Features of pregnancy, childbirth and postpartum period in sexually transmitted infections

2020 ◽  
pp. 63-65
Author(s):  
O.І. Krotik ◽  
Keyword(s):  
Pregnant Women ◽  
Sexually Transmitted Infections ◽  
Premature Birth ◽  
Main Group ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Sexually Transmitted ◽  
Placental Dysfunction ◽  
Group 12

The objective: to identify the features of pregnancy, childbirth, the postpartum period in patients with sexually transmitted infections. Materials and methods. A retrospective analysis of 150 pregnancy and childbirth histories was performed: the main group included 100 pregnant women with a history of sexually transmitted infections (STIs) and episodes of manifestations during this pregnancy and 50 pregnant women in the control group without this pathology. The exclusion criteria were pregnant women with sexually transmitted infections whose pregnancies ended in short-term abortions. Results. The threat of abortion was detected in 46% of the main group, against 26% of the control group. Oligohydramnios 13% in the main group against 8% in the control group. Preeclampsia in the main group 12%, against 5% in the control group. FGR in the main group 10% vs. 6% in the control. Placental dysfunction in the main group of 20% vs. 16% in the control. Bacterial vaginosis was 67% in the main group versus 14% in the control group. The risk of miscarriage, premature birth in the main group is 20% compared with the control group of 4%. Premature rupture of membranes was observed in 33% of women in the main group against 16% in the control group. Conclusions. The threat of abortion occurred in women of the main group (46%), which is 1.7 times more often than in the control group (26%). Oligohydramnios was observed in (13%) of the main group, which is 1.6 times more than in the control group (8%). Preeclampsia occurred 2 times more often in the main group (12%) than in the control group (6%). FGR occurred 1.7 times more often in the main group (10%) than in the control group (6%). Placental dysfunction was 1.25 times more common in the main group (20%) than in the control group (16%). A high percentage of bacterial vaginosis (67%) was observed in patients of the main group, which is 4.8 times higher than in the control group (14%). The risk of miscarriage, premature birth in the main group was higher (20%) and was observed 5 times more often than in the control group (4%). Premature rupture of membranes is observed in (33%) women in the main group, which is 2 times higher than in the control group (16%). Keywords: sexually transmitted infections (STIs), pregnancy, childbirth.

scholarly journals Features of systemic and local immunity in pregnant women with a history of sexually transmitted infections

2021 ◽  
Vol 4 ◽  
pp. 70-75
Author(s):  
E.I. Krotik
Keyword(s):  
Pregnant Women ◽  
Sexually Transmitted Infections ◽  
Control Group ◽  
Local Immunity ◽  
Sexually Transmitted ◽  
Placental Dysfunction ◽  
Infectious Origin ◽  
Tnf Α ◽  
History Of

The objective: to study the features of systemic and local immunity in pregnant women with a history of sexually transmitted infections.Materials and methods. We examined 100 patients, which were divided into groups: Group I (main) – 50 pregnant women with a history of sexually transmitted infections, with a high risk of placental dysfunction of infectious origin; Group II (control) – 50 pregnant women without obstetric and somatic pathology, who became pregnant spontaneously and had vaginal delivery.In-depth immunological examination included: determination of absolute (×109/л) and relative (%) number of subpopulations of CD3+ lymphocytes (T-lymphocytes), CD4+ (helpers-inductors), CD8+ (cytotoxic suppressors), CD56+ (natural killers), CD19 + (B-lymphocytes); determination of levels of IgG, IgM, IgA in serum and vaginal secretions; studied the content of a number of cytokines (interleukins – IL-1, IL-2, IL-4, IL-10, TNF-α, INFγ) in serum and vaginal contents.Results. The results of studies indicate that in pregnant women with a history of sexually transmitted infections (STIs), that formulate a group of high infectious risk, changes in systemic and local immunity, cytokine status are statistically prognostic. Levels of pro-inflammatory cytokines IL-1, IL-2, TNF-α and anti-inflammatory cytokines IL-4, IL-10 and γ IFN in serum and vaginal contents can be used as prognostic criteria for complications before their clinical manifestations and clinical features of pregnancy. It was also detected that the percentage of СD56+-lymphocytes with properties of natural killers was greater in group of pregnant women with a history of sexually transmitted infections than in the control group dynamically throughout pregnancy (12,3±1,7%, 15,1±1,7%, 13,9±1,73% against 8,6±1,4%, 8,1±1,18%, 7,2±0,98%; р<0,05). Studies also showed a significant increase in IgG levels in pregnant women with a history of sexually transmitted infections compared to the pregnant women in the control group (p <0,05).Conclusion. The study of systemic and local immunity, cytokine status in pregnant women with a history of sexually transmitted infections expands the possibilities of choice of rational, pathogenetic therapy, thereby reducing the incidence of early placental dysfunction of infectious origin, intrauterine infection, obstetric and perinatal complications in these patients.

scholarly journals High-density cervical ureaplasma urealyticum colonization in pregnant women

2006 ◽  
Vol 63 (8) ◽  
pp. 737-741 ◽  
Author(s):  
Gordana Randjelovic ◽  
Branislava Kocic ◽  
Biljana Miljkovic-Selimovic ◽  
Snezana Mladenovic-Antic ◽  
Predrag Stojanovic ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Ureaplasma Urealyticum ◽  
High Density ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Risk Pregnancy ◽  
Normal Term ◽  
Term Delivery

Background/aim: Ureaplasma urealyticum, a common commensal of the female lower genital tract, has been observed as an important opportunistic pathogen during pregnancy. The aims of this study were to determine the degree of cervical colonization with U. urealyticum in pregnant women with risk pregnancy and in pregnant women with normal term delivery and to evaluate the correlation between high-density cervical U. urealyticum colonization and premature rupture of membranes (PROM) as well. Methods. This research was conducted on the samples comprising 130 hospitalized pregnant women with threatening preterm delivery and premature rupture of membranes. The control group consisted of 39 pregnant women with term delivery without PROM. In addition to standard bacteriological examination and performing direct immunofluorescence test to detect Chlamydia trachomatis, cervical swabs were also examined for the presence of U. urealyticum and Mycoplasma hominis by commercially available Mycofast Evolution 2 test (International Microbio, France). Results. The number of findings with isolated high-density U. urealyticum in the target group was 69 (53.08%), while in the control group was 14 (35.90%). Premature rupture of membranes (PROM) occurred in 43 (33.08%) examinees: 29 were pPROM, and 14 were PROM. The finding of U.urealyticum ?104 was determined in 25 (58.14%) pregnant women with rupture, 17 were pPROM, and 8 were PROM. There was statistically significant difference in the finding of high-density U. urealyticum between the pregnant women with PROM and the control group (?? = 4.06, p < 0.05). U. urealyticum was predominant bacterial species found in 62.79% of isolates in the PROM cases, while in 32.56% it was isolated alone. Among the 49 pregnant women with preterm delivery, pPROM occurred in 29 (59.18%) examinees, and in 70.83% of pregnant women with findings of high-density U. urealyticum pPROM was observed. Conclusion. Cervical colonization with U. urealyticum ? 104 is more frequent in pregnant women with risk pregnancy than in pregnant women with normal term delivery. High-density cervical U. urealyticum colonization should be observed as a possible etiological factor for PROM.

Complex therapy of placental dysfunction in pregnant women with oligohydramnios

2017 ◽  
pp. 50-53
Author(s):  
I.E. Basiuga ◽  
Keyword(s):  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Water Shortage ◽  
Main Group ◽  
Control Group ◽  
Compensatory Mechanisms ◽  
Placental Dysfunction ◽  
Trust Relationships ◽  
Personal Anxiety ◽  
Psychological Features

The objective: to improve the treatment of placental dysfunction in pregnant women with oligohydramnios regarding their psychological condition. Patients and methods. Survey was conducted in 120 pregnant women with oligohydramnios the gestational age of 27-29 weeks (main group) and 30 physiologically healthy pregnant women (control group) on the basis of the city clinical hospital of Ivano-Frankivsk. Results. During the study of psychological features we have not yet determined significant differences in the level of personal anxiety with oligohydramnios as compared with pregnant women with physiological gestation. Also, was found the division of examined for low, medium, and high levels of this indicator between the two pregnant groups. In particular, approximately half of the individuals had an average level of personal anxiety – 14 (46.67±9.11%) and 57 healthy pregnant women (47.50±4.56%) with oligohydramnios, third – highest, respectively 11 (36.67±8.80%) and 39 (32.50±4.58%), the lowest level recorded in 5 (16.67±6.80 per cent) and 24 (20.00±3.65%) patients. A comprehensive approach to correction of the condition of water shortage has been applied in women of the main group, which included: psychological support for couples with sessions with a psychologist to control emotions. Establishing emotional contact with a woman, trust relationships, discussion of physical and emotional changes is a part of pregnancy. Conclusion. In the result of the researches, the approach proposed by us to the treatment of pregnancy with oligohydramnios, allowed to reduce the stress of compensatory mechanisms of the fetoplacental unit, which contributed to the reduction of anxiety in pregnant and have improved not only obstetric but also perinatal outcomes in women of the main group. Key words: pregnancy, placental dysfunction, oligohydramnios, Cytoflavin.

scholarly journals Prevention of primary placental dysfunction with low location of the chorion

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 80-84
Author(s):  
S. Pecheriaha ◽  
I. Marynchyna
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Gestational Age ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Main Group ◽  
Control Group ◽  
Low Grade ◽  
Doppler Examination ◽  
Placental Dysfunction

Objective is to develop new methods to prevent primary placental dysfunction (PD) in early gestational age with low placentation.Material and methods. We have examined 119 pregnant women with low placentation. This diagnosis was made from 6-7 weeks of gestation on the basis of echographic research. The main group consisted of 64 pregnant women with low chorionic location, which was used to prevent PD from the early gestational age by the complex of medicines developed by us and a control group of 55 women with low placentation that had not undergone PD prophylaxis from early gestational periods. The treatment and prophylactic complex included: Luteina, ginkgo biloba extract, folio and biolectra. In the main and control groups, all pregnant women underwent Doppler examination in the uterine and spiral arteries, as well as determined the volume of the chorion and the volume of blood flow in the chorion.Results. Doppler examination in the main group showed a decrease in all indices of resistance in the uterine and spiral arteries, as well as a significant increase in chorionic volume and vascularization index in three-dimensional ultrasound compared with the control group.Conclusions. The proposed treatment and prophylactic complex agents (Luteina, ginkgo biloba extract, folio and biolectra) helps to normalize uterine-chorionic blood flow, restore effective embryo-chorionic relationships and significantly reduces the frequency of further development of primary placental dysfunction in pregnant women with low-grade pregnancy.

scholarly journals Prevention of pregnancy complications and delivery at low placentation

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 83-88
Author(s):  
S. Pecheriaha ◽  
I. Marynchyna
Keyword(s):  
Pregnant Women ◽  
Pregnancy Complications ◽  
Uterine Cavity ◽  
Main Group ◽  
Late Gestation ◽  
Lower Percentage ◽  
Control Group ◽  
Early Gestation ◽  
Placental Dysfunction ◽  
Pregnancy And Delivery

Objective is to evaluate the effectiveness of the developed method of preventing pregnancy complications with low placentation from early gestation.Material and methods. We have examined 119 pregnant women with low placentation. This diagnosis was made at 6-7 weeks of gestation on the basis of echographic research. The main group consisted of 64 pregnant women with low chorionic location who underwent prevention from pregnancy complications in early gestation by the complex of medicines developed by us and a control group -55 women with low placentation who had not undergone complications prophylaxis from early gestational periods. The prophylactic complex included Luteina, ginkgo biloba extract, folio and biolectra. To assess the effectiveness of the therapy in the study groups, we analyzed the course of pregnancy in early and late gestation, as well as complications of pregnancy and delivery.Results. The frequency of pregnancy pathologies in the main group, where the prevention of pregnancy complications from early gestation with low placentation, was significantly lower than in the control group. According to the study, the risk of abortion with bleeding and without bleeding in the first and second trimesters significantly decreased in the main group of pregnant women (p<0.05). In the third trimester of gestation in the group where the prevention of pregnancy complications was significantly reduced, the incidence of preterm birth, premature detachment of the low-lying placenta, fetoplacental dysfunction, fetal developmental delay syndrome and fetal distress during pregnancy (p<0.05). Also, in the main group there was a lower percentage of premature births and births that ended by cesarean section.Conclusions. 1. The place of attachment of the placenta in the uterine cavity is closely related to its function, the development of placental dysfunction, pregnancy and delivery. 2. Studies have shown the effectiveness of our proposed comprehensive drug prevention of complications of pregnancy with low placentation, which in turn has led to improved pregnancy and delivery and has become an effective means of preventing placental dysfunction.

scholarly journals Clinical Significance of Oligohydramnios in Patients with Preterm Premature Rupture of Membranes

2021 ◽  
Vol 6 (2) ◽  
pp. 9-15
Author(s):  
O. M. Chistyakova ◽  
L. V. Gureeva ◽  
O. V. Radkov
Keyword(s):  
Neonatal Intensive Care ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Amniotic Fluid Index ◽  
Reactive Protein ◽  
Preterm Premature Rupture

Background. Preterm premature rupture of membranes (PPROM) is one of the main causes of perinatal morbidity and mortality. Associated oligohydramnios may further exacerbate the condition leading to intra-amniotic inflammation and adverse obstetric and perinatal outcomes in preterm labor.Aim of the research. To determine an impact of oligohydramnios on patients with preterm premature rupture of membranes.Materials and methods. We performed a retrospective analysis of two groups of patients with PPROM: 56 patients with oligohydramnios were included in the main group, 111 patients without oligohydramnios were included in the control group. The gestational age varied from 24+0 weeks to 33+6 weeks. Amniotic fluid index, endocervical culture, leukogram and neutrophil-to-lymphocyte ratio (NLR), serum procalcitonin and C-reactive protein levels were assessed in all participants.Results. We witnessed a plethora of consequences in the group of women with PPROM and oligohydramnios: shorter latent phase, higher incidence of clinical chorioamnionitis, antenatal fetal distress, higher levels of C-reactive protein, leukocytes, neutrophils and NLR, lower level of lymphocytes, and increased growth of potentially pathogenic cervical flora. Moreover, the patients with oligohydramnios demonstrated a significantly higher rate of cesarean delivery. The combination of PPROM and oligohydramnios also take a toll on the condition of the newborns: they have lower 5-minute Apgar score and higher prevalence of respiratory distress syndrome, congenital pneumonia, and necrotizing enterocolitis. Furthermore, newborns from the main group are more likely to be admitted to the neonatal intensive care unit, compared with newborns from the control group.Conclusion. Oligohydramnios in PPROM is associated with a dramatic rise of numerous complications affecting both the women and the newborns. 

scholarly journals Morphological and electron-microscopic features of the investigated placente in very early previous delivery, complicated premature rupture of membranes

2021 ◽  
Vol 1 ◽  
pp. 54-60
Author(s):  
O.B.  Malanchuk ◽  
I.V.  Poladich ◽  
O.Yu.  Kostenko ◽  
S.O. Avramenko
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Gestational Age ◽  
Progesterone Receptors ◽  
Study Groups ◽  
Main Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Electron Microscopic ◽  
Microscopic Features

The article presents modern phenomena about morphological and electron microscopic features of the studied placentas in very early premature birth, complicated by premature rupture of membranes. These features were studied in different tactics of data management of pregnant women. The objective: study of morphological and electron microscopic features of the studied placentas in very early preterm birth, complicated by PRPO.Materials and methods. All 206 patients were divided into two groups. The main group included 150 pregnant women with PRPO at a gestational age of 22–28 weeks, and the control group included 56 pregnant women with a physiological course of gestation at a period of 22–28 weeks. The main group is divided into 2 groups depending on the duration of waiting tactics and the method of delivery. Group I patients received treatment in accordance with clinical protocols by orders of the Ministry of Health of Ukraine. Pregnant women of group II were offered a tactic that involves prolonging gestation for 5 days (antibiotic therapy, RDS prophylaxis, magnesium therapy, in the presence of streptococcus B – treatment) followed by delivery by cesarean section. All patients with PRPO received antibacterial therapy from the day of hospitalization. Results. The results of the study indicate that no significant differences between the study groups during the study were found. The expression data of progesterone receptors correspond to the results of hormonal research, which also did not reveal significant changes in the study groups, and confirm the theory of finding new provoking factors of PRPO in preterm birth. Conclusions. Thus, it was first demonstrated that the content of progesterone in blood plasma and immunohistochemical expression of progesterone receptors in the placenta on the background of DRPP depends on the gestational age and not on the duration of the anhydrous period.

scholarly journals COURSE AND OUTCOME OF PREGNANCY, OBSTETRIC TACTICS BY PRETERM RUPTURE OF MEMBRANES AT THE TERM OF 24-32 WEEKS

2018 ◽  
Vol 24 (5) ◽  
pp. 237-241
Author(s):  
Yulia A. Dudareva ◽  
V. A Guryeva ◽  
O. N Filchakova
Keyword(s):  
Perinatal Outcomes ◽  
Expectant Management ◽  
Main Group ◽  
Gestation Period ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Septic Complications ◽  
Inflammatory Processes ◽  
Premature Discharge

The birth of premature children is the cause of the increase in morbidity and perinatal mortality in the country, that is why it is necessary to carry out not only prognosis of premature births but also to correctly determine the tactics of managing patients with premature rupture of membranes. The objective of the study was to evaluate the course of pregnancy, perinatal outcomes, depending on the chosen tactics of managing women with premature discharge of amniotic fluid in the period of 24-32 weeks of pregnancy. Materials and methods: 46 patients were included in this study, 26 of them were the main group with premature rupture of membranes at a gestation period of 24-32 weeks, long anhydrous period (more than 48 hours), and 20 patients were included into the control group. The main criterion for inclusion in the control group was a spontaneous active onset of labor at a gestation period of 24-32 weeks, with an anhydrous period of less than 12 hours. Results: Patients of both groups were comparable in age, frequency of extragenital and gynecological pathology, main characteristics of menstrual function, parity and outcomes of pregnancies. In the presence of certain conditions in the main group, it was possible to apply expectant management tactics, which, on average, prolonged the pregnancy by 12.0 ± 2.3 days, which in 30.8% of cases was accompanied by the development of chorionamnionitis (p = 0.020), without interrelation with duration of anhydrous period and frequency of postpartum purulent-septic complications. It was found that perinatal outcomes, weight and condition of newborns at birth were much better in women in the main group. Conclusion: The reasonably chosen expectant management strategy for women with premature rupture of membranes at the gestational period of 24-32 weeks, subject to certain conditions, will improve perinatal outcomes without significantly increasing the incidence of infectious and inflammatory processes in the mother and newborn.

scholarly journals Features of the functional state of the fetoplacental complex in pregnant women with a history of sexually transmitted infections

2021 ◽  
Vol 5 ◽  
pp. 43-47
Author(s):  
E.I. Krotik
Keyword(s):  
Pregnant Women ◽  
Sexually Transmitted Infections ◽  
Functional State ◽  
Placental Lactogen ◽  
Control Group ◽  
Perinatal Complications ◽  
Sexually Transmitted ◽  
Fetoplacental Complex ◽  
Biophysical Profile ◽  
History Of

The objective: a study of the features for the formation and functioning of the fetoplacental complex in pregnant women with a history of sexually transmitted infections.Materials and methods. We examined 50 pregnant women with a history of sexually transmitted infections (I group – the main group). The control group consisted of 30 pregnant women without somatic and gynecological pathology, who had vaginal delivery. All pregnant women underwent a comprehensive clinical examination, taking into account complaints, medical history, objective and additional methods of examination. The levels of estriol, cortisol, placental lactogen and progesterone in the blood serum of pregnant women and the state of fetoplacental complex in terms of 18–20th, 28–30th and 38–40th weeks were determined.Results. In the pregnant women in I group, starting from the 18th weeks there was a significant decrease in the secretion of progesterone (160,8±15,9 nmol/L versus 202,4±5,5 nmol/L, respectively; p<0,05), placental lactogen (77,5±13,2 nmol/L versus 91,3±23,8 nmol/L)/ This means that already in these stages of pregnancy there are signs of placental dysfunction in pregnant women with a history of sexually transmitted infections. The changes in the functional state of the fetoplacental complex at the 28–30th weeks are more pronounced, as evidenced by an increase in the frequency of early intrauterine growth restriction (12.0 %), disorders of fetal breathing (11.0 %) and fetal movements (18.0 %) (according to the biophysical profile score assessment); premature of the placenta, increased hormonal insufficiency of the fetoplacental complex and the first signs of hemodynamic disorders (an increased blood flow in the umbilical artery and uterine arteries and a slight decrease in blood circulation in the middle cerebral artery of the fetus). At the final assessment of the condition of the fetoplacental complex at the 38–40th weeks in pregnant women with a history of sexually transmitted infections, a satisfactory condition was observed in 24 % of cases, compensated ultrasound changes occurred in 46.0 % of cases; subcompensated – in 20.0 % and decompensated – in 10.0 % of cases, respectively, which causes a high frequency of obstetric and perinatal complications in this group of pregnant women.Conclusions. The formation and functional state of the fetoplacental complex in pregnant women with a history of sexually transmitted infections, from early pregnancy is characterized by a significant level of functional disorders of the fetus, placenta and the amount of amniotic fluid on the background of pronounced hemodynamic and endocrinological disorders, which requires prevention in the pre-pregnancy period.

Laws of changes of immune status of mother and child at pregnancy prolongation, complicated by premature rupture of amniotic membranes

2014 ◽  
Vol 63 (2) ◽  
pp. 35-41
Author(s):  
Larisa Ivanovna Dyatlova ◽  
Aleksandr Viktorovich Mikhaylov ◽  
Nina Pavlovna Chesnokova ◽  
Yelena Vyacheslavovna Ponukalina ◽  
Tatyana Nikolayevna Glukhova
Keyword(s):  
Pregnant Women ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Normal Pregnancy ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Laboratory Examination ◽  
Premature Rupture ◽  
Cell Immunity

Purpose and tasks: to establish new prognostic criteria of date of prolongation of pregnancy with premature discharge of amniotic fluid on the basis of performance monitoring of cell immunity of mother in the dynamics of observation and the child at the time of completion childbirth. Material and methods. A clinical and laboratory examination of 50 pregnant women, the pregnancy of women was complicated by premature rupture of membranes at 22-34 weeks of gestation. The control group consisted of 40 women with normal pregnancy with the same time of gestation. The traditional methods of clinical and laboratory examination were used to assess the status of pregnant women. The study of peripheral blood was performed with hematological analyzer BC- 3000+. Subpopulations of peripheral blood lymphocytes was studied by cytometry using monoclonal antibodies (apparatus «FAC SCalibur» company «BectonDickinson», USA). Results. The development of leukocytosis with absolute and relative lymphopenia, reduction of CD16+56+lymphocytes and CD19 B lymphocytes were revealed in pregnant women with premature rupture of membranes. The failure of proliferative activity CD3+4+ T-helper cells, the increase of level of CD3+8+ cytotoxic T lymphocytes were revealed at the time of onset of labor after the prolongation of pregnancy. Prolongation of pregnancy at patients with premature rupture of membranes combined with the development of leukocytosis in the fetus, as well as the mother in the same period of observation. At the same time, unlike the parent organism, activation of B-lymphocyte proliferation and humoral immunity at fetus were occurred.

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