scholarly journals Urachal adenocarcinoma - case report and literature review

2018 ◽  
Vol 75 (10) ◽  
pp. 1045-1048
Author(s):  
Milan Petrovic ◽  
Vladimir Vasic ◽  
Ljubinka Jankovic-Velickovic ◽  
Srdjan Sterovic ◽  
Tomislav Pejcic ◽  
...  
Keyword(s):  
Case Report ◽  
Early Stage ◽  
Histopathological Analysis ◽  
Complete Excision ◽  
Urachal Carcinoma ◽  
Term Survival ◽  
Histologic Subtype ◽  
Mucin Production ◽  
Common Histologic Subtype ◽  
Urachal Adenocarcinoma

Introduction. Urachal adenocarcinoma is extremely rare and comprises from 0.35% to 0.7% of all bladder tumors. The most common histologic subtype of urachal tumors is adenocarcinoma which can be associated with intestinal metaplasia and mucin production. Case report. We report a case of a 53-year-old patient who attented a urologist because of an intermittent haematuria lasting for three months. The ultrasound examination detected infiltration of the bladder at the fundus, 24 ? 29 mm in diameter. By the same wall, next to the tumor, there was an oval hypoechoic lesion about 40 mm in diameter. Computed tomography scan showed a solid, echogenic, strictly limited tumor at the fundus of the bladder, anteriorly, 32 ? 35 ? 22 mm in diameter which was positive after contrast application. The patient underwent partial cystectomy with complete excision of the tumor lesion 1.5 cm in healthy tissue. Histopathological analysis showed diagnosis of Adenocarcinoma mucinosum vesicae urinariae infiltrans. Patohistological findings detected a part of the urachal wall with a thin layer of fibromuscular tissue, chronic inflammation, microcalcifications in the lumen, flattened and desquamated epithelium. One year after the surgery, there were no signs of primary disease or metastases in other organs. Conclusion. Urachal adenocarcinoma is extremely rare. Long term survival could be achieved by surgical treatment in the early stage of the disease which consists of complete resection of urachal carcinoma and partial or total cystectomy.

scholarly journals Primary Seminoma Localized in Mediastinum: Case Report

2019 ◽  
Vol 7 (3) ◽  
pp. 384-387
Author(s):  
Deva Petrova ◽  
Slavica Kraleva ◽  
Lilijana Muratovska ◽  
Biljana Crcareva
Keyword(s):  
Case Report ◽  
Fdg Pet ◽  
Pet Scan ◽  
Histopathological Analysis ◽  
Tumour Mass ◽  
Residual Tumour ◽  
Term Survival ◽  
Fdg Pet Scan ◽  
Β Hcg ◽  
Mediastinal Seminoma

BACKGROUND: Primary mediastinal seminomas most commonly occur in young men, and they are localised in the anterior mediastinum. CASE PRESENTATION: The presented study is a case report of a 34-year-old man suffering from a mediastinal tumour in size of 19 cm, with pleural and pericardial effusion. The patient complains of cough, difficulty breathing, weight loss, and pronounced tiredness. CT of lungs and biopsy of the mediastinal change was performed. The histopathological analysis was in favour of a primary mediastinal seminoma. The patient initially had pronouncedly increased levels of LDH and β-hCG tumour marker. Pericardiocentesis was realised due to threatening tamponade of the heart, followed by 4 cycles of chemotherapy by BEP protocol. Following 2 cycles of chemotherapy, normalisation of LDH and β-HCG levels and significantly improved the clinical condition in the patient was found. Upon completion of 4 chemotherapy cycles by BEP protocol, the patient performed an FDG-PET scan with partial response and reduced dimension of a primary tumour in the mediastinum. Radiotherapy of residual tumour mass up to a total dose of 40Gy in 20 fractions was realised. Control FDG-PET scan had a finding of complete response to a tumour and absence of FDG uptake. The last follow-up examination was performed in October 2018, and the patient was disease-free for 54 months. CONCLUSION: Multimodality treatment approach of chemotherapy followed by radiation consolidation ensured long-term survival in primary advanced mediastinal seminoma.

scholarly journals Pleomorphic adenoma of the upper lip: A case report

1970 ◽  
Vol 6 (1) ◽  
pp. 51-53 ◽  
Author(s):  
A Shrestha ◽  
NS Reddy ◽  
SN Ganguly
Keyword(s):  
Case Report ◽  
Pleomorphic Adenoma ◽  
Relevant Literature ◽  
Minor Salivary Gland ◽  
Histopathological Analysis ◽  
Medical Sciences ◽  
Upper Lip ◽  
Complete Excision ◽  
Nasal Vestibule ◽  
Minor Salivary Gland Tumors

This case report describes a rare and unusual lesion found in 27 year old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed, large firm mass, about 5 cm in diameter, almost obstructing the nasal vestibule and characterized by slow growth. Complete excision was performed and the histopathological analysis showed pleomorphic adenoma. The tumor did not recur. A brief review of the relevant literature is also presented. Keywords: Pleomorphic adenoma; minor salivary gland tumors; nasal vestibule DOI: 10.3126/jcmsn.v6i1.3603 Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 51-53

Metastatic primary urothelial carcinoma of the prostatic urethra: A case report

2018 ◽  
Vol 86 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Erdem Kisa ◽  
Hüseyin Salih Semiz ◽  
Ülkü Küçük ◽  
Yusuf Özlem İlbey
Keyword(s):  
Case Report ◽  
Urothelial Carcinoma ◽  
Early Stage ◽  
Transrectal Ultrasound ◽  
Distant Metastases ◽  
Prostatic Urethra ◽  
Histologic Subtype ◽  
High Propensity ◽  
Multiple Metastases ◽  
Proximal Urethra

Introduction: Primary carcinomas of the urethra differ by location and histologic subtype. Primary urethral cancer of the proximal urethra is rare and aggressive tumor with a high propensity for regional and distant metastases. Case description: In this case report, we present primary urothelial carcinoma of the prostatic urethra, diagnosed by transrectal ultrasound-guided biopsy of the prostate and having multiple metastases at the time of diagnosis. Metastatic patients were initiated chemotherapy according to the histological type of urethral cancer. Conclusion: Urothelial carcinomas of the urethra are rarely seen, and therefore there is no standard treatment regimen for early-stage or metastatic disease. Gemcitabine-, platinum-, and taxane-based treatments are used in the metastatic stage.

DIGITAL FIBROMYXOMA: A CASE REPORT

2021 ◽  
pp. 2172001
Author(s):  
Mahmood Ajawi ◽  
Irfan Abdulkareem ◽  
Abdullah H. Darwish ◽  
Iftikhar A. Mukhtar ◽  
Noora Iftikhar
Keyword(s):  
Case Report ◽  
Tissue Sample ◽  
Ring Finger ◽  
High Rate ◽  
Excision Biopsy ◽  
Histopathological Analysis ◽  
Complete Excision ◽  
The Right ◽  
Hands And Feet

Digital fibromyxoma is a rare soft tissue tumor with a propensity to grow in the digits of the hands and feet. While mostly asymptomatic, the tumors can grow and cause discomfort and eventually pain. It is a benign tumor, with treatment revolving around complete excision to prevent recurrence. In this case report, we discuss the case of a 11-year old boy presented with a swelling in the right ring finger that had been increasing in size for over a year. Despite the lack of pain or limitation of movement in the finger, the swelling caused concern to the patient and family due to cosmetic appearance. An excision biopsy with histopathological analysis of the tissue sample suggested the diagnosis of digital fibromyxoma. The high rate of recurrence is due to incomplete excision, and therefore regular follow up is recommended to monitor for recurrence.

scholarly journals Invasive Lower Lip Squamous Cell Carcinoma Mimicking Traumatic Fibroma: Case Report

2020 ◽  
Vol 1 (2) ◽  
pp. 133-139
Author(s):  
Venkatesh Hange
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Neck Region ◽  
Term Survival ◽  
Lower Lip ◽  
Oral Cavity Carcinoma

Carcinoma of lip develops due to formation of malignant cells in the lips and it is the most common site for squamous cell carcinoma (SCC) in the head and neck region. Oral cavity is among top five leading sites of cancer, regardless of gender distribution across India. Squamous cell carcinoma of lip occurs at myriad locations along the upper or lower lip or commissure of lip, but majority (80% to 95%) of cases are seen on the lower lip region. Majority of oral cavity carcinoma cases (> 90%) are seen in patients above the age of 45, having a male predilection in distribution. Lesions that includes up to one third of the lower lip are typically treated with V-type or W-type excisions. Lesions affecting between one to two thirds of the lower lip are typically treated by regional flaps of Abbe or Estlander. Larger lesions involving more than two thirds of the lower lip are treated with Bernard flap for middle lesions and nasolabial transpositional flap for lateral lesions. Alternatively, definitive radiotherapy can be used for local control of early-stage epithelial malignancies of the lips such as basal cell and squamous cell carcinomas, but usually reserved for selected situations, also side effects of irradiation limits its use. Local resection along with elective SOHND is mandatory for long term survival rate and to avoid substantial worse prognosis. This case report describes an unusual presentation of carcinoma of lip mimicking benign soft tissue swelling.

scholarly journals The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3730
Author(s):  
Berend R. Beumer ◽  
Roeland F. de Wilde ◽  
Herold J. Metselaar ◽  
Robert A. de Man ◽  
Wojciech G. Polak ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Resection ◽  
Early Stage ◽  
Disease Free Survival ◽  
Milan Criteria ◽  
Term Survival ◽  
Equal Distribution ◽  
Intention To Treat ◽  
Treat Analysis

For patients presenting with hepatocellular carcinoma within the Milan criteria, either liver resection or liver transplantation can be performed. However, to what extent either of these treatment options is superior in terms of long-term survival is unknown. Obviously, the comparison of these treatments is complicated by several selection processes. In this article, we comprehensively review the current literature with a focus on factors accounting for selection bias. Thus far, studies that did not perform an intention-to-treat analysis conclude that liver transplantation is superior to liver resection for early-stage hepatocellular carcinoma. In contrast, studies performing an intention-to-treat analysis state that survival is comparable between both modalities. Furthermore, all studies demonstrate that disease-free survival is longer after liver transplantation compared to liver resection. With respect to the latter, implications of recurrences for survival are rarely discussed. Heterogeneous treatment effects and logical inconsistencies indicate that studies with a higher level of evidence are needed to determine if liver transplantation offers a survival benefit over liver resection. However, randomised controlled trials, as the golden standard, are believed to be infeasible. Therefore, we suggest an alternative research design from the causal inference literature. The rationale for a regression discontinuity design that exploits the natural experiment created by the widely adopted Milan criteria will be discussed. In this type of study, the analysis is focused on liver transplantation patients just within the Milan criteria and liver resection patients just outside, hereby ensuring equal distribution of confounders.

Immunohistochemical expression of p53, bcl-2, and p21WAF1/CIP1 in early cervical carcinoma: Correlation with clinical outcome

2002 ◽  
Vol 12 (3) ◽  
pp. 290-298 ◽  
Author(s):  
M Graflund ◽  
B Sorbe ◽  
M Karlsson
Keyword(s):  
Survival Rate ◽  
Clinical Outcome ◽  
Cervical Carcinoma ◽  
Early Stage ◽  
Tumor Grade ◽  
Figo Stage ◽  
Immunohistochemical Expression ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Cervical Carcinomas

Abstract.Graflund M, Sorbe B, Karlsson M. Immunohistochemical expression of p53, bcl-2, and p21 WAF1/CIP1 in early cervical carcinoma: Correlation with clinical outcome.The objective of this study was to assess the value of p53, bcl-2, and p21WAF1/CIP1 immunoreactivity as predictors of pelvic lymph node metastases (LNM), recurrences, and death due to the disease in early stage (FIGO I-II) cervical carcinomas. FIGO stage, type of histopathology, and tumor grade were also evaluated in this series of patients treated by radical hysterectomy (Wertheim-Meigs) between 1965 and 1990. A total of 172 patients were included. A tumor was regarded as positive when more than 30% of the neoplastic cells exhibited immunoreactivity. Positive immunostaining was found in 8.9% for p53, in 43.5% for bcl-2, and in 25.0% for p21WAF1/CIP1. None of them was able to predict LNM or clinical outcome. Presence of LNM, tumor recurrence, and death from disease were significantly associated with the FIGO stage (P = 0.014, P = 0.009, and P = 0.001, respectively). The 5-year cancer-specific survival rate was 91.6% and the overall survival rate was 90.5%. It was concluded that immunohistochemically detected p53, bcl-2, and p21WAF1/CIP1 appeared to be of no predictive value with regard to LNM, tumor recurrences, or long-term survival in early cervical carcinomas.

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