scholarly journals Patterns of clinical nail appearances in patients with cutaneous psoriasis

2017 ◽  
Vol 90 (1) ◽  
pp. 22-27
Author(s):  
Elena Mihaela Marina ◽  
Carolina Botar-Jid ◽  
Sorana Daniela Bolboaca ◽  
Iulia Ioana Roman ◽  
Corina Simona Senila ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Early Stage ◽  
Severity Index ◽  
University Hospital ◽  
Joint Involvement ◽  
Early Stage Disease ◽  
North West ◽  
The North ◽  
Plaque Type ◽  
Nail Changes

Background and aims. Nail manifestations are often an overlooked aspect in psoriatic disease, cutaneous and joint involvement being far more often reported and investigated. The reported prevalence of nail changes varies in literature, specific fingernail clinical features having different degrees of occurrence. The aim of this study was to describe specific clinical patterns of fingernail alterations in adult patients with plaque-type psoriasis in a university hospital in the North-West of Romania.Methods. Clinical data of 35 patients with fingernail psoriasis were collected and analyzed. Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI) scores were used to quantify disease extension in each patient.Results. PASI score proved linearly correlated with NAPSI score (p<0.05). The age of onset of fingernail psoriasis was positively correlated with age of onset cutaneous psoriasis (p<0.0001). Furthermore, the duration of cutaneous involvement and NAPSI proved significantly related (p<0.05). The third fingernail in the right hand and first fingernail in the left hand were in most of the cases severely affected. The most common observed nail pattern was pitting, followed by salmon patches and subungual hyperkeratosis.Conclusion. Important nail changes appear even in moderate forms of cutaneous psoriasis. Particular localization of specific fingernail psoriasis pattern enables the possibility of detecting early stage disease.

Clinico-Epidemiological Characteristics and Impact on Quality of Life in Psoriatic Patients with and without Nail Changes - A Nepalese Experience

2021 ◽  
Vol 8 (06) ◽  
pp. 306-312
Author(s):  
Shikha Khare ◽  
Sudha Agrawal
Keyword(s):  
Quality Of Life ◽  
Age Of Onset ◽  
Severity Index ◽  
Joint Involvement ◽  
Skin Involvement ◽  
Nail Psoriasis ◽  
Nail Changes ◽  
Epidemiological Characteristics ◽  
Nail Involvement

BACKGROUND Nail involvement in psoriasis is likely to influence the quality of life (QOL) because of its highly visible site; however, the impact of this disease on QOL is an underexplored area. Similarly, the relationship between severity of skin involvement and nail involvement has been overlooked. The study was conducted to evaluate the clinico-epidemiological characteristics of psoriasis patients with and without nail changes and assess the health-related quality of life (HRQOL). Furthermore, the correlation of severity of nail involvement with the severity of skin involvement and its impact on quality of life was assessed. METHODS A total of 370 adult psoriasis patients with or without nail changes was studied. Skin severity was assessed by body surface area (BSA) and Psoriasis Area and Severity Index (PASI) while nail severity was assessed using Nail Psoriasis Severity Index (NAPSI). Patients’ quality of life was measured using the Nepali Version of Dermatology Life Quality Index (DLQI). RESULTS Nail psoriasis was more prevalent in males in both the groups; females were having more nail involvement (0.041). There were no significant diff erences in other clinico-epidemiologic characteristics between these two groups except the late onset of psoriasis in the age group > 30 years, scalp involvement and absence of family history of psoriasis (P ≤ 0.05). There was a strong positive correlation between the age of onset of skin changes with age of onset of nail involvement (r = 0.799) and the joint involvement (r = 0.742) as well as the age of onset of joint involvement with nail changes (r = 0.838). The mean PASI was 7.265 ± 7.153 vs. 6.189 ± 7.153 in patients with > 10 vs. ≤ 10 total NAPSI score and it was statistically significant (P = 0.011), however, there was a moderate positive correlation between PASI and NAPSI (r = 0.32). Almost half of psoriasis patients had very large to extremely large effects on quality of life but leisure and treatment domain were affected more amongst patients with nail changes. Early onset of joint involvement, body surface area of > 3 % involvement and PASI score > 5 had significant effect on quality of life. CONCLUSIONS The nail involvement is an important finding in determining the severity of skin involvement and had very large to extremely large effect on quality of life particular on leisure and treatment domain. Therefore, nail examination must be done in all psoriatic patients. KEYWORDS Nail Psoriasis, Quality of Life, Dermatology Life Quality Index, Psoriasis Area and Severity Index, Nail Psoriasis Severity Index

Temporal patterns in distributions of tropical fish larvae on the North West Shelf of Australia

2004 ◽  
Vol 55 (5) ◽  
pp. 473 ◽  
Author(s):  
A. Sampey ◽  
M. G. Meekan ◽  
J. H. Carleton ◽  
A. D. McKinnon ◽  
M. I. McCormick
Keyword(s):  
Southern Oscillation ◽  
Fish Larvae ◽  
Early Stage ◽  
Larval Survival ◽  
Zooplankton Biomass ◽  
Tropical Fish ◽  
North West ◽  
Larval Fishes ◽  
The North ◽  
Abundance And Diversity

Information on the temporal distributions of tropical fish larvae is scarce. Early stage larval fishes were sampled using towed bongo plankton nets at sites on the southern North West Shelf of Australia (21°49′S, 114°14′E), between October and February of 1997/98 and 1998/99. The first summer was characterised by El Niño–Southern Oscillation-driven upwelling and high primary productivity, whereas in the second summer water temperatures were warmer and primary production was lower. Benthic percoid shorefishes dominated surface assemblages in both summers and this pattern may be typical of tropical shelf environments.The abundance and diversity of larval fishes were lowest in October and increased from November through to February. Assemblages displayed weak cross-shelf patterns, with a few taxa being more abundant at inshore sites (e.g. monacanthids), whereas others were more abundant offshore (e.g. scombrids). Although the composition of assemblages remained relatively consistent, many taxa (e.g. pomacentrids and carangids) showed differences in abundance between summers. Multivariate analyses found no relationships between abundance patterns of larval fishes and biophysical variables, such as temperature, salinity, and zooplankton biomass. Thus, seasonal changes in abundance may reflect differences in the spawning activities of adult fishes and/or larval survival.

Cost Comparison of Psoriasis Treatments

2009 ◽  
Vol 13 (6) ◽  
pp. 303-307 ◽  
Author(s):  
Dalia Mikhael ◽  
Kelly Babcock ◽  
Jean-Pierre DesGroseilliers
Keyword(s):  
Financial Burden ◽  
Severity Index ◽  
Ultraviolet B ◽  
Cost Comparison ◽  
Insurance Companies ◽  
Joint Involvement ◽  
Plaque Type ◽  
Hypothetical Patient ◽  
Costly Treatment ◽  
The Cost

Background: Knowledge of the cost of various psoriasis therapeutic options is essential to the prescribing clinician. Objective: To compare the cost of various psoriasis treatments over a 10-year period in the province of Ontario, Canada. Methods: We used a hypothetical patient with plaque-type psoriasis of moderate severity with a Psoriasis Area and Severity Index of 10, body surface area of 20%, and no joint involvement. The costs to treat this hypothetical patient with different therapeutic regimens were compared in this study. Results: In a 60 kg patient, alefacept was the most costly form of therapy, based on two 12-week treatments per year, followed by infliximab 5 mg/kg. In a 90 kg patient, infliximab 5 mg/kg was the most costly, followed by alefacept. The least costly treatment was ultraviolet B phototherapy. Conclusion: With the knowledge of these data, informed prescribing by the dermatologist may reduce the financial burden to the patient, the provincial health care system, and insurance companies.

scholarly journals Role of PET/CT in Assessment of Recurrent Ovarian Tumors

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S Kadry ◽  
A Haggag ◽  
A Ekbal
Keyword(s):  
Ovarian Cancer ◽  
Tumor Marker ◽  
Early Stage ◽  
Ovarian Tumors ◽  
University Hospital ◽  
Ca 125 ◽  
Early Stage Disease ◽  
Major Health Problem ◽  
Pet Ct ◽  
Suspected Recurrence

Abstract Background Ovarian cancer remains a major health problem worldwide, with over 225,000 new cases and 140,000 deaths reported annually. Despite high response after initial treatment, 20-30% of patients with early-stage disease and up to 75% of patients with advanced disease present with recurrence within two years. Early diagnosis of recurrence is crucial for determination of the best treatment. Aim of the Work is to detect the significance of PET/CT in the early detection of recurrent ovarian tumors. Patients and Method The study included 25 patients who have been diagnosed with ovarian cancer, received treatment and achieved complete response. All of the 25 patients had suspected recurrence either due to elevated tumor markers or suspicious clinical findings. The 25 patients have been referred for PET/CT scan at ElDemerdash university hospital from July 2017 to August 2018. Results Total of 25 patients were included in the study. 18 of 25 patients had high tumor marker (CA 125) level. The remaining 7 patients had suspected recurrence with normal tumor marker levels. Recurrence was confirmed by histopathology or clinical and imaging follow up in 19 patients of the 25 patients. Recurrent disease was not shown in 5 of 19 patients on CECT imaging and 1 of 19 patients on PET/CT imaging. PET/CT had a sensitivity of (94.74%), specificity of (100%) and accuracy of (96%). CECT has been reported with sensitivity of (73.68), specificity of (83.33%) and accuracy of (76%). Conclusion PET/CT is a useful tool and has a higher sensitivity, specificity and accuracy than CECT in detection of recurrent ovarian cancer.

scholarly journals The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Nahide Onsun ◽  
Serpil Pirmit ◽  
Dilek Ozkaya ◽  
Şirin Çelik ◽  
Aylin Rezvani ◽  
...  
Keyword(s):  
Strong Association ◽  
Turkish Population ◽  
Severity Index ◽  
Joint Involvement ◽  
Psoriasis Area Severity Index ◽  
Plaque Type ◽  
Immune Mediated ◽  
Genetic And Environmental Factors ◽  
And Gender ◽  
The Relationship

Background. Psoriasis is a multifactorial immune-mediated inflammatory disease triggered by both genetic and environmental factors. The strong association between psoriasis and HLA-C⁎06 allele has been demonstrated in various races. The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. The present study aims to determine this relationship. Methods. This case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C⁎06, HLA-C⁎12, and HLA-C⁎04 alleles were most commonly observed in psoriasis patients. HLA-C⁎06 and HLA-C⁎12 were significantly more frequent in the psoriasis group. HLA-C⁎06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C⁎12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C⁎12 allele. Conclusions. HLA-C⁎12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.

GEOLOGICAL FRAMEWORK OF THE GREAT AUSTRALIAN BIGHT

1969 ◽  
Vol 9 (1) ◽  
pp. 60
Author(s):  
R. Smith ◽  
P. Kamerling
Keyword(s):  
Middle Eocene ◽  
Early Stage ◽  
Upper Jurassic ◽  
The South ◽  
The West ◽  
Offshore Area ◽  
North West ◽  
Carbonate Sedimentation ◽  
The North ◽  
Great Australian Bight

Geophysical exploration carried out in the Great Australian Bight since 1966, combined with geological fieldwork in the adjacent land areas, has made it possible to outline the broad geological framework of the area.The "basement" consists of two major units, an offshore extension of the locally metamorphic Cambrian Kanmantoo Group in the south-east and the extension of the West Australian Archaean shield in the north-west. The boundary is thought to follow a trend extending westerly from the Cygnet-Snelling fault zone on Kangaroo Island.In two areas the basement has been downfaulted, thus creating depositional areas for thick sequences of sediments, namely the Elliston trough to the west of Eyre Peninsula and the Duntroon basin, south of Eyre Peninsula and west of Kangaroo Island.The geological setting of the Duntroon basin appears to be comparable with the Otway basin and a Jurassic- Cretaceous age is assumed for the folded sequence of sediments overlying the basement and underlying the Tertiary with angular unconformity. The basin was possibly partially and temporarily closed to the south and open to marine influences from the west.In the Elliston trough the lower part of the section which has low to medium velocity seismic character, is probably Mesozoic, as is evidenced by the Upper Jurassic encountered in its onshore extension. Proterozoic-Cambrian sediments may overlie the basement in the eastern part of the trough. Deformation of the Mesozoic is limited to the mouth of the trough where there is indication of a base- Tertiary unconformity. This trough was probably also open to marine influences to the west.Along the continental margin between the basins and also south of the Eucla basin a thin Mesozoic section, conformably underlying the Tertiary, is probably present, gradually thickening towards the continental slope.In the onshore area Tertiary sedimentation started with local deposition of clastics during the Middle Eocene, which also may have been the case off the Eucla basin, in the Elliston trough and in the Duntroon basin. Carbonate sedimentation took place from the Middle-Upper Eocene onwards, to reach its widest areal extent during the Lower Miocene. A hiatus during the Oligocene may have occurred in the western part of the Bight as is the case in the Eucla basin.Only weak deformation of the Tertiary in the offshore area has been observed. This generally occurs over Mesozoic structures in the Duntroon basin and as draping over topographic basement highs at the mouth of the Elliston trough.No significant hydrocarbon indications are known from the surrounding land areas, but the well-documented bitumen strandings along the coast point to offshore seepages indicating generation of hydrocarbons in the general area.At this stage prospects must be regarded as speculative.although a folded probable Mesozoic sequence forms an objective in the Duntroon basin while prospective Mesozoic-Tertiary section appears to be present in the Elliston trough, where structural evaluation is still at a relatively early stage.

scholarly journals Prevalence, clinical profile, and severity of nail involvement in psoriasis – A hospital-based cross-sectional study from a tertiary care center in North Kerala

2019 ◽  
Vol 1 ◽  
pp. 72-76
Author(s):  
Vivek Prabhakar ◽  
Bifi Joy ◽  
Anoop Thyvalappil ◽  
Rajiv Sridharan ◽  
Ajayakumar Sreenivasan ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Late Onset ◽  
Tertiary Care ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nail Psoriasis ◽  
Nail Changes ◽  
Nail Involvement

Objectives: Nail changes are present in 25–50% of psoriatic cases. Nail Psoriasis Severity Index (NAPSI) assess the extent of the involvement of the psoriatic nail unit. This study was conducted with the aim of finding the prevalence, clinical characteristics and severity of nail psoriasis. Methods and Materials: In this cross-sectional study, a thorough clinical examination was done to determine the type and extent of skin disease including PASI (psoriasis area severity index) score, and all the fingernails and toenails were examined in a well-lit environment, under a magnifying lens to visualize the nail findings, and NAPSI score was calculated for each patient. Statistical Package for the Social Sciences (SPSS v. 11.0) software was used to analyze the data collected. Results: Of the100 patients studied, 73% of patients with psoriasis had nail involvement. Mean total NAPSI was 30.97 ± 30.79. Mean age of onset of psoriasis was 43.62 ± 15.31 and 33.04 ± 12.80 in those with and without nail involvement respectively (P-value 0.002). The majority without nail involvement (77.8%) belonged to the early- onset group, while 22.2% of those without nail involvement had late-onset psoriasis (P-value 0.001). The most common nail pattern in our study was Pitting (93.2%). Limitation: Nail changes in severe forms of disease could not be studied since patients receiving systemic drugs for the disease were excluded from the study. Conclusion: The mean duration of psoriasis in those with nail involvement in our study was 5 years more than in those without nail disease. Our study demonstrated a significant association between higher PASI scores and nail involvement. All patients with severe psoriasis (PASI >20) in our study had nail involvement.

scholarly journals Frequency of distribution of joint involvement in rheumatoid arthritis patients.

2021 ◽  
Vol 28 (04) ◽  
pp. 539-547
Author(s):  
Zafar Ali Zafar ◽  
Naveed Ur Rehman ◽  
Muhammad Absar Alam ◽  
Touseef Anwar ◽  
Muhammad Sarfraz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Distribution ◽  
Disease Duration ◽  
Age Of Onset ◽  
Joint Damage ◽  
University Hospital ◽  
Joint Involvement ◽  
Cross Sectional ◽  
Small Joint ◽  
Independent University

Objectives: To determine the frequency of joint distribution in rheumatoid arthritis presenting at Independent University Hospital Faisalabad. Assessment of joint involvement in RA patients is not only important to determine the disease activity but also to assess the future joint damage. Study Design: Cross Sectional Study. Setting: Independent University Hospital Faisalabad. Period: July 2019 to Jan 2020. Material & Methods: 384 consecutive RA patients fulfilling inclusion and exclusion criteria, of either sex between age of 17- 60 years were enrolled from Rheumatology division of Independent University Hospital Faisalabad from July 2019 to Jan 2020. Frequency of joint distribution was assessed. Chi square test was used to compare the frequency of joint distribution among different treatment groups, age groups and gender, disease duration. A p-valve of < 0.05 was considered statistically significant. Results: In this study 384 patients with RA were studied. Joint distribution was determined according to pattern of joint involved at presentation. More patients (178) were noted in oligoarticular group, with predominant small joint involvement 111 (28.9%). 173 patients were noted in poly-articular group with 102 (26.6%) were in predominant small joint involvement. Conclusion: Pattern of joint distribution in RA patients is very important especially if there is monoarthritis or oligoarthritis, along with its association with gender, age of onset, disease duration, investigations.

scholarly journals Impact of COVID-19 on small biopsy diagnostic procedures and cancer resection surgeries in the North-West of Ireland

2021 ◽  
pp. jclinpath-2021-207425
Author(s):  
Eoghan O'Connor ◽  
Gerard O'Dowd ◽  
Sine Phelan
Keyword(s):  
Information Systems ◽  
Diagnostic Procedures ◽  
University Hospital ◽  
Cancer Resection ◽  
North West ◽  
The North ◽  
Therapeutic Services ◽  
Laboratory Information Systems ◽  
The Impact ◽  
West Of Ireland

AimsTo quantify the impact of COVID-19 on small biopsy procedures and cancer resection surgeries in the North-West of Ireland.MethodsData was obtained from the Histopathology Departments of University Hospital Galway (UHG) and Letterkenny University Hospital (LUH) Laboratory Information Systems to establish the impact of COVID-19 on both the small biopsy (coded P01) and cancer resection (coded P03) caseloads reported from January to June 2020, with comparison made to January to June 2019.ResultsFrom January to June 2020 compared with January to June 2019, UHG had an overall decrease of 714 P01 cases (21.5%) and a decrease of 152 P03 cases (14.4%). In this time, LUH had an increase of 9 P01 cases (0.8%) but a decrease of 48 P03 cases (58.5%).ConclusionsThere has been a significant impact on the provision of both diagnostic and therapeutic services in North-West of Ireland due to the COVID-19 pandemic.

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