Change processes in long-term recovery for individuals with present and former substance-use dependence

AbstractContradictory data have been reported concerning neuropsychiatric side effects of the first-line antiretroviral drug dolutegravir, which may be partly due to lack of control groups or psychiatric assessment tools. Using validated self-report questionnaires, we compared mood and anxiety (DASS-42), impulsivity (BIS-11), and substance use (MATE-Q) between dolutegravir-treated and dolutegravir-naive people living with HIV (PLHIV). We analyzed 194, mostly male, PLHIV on long-term treatment of whom 82/194 (42.3%) used dolutegravir for a median (IQR) of 280 (258) days. Overall, 51/194 (26.3%) participants reported DASS-42 scores above the normal cut-off, 27/194 (13.5%) were classified as highly impulsive, and 58/194 (29.9%) regularly used recreational drugs. Regular substance use was positively associated with depression (p = 0.012) and stress scores (p = 0.045). We observed no differences between dolutegravir-treated and dolutegravir-naive PLHIV. Our data show that depressed and anxious moods and impulsivity are common in PLHIV and associate with substance use and not with dolutegravir use.

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Understanding the interplay of individual and social–developmental factors in the progression of substance use and mental health from childhood to adulthood

Development and Psychopathology ◽

10.1017/s0954579416000274 ◽

2016 ◽

Vol 28 (3) ◽

pp. 721-741 ◽

Cited By ~ 7

Author(s):

Tiffany M. Jones ◽

Karl G. Hill ◽

Marina Epstein ◽

Jungeun Olivia Lee ◽

J. David Hawkins ◽

...

Keyword(s):

Mental Health ◽

Substance Use ◽

Social Environments ◽

Developmental Factors ◽

Substance Use Problems ◽

History Of ◽

Individual Functioning ◽

Family History Of Depression ◽

History Of Depression

AbstractThis study examines the interplay between individual and social–developmental factors in the development of positive functioning, substance use problems, and mental health problems. This interplay is nested within positive and negative developmental cascades that span childhood, adolescence, the transition to adulthood, and adulthood. Data are drawn from the Seattle Social Development Project, a gender-balanced, ethnically diverse community sample of 808 participants interviewed 12 times from ages 10 to 33. Path modeling showed short- and long-term cascading effects of positive social environments, family history of depression, and substance-using social environments throughout development. Positive family social environments set a template for future partner social environment interaction and had positive influences on proximal individual functioning, both in the next developmental period and long term. Family history of depression adversely affected mental health functioning throughout adulthood. Family substance use began a cascade of substance-specific social environments across development, which was the pathway through which increasing severity of substance use problems flowed. The model also indicated that adolescent, but not adult, individual functioning influenced selection into positive social environments, and significant cross-domain effects were found in which substance-using social environments affected subsequent mental health.

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Consequences of prenatal substance use

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh.2012.016 ◽

2012 ◽

Vol 24 (2) ◽

Cited By ~ 24

Author(s):

Thitinart Sithisarn ◽

Don T. Granger ◽

Henrietta S. Bada

Keyword(s):

Mental Health ◽

Substance Use ◽

Behavioral Problems ◽

Drug Exposure ◽

Public Health Problem ◽

Child And Adolescent ◽

In Utero ◽

Major Public Health Problem ◽

Prenatal Substance Use

Abstract Background: Prenatal substance use is a major public health problem and a social morbidity, with consequences on the drug user and the offspring. Objective: This review focuses on the child and adolescent outcomes following in utero drug exposure. Methods: Studies on the effects of specific substances, legal and illegal; i.e., tobacco or nicotine, alcohol, marijuana, cocaine, opiates, and methamphetamine were evaluated and analyzed. Results: In general, manifestations of prenatal exposure to legal and illegal substances include varying deficits in birth anthropometric measurements, mild-to-moderate transient neurobehavioral alterations in infancy and long-term behavioral problems noted from early childhood to adolescence. Severity of expression of behavioral problems is influenced by environmental factors. Further, behavioral alterations following in utero drug exposure often exist with mental health co-morbidities. Conclusion: Because of the long-term consequences of prenatal drug exposure on child and adolescent mental health, health providers need to promote substance use prevention, screen for exposure effects and provide or refer affected youths for intervention services. Preventive measures and treatment should consider other factors that may further increase the risk of psychopathology in the exposed children.

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Recovery-informed Theory: Situating the Subjective in the Science of Substance Use Disorder Recovery

Journal of Recovery Science ◽

10.31886/jors.13.2019.38 ◽

2019 ◽

Vol 1 (3) ◽

pp. 1-15 ◽

Cited By ~ 5

Author(s):

Austin M Brown ◽

Robert D Ashford

Keyword(s):

Substance Use ◽

Substance Use Disorders ◽

Substance Use Disorder ◽

Systems Of Care ◽

Grand Theory ◽

Recovery Strategies ◽

Recovery Capital ◽

New Ideas

As recovery from substance use disorder becomes more than a mere quantifiable outcome, there exists a need to discuss and propose the underlying theoretical constructs that ultimately describe and identify the science of recovery. In this abstract undertaking, we propose an initial formulation of a grand theory of recovery science, built upon the seminal theories of recovery capital, recovery-oriented systems of care, and socioecological theory. This grand theory - labeled recovery-informed theory (RIT) - states that successful long-term recovery is self-evident and is a fundamentally emancipatory set of processes. This paper will discuss, analyze, and explore this theory as it is situated within the larger substance use, misuse, and disorder contexts. The uses, implications, and benefits of RIT as an organizing point of inquiry for recovery science are also discussed. By promoting the role of subjective recovery experience in the formulation of the study of recovery, it may be possible to summon new ideas, metrics, and strategies that can directly address substance use disorders in society. Adopting a recovery-informed understanding as follows from this grand theory may allow individual recovery and wellness trajectories to be explored, adapted, and modified to exemplify person-centered and individualized recovery strategies.

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Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders

The British Journal of Psychiatry ◽

10.1192/bjp.178.41.s184 ◽

2001 ◽

Vol 178 (S41) ◽

pp. s184-s190 ◽

Cited By ~ 68

Author(s):

Leonardo Tondo ◽

Ross J. Baldessarini ◽

Gianfranco Floris

Keyword(s):

Substance Use ◽

Substance Use Disorder ◽

Lithium Treatment ◽

Bipolar Disorders ◽

Clinical Effectiveness ◽

Type I ◽

Rapid Cycling ◽

Single Episode ◽

Episode Frequency

BackgroundThe effectiveness of lithium is being questioned increasingly and requires clarification.AimsTo assess the effectiveness of lithium treatment in depression and mania, syndromal types I and II, with predominantly mixed or psychotic episodes or rapid cycling, during treatment resumed following discontinuation, and across three decades.MethodThe longitudinal course of 360 patients with bipolar disorder compliant with lithium treatment for at least 1 year and without comorbidity for substance use disorder was reviewed.ResultsRisk of single-episode recurrences, a common index of treatment failure, was similar to that in other reports. Both episode frequency and ‘time ill’ improved more in type II than type I cases. Reduced morbidity during treatment was similar in patients with mixed or psychotic episodes, or rapid cycling, and in less complex cases. Retreatment yielded minor decrements in response, and there was no tendency for lesser responses in more recent years.ConclusionsBased on overall affective morbidity, long-term lithium treatment in compliant patients without comorbid substance use disorder, though imperfect, remains effective, even in subgroups of supposedly poor prognosis.

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Psychosocial Therapies for Substance Use Disorders

Managing Substance Use Disorder ◽

10.1093/med-psych/9780190926717.003.0005 ◽

2019 ◽

pp. 41-52

Author(s):

Dennis C. Daley ◽

Antoine Douaihy

Keyword(s):

Substance Use ◽

Substance Use Disorders ◽

Psychosocial Interventions ◽

Alcohol Problems ◽

Support Programs ◽

Treatment Programs ◽

Mutual Support ◽

Professional Treatment ◽

Drug Problems

There are many counseling approaches, treatment programs, and psychosocial interventions for individuals with substance use disorders (SUDs). Although some have been shown in clinical trials to be more effective than others, to date there is no single, superior treatment approach appropriate for all clients. While brief treatments have been successful with alcohol problems, longer term treatments are often needed for drug problems. For clients with more severe SUDs, long-term involvement in professional treatment (including medication-assisted therapies), mutual support programs, or both may be needed. This chapter includes a summary of treatment principles and guidelines that can serve as a framework for helping clients with SUDs.

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