Management of dorsal and lateral curvature of the penis in children with hypospadias

2020 ◽  
Vol 8 (1) ◽  
pp. 10-14
Author(s):  
D.Т. Manasherova ◽  
◽  
G.А. Аbdulkarimov ◽  
F.K. Аbdullaev ◽  
G.V. Kozyrev ◽  
...  
Keyword(s):  
Corpus Cavernosum ◽  
Penile Curvature ◽  
Curvature Correction ◽  
Corpora Cavernosa ◽  
Post Operative Period ◽  
Lateral Curvature ◽  
Cosmetic Outcomes ◽  
Group 2 ◽  
The Right ◽  
Group 1

Lateral and dorsal curvature of the penis in hypospadias in children are very rare conditions. Articles dealing with correction of these rare forms of curvature in children are not easy to find. The objective of this work was to improve the outcomes of treating children with hypospadias and rare (dorsal/lateral) forms of penile curvature. Patients and methods. The study included 49 patients with coronary and penile hypospadias, chordee with hypospadias, and also with rare forms of curvature – dorsal and lateral at 30-45 degrees. Depending on the form of penile curvature the patients were divided into 2 groups. Group 1 – 36 patients with dorsal curvature, who underwent ventral plication of the corpora cavernosa; group 2 – 13 patients with lateral curvature and lateral plication of the contralateral corpus cavernosum (9 patients had a curve to the left and 4 – to the right). Results. No penile curvature in the early post-operative period and a year afterwards was not noted in patients of both groups. Dorsal penile curvature occurs in 5% of cases, and lateral in 1.7% of cases. Conclusion. The use of the method of plication of the corpora cavernosa opposite the curvature makes it possible to obtain good functional and cosmetic outcomes of management of hypospadias. Key words: lateral curvature, dorsal curvature, hypospadias, curvature correction

scholarly journals A tissue-engineered urinary conduit in a porcine urinary diversion model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arkadiusz Jundziłł ◽  
Piotr Kwieciński ◽  
Daria Balcerczyk ◽  
Tomasz Kloskowski ◽  
Dariusz Grzanka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Urinary Diversion ◽  
Porcine Model ◽  
Histological Evaluation ◽  
Metabolic Complications ◽  
Group 3 ◽  
Group 2 ◽  
The Right ◽  
Group 1

AbstractThe use of an ileal segment is a standard method for urinary diversion after radical cystectomy. Unfortunately, utilization of this method can lead to numerous surgical and metabolic complications. This study aimed to assess the tissue-engineered artificial conduit for urinary diversion in a porcine model. Tissue-engineered tubular polypropylene mesh scaffolds were used for the right ureter incontinent urostomy model. Eighteen male pigs were divided into three equal groups: Group 1 (control ureterocutaneostomy), Group 2 (the right ureter-artificial conduit-skin anastomoses), and Group 3 (4 weeks before urostomy reconstruction, the artificial conduit was implanted between abdomen muscles). Follow-up was 6 months. Computed tomography, ultrasound examination, and pyelogram were used to confirm the patency of created diversions. Morphological and histological analyses were used to evaluate the tissue-engineered urinary diversion. All animals survived the experimental procedures and follow-up. The longest average patency was observed in the 3rd Group (15.8 weeks) compared to the 2nd Group (10 weeks) and the 1st Group (5.8 weeks). The implant’s remnants created a retroperitoneal post-inflammation tunnel confirmed by computed tomography and histological evaluation, which constitutes urostomy. The simultaneous urinary diversion using a tissue-engineered scaffold connected directly with the skin is inappropriate for clinical application.

Systemic to Pulmonary Collaterals in Extremely Low Birth Weight Infants: Incidence, Clinical Significance, and Hemodynamic Features

2019 ◽  
Author(s):  
Cynthia Hayek ◽  
Rowena Cayabyab ◽  
Ima Thompson ◽  
Mahmood Ebrahimi ◽  
Bijan Siassi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Clinical Outcomes ◽  
Left Ventricular ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Echocardiographic Parameters ◽  
Group 2 ◽  
The Right ◽  
Group 1

Abstract Objective To determine the incidence of systemic to pulmonary collaterals (SPCs) in extremely low birth weight infants and to assess its clinical and hemodynamic significance beyond the neonatal period. Study Design Retrospective cohort study was conducted on 61 infants with echocardiogram performed at the time of discharge to determine the presence of SPC and to measure the right and left ventricular outputs and left atrium to aortic ratio. We compared two groups: small or no SPC (Group 1) to moderate or large SPC (Group 2) on demographics, clinical outcomes, and echocardiographic parameters. Results Sixty-one infants were included. The incidence of SPC was 57%; 21% of infants had moderate or large shunts and 31% had small SPC. Demographics, clinical outcomes, and echocardiographic parameters were not significantly different between small or no SPC and moderate to large SPC. Conclusion More than half of the infants had SPC. The size of the shunt did not affect the clinical outcomes nor the echocardiographic parameters measured. All infants had cardiac output above the normative mean.

Independent Processing of the Temporal and Ordinal Structure of Movement Sequences

2003 ◽  
Vol 90 (6) ◽  
pp. 3725-3735 ◽  
Author(s):  
Fredrik Ullén ◽  
Sara L. Bengtsson
Keyword(s):  
Motor Control ◽  
Implicit Learning ◽  
Index Finger ◽  
Temporal Structure ◽  
Transfer Effects ◽  
Fast Learning ◽  
Group 2 ◽  
The Right ◽  
Temporal Sequences ◽  
Group 1

We investigated if the temporal and ordinal structures of sequences can be represented and learned independently. In Experiment 1, subjects learned three rhythmic sequences of key presses with the right index finger: Combined consisted of nine key presses with a corresponding temporal structure of eight intervals; Temporal had the temporal structure of Combined but was performed on one key; Ordinal had the ordinal structure of Combined but an isochronous rhythm. Subjects were divided into two groups. Group 1 first learned Combined, then Temporal and Ordinal; Group 2 first learned Temporal and Ordinal, then Combined. Strong transfer effects were seen in both groups. In Group 1, having learned combined facilitated the learning of the temporal ( Temporal) or ordinal ( Ordinal) sequence alone; in Group 2, having learned Temporal and Ordinal facilitated the learning of Combined, where the two are combined. This supports that subjects had formed independent temporal and ordinal representations. In Experiment 2, we investigated if these can be learned independently. Subjects repeatedly reproduced sequences with fixed temporal and random ordinal structure; random temporal and fixed ordinal structure; and random temporal and ordinal structures. Temporal and ordinal learning was seen only in the first and second sequences, respectively. In summary, we provide evidence for the existence of independent systems for learning and representation of ordinal and temporal sequences and for implicit learning of temporal sequences. This may be important for fast learning and flexibility in motor control.

scholarly journals Unilateral Versus Bilateral Frontalis Suspension Sling Surgery for Correction of Severe Unilateral Congenital Ptosis.

2020 ◽  
Vol 9 (1) ◽  
pp. OT05-OT08
Author(s):  
Jyoti Dhaka ◽  
Ashok Kumar Grover
Keyword(s):  
Comparative Study ◽  
Surgical Outcome ◽  
Fascia Lata ◽  
P Value ◽  
Congenital Ptosis ◽  
Sling Surgery ◽  
Frontalis Suspension ◽  
Cosmetic Outcomes ◽  
Group 2 ◽  
Group 1

Background: To compare the surgical outcome of unilateral silicone sling with bilateral fascia latafrontalis suspension surgery for severe unilateral congenital ptosis.Subjects and Methods:This prospective, interventional and comparative study examined 30 patients of severe unilateral congenital ptosis. 30 patients were divided in to 2 groups, group 1 included 15 patients who underwent unilateral silicone sling frontalis suspension surgery and group 2 included 15 patients who underwent contralateral levator excision with bilateral fascia latafrontalis sling surgery.Results:Mean improvement in MRD1 after surgery in group 1 who underwent unilateral silicone sling surgery was 3.9+1.18 mm and in group 2 who underwent bilateral fascia lata it was 4.9+0.89 mm (p value 0.0001). Excellent results (difference of lid height <1 mm) were seen in 93.3% patients who underwent bilateral fascia latafrontalis sling while in 73.3% patients of unilateral silicone sling. All patients who underwent bilateral fascia lata showed excellent lid crease (symmetric without obliteration) and 80% of the patients who underwent unilateral silicone sling surgery (p value 0.032).Conclusion: Functional and cosmetic outcomes regarding MRD1, symmetry of lid height, lid crease were noted better in group 2 patients who underwent contralateral levator excision with bilateral fascia latafrontalis suspension surgery as compared to group 1 patients who underwent unilateral silicone sling surgery.

Vasoactive intestinal peptide in canine hearts: effect of total cardiac denervation

1992 ◽  
Vol 262 (2) ◽  
pp. H598-H602 ◽  
Author(s):  
F. L. Anderson ◽  
J. R. Wynn ◽  
J. Kimball ◽  
G. R. Hanson ◽  
E. Hammond ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Vasoactive Intestinal Peptide ◽  
Coronary Arteries ◽  
Canine Heart ◽  
Cardiac Denervation ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
The Right ◽  
Group 1

The effect of total cardiac denervation on the distribution of cardiac immunoreactive vasoactive intestinal peptide (IR-VIP) was determined in four groups of dogs. Denervated dogs killed at either 7 days (group 1) or 30 days (group 3) were compared with sham-operated dogs killed at either 7 days (group 2) or 30 days (group 4). The highest concentrations of IR-VIP were found in the left atrium and proximal left anterior descending and circumflex coronary arteries and were not affected by denervation. Concentrations of IR-VIP in the left ventricle were barely detectable. Only right ventricular IR-VIP concentrations were significantly lower in denervated compared with sham-operated dogs in both groups. Thus these data provide evidence of intrinsic VIP innervation of the atria and epicardial coronary arteries and localized extrinsic VIP innervation of the right ventricle of the canine heart.

scholarly journals Neural mechanisms of coarse-to-fine discrimination in the visual cortex

2014 ◽  
Vol 112 (11) ◽  
pp. 2822-2833 ◽  
Author(s):  
Gopathy Purushothaman ◽  
Xin Chen ◽  
Dmitry Yampolsky ◽  
Vivien A. Casagrande
Keyword(s):  
Visual Cortex ◽  
Tuning Curve ◽  
Discrimination Performance ◽  
Neural Mechanisms ◽  
Initial Increase ◽  
Group 2 ◽  
The Right ◽  
Neuronal Groups ◽  
Coarse To Fine ◽  
Group 1

Vision is a dynamic process that refines the spatial scale of analysis over time, as evidenced by a progressive improvement in the ability to detect and discriminate finer details. To understand coarse-to-fine discrimination, we studied the dynamics of spatial frequency (SF) response using reverse correlation in the primary visual cortex (V1) of the primate. In a majority of V1 cells studied, preferred SF either increased monotonically with time ( group 1) or changed nonmonotonically, with an initial increase followed by a decrease ( group 2). Monotonic shift in preferred SF occurred with or without an early suppression at low SFs. Late suppression at high SFs always accompanied nonmonotonic SF dynamics. Bayesian analysis showed that SF discrimination performance and best discriminable SF frequencies changed with time in different ways in the two groups of neurons. In group 1 neurons, SF discrimination performance peaked on both left and right flanks of the SF tuning curve at about the same time. In group 2 neurons, peak discrimination occurred on the right flank (high SFs) later than on the left flank (low SFs). Group 2 neurons were also better discriminators of high SFs. We examined the relationship between the time at which SF discrimination performance peaked on either flank of the SF tuning curve and the corresponding best discriminable SFs in both neuronal groups. This analysis showed that the population best discriminable SF increased with time in V1. These results suggest neural mechanisms for coarse-to-fine discrimination behavior and that this process originates in V1 or earlier.

scholarly journals Effect of cilostazol on neointimal hyperplasia in iliac arteries of pigs after transluminal angioplasty

2015 ◽  
Vol 42 (3) ◽  
pp. 175-180
Author(s):  
Joel Alex Longhi ◽  
Adamastor Humberto Pereira
Keyword(s):  
Histological Analysis ◽  
Common Iliac Artery ◽  
Neointimal Hyperplasia ◽  
Balloon Catheter ◽  
Transluminal Angioplasty ◽  
Iliac Arteries ◽  
Group 2 ◽  
The Right ◽  
Group 1 ◽  
Tunica Intima

<sec><title>OBJECTIVE:</title><p> to evaluate whether systemic administration of cilostazol reduces neointimal hyperplasia in iliac arteries of pigs submitted to balloon catheter angioplasty.</p></sec><sec><title>METHODS:</title><p> twenty pigs underwent angioplasty with a 6x40 mm balloon catheter in the right common iliac artery, guided by Doppler ultrasound. The animals were randomized into two groups: group 1 (n=10), which received 50mg cilostazol twice a day, and group 2 (n=10), control. After 30 days, the animals were killed and the iliac arteries prepared for histological analysis. The histological sections were digitized and analyzed by digital morphometry. Statistical analysis was performed using the Student t and Mann-Whitney tests.</p></sec><sec><title>RESULTS:</title><p> when comparing the iliac arteries submitted to angioplasty with those not subjected to angioplasty, there was significant neointimal hyperplasia (0.228 versus 0.119 mm<sup>2</sup>; p=0.0001). In arteries undergoing angioplasty, there was no difference between group 1 (cilostazol) and group 2 (control) as for the lumen area (2.277 versus 2.575 mm<sup>2</sup>; p=0.08), the tunica intima (0.219 versus 0.237 mm<sup>2</sup>; p=0.64), the tunica media (2.262 vs. 2.393 mm<sup>2</sup>; p=0.53) and the neointimal occlusion percentage (8.857 vs. 9.257 %; p=0.82).</p></sec><sec><title>CONCLUSION:</title><p> the use of cilostazol 50mg administered in two daily doses did not reduce neointimal hyperplasia in iliac arteries of pigs submitted to balloon angioplasty catheter.</p></sec>

scholarly journals Shear wave elastography: Can it be a new radiologic approach for the diagnosis of erectile dysfunction?

Ultrasound ◽  
2017 ◽  
Vol 25 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Rustu Turkay ◽  
Ercan Inci ◽  
Mustafa Gurkan Yenice ◽  
Volkan Tugcu
Keyword(s):  
Erectile Dysfunction ◽  
Positive Predictive Value ◽  
Shear Wave ◽  
Predictive Value ◽  
Corpus Cavernosum ◽  
Shear Wave Elastography ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Introduction Erectile dysfunction (ED) is a common health problem among males, and radiology has limited use in its diagnosis and treatment. Shear wave elastography (SWE) is a new sonographic technique. In this study, we examined the significance of SWE in the diagnosis of ED. Methods The study included a total number of 70 participants. The mean age of the participants was 54.14 ± 8.03 years (range: 39 and 71 years old). We composed two groups. Group 1 had 35 patients who presented to the urology clinic in our hospital complaining of ED, and had a score of 17 or lower from the International Index of Erectile Function (IIEF) questionnaire. Group 2 consisted of 35 healthy volunteers who did not have ED. SWE measurements were performed from corpus cavernosum penis in both groups, and the results were noted. Differences between the groups were evaluated statistically. Results The difference between the mean SWE measurements of two groups (Group 1: 20.94 ± 6.23 kPa and group 2: 24.63 ± 7.58 kPa) was found to be statistically significant ( p = 0.027; p < 0.05). For a cut-off value of 17.1 kPa, the SWE method has specificity, sensitivity, positive predictive value, and negative predictive value regarding diagnosis of ED as 94.29%, 34.29%, 85.71%, and 58.93%, respectively. The mean age of the groups did not show a statistically significant difference ( p = 0.287; p > 0.05). Conclusions Due to its high specificity and positive predictive value, SWE can offer useful data in the radiologic evaluation of ED cases.

Effects of Acupuncture and An Agonist of Opiate Receptors on Heroin Dependent Patients

1999 ◽  
Vol 27 (02) ◽  
pp. 143-148 ◽  
Author(s):  
M. F. Timofeev
Keyword(s):  
Opiate Receptors ◽  
Acupuncture Points ◽  
Interhemisphere Asymmetry ◽  
Drug Addicts ◽  
Treatment Results ◽  
Before And After ◽  
Left And Right ◽  
Group 2 ◽  
The Right ◽  
Group 1

This study examined the influence of acupuncture and an agonist of opiate receptors (Procedol) by means of temperature in both the left and right auricular "Lung" points, and on the coefficIent of interhemisphere asymmetry. Twenty heroin dependent patients participated in this research. They were evenly divided into two groups. Both groups consisted of 10 male drug addicts (18-19 years old) who had been using heroin for 8-10 months. Group 1 received 1.0 ml procedol (i. m.). Group 2 were treated with acupuncture. Temperature was measured on the acupuncture points before and after treatment. Results of this study showed that temperature increased on the left and decreased on the right acupuncture points in both the procedol and acupuncture treated groups. The net changes before and after treatment were 92.87% and 92.53% in groups 1 and 2 respectively. The therapeutic effect of acupuncture on treatment of heroin dependence is through the same pathway as the agonist on opiate receptors, 20% of patients are resisted to acupuncture.

scholarly journals Spatial Distribution of the N2 and P300 Components of the Auditory Evoked Potential in Women with Arterial Hypertension: A study in the Russian Arctic

2021 ◽  
Vol 11 (3) ◽  
pp. 281-285
Author(s):  
Olga V. Krivonogova ◽  
Elena V. Krivonogova ◽  
Liliya V. Poskotinova
Keyword(s):  
Spatial Distribution ◽  
Auditory Evoked Potential ◽  
P300 Amplitude ◽  
Oddball Paradigm ◽  
Russian Arctic ◽  
Working Age ◽  
P3 Amplitude ◽  
Group 2 ◽  
The Right ◽  
Group 1

The aim of this study was to evaluate the spatial distribution of the latencies and amplitudes of the N2 and P3 (or P300) components of the AEP in the Russian Arctic working-age women with different levels of BP. Methods and Results: A total of 25 working-age women living in Nadym city for more than 20 years took part in this study. Group 1 (n=12, control group) consisted of women with BP within the normal range (<130/90 mmHg); Group 2 (n=13) consisted of women with AH (AH duration from 1 to 10 years). The parameters of the N2 and P300) components of the AEP were evaluated using an electroencephalograph (Neuron-Spectrum-4/VPM, Russia). An auditory oddball paradigm was used to elicit the oddball ERPs. In Group 2, compared with Group 1, the N2 latency was more pronounced in the parietal (P4, P3), central (C4, C3), frontal (F4, F3), and left temporal (T3, F7) regions. The N2 amplitude in all studied brain regions in individuals of both groups was comparable. The P300 latency did not differ between the two groups. In Group 2, the P300 amplitude was significantly lower in the parietal region (P3) on the left, and in the central and temporal regions on the right (C4, T4). In Group 2, inverse correlations between DBP and the P3 amplitude were revealed in the central (C4: r=-0.88, P=0.001; C3: r=-0.86, P=0.001), frontal (F4: r=-0.76; P=0.01; F3: r=-0.93, P=0.001), and anterior-temporal cerebral regions (F8: r=-0.65, P=0.04; F7: r=-0.64, P=0.04). SBP correlated with the P3 amplitude in the right mid-temporal region (T4: r=0.64, P=0.04). Conclusion: The features of the spatial distribution of the N2 and P3 components of the AEP can be used for early diagnosis of the risk of developing cognitive disorders in AH patients.

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