  
Environmental Controls ◽  
Drug Combination Therapy ◽  
Anti Inflammatory ◽  
Pharmacologic Treatments ◽  
Important Disease

Asthma is a chronic inflammatory disease of the lower respiratory tract which is triggered by exposure to allergens or other airway irritants, and is commonly encountered in otolaryngologic practice. This three-part review is designed to assist otolaryngologists in effectively managing their asthmatic patients. In Part I, current information on the pathophysiology and increasing prevalence of asthma, its clinical variability, the assessment of asthma severity and methods for diagnosis of asthma were summarized. Part 11 discusses a tripartite strategy for asthma management, based on environmental controls, the use of anti-inflammatory therapies and patient education. In addition, pharmacologic treatments which are not primarily anti-inflammatory are reviewed in detail. The uses, effectiveness, side effects and suitability for drug combination therapy for mucolytic, anticholinergic, antihistamine, theophylline and beta agonist drugs are compared, and the disadvantages of beta antagonists are summarized. Part III concludes with an overview of antiinflammatory therapies for asthma control.

scholarly journals Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Bassam Mahboub ◽  
Saba Al Heialy ◽  
Mahmood Yaseen Hachim ◽  
Rakhee K. Ramakrishnan ◽  
Ashraf Alzaabi ◽  
...  
Keyword(s):  
Vitamin D ◽  
In Silico ◽  
Glucocorticoid Receptors ◽  
Hypovitaminosis D ◽  
Asthma Severity ◽  
Health Concern ◽  
Blood Levels ◽  
Asthmatic Patients ◽  
Severe Asthmatic

Purpose. Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe and has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked to a decreased glucocorticoid receptor (GR) ratio (GR-α/GR-β ratio), indicating steroid hyporesponsiveness. Using a combination of in silico and in vivo approaches, we aimed to explore the immunomodulatory effect of VitD on asthmatic patients diagnosed with hypovitaminosis D. Methods. In silico tools were used to identify the regulatory effect of VitD supplementation on GR genes. We measured the expression levels of GR-α and the inactive isoform, GR-β, in the blood of adult asthmatics diagnosed with hypovitaminosis D before and after VitD supplementation. Moreover, the blood levels of inflammatory cytokines associated with asthma severity were determined. Results. Using an in silico approach, we identified specific genes commonly targeted by VitD as well as corticosteroids, the mainstay of asthma therapy. NR3C1 gene encoding GR was found to be significantly upregulated on Th2 CD4 cells and NK cells. Interestingly, blood expression level of NR3C1 was lower in severe asthmatics compared to nonsevere asthmatics and healthy controls, while the blood level of VitD receptor (VDR) was higher. Upon VitD supplementation of severe asthmatic patients, there was a significant increase in the blood levels of GR-α with no change in GR-β mRNA expression. VitD supplementation also suppressed the blood levels of IL-17F and IL-4. Conclusion. VitD may enhance steroid responsiveness by upregulating the expression of steroid receptor GR-α.

scholarly journals Relation of Asthma Control with Quality of Life among a Sample of Egyptian Asthmatic School Children

2019 ◽  
Vol 7 (17) ◽  
pp. 2780-2785
Author(s):  
Hala G. Elnady ◽  
Lobna S. Sherif ◽  
Rania N. Sabry ◽  
Dina Abu Zeid ◽  
Hanan Atta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Asthma Severity ◽  
Physical Symptoms ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Asthmatic Children ◽  
Asthmatic Patients ◽  
Egyptian Children

BACKGROUND: Asthma is considered a chronic health illness that not only resulted in physical symptoms but also emotional effects. It is; therefore, so important to assess the quality of life of asthmatic patients besides their level of disease control. AIM: To determine the correlation of asthma control with the health-related quality of life (HRQOL) of asthmatic children in Egypt. METHODS: One hundred and twenty-eight asthmatic Egyptian children were enrolled in the study. They were subjected to asthma severity grading, asthma control questionnaire (ACQ) and pediatric asthma quality of life questionnaire (PAQLQ). Studied cases were taken from 6 primary and preparatory schools, Giza governorate. RESULTS: The mean child control score was significantly higher in not well-controlled asthmatics compared to well-controlled asthmatics (p < 0.005). The not well controlled asthmatic children showed significantly lower activity limitation score, symptoms score, and overall asthmatic score compared to controlled asthmatic children (p < 0.05). The severity of asthma shows significant positive correlation with symptoms score, emotional function score and overall asthmatic score (p < 0.05). CONCLUSION: The quality of life for the asthmatic children is strongly correlated with the level of asthma control and severity.

scholarly journals Asthma severity as a contributing factor to cancer incidence: A cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250430
Author(s):  
Laila Salameh ◽  
Bassam Mahboub ◽  
Amar Khamis ◽  
Mouza Alsharhan ◽  
Syed Hammad Tirmazy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Incidence ◽  
Asthma Severity ◽  
Asthmatic Patients ◽  
Increased Risk ◽  
Different Types ◽  
Asthma Patients ◽  
Main Factors ◽  
Population Source

Background A putative link between asthma and asthma severity with the occurrence of cancer has been suggested but has not been fully investigated. The objective of this study is to assess the incidence of all types of cancer in a cohort of asthmatic patients. Methods and findings A single center cohort retrospective study was conducted to investigate the role of asthma as a potential risk factor for various cancers. Participants were followed for a period of 9 years from 01/01/2010 to 30/12/2018 and cancer incidence and its determinants were collected in asthmatic patients and controls from the same population source but without any respiratory disease. Overall, 2,027 asthma patients and 1,637 controls were followed up for an average of 9 years. The statistical analysis showed that 2% of asthma patients were diagnosed with various cancers, resulting in an incidence rate of cancer of 383.02 per 100,000 persons per year which is significantly higher than the 139.01 per 100,000 persons per year observed in matched controls (p-value < 0.001). The top four cancers reported among asthmatics were breast, colon, lung and prostate cancer. Lung cancer in asthmatics had the longest diagnosis period with a mean of 36.6 years compared to the shortest with prostate cancer with 16.5 years. Conclusions This study shows that asthma patients are at increased risk of different types of cancers with asthma severity and goiter as the main factors that may increase the risk of developing cancers among asthmatic patients.

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