scholarly journals High-density cervical ureaplasma urealyticum colonization in pregnant women

2006 ◽  
Vol 63 (8) ◽  
pp. 737-741 ◽  
Author(s):  
Gordana Randjelovic ◽  
Branislava Kocic ◽  
Biljana Miljkovic-Selimovic ◽  
Snezana Mladenovic-Antic ◽  
Predrag Stojanovic ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Ureaplasma Urealyticum ◽  
High Density ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Risk Pregnancy ◽  
Normal Term ◽  
Term Delivery

Background/aim: Ureaplasma urealyticum, a common commensal of the female lower genital tract, has been observed as an important opportunistic pathogen during pregnancy. The aims of this study were to determine the degree of cervical colonization with U. urealyticum in pregnant women with risk pregnancy and in pregnant women with normal term delivery and to evaluate the correlation between high-density cervical U. urealyticum colonization and premature rupture of membranes (PROM) as well. Methods. This research was conducted on the samples comprising 130 hospitalized pregnant women with threatening preterm delivery and premature rupture of membranes. The control group consisted of 39 pregnant women with term delivery without PROM. In addition to standard bacteriological examination and performing direct immunofluorescence test to detect Chlamydia trachomatis, cervical swabs were also examined for the presence of U. urealyticum and Mycoplasma hominis by commercially available Mycofast Evolution 2 test (International Microbio, France). Results. The number of findings with isolated high-density U. urealyticum in the target group was 69 (53.08%), while in the control group was 14 (35.90%). Premature rupture of membranes (PROM) occurred in 43 (33.08%) examinees: 29 were pPROM, and 14 were PROM. The finding of U.urealyticum ?104 was determined in 25 (58.14%) pregnant women with rupture, 17 were pPROM, and 8 were PROM. There was statistically significant difference in the finding of high-density U. urealyticum between the pregnant women with PROM and the control group (?? = 4.06, p < 0.05). U. urealyticum was predominant bacterial species found in 62.79% of isolates in the PROM cases, while in 32.56% it was isolated alone. Among the 49 pregnant women with preterm delivery, pPROM occurred in 29 (59.18%) examinees, and in 70.83% of pregnant women with findings of high-density U. urealyticum pPROM was observed. Conclusion. Cervical colonization with U. urealyticum ? 104 is more frequent in pregnant women with risk pregnancy than in pregnant women with normal term delivery. High-density cervical U. urealyticum colonization should be observed as a possible etiological factor for PROM.

scholarly journals Factores de riesgo asociados al parto pre término en el hospital nacional Guillermo Almenara Irigoyen de enero a junio del 2010.

2019 ◽  
pp. 143-149
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Multiple Pregnancy ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
National Hospital ◽  
Factors Associated ◽  
Factores De Riesgo

Factores de riesgo asociados al parto pre término en el hospital nacional Guillermo Almenara Irigoyen de enero a junio del 2010. Risk factors associated with preterm delivery in the Guillermo Almenara Irigoyen National Hospital from January to June 2010 Lizbeth Estefanía Díaz Polo Universidad de San Martin de Porres. Lima 12 DOI: https://doi.org/10.33017/RevECIPeru2011.0036/ RESUMEN El parto pre término ocurre entre las 22 y antes de las 37 semanas. Su etiología es multifactorial y es causa principal de morbilidad y mortalidad perinatal. El objetivo fue determinar los factores de riesgo asociados al parto pre término en gestantes del Hospital Nacional Guillermo Almenara Irigoyen de Enero a Junio del 2010. Se realizó un estudio retrospectivo, caso - control y descriptivo. Las historias clínicas de pacientes casos y controles, fueron revisadas y registradas en fichas y se procesaron con el SPSS versión 15. Los resultados fueron 81 pacientes con diagnóstico de parto pre término, con significancia estadística en las siguientes variables: ausencia de atención prenatal (OR 3.07, P>0.05), pre eclampsia (OR 20.86, P>0.001), ruptura prematura de membranas (OR 4.03, P>0.005), embarazo múltiple (OR 5.64, P>0.01), corioamnionitis (OR 2.02, P>0.1), lugar de nacimiento: sierra (OR 3.88, P>0.05) y nivel socioeconómico D-E (OR12.73, P>0.05). Se evidencio que gestantes más pobres y con menor nivel educativo presentan mayor incidencia de parto pre término [1] [2] [3]. Que el 21% de los partos pre término, estuvo asociado a la ruptura prematura de membranas (OR 4.03) dato que se encuentra dentro del rango de incidencia, ya que Aagaard-Tillery [4] (2005) señala una incidencia de la ruptura prematura de membrana pre término entre 30 y 40% y Fabián (2008) observó 11.67% de ruptura prematura de membranas [5]. Las gestantes con pre eclampsia tuvieron un riesgo 20 veces más de presentar parto pre término. El 34.6% con parto pre término presentó pre eclampsia, de ellas el 42.8% fue pre eclampsia severa, 25% leve y 32.14% síndrome de HELLP; dato similar al observado por Salviz en su estudio en el Hospital Cayetano Heredia, donde encontró un 30 % de parto pre término en pacientes con pre eclampsia; si bien es conocido que la pre eclampsia afecta del 3 al 5% de las gestaciones, no existen estudios sobre la incidencia de la pre eclampsia en el parto pre término [6]. Se concluye que el principal factor de riesgo asociado al parto pre término fue la pre eclampsia. Haber nacido en la sierra, pertenecer a nivel socioeconómico D-E, ausencia de atención prenatal, ruptura prematura de membranas, coriomanionitis y embarazo múltiple fueron también significativos. Descriptores: factores de riesgo, parto pre término, parto a término, pre eclampsia. ABSTRACT Preterm birth occurs between 22 and before 37 weeks. Its etiology is multifactorial and is a major cause of perinatal morbidity and mortality. The objective was to determine the risk factors associated with preterm delivery in pregnant women Guillermo Almenara Irigoyen National Hospital from January to June 2010. We performed a retrospective case - control and descriptive. The case histories of patients and controls were reviewed and recorded in chips and processed with SPSS version 15. The results were 81 patients diagnosed with preterm birth, with statistical significance in the following variables: absence of prenatal care (OR 3.07, P> 0.05), pre-eclampsia (OR 20.86, P <0.001), premature rupture of membranes (OR 4.03, P> 0,005), multiple pregnancy (OR 5.64, P> 0.01), chorioamnionitis (OR 2.02, P> 0.1), place of birth: saw (OR 3.88, P> 0.05) and socioeconomic status (OR12.73, P> 0.05). It was evident that more poor pregnant women with less education have a higher incidence of preterm delivery [1] [2] [3]. That 21% of preterm births was associated with premature rupture of membranes (OR 4.03) data that is within the range of incidence, as Aagaard-Tillery [4] (2005) noted an incidence of premature rupture preterm membrane between 30 and 40% and Fabian (2008) observed 11.67% of premature rupture of membranes [5]. Pregnant women with preeclampsia had a 20 times higher risk of preterm birth present. 34.6% presented with preterm birth pre-eclampsia, of which 42.8% was severe preeclampsia, 25% and 32.14% mild HELLP syndrome; data Salviz similar to that observed in their study in the Cayetano Heredia Hospital, where he found a 30 % of preterm birth in patients with preeclampsia, although it is known that pre-eclampsia affects 3 to 5% of pregnancies, no studies on the incidence of preeclampsia in preterm labor [6]. We conclude that the main risk factor associated with preterm delivery was preeclampsia. Being born in the mountains, belong to socioeconomic status, lack of prenatal care, premature rupture of membranes, coriomanionitis and multiple pregnancy were also significant. Keywords: risk factors, preterm delivery, term delivery, pre-eclampsia.

Features of pregnancy, childbirth and postpartum period in sexually transmitted infections

2020 ◽  
pp. 63-65
Author(s):  
O.І. Krotik ◽  
Keyword(s):  
Pregnant Women ◽  
Sexually Transmitted Infections ◽  
Premature Birth ◽  
Main Group ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Sexually Transmitted ◽  
Placental Dysfunction ◽  
Group 12

The objective: to identify the features of pregnancy, childbirth, the postpartum period in patients with sexually transmitted infections. Materials and methods. A retrospective analysis of 150 pregnancy and childbirth histories was performed: the main group included 100 pregnant women with a history of sexually transmitted infections (STIs) and episodes of manifestations during this pregnancy and 50 pregnant women in the control group without this pathology. The exclusion criteria were pregnant women with sexually transmitted infections whose pregnancies ended in short-term abortions. Results. The threat of abortion was detected in 46% of the main group, against 26% of the control group. Oligohydramnios 13% in the main group against 8% in the control group. Preeclampsia in the main group 12%, against 5% in the control group. FGR in the main group 10% vs. 6% in the control. Placental dysfunction in the main group of 20% vs. 16% in the control. Bacterial vaginosis was 67% in the main group versus 14% in the control group. The risk of miscarriage, premature birth in the main group is 20% compared with the control group of 4%. Premature rupture of membranes was observed in 33% of women in the main group against 16% in the control group. Conclusions. The threat of abortion occurred in women of the main group (46%), which is 1.7 times more often than in the control group (26%). Oligohydramnios was observed in (13%) of the main group, which is 1.6 times more than in the control group (8%). Preeclampsia occurred 2 times more often in the main group (12%) than in the control group (6%). FGR occurred 1.7 times more often in the main group (10%) than in the control group (6%). Placental dysfunction was 1.25 times more common in the main group (20%) than in the control group (16%). A high percentage of bacterial vaginosis (67%) was observed in patients of the main group, which is 4.8 times higher than in the control group (14%). The risk of miscarriage, premature birth in the main group was higher (20%) and was observed 5 times more often than in the control group (4%). Premature rupture of membranes is observed in (33%) women in the main group, which is 2 times higher than in the control group (16%). Keywords: sexually transmitted infections (STIs), pregnancy, childbirth.

scholarly journals Preterm Premature Rupture of the Membranes and Genital Mycoplasmas

2009 ◽  
Vol 52 (3) ◽  
pp. 117-120 ◽  
Author(s):  
Marian Kacerovský ◽  
Michal Pavlovský ◽  
Jindřich Tošner
Keyword(s):  
Pregnant Women ◽  
Bacterial Culture ◽  
Ureaplasma Urealyticum ◽  
Mycoplasma Hominis ◽  
Normal Pregnancy ◽  
Control Group ◽  
Vaginal Smears ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Genital Mycoplasmas

Objective: The purpose of this study was to evaluate the prevalence of cervical colonization by genital mycoplasmas in patients with preterm premature rupture of the membranes (PPROM). Method: We studied 225 women between 24 and 36 weeks of gestation with PPROM. Cervical swabs were obtained for genital mycoplasmas and standard vaginal smears of bacterial culture were performed at the time of patients’ admission. In the control group were 225 women with a normal pregnancy. Results: Ureaplasma urealyticum was detected in 68 % (152/225) and Mycoplasma hominis was detected in 28 % (63/225) of the patients with PPROM between 24 and 36 weeks of gestation and. In the control group Ureaplasma urealyticum was found in 17 % (38/225) and Mycoplasma hominis in 15 % (35/225) pregnant women. Conclusion: Our results provide evidence of an association between cervical colonization with genital mycoplasmas and preterm premature rupture of the membranes.

scholarly journals The association between COVID-19 and preterm delivery: A cohort study with a multivariate analysis

2020 ◽  
Author(s):  
◽  
Oscar Martinez Perez ◽  
Pilar Prats Rodriguez ◽  
Marta Muner Hernandez ◽  
Maria Begona Encinas Pardilla ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Cohort Study ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Neonatal Intensive Care ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Obstetric Morbidity

Structured abstract Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS CoV 2, the cause of COVID 19 disease) exposure in pregnancy, compared to non exposure, is associated with infection related obstetric morbidity. Design and setting: Throughout Spain, 45 hospitals took part in the universal screening of pregnant women going into labour using polymerase chain reaction (PCR) for COVID 19 since late March 2020. Methods: The cohort of exposed and unexposed pregnancies was followed up until 6 weeks postpartum. Multivariate logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of COVID 19 exposure, compared to non exposure, with infection related obstetric outcomes. Main outcome measures: Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. Results: In the cohort of 1,009 screened pregnancies, 246 were COVID 19 positive. Compared to non exposure, COVID 19 exposure increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32 3.36, p=0.002), premature rupture of membranes at term (39 vs 75, % vs 9.8%, aOR 1.70, 95% CI 1.11 2.57, p=0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43 8.94, p<0.001). Conclusion: This first prospective cohort study demonstrated that pregnant women infected with SARS CoV 2 have more infection related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.

Laws of changes of immune status of mother and child at pregnancy prolongation, complicated by premature rupture of amniotic membranes

2014 ◽  
Vol 63 (2) ◽  
pp. 35-41
Author(s):  
Larisa Ivanovna Dyatlova ◽  
Aleksandr Viktorovich Mikhaylov ◽  
Nina Pavlovna Chesnokova ◽  
Yelena Vyacheslavovna Ponukalina ◽  
Tatyana Nikolayevna Glukhova
Keyword(s):  
Pregnant Women ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Normal Pregnancy ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Laboratory Examination ◽  
Premature Rupture ◽  
Cell Immunity

Purpose and tasks: to establish new prognostic criteria of date of prolongation of pregnancy with premature discharge of amniotic fluid on the basis of performance monitoring of cell immunity of mother in the dynamics of observation and the child at the time of completion childbirth. Material and methods. A clinical and laboratory examination of 50 pregnant women, the pregnancy of women was complicated by premature rupture of membranes at 22-34 weeks of gestation. The control group consisted of 40 women with normal pregnancy with the same time of gestation. The traditional methods of clinical and laboratory examination were used to assess the status of pregnant women. The study of peripheral blood was performed with hematological analyzer BC- 3000+. Subpopulations of peripheral blood lymphocytes was studied by cytometry using monoclonal antibodies (apparatus «FAC SCalibur» company «BectonDickinson», USA). Results. The development of leukocytosis with absolute and relative lymphopenia, reduction of CD16+56+lymphocytes and CD19 B lymphocytes were revealed in pregnant women with premature rupture of membranes. The failure of proliferative activity CD3+4+ T-helper cells, the increase of level of CD3+8+ cytotoxic T lymphocytes were revealed at the time of onset of labor after the prolongation of pregnancy. Prolongation of pregnancy at patients with premature rupture of membranes combined with the development of leukocytosis in the fetus, as well as the mother in the same period of observation. At the same time, unlike the parent organism, activation of B-lymphocyte proliferation and humoral immunity at fetus were occurred.

scholarly journals Urocortin in Second Trimester Amniotic Fluid: Its Role as Predictor of Preterm Labor

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
C. Iavazzo ◽  
K. Tassis ◽  
D. Gourgiotis ◽  
M. Boutsikou ◽  
S. Baka ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Preterm Delivery ◽  
Preterm Labor ◽  
Conditional Logistic Regression ◽  
Second Trimester ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Human Trophoblast ◽  
Conditional Logistic Regression Analysis ◽  
Term Delivery

Backgound. The existence of a “placental clock” which determines the duration of gestation has been previously proposed. It is related to placental CRH secretion and is active from an early phase in human pregnancy. Urocortin is a specific ligand for the corticotropin-releasing factor (CRF) receptor expressed by human trophoblast and fetal membranes. The purpose of this study was to evaluate whether urocortin concentrations in the early second trimester amniotic fluid might serve to predict preterm delivery.Method. The urocortin concentrations in early second trimester amniotic fluid were measured in 41 pregnancies with term delivery and in 41 pregnancies with preterm delivery by using an immunoradiometric assay. Conditional logistic regression analysis was used for statistical analysis.Results. Mean amniotic fluid urocortin concentrations in women with preterm labor were1.55±0.63 ng/mL while those in women with term labor were1.6±0.49 ng/mL (p: NS). No statistical significant results were found when comparing amniotic fluid urocortin concentrations in women with preterm premature rupture of membranes leading to preterm labor (n=19) to women with term delivery without premature rupture of membranes.Conclusion. These results suggest that urocortin concentrations in the amniotic fluid of genetic amniocentesis are not predictive of preterm labor and birth.

scholarly journals Risk Factors for Neonatal Bronchopulmonary Dysplasia in Extremely Preterm Premature Rupture of Membranes: A Retrospective Study

2020 ◽  
Author(s):  
Eishin Nakamura ◽  
Shigetaka Matsunaga ◽  
Yoshihisa Ono ◽  
Yasushi Takai ◽  
Hiroyuki Seki
Keyword(s):  
Risk Factors ◽  
Preterm Delivery ◽  
Bronchopulmonary Dysplasia ◽  
Roc Curve ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Extremely Preterm ◽  
Gestational Week ◽  
The Mean

Abstract Background: Determination of the optimal timing for termination of pregnancy in cases of preterm premature rupture of membranes (pPROM) during the extremely preterm period is still difficult. Bronchopulmonary dysplasia (BPD) is a major disease widely taken into account when determining the prognosis of respiratory disorders in a neonate. Many aspects of this disease remain unclear. With the aim of further improving the prognosis of neonates born to mothers with pPROM, this study examined cases who were diagnosed with pPROM before 28 weeks of gestation. The study analysed risk factors for neonatal BPD. Methods: This study included 73 subjects with singleton pregnancy, diagnosed with pPROM during the gestational period from 22 weeks and 0 days to 27 weeks and 6 days. The following factors were retrospectively examined: the gestational week at which pPROM was diagnosed, the gestational week at which delivery occurred, the period for which the volume of amniotic fluid was maintained, and neonatal BPD as a complication. Receiver operating characteristic (ROC) curve analyses were conducted to analyse the relationship of the onset of BPD with the duration of oligohydramnios and the gestational weeks of delivery. Results: The mean gestational week at which a diagnosis of amniorrhexis was made was 24.5±1.9 weeks (mean±SD), and that at which delivery occurred was 27.0±3.0 weeks. Fifty-seven cases (78.1%) were diagnosed with oligohydramnios, the mean duration of which was 17.4±20.5 days. The mean birth weight of neonates was 1000±455 g, of which 49 (67.1%) were diagnosed with BPD following birth. No neonates died in this study. The ROC curve indicated that the cut-off values for the duration of oligohydramnios and gestational age at delivery were 4 days and 24.1 weeks, respectively. Multivariate analysis indicated that the duration of oligohydramnios for more than 4 days before delivery and preterm delivery at less than 24.1 weeks were risk factors for the onset of BPD. Conclusion: Our findings suggest that duration of oligohydramnios for more than 4 days before delivery and preterm delivery less than 24.1 weeks are risk factors for BPD in cases who are diagnosed with pPROM before 28 weeks of gestation.

Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery

2021 ◽  
pp. 48-53
Author(s):  
Zachary Colvin ◽  
Anna Palatnik
Keyword(s):  
England Journal ◽  
New England ◽  
Preterm Delivery ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Fetal Fibronectin ◽  
Preterm Premature Rupture ◽  
Vaginal Secretions

This article reviews the study “Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery,” published in The New England Journal of Medicine in 1991 by Lockwood et al. The study examined the use of fetal fibronectin found in cervicovaginal secretions as a marker for preterm delivery in symptomatic women presenting with preterm contractions or with preterm premature rupture of membranes. The chapter reviews the findings of this study as well as the place of fetal fibronectin testing in current obstetrical practice based on subsequent studies.

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