scholarly journals Induratio penis plastica: Localized or diffusive fibromatosis of tunica albuginea penis

2006 ◽  
Vol 63 (11) ◽  
pp. 939-944 ◽  
Author(s):  
Djordje Nale ◽  
Sava Micic ◽  
Ivan Vukovic ◽  
Radoslav Radosavljevic
Keyword(s):  
Tunica Albuginea ◽  
Phenotypic Expression ◽  
Corpus Cavernosum ◽  
Penile Curvature ◽  
Histological Changes ◽  
Induratio Penis Plastica ◽  
Significant Difference ◽  
Lateral Curvature ◽  
Histological Results ◽  
Histological Result

Background/Aim. The part of the tunica albuginea that is not affected by localized pathological fibrosis is excised by the Nesbit contralateral excisional corporalplasty in patients with induratio penis plastica (IPP). The aim of this study was to find out if there were any histological changes of the macroscopically normal tunica albuginea excised during the Nesbit corporalplasty. Methods. A total of 31 patients, mean age 45 ? 7.65 years, were surgical treated for extensive penile curvature (impossible or difficult penile imission in the vagina), using the Nesbit surgical technique. The tunica albuginea tissue was manipulated by Allis?s clamps and excised in the shape of a diamond and placed in the 4% formaldehyde solution for histological analysis. The excised tunica albuginea was not wider than 1 cm, while the histological preparations were 3 to 5 ?m thick, and they were stained with hematoxylin-eosin. The excised tunica albuginea tissue appeared macroscopically (anatomically) normal in all of the operated patients. In 28 (90.3%) patients operated for dorsal curvature of the penis, the tissue of the tunica albuginea was excised from the urethral ridge, while in 3 (9.7%) patients operated for lateral curvature, the tissue was excised from the lateral corpus cavernosum. Results. The histological results were normal in 12 (38.7%) patients, while in 19 (61.3%) cases the findings indicated fibrosis of tunica albuginea. No significant difference in the patients age was found between these two groups (p = 0.09). The analysis of a total number of histological results of the patients with tunica albuginea fibrosis in relation to the patients with normal results showed that there was no significant difference (?? = 1,2; df = 1; p > 0.05), suggesting that the macroscopically normal tunica albuginea is not always expected to yield normal histological result. Conclusion. Significantly more reported histological results of tunica albuginea fibrosis in the location that appeared normal macroscopically (?2 = 27.5; df = 1; p < 0.01) indicated that, in the majority of IPP patients (61.3%), pathological lesion was diffusive with localized phenotypic expression plaque in the tunica albuginea, showing that, in the majority of cases noxa acted diffusely.

scholarly journals Stereological study of the elastic fiber and smooth muscle cell system in the bovine and buffalo penis

2013 ◽  
Vol 33 (suppl 1) ◽  
pp. 107-112 ◽  
Author(s):  
Ilma C.A. Ribeiro ◽  
Marcelo Abidu-Figueiredo ◽  
Fabíola B. Costa ◽  
Marco A. Pereira-Sampaio ◽  
Maurício A. Chagas
Keyword(s):  
Smooth Muscle ◽  
Elastic System ◽  
Tunica Albuginea ◽  
Elastic Fiber ◽  
Corpus Cavernosum ◽  
Volume Density ◽  
Cell System ◽  
Elastic Fibers ◽  
Corpus Spongiosum ◽  
Significant Difference

Samples of ten penises of Mediterranean buffaloes and ten penises of Red Sindhi cattle were used. The thickness of the tunica albuginea (TA), distribution of smooth muscle cells (SMC) and volume density (Vv) of elastic system fibers in TA, corpus cavernosum (CC) and corpus spongiosum (CS) were evaluated. The Vv of elastic system fibers in buffalo and bovine penis was respectively 4.07% ±0.88% and 3.36% ±1.21% in TA; 17.32% ±2.21% and 13.14% ±1.27% (CC), 26.58% ±4.31% and 31.36% ±3.67% (CS). The CC of buffalo presented higher Vv of elastic fibers than bovine, while in the CS the Vv of elastic fibers in buffaloes was smaller than in cattle. The TA thickness showed a significant difference among the species studied. The arrangement of SMC in the bovine penises and in the water buffalo suggests that this pattern is common to animals that have fibroelastic penises.

scholarly journals Fracture penis: rare occurrence

2018 ◽  
Vol 5 (11) ◽  
pp. 3747
Author(s):  
Akhilesh Kumar Yadav ◽  
Sankalp Dwivedi ◽  
Sagar Bassi ◽  
Sunil Kumar Singh
Keyword(s):  
Blunt Trauma ◽  
Tunica Albuginea ◽  
Corpus Cavernosum ◽  
Penile Curvature ◽  
Corpus Spongiosum ◽  
Penile Fracture ◽  
Immediate Surgery ◽  
Almost All ◽  
Erect Penis

Fracture Penis is not usual. It is a tear in the tunica albuginea of the corpora cavernosa with or without involvement of corpus spongiosum and urethra. The usual cause is abrupt bending of the erect penis by blunt trauma, most commonly during sexual intercourse. A crackling sound, pain, detumescences, bruising, swelling, and bleeding per urethra are the common symptoms reported by the patients. Early surgical management is treatment of choice. Diagnosis of Penile Fracture refers to a rupture of the corpus cavernosum induced by blunt trauma to erect penis. Mainly diagnosed clinically from their stereotypical crackling sound from the erect penis at the moment of injury, rapidly followed by acute swelling, pain and penile deformity. Treatment recommendations include immediate exploration and repair. Surgical repair requires evacuation of hematoma, identification of tear, repair of the tear and ligation of any disrupted vasculature. Long term complications after repair include penile deviation, painful intercourse, painful erection and erectile dysfunction. The diagnosis of penile fracture is mostly clinical. Based on physical examination and typical crackling sound at the time of injury. Prompt surgical exploration and repair are advocated in almost all cases. Immediate surgery reduces long term complication which is post-traumatic penile curvature.

Management of dorsal and lateral curvature of the penis in children with hypospadias

2020 ◽  
Vol 8 (1) ◽  
pp. 10-14
Author(s):  
D.Т. Manasherova ◽  
◽  
G.А. Аbdulkarimov ◽  
F.K. Аbdullaev ◽  
G.V. Kozyrev ◽  
...  
Keyword(s):  
Corpus Cavernosum ◽  
Penile Curvature ◽  
Curvature Correction ◽  
Corpora Cavernosa ◽  
Post Operative Period ◽  
Lateral Curvature ◽  
Cosmetic Outcomes ◽  
Group 2 ◽  
The Right ◽  
Group 1

Lateral and dorsal curvature of the penis in hypospadias in children are very rare conditions. Articles dealing with correction of these rare forms of curvature in children are not easy to find. The objective of this work was to improve the outcomes of treating children with hypospadias and rare (dorsal/lateral) forms of penile curvature. Patients and methods. The study included 49 patients with coronary and penile hypospadias, chordee with hypospadias, and also with rare forms of curvature – dorsal and lateral at 30-45 degrees. Depending on the form of penile curvature the patients were divided into 2 groups. Group 1 – 36 patients with dorsal curvature, who underwent ventral plication of the corpora cavernosa; group 2 – 13 patients with lateral curvature and lateral plication of the contralateral corpus cavernosum (9 patients had a curve to the left and 4 – to the right). Results. No penile curvature in the early post-operative period and a year afterwards was not noted in patients of both groups. Dorsal penile curvature occurs in 5% of cases, and lateral in 1.7% of cases. Conclusion. The use of the method of plication of the corpora cavernosa opposite the curvature makes it possible to obtain good functional and cosmetic outcomes of management of hypospadias. Key words: lateral curvature, dorsal curvature, hypospadias, curvature correction

Initial experience in the treatment of Peyronie’s disease using testicular vaginal tunica graft

2021 ◽  
pp. 205141582110166
Author(s):  
Rico Luis ◽  
Villasante Nicolás ◽  
Blas Leandro ◽  
Bonnano Nicolás ◽  
Ameri Carlos
Keyword(s):  
Sexual Function ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Sexual Life ◽  
Rank Test ◽  
Penile Curvature ◽  
Initial Experience ◽  
Level Of Evidence ◽  
Paired Samples ◽  
Peyronie's Disease

Background: Peyronie’s disease (PD) is a progressive disorder of the connective tissue of the tunica albuginea of the penis that produces an abnormal curvature, painful erections and different degrees of erectile dysfunction (ED). The aim of this study is to evaluate our initial experience in the surgical treatment of PD using an autologous graft of testicular vaginal tunica. Materials and methods: A retrospective study of 23 patients was carried out between 2015 and 2019. The successful surgical stretching rate was defined as a functional 20 degrees of curvature or less. Postoperative sexual function and complications rate were evaluated as secondary objectives. We used the abbreviated IIEF-5 questionnaire and evaluated the sexual function before and after the surgical procedure. Wilcoxon signed-rank test for paired samples (U test) was used, considering a value of p<0.05 to be statistically significant. Results: Only one patient presented a recurrence of the penile curvature, resulting in a 95.6% success rate of functional stretching. We observed a 1.6 and 0.9 difference between pre- and postoperative total score and satisfaction ( p = 0.002 and p = 0.003 respectively) Conclusion: In this series, the use of testicular vaginal tunic was found to be safe and effective with a significant change in the quality of sexual life, especially reflected in the overall satisfaction after the procedure and a low rate of complications. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole–Protein Adducts

Toxins ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 723
Author(s):  
Jiang Ma ◽  
Mi Li ◽  
Na Li ◽  
Wood Yee Chan ◽  
Ge Lin
Keyword(s):  
Natural Products ◽  
Pyrrolizidine Alkaloids ◽  
Pyrrolizidine Alkaloid ◽  
Protein Adducts ◽  
Dependent Manner ◽  
Histological Changes ◽  
Histological Results ◽  
Dose Dependent ◽  
Different Doses ◽  
Alt Activity

Pyrrolizidine alkaloids (PAs) with 1,2-unsaturated necine base are hepatotoxic phytotoxins. Acute PA intoxication is initiated by the formation of adducts between PA-derived reactive pyrrolic metabolites with cellular proteins. The present study aimed to investigate the correlation between the formation of hepatic pyrrole–protein adducts and occurrence of PA-induced liver injury (PA-ILI), and to further explore the use of such adducts for rapidly screening the hepatotoxic potency of natural products which contain PAs. Aqueous extracts of Crotalaria sessiliflora (containing one PA: monocrotaline) and Gynura japonica (containing two PAs: senecionine and seneciphylline) were orally administered to rats at different doses for 24 h to investigate PA-ILI. Serum alanine aminotransferase (ALT) activity, hepatic glutathione (GSH) level, and liver histological changes of the treated rats were evaluated to assess the severity of PA-ILI. The levels of pyrrole–protein adducts formed in the rats’ livers were determined by a well-established spectrophotometric method. The biological and histological results showed a dose-dependent hepatotoxicity with significantly different toxic severity among groups of rats treated with herbal extracts containing different PAs. Both serum ALT activity and the amount of hepatic pyrrole–protein adducts increased in a dose-dependent manner. Moreover, the elevation of ALT activity correlated well with the formation of hepatic pyrrole–protein adducts, regardless of the structures of different PAs. The findings revealed that the formation of hepatic pyrrole–protein adducts—which directly correlated with the elevation of serum ALT activity—was a common insult leading to PA-ILI, suggesting a potential for using pyrrole–protein adducts to screen hepatotoxicity and rank PA-containing natural products, which generally contain multiple PAs with different structures.

scholarly journals Troponin T and Histological Characteristics of Rat Myocardial Infarction Induced by Isoproterenol

2007 ◽  
Vol 7 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Sabaheta Hasić ◽  
Radivoj Jadrić ◽  
Emina Kiseljaković ◽  
Zakira Mornjaković ◽  
Mira Winterhalter-Jadrić
Keyword(s):  
Myocardial Infarction ◽  
Troponin T ◽  
Myocardial Necrosis ◽  
Control Group ◽  
High Dose ◽  
Male Adult ◽  
Histological Changes ◽  
Significant Difference ◽  
Intraperitoneal Dose ◽  
Histological Characteristics

In our investigation, we used short-time model of myocardial infarction of rats induced by high dose of isoproterenol (ISP). We investigated cardiac troponin T blood level (cTnT) and histological characteristics of rat myocardium. ISP, single, intraperitoneal dose 250 mg/kg was given to male, adult, Wistar rats (n=12). Rats were distributed depending on their body weight in subgroups: ISP I (BW 260-280g) and ISP II (BW 250-400g). Control group (n=9) was treated with intraperitoneal dose of 0,95% NaCl. Cardiac TnT was measured by electrochemiluminiscence (ECLA) sandwich immunoassay in rat serum 4 hours after ISP application. Rats’ hearts were dissected and examined by qualitative histological method (HE). Statistical significance was set at 0,05. There was significant difference in cTnT of ISP II (p=0,0001) vs. control and ISP I (p<0,05) vs. control. Significant difference was beetween ISP I and ISP II subgroups (p<0.001). The accent of histological changes of myocardium was on nuclei of cell. Cells showed acydophilic changes and nuclei disappearance as signs of coagulative necrosis development. Extensivity of histological changes were different beetween ISP I and ISP II subgroup. Used dose of ISP induced development of myocardial necrosis in rats. Suben-docardial portion of myocardium was more vulnerability than subepicardial portion. Rats of ISP II had more extensive histological changes than these in ISP I. Administered doses of ISP enabled cTnT utilization as a marker of myocardial necrosis.

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