Changes in DNA Secondary Structure after X-Irradiation

1971 ◽  
Vol 47 (1) ◽  
pp. 51 ◽  
Author(s):  
E. Lukášová ◽  
E. Paleček ◽  
E. Lukasova ◽  
E. Palecek
Keyword(s):  
Secondary Structure ◽  
Dna Secondary Structure ◽  
X Irradiation

scholarly journals Emerging Role of the Guanine-Quadruplex DNA Secondary Structure in Epigenetics

2015 ◽  
pp. 271-284
Author(s):  
Aradhita Baral ◽  
Dhurjhoti Saha ◽  
Shantanu Chowdhury
Keyword(s):  
Secondary Structure ◽  
Dna Secondary Structure ◽  
Quadruplex Dna ◽  
Guanine Quadruplex

The influence of nitrous bases interactions on the DNA secondary structure formation

1975 ◽  
Vol 55 (2) ◽  
pp. 491-503 ◽  
Author(s):  
R.V. Polozov ◽  
V.I. Poltev ◽  
B.I. Sukhorukov
Keyword(s):  
Secondary Structure ◽  
Structure Formation ◽  
Dna Secondary Structure ◽  
Secondary Structure Formation

scholarly journals DNA secondary structure formation by DNA shuffling of the conserved domains of the Cry protein of Bacillus thuringiensis

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Efrain H. Pinzon ◽  
Daniel A. Sierra ◽  
Miguel O. Suarez ◽  
Sergio Orduz ◽  
Alvaro M. Florez
Keyword(s):  
Bacillus Thuringiensis ◽  
Secondary Structure ◽  
Structure Formation ◽  
Dna Shuffling ◽  
Dna Secondary Structure ◽  
Cry Protein ◽  
Conserved Domains ◽  
Secondary Structure Formation

scholarly journals Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Karol Szlachta ◽  
Ryan G. Thys ◽  
Naomi D. Atkin ◽  
Levi C. T. Pierce ◽  
Stefan Bekiranov ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Structure Formation ◽  
Dna Secondary Structure ◽  
Secondary Structure Formation

scholarly journals Single-cell mapping of DNA G-quadruplex structures in human cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Winnie W. I. Hui ◽  
Angela Simeone ◽  
Katherine G. Zyner ◽  
David Tannahill ◽  
Shankar Balasubramanian
Keyword(s):  
Secondary Structure ◽  
Single Cell ◽  
Genome Instability ◽  
Human Cancer ◽  
Single Cells ◽  
Dna Secondary Structure ◽  
Genomic Locus ◽  
Mixed Cell ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells

AbstractG-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability and cancer. Thus far most work has profiled the G4 landscape in an ensemble of cell populations, therefore it is critical to explore the structure–function relationship of G4s in individual cells to enable detailed mechanistic insights into G4 function. With standard ChIP-seq methods it has not been possible to determine if G4 formation at a given genomic locus is variable between individual cells across a population. For the first time, we demonstrate the mapping of a DNA secondary structure at single-cell resolution. We have adapted single-nuclei (sn) CUT&Tag to allow the detection of G4s in single cells of human cancer cell lines. With snG4-CUT&Tag, we can distinguish cellular identity from a mixed cell-type population solely based on G4 features within individual cells. Our methodology now enables genomic investigations on cell-to-cell variation of a DNA secondary structure that were previously not possible.

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