scholarly journals Immunohistochemical expression of p53 oncoprotein in Wilms tumour in relation to histological components, histological types and preoperative chemotherapy

2008 ◽  
Vol 136 (Suppl. 4) ◽  
pp. 298-306 ◽  
Author(s):  
Slavisa Djuricic ◽  
Dragomir Djokic ◽  
Dragana Vujic ◽  
Gordana Basta-Jovanovic ◽  
Vera Todorovic ◽  
...  
Keyword(s):  
Preoperative Chemotherapy ◽  
Nuclear Staining ◽  
Immunohistochemical Detection ◽  
Wilms Tumour ◽  
Immunohistochemical Expression ◽  
Single Institution ◽  
Histological Types ◽  
Renal Tumours ◽  
Stromal Component

INTRODUCTION. There have been only few studies of immunoexpression of p53 in Wilms tumour (WT), and their results are somewhat contradictory. OBJECTIVE. The aim of the study was to determine p53 immunohistochemical expression in WT in relation to its histological components, histological prognostic types classified according to the SIOP Working Classification of Renal Tumours of Childhood (2001), and influence of preoperative chemotherapy. METHOD. The analyses are based on 79 primary WTs treated in single institution according to SIOP protocols between 1983-2001. For the immunohistochemical detection of p53, the monoclonal p53 antibody (DO-7, DAKO) was used. Semiquantitative grading of nuclear staining was done. RESULTS. The immunoexpression of p53 was significantly higher in the blastemal and epithelial than in the stromal component (p<0.001). It was significantly correlated to WT histological prognostic types (p=0.039). The exensivity of p53 immunoexpression was higher in anaplastic components but a difference between WT type of diffuse anaplasia and all other types was nonsignificant (p=0.10). Five blastemal type WTs were p53 immunopositive and four immunonegative. There was no difference in p53 immunopositivity between WT treated with the preoperative chemotherapy and primary resected WT (p=0.88). CONCLUSION. The immunoexpression of p53 in WT was significantly higher in the blastemal and epithelial than in the stromal component. It was in significant correlation with histological types of WT. The anaplastic component had noticeable but statistically not significantly higher p53 immunoexpression than non-anaplastic. The preoperative chemotherapy did not modify p53 immunoexpression of WT which had been found in other similar studies.

scholarly journals Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period

2017 ◽  
Vol 118 (4) ◽  
pp. 119-127
Author(s):  
Selahattin Çalışkan ◽  
Orhan Koca ◽  
Mehmet Akyüz ◽  
Metin İshak Öztürk ◽  
Muhammet Ihsan Karaman
Keyword(s):  
Renal Cell ◽  
Imaging Techniques ◽  
Transitional Cell ◽  
Renal Cell Carcinomas ◽  
Small Renal Masses ◽  
Renal Masses ◽  
Renal Tumours ◽  
Group 2 ◽  
Group 1

Renal cell carcinomas (RCCs) account 80–85% of all primary renal neoplasms and originate from the renal cortex. The patients who underwent radical or partial nephrectomy for renal tumour in our unit between January 2005 and 2015 were evaluated retrospectively. The patients were divided into two groups; group 1 includes patients who were treated between January 2005 and December 2009, group 2 those from January 2010 to 2015. There were 103 patients in group 1. The patients were between 21 and 89 years with mean age of 61.46 year. Renal cell carcinomas account 83.4% of the patients, benign renal tumours were 8.7% and transitional cell carcinomas were 7.7% of the patients in group 1. A total of 32.5% RCCs were classified as pT1a, 24.4% as pT1b, 15.1% as pT2a, 11.6% as pT2b, 15.1% as pT3a and 1.1% as pT4. There were 202 patients in group 2 and the patients were between 27 and 81 years with mean age of 58.5 year. Renal cell carcinomas comprised the main bulk of the tumours with 182 nephrectomy specimens. According to the pathological classification of RCCs, 51 specimens were found as pT1a, 54 were pT1b, 13 were pT2a, 14 were pT2b, 48 were pT3a and 2 were pT4. Although, the incidence of small renal masses has been increasing with widespread use of imaging techniques and recent advancements, the proportion of high grade and advanced stage renal tumours increased during the study period.

Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms’ tumour: Results of a randomised trial (UKW3) by the UK Children’s Cancer Study Group

2006 ◽  
Vol 42 (15) ◽  
pp. 2554-2562 ◽  
Author(s):  
Christopher Mitchell ◽  
Kathy Pritchard-Jones ◽  
Rosemary Shannon ◽  
Carolyn Hutton ◽  
Suzanne Stevens ◽  
...  
Keyword(s):  
Preoperative Chemotherapy ◽  
Randomised Trial ◽  
Study Group ◽  
Wilms Tumour ◽  
Cancer Study ◽  
Cancer Study Group ◽  
The Uk

ATOM Classification of Bile Duct Injuries During Laparoscopic Cholecystectomy: Analysis of a Single Institution Experience

2019 ◽  
Vol 29 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Andrea Balla ◽  
Silvia Quaresima ◽  
Mario Corona ◽  
Pierleone Lucatelli ◽  
Fausto Fiocca ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Bile Duct ◽  
Single Institution ◽  
Bile Duct Injuries

Evaluation of immunohistochemical expression of mismatch repair proteins in endometrioid and seromucinous borderline ovarian tumors a 10-year experience in a large health care institution.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17557-e17557
Author(s):  
Hector Chavarria ◽  
Marina Frimer ◽  
Noah D. Kauff ◽  
Veena S. John ◽  
Seema Khutti
Keyword(s):  
Mismatch Repair ◽  
Ovarian Tumors ◽  
Borderline Tumor ◽  
Nuclear Staining ◽  
Immunohistochemical Expression ◽  
Stromal Invasion ◽  
Borderline Tumors ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

e17557 Background: Borderline tumors (BT) are atypical proliferation of epithelium in the ovary in the absence of destructive stromal invasion, representing for 15% of all epithelial ovarian cancers. [1] Around 10% of the ovarian tumors are hereditary, and approximately 10% of all the hereditary forms of epithelial ovarian tumors are result of a loss of DNA mismatch repair (MMR). [2] Endometrioid borderline tumor (EBT) and Seromucinous borderline tumors (SMBT) are rare tumors in ovary and there is limited literature available on immunohistochemical (IHC) expression of Mismatch repair proteins(MMRP)in these tumors.[3, 4] The aim of this study is to evaluate IHC expression of MMRP in EBT and SMBT of ovary. Methods: Pathology database was searched for ovarian Endometrioid borderline tumor (EBT) and Seromucinous borderline tumor (SMBT) for a 10-year period (2010-2020). The cohort consisted of 10 EBT (6 of which had focal microinvasion or carcinoma) and 12 SMBT(2 of which had focal carcinoma ). For comparison, 1 borderline Brenner. 15 serous borderline tumors (SBT) and 15 mucinous borderline tumors (MBT) were also included. After reviewing slides, a block with adequate borderline tumor was selected for IHC stains. For the cases with carcinoma, two different blocks with each component were selected. In all selected blocks, IHC stains for four MMRP (MLH1, PMS2, MSH2, MSH6) were performed. The complete absence of nuclear staining in tumor cells was considered as “loss” of the MMRP expression. Any “weak” or “focal” nuclear staining was considered intact. Results: Total 53 cases were evaluated for MMRP IHC. All cases had intact MMRP expression. In cases with carcinoma, both components (BT and carcinoma) have intact MMR IHC expression. See table. Conclusions: Our study did not show loss of MMRP IHC expression in EMT or SMBT. However, our study consisted of a small number of cases. Multi Institutional study with a large number of cases can be helpful in future to further evaluate the role of MMRP IHC in EMT and SMBT. [Table: see text]

scholarly journals The Pathology of Tumours of the Urinary Tract

1939 ◽  
Vol 32 (11) ◽  
pp. 1455-1467
Author(s):  
W. D. Newcomb
Keyword(s):  
Urinary Tract ◽  
Connective Tissue ◽  
Renal Pelvis ◽  
Clinical Importance ◽  
Point Of View ◽  
Renal Tubules ◽  
Clear Cut ◽  
Renal Tumours ◽  
The Difference

Attention is called to the difference between the pathologist's and the radiologist's point of view. The reasons for this difference are discussed with special emphasis on renal tumours. Classification of renal tumours. The first main groups are innocent and malignant. Are these really clear-cut or do they blend into one another? The commoner innocent renal tumours are adenoma, fibroma, myoma, lipoma, and angioma. These are rarely of any clinical importance but adenoma is a possible source of hypernephroma. Many elaborate classifications of cancer of the kidney have been proposed but the following four groups are sufficient for most puposes: Carcinoma, hypernephroma, sarcoma, and teratoid tumours. Much the commonest malignant renal tumour in adults is the hypernephroma, thought by Grawitz and others to be derived from ectopic adrenal rests. There is still no agreement concerning their origin but three views are held at the present time: ( a) All are carcinoma of renal tubules. ( b) Some are derived from renal tubules and some from ectopic adrenal. ( c) All are formed from adrenal tissue. These views are discussed with special reference to material in St. Mary's Hospital Museum, and it is suggested that the first view is the most probable although the second cannot be excluded. The teratoid tumours are the commonest in infants and swine. The differences between them and hypernephromata are described. The renal Pelvis, ureter, and bladder all have tumours of the same type and can conveniently be considered together. Connective tissue tumours, both innocent and malignant, are very rare. Papilloma and carcinoma are rare in the pelvis and ureter, but commoner in the bladder. The relation between these two tumours is discussed.

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