Cost Comparison of Psoriasis Treatments

2009 ◽  
Vol 13 (6) ◽  
pp. 303-307 ◽  
Author(s):  
Dalia Mikhael ◽  
Kelly Babcock ◽  
Jean-Pierre DesGroseilliers
Keyword(s):  
Financial Burden ◽  
Severity Index ◽  
Ultraviolet B ◽  
Cost Comparison ◽  
Insurance Companies ◽  
Joint Involvement ◽  
Plaque Type ◽  
Hypothetical Patient ◽  
Costly Treatment ◽  
The Cost

Background: Knowledge of the cost of various psoriasis therapeutic options is essential to the prescribing clinician. Objective: To compare the cost of various psoriasis treatments over a 10-year period in the province of Ontario, Canada. Methods: We used a hypothetical patient with plaque-type psoriasis of moderate severity with a Psoriasis Area and Severity Index of 10, body surface area of 20%, and no joint involvement. The costs to treat this hypothetical patient with different therapeutic regimens were compared in this study. Results: In a 60 kg patient, alefacept was the most costly form of therapy, based on two 12-week treatments per year, followed by infliximab 5 mg/kg. In a 90 kg patient, infliximab 5 mg/kg was the most costly, followed by alefacept. The least costly treatment was ultraviolet B phototherapy. Conclusion: With the knowledge of these data, informed prescribing by the dermatologist may reduce the financial burden to the patient, the provincial health care system, and insurance companies.

scholarly journals Patterns of clinical nail appearances in patients with cutaneous psoriasis

2017 ◽  
Vol 90 (1) ◽  
pp. 22-27
Author(s):  
Elena Mihaela Marina ◽  
Carolina Botar-Jid ◽  
Sorana Daniela Bolboaca ◽  
Iulia Ioana Roman ◽  
Corina Simona Senila ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Early Stage ◽  
Severity Index ◽  
University Hospital ◽  
Joint Involvement ◽  
Early Stage Disease ◽  
North West ◽  
The North ◽  
Plaque Type ◽  
Nail Changes

Background and aims. Nail manifestations are often an overlooked aspect in psoriatic disease, cutaneous and joint involvement being far more often reported and investigated. The reported prevalence of nail changes varies in literature, specific fingernail clinical features having different degrees of occurrence. The aim of this study was to describe specific clinical patterns of fingernail alterations in adult patients with plaque-type psoriasis in a university hospital in the North-West of Romania.Methods. Clinical data of 35 patients with fingernail psoriasis were collected and analyzed. Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI) scores were used to quantify disease extension in each patient.Results. PASI score proved linearly correlated with NAPSI score (p<0.05). The age of onset of fingernail psoriasis was positively correlated with age of onset cutaneous psoriasis (p<0.0001). Furthermore, the duration of cutaneous involvement and NAPSI proved significantly related (p<0.05). The third fingernail in the right hand and first fingernail in the left hand were in most of the cases severely affected. The most common observed nail pattern was pitting, followed by salmon patches and subungual hyperkeratosis.Conclusion. Important nail changes appear even in moderate forms of cutaneous psoriasis. Particular localization of specific fingernail psoriasis pattern enables the possibility of detecting early stage disease.

scholarly journals The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Nahide Onsun ◽  
Serpil Pirmit ◽  
Dilek Ozkaya ◽  
Şirin Çelik ◽  
Aylin Rezvani ◽  
...  
Keyword(s):  
Strong Association ◽  
Turkish Population ◽  
Severity Index ◽  
Joint Involvement ◽  
Psoriasis Area Severity Index ◽  
Plaque Type ◽  
Immune Mediated ◽  
Genetic And Environmental Factors ◽  
And Gender ◽  
The Relationship

Background. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. The present study aims to determine this relationship. Methods. This case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C⁎06, HLA-C⁎12, and HLA-C⁎04 alleles were most commonly observed in psoriasis patients. HLA-C⁎06 and HLA-C⁎12 were significantly more frequent in the psoriasis group. HLA-C⁎06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C⁎12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C⁎12 allele. Conclusions. HLA-C⁎12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.

scholarly journals Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience

2019 ◽  
Vol 7 (2) ◽  
pp. 253-255
Author(s):  
Em Dang Van ◽  
Thuy Pham Diem ◽  
Van Bui Thi ◽  
Tam Huynh Thi Xuan ◽  
Khai Ly Tuan ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Recurrence Rate ◽  
Plaque Psoriasis ◽  
Severity Index ◽  
Ultraviolet B ◽  
Chronic Plaque Psoriasis ◽  
Oral Methotrexate ◽  
Psoriasis Treatment ◽  
Plaque Type ◽  
Better Than

AIM: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018. METHODS: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI). RESULTS: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05. CONCLUSION: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.

The Unusual Cruelty of Nursing Homes Behind Bars

2020 ◽  
Vol 32 (5) ◽  
pp. 264-271
Author(s):  
Rachel E. López
Keyword(s):  
Nursing Homes ◽  
Human Dignity ◽  
Prison Population ◽  
Financial Burden ◽  
The Elderly ◽  
The United States ◽  
Term Care ◽  
Trained Staff ◽  
State Prisons ◽  
The Cost

The elderly prison population continues to rise along with higher rates of dementia behind bars. To maintain the detention of this elderly population, federal and state prisons are creating long-term care units, which in turn carry a heavy financial burden. Prisons are thus gearing up to become nursing homes, but without the proper trained staff and adequate financial support. The costs both to taxpayers and to human dignity are only now becoming clear. This article squarely addresses the second dimension of this carceral practice, that is the cost to human dignity. Namely, it sets out why indefinitely incarcerating someone with dementia or other neurocognitive disorders violates the Eighth Amendment of the United States Constitution’s prohibition on cruel and unusual punishment. This conclusion derives from the confluence of two lines of U.S. Supreme Court precedent. First, in Madison v. Alabama, the Court recently held that executing someone (in Madison’s case someone with dementia) who cannot rationally understand their sentence amounts to cruel and unusual punishment. Second, in line with Miller v. Alabama, which puts life without parole (LWOP) sentences in the same class as death sentences due to their irrevocability, this holding should be extended to LWOP sentences. Put another way, this article explains why being condemned to life is equivalent to death for someone whose neurodegenerative disease is so severe that they cannot rationally understand their punishment.

scholarly journals The financial burden of PARP inhibitors on patients, payors, and financial assistance programs: Who bears the cost?

2021 ◽  
Author(s):  
Whitney N. Goldsberry ◽  
Sarah S. Summerlin ◽  
Allison Guyton ◽  
Brittani Caddell ◽  
Warner K. Huh ◽  
...  
Keyword(s):  
Financial Burden ◽  
Parp Inhibitors ◽  
Financial Assistance ◽  
Assistance Programs ◽  
The Cost

A Comparative Study on the Efficacy of Treatment with 585 nm Pulsed Dye Laser and Ultraviolet B-TL01 in Plaque Type Psoriasis

2009 ◽  
Vol 35 (1) ◽  
pp. 80-91 ◽  
Author(s):  
JAAP DE LEEUW ◽  
ROSANNE G. VAN LINGEN ◽  
HILDE BOTH ◽  
BHUPENDRA TANK ◽  
TAMAR NIJSTEN ◽  
...  
Keyword(s):  
Comparative Study ◽  
Dye Laser ◽  
Ultraviolet B ◽  
Pulsed Dye Laser ◽  
Plaque Type ◽  
Efficacy Of Treatment

Cost of therapy for cystic fibrosis in different age groups with consideration to the respiratory tract infection and complications

2021 ◽  
Vol 31 (2) ◽  
pp. 238-249
Author(s):  
E. G. Furman ◽  
V. V. Shadrina ◽  
T. Yu. Maksimycheva ◽  
V. D. Sherman ◽  
E. I. Kondratyeva
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Tract ◽  
Pharmacoeconomic Analysis ◽  
Age Groups ◽  
Eradication Therapy ◽  
Cost Savings ◽  
Hypothetical Patient ◽  
Severity Of The Disease ◽  
Cost Of Drugs ◽  
The Cost

Despite the low prevalence of cystic fibrosis (CF), the costs of treating this disease are significant for the healthcare system. The aim of this economic study was to assess the total cost of drugs per year for children with CF, depending on age and course of the disease.Methods. For this pharmacoeconomic analysis, groups of “hypothetical” patients were formed according to the characteristics of the course of CF, taking into account the required volume of basic CF therapy, antibiotic therapy, and complications.Results. The cost of basic treatment for CF patients of different ages and disease progression in the hypothetical patient models can vary greatly. The cost of CF therapy increases significantly with age and Pseudomonas aeruginosa respiratory infection, especially in the patients with chronic infection, concomitant polyposis sinusitis, and low nutritional status.Conclusion. Patients with CF require regular follow-up with control of the microflora of the respiratory tract and effective eradication therapy for P. aeruginosa and other pathogenic microorganisms. Reducing infection rates and the severity of the disease can lead to significant cost savings.

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