FUNCTIONAL CHANGE

2021 ◽  
pp. 86-89
Keyword(s):  
Functional Change

Gentrification and functional change in Budapest – ‘ruin bars’ and the commodification of housing in a post-socialist context

2020 ◽  
Vol 65 (1) ◽  
pp. 17-26
Author(s):  
Gergely Olt ◽  
Adrienne Csizmady
Keyword(s):  
Ownership Structure ◽  
Hospitality Industry ◽  
Housing Stock ◽  
Field Research ◽  
Functional Change ◽  
Global Changes ◽  
Heritage Buildings ◽  
The Subject ◽  
Tourism And Hospitality Industry ◽  
Tourism And Hospitality

AbstractThe growth of the tourism and hospitality industry played an important role in the gentrification of the post-socialist city of Budapest. Although disinvestment was present, reinvestment was moderate for decades after 1989. Privatisation of individual tenancies and the consequent fragmented ownership structure of heritage buildings made refurbishment and reinvestment less profitable. Because of local contextual factors and global changes in consumption habits, the function of the dilapidated 19th century housing stock transformed in the 2000s, and the residential neighbourhood which was the subject of the research turned into the so called ‘party district’. The process was followed in our ongoing field research. The functional change made possible speculative investment in inner city housing and played a major role in the commodification of the disinvested housing stock.

scholarly journals Change of the functional purpose of the object through urbanistic analysis

2018 ◽  
Vol 170 ◽  
pp. 02011 ◽  
Author(s):  
Liliia Talipova ◽  
Egor Kosyakov ◽  
Marina Romanovich ◽  
Mikhail Lunyakov
Keyword(s):  
Social Environment ◽  
Business Model ◽  
Home Environment ◽  
Swot Analysis ◽  
Payback Period ◽  
Functional Change ◽  
Saint Petersburg ◽  
Emergency Condition ◽  
The World ◽  
Functional Purpose

This article is devoted to changing the functional purpose of the object in an emergency condition and included in the "gray belt" of Saint Petersburg. The analysis of the physical and social environment of the study area was carried out. By results of the study, a SWOT analysis was compiled, and the option of the functional change for co-living was considered. The purpose of co-living is to create a home environment that inspires and empowers its residents to be active creators and participants in the world around them. The necessary investments and the payback period of this project were calculated, the business model was developed.

scholarly journals Evaluating functional change using the Physical Abilities and Mobility Scale in acute paediatric neurorehabilitation

2020 ◽  
Vol 27 (12) ◽  
pp. 1-11
Author(s):  
David K Young ◽  
Helen E Starace ◽  
Hannah I Boddy ◽  
Keira MD Connolly ◽  
Kieren J Lock ◽  
...  
Keyword(s):  
Brain Injury ◽  
Motor Function ◽  
Acquired Brain Injury ◽  
Functional Change ◽  
Acute Hospital ◽  
Rate Of Change ◽  
Interquartile Range ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Physical Abilities

Background/Aims Childhood acquired brain injury is the leading cause of death and long-term disability among children and young people in the UK. Following a childhood brain injury, function is shown to improve within a specialist neurorehabilitation setting. Little evidence currently exists to demonstrate gross motor functional change within an acute hospital setting. The Physical Abilities and Mobility Scale is a valid and reliable outcome measure for use within inpatient paediatric neurorehabilitation following brain injury. The primary aim of this study was to evaluate how the gross motor function of paediatric patients with a new acquired brain injury changes during an acute hospital admission. Methods Data were collected for all patients admitted as an inpatient to one acute hospital over a 12-month period. The Physical Abilities and Mobility Scale was completed at baseline, at least weekly and again at discharge. Views relating to the utility of the Physical Abilities and Mobility Scale were sought among physiotherapists using the measure in order to inform acceptability. Results A total of 28 patients were included in this study. A Wilcoxon signed rank test was performed, which showed a highly significant improvement in function as scored on the Physical Abilities and Mobility Scale between baseline assessment (median 29.00, interquartile range 25.00–35.50) and discharge (median 85.00, interquartile range 75.00–95.00, Z=-4.624, P<0.001). A total of five patients (17.86%) were referred on for specialist residential neurorehabilitation. A post hoc analysis found that the rate of change of the Physical Abilities and Mobility Scale appeared to have an impact on final discharge destination, with slow improvers 18.60 times more likely to require specialist rehabilitation than others. The Physical Abilities and Mobility Scale was found to be acceptable among physiotherapists using it. Conclusions Children with a new acquired brain injury make significant improvements in gross motor function during a period of acute inpatient neurorehabilitation. Further work should look to refine the measure and gain a full understanding of its clinical utilities.

scholarly journals The Minimal Clinical Important Difference (MCID) in Annual Rate of Change of Timed Function Tests in Boys with DMD

2021 ◽  
pp. 1-10
Author(s):  
Tina Duong ◽  
Jennifer Canbek ◽  
Marisa Birkmeier ◽  
Leslie Nelson ◽  
Catherine Siener ◽  
...  
Keyword(s):  
Disease Progression ◽  
Muscle Weakness ◽  
Genetic Disorder ◽  
Functional Change ◽  
Rate Of Change ◽  
Minimal Detectable Change ◽  
Natural History Study ◽  
Clinical Endpoints ◽  
Function Tests ◽  
Standard Error Of Measurement

Background: Duchenne muscular dystrophy (DMD) is a rare x-linked recessive genetic disorder affecting 1 in every 5000–10000 [1, 2]. This disease leads to a variable but progressive sequential pattern of muscle weakness that eventually leads to loss of important functional milestones such as the ability to walk. With promising drugs in development to ameliorate the effects of muscle weakness, these treatments must be associated with a clinically meaningful functional change. Objective: The objective of this analysis is to determine both distribution, minimal detectable change (MDC), and anchor-based, minimal clinically important difference, (MCID) of 12 month change values in standardized time function tests (TFT) used to monitor disease progression in DMD. Method: This is a retrospective analysis of prospectively collected data from a multi-center prospective natural history study with the Cooperative International Neuromuscular Research Group (CINRG). This study calculated MDC and MCID values for 3 commonly used timed function tests typically used to monitor disease progression; supine to stand (STS), 10 meter walk/run(10MWT), and 4 stair climb(4SC). MDC used standard error of measurement (SEM) while MCID measurements used the Vignos scale as an anchor to determine clinical change in functional status. Results: All 3 TFT were significantly important clinical endpoints to detect MDC and MCID changes. MDC and MCID 12 month changes were significant in 10MWT(–0.138, –0.212), Supine to Stand (–0.026, –0.023) and 4 stair climb (–0.034, –0.035) with an effect size greater or close to 0.2. Conclusion: The 3 TFT are clinically meaningful endpoints used to establish change in DMD. MCID values were higher than MDC values indicating that an anchor-based approach using Vignos as a clinically meaningful loss of lower extremity abilities is appropriate to assess change in boys with DMD.

Does functional change predict the course of improvement in geriatric inpatient rehabilitation?

2010 ◽  
Vol 24 (5) ◽  
pp. 463-470 ◽  
Author(s):  
Michael D Denkinger ◽  
Wilmar Igl ◽  
Michael Jamour ◽  
Anne Bader ◽  
Stefanie Bailer ◽  
...  
Keyword(s):  
Inpatient Rehabilitation ◽  
Functional Change

Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats

2005 ◽  
Vol 289 (5) ◽  
pp. H2234-H2243 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Kentaro Wakabayashi ◽  
Tsuneo Kobayashi ◽  
Katsuo Kamata
Keyword(s):  
Mesenteric Artery ◽  
Diabetic Rats ◽  
Functional Change ◽  
Water Soluble ◽  
Mesenteric Arteries ◽  
Diabetic Rat ◽  
Adenylyl Cyclases ◽  
Camp Production ◽  
Functional Changes ◽  
Rat Mesenteric Artery

To assess the functional change in adenylyl cyclases (AC) associated with the diabetic state, we investigated AC-mediated relaxations and cAMP production in mesenteric arteries from rats with streptozotocin (STZ)-induced diabetes. The relaxations induced by the water-soluble forskolin (FSK) analog NKH477, which is a putative AC5 activator, but not by the β-adrenoceptor agonist isoproterenol (Iso) and the AC activator FSK, were reduced in intact diabetic mesenteric artery. In diabetic rats, however, Iso-, FSK-, and NKH477-induced relaxations were attenuated in the presence of inhibitors of nitric oxide synthase and cyclooxygenase. To exclude the influence of phosphodiesterase (PDE), we also examined the relaxations induced by several AC activators in the presence of 3-isobutyl-1-methylxanthine (IBMX; a PDE inhibitor). Under these conditions, the relaxation induced by Iso was greatly impaired in STZ-diabetic rats. This Iso-induced relaxation was significantly attenuated by pretreatment with SQ-22536, an AC inhibitor, in mesenteric rings from age-matched controls but not in those from STZ-diabetic rats. Under the same conditions, the relaxations induced by FSK or NKH477 were impaired in STZ-diabetic rats. Neither FSK- nor A-23187 (a Ca2+ ionophore)-induced cAMP production was significantly different between diabetics and controls. However, cAMP production induced by Iso or NKH477 was significantly impaired in diabetic mesenteric arteries. Expression of mRNAs and proteins for AC5/6 was lower in diabetic mesenteric arteries than in controls. These results suggest that AC-mediated relaxation is impaired in the STZ-diabetic rat mesenteric artery, perhaps reflecting a reduction in AC5/6 activity.

Functional Change in Early English.

1949 ◽  
Vol 64 (7) ◽  
pp. 498
Author(s):  
Stefan Einarsson ◽  
Donald W. Lee
Keyword(s):  
Functional Change ◽  
Early English

Agammaglobulinemia, by Col. Ogden C. Bruton, MC, USA,Pediatrics, 1952;9:722–728

PEDIATRICS ◽  
1998 ◽  
Vol 102 (Supplement_1) ◽  
pp. 213-215
Author(s):  
Rebecca H. Buckley
Keyword(s):  
Gamma Globulin ◽  
Serum Proteins ◽  
Good Health ◽  
Electrophoretic Analysis ◽  
Functional Change ◽  
Extensive Study ◽  
Normal Serum ◽  
Dramatic Improvement ◽  
Serum Globulin ◽  
Pneumococcal Sepsis

A hitherto unrecognized entity manifested by complete absence of gamma globulin with otherwise normal serum proteins and recurrent pneumococcal sepsis is described in an 8-year-old male. The patient appeared to be normal in other respects and, after extensive study, no structural or functional change could be demonstrated in any body system. He was unable to produce antibody to the pneumococcus with the four antigenic substances used; a positive Schick test persisted despite numerous attempts to reverse it with diphtheria toxoid. No antibody could be demonstrated following administration of typhoid vaccine in the usual manner, and his serum was negative for complement-fixing antibodies of epidemic parotitis after he experienced a typical clinical picture of that disease. Gamma globulin could be demonstrated in his serum after concentrated immune human serum globulin was administered subcutaneously, and its gradual disappearance could be followed by electrophoretic analysis over a period of approximately six weeks. Concurrently, and following administration of human gamma globulin (3.2 gm. gamma globulin) at monthly intervals, he had been free of pneumococcal sepsis for more than a year, whereas he had experienced clinical sepsis at least 19 times in the previous four years. Eight different types of pneumococci had been recovered from blood cultures during 10 different episodes of sepsis. In the Discussion, [the author] concluded that there was a cause-and-effect relationship between the absence of gamma globulin and the repeated infections, based on the child's dramatic improvement after beginning gamma globulin therapy. [The author] proposed two possible causes–congenital or acquired. While [he] felt that the patient's good health for the first 4.5 years of life argued against a congenital cause, the persistence of the defect supported it.

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