scholarly journals Benign Lymphoepithelial Cyst: An Unusual Cause of Parotid Swelling in Two Immunocompetent Patients

2019 ◽  
Vol 7 (13) ◽  
pp. 2142-2145
Author(s):  
How Kit Thong ◽  
Primuharsa Putra Sabir Husin Athar ◽  
Wan Muhaizan Wan Mustaffa
Keyword(s):  
Histopathological Examination ◽  
Surgical Excision ◽  
Case Presentation ◽  
Important Differential Diagnosis ◽  
Immunodeficiency Virus ◽  
Lymphoepithelial Cysts ◽  
Parotid Swelling ◽  
Slow Growing ◽  
Immunocompetent Patients ◽  
Hiv Negative

BACKGROUND: Lymphoepithelial cysts, which are benign and slow-growing tumours, usually involve the head and neck regions. Benign lymphoepithelial cysts (BLECs) are the most common cause of parotid swelling in human immunodeficiency virus (HIV)-positive patients and are less common in immunocompetent patients. CASE PRESENTATION: Here, we present two cases of immunocompetent patients with long-standing, progressively enlarging parotid swelling. Postoperative histopathological examination of these patients revealed features of BLEC. CONCLUSION: Wide surgical excision is the gold standard for treatment and recurrences is rare. These cases are of particular interest because of the rarity of BLEC in HIV-negative patients and highlight an important differential diagnosis of parotid swelling.

Kaposi Sarcoma of the Penis in an HIV-Negative Patient

2011 ◽  
Vol 15 (2) ◽  
pp. 118-120 ◽  
Author(s):  
Roberto Cecchi ◽  
Michela Troiano ◽  
Maurizia Ghilardi ◽  
Laura Bartoli
Keyword(s):  
Unusual Case ◽  
Kaposi Sarcoma ◽  
Unusual Site ◽  
Case Presentation ◽  
Negative Patient ◽  
Immunodeficiency Virus ◽  
Nodular Lesions ◽  
Immunocompetent Patients ◽  
Hiv Negative

Background: The penis is an unusual site of presentation for Kaposi sarcoma, especially in immunocompetent patients. Case Presentation: A 52-year-old human immunodeficiency virus (HIV)-seronegative man presented with a reddish, 8 mm in diameter nodule on the glans penis near the coronal sulcus. Histopathology after excision of the lesion was consistent with Kaposi sarcoma. No other cutaneous or mucosal manifestations were present. After a follow-up period of 2 years, no recurrence was observed. Conclusion: This unusual case suggests that Kaposi sarcoma should be considered in the differential diagnosis of macular, papular, and nodular lesions involving the penis.

scholarly journals Plasmablastic Lymphoma Mimicking Acute Pancreatitis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Faisal Inayat ◽  
Hafeez Ul Hassan Virk ◽  
Ahmad R. Cheema ◽  
Muhammad Wasif Saif
Keyword(s):  
Acute Pancreatitis ◽  
Histopathological Examination ◽  
Plasmablastic Lymphoma ◽  
Hiv Positive ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Rna In Situ Hybridization ◽  
Epstein Barr

Background.Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm. It predominantly occurs in the oral cavity of human immunodeficiency virus (HIV)-positive patients and exhibits a highly aggressive clinical behavior.Case Presentation.We describe an unusual case of a 37-year-old HIV-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts. The neoplastic cells were positive for BOB1 and MUM1, partially positive for CD79a, and negative for CD20, CD56, CD138, CD3, CD5, AE1/AE3, and HHV8. Epstein-Barr virus-encoded RNA in situ hybridization was positive. These features were consistent with PBL. The patient was initiated on cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy, demonstrating a striking response.Conclusion.To our research, this is the first report of PBL with the initial presentation of acute pancreatitis. The findings in this case suggest that PBL should be included in the differential diagnosis of pancreatic and peripancreatic tumors.

scholarly journals Pulmonary Malakoplakia by Rhodococcus equi in an HIV-Infected Patient in Mexico: A Case Report

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Victor H. Ahumada ◽  
Ivan Ortiz-Monasterio ◽  
Jose L. Hernandez ◽  
Amy B. Peralta
Keyword(s):  
Infected Patient ◽  
Susceptibility Testing ◽  
Rare Condition ◽  
Mortality Rates ◽  
Rhodococcus Equi ◽  
Case Presentation ◽  
Immunodeficiency Virus ◽  
Pathologic Findings ◽  
Immunocompetent Patients ◽  
Inflammatory Tissue

Background. Rhodococcus equi-related pulmonary malakoplakia is a rare condition with few reported cases; hereby, we present a case associated with advanced human immunodeficiency virus (HIV) infection, and thus far to our knowledge, the first report in Mexico. It is estimated that approximately 10% of the infections occur in immunocompetent patients, whereas the rest are immune deficient, targeting virtually any organ. Histologically, malakoplakia is characterized by the buildup of infiltrated inflammatory tissue as a consequence of the gathering of histiocytes embedded with concentric inclusions. The diagnosis relies on the cultures and the susceptibility testing as well as the pathologic findings compatible with the disease. Case Presentation. We present a 25-year-old male patient with persistent nonproductive cough for over a year and with weight loss, who comes to the emergency department with recent fever, swollen and tender lymph nodes, and hemoptysis. The patient gets diagnosed and treated for Rhodococcus equi-related pulmonary malakoplakia. Conclusion. Knowing the involvement of Rhodococcus in HIV is fundamental for the diagnosis and optimal treatment, which although unknown, a combination of antibiotics with intracellular penetration, on-time resection, and a proper immune reconstitution represents the best approach. Prognosis varies with mortality rates from 34% to 54%.

TRICHILEMMAL CYST OF THE THIRD FINGERTIP: A CASE REPORT

Hand Surgery ◽  
2014 ◽  
Vol 19 (01) ◽  
pp. 131-133 ◽  
Author(s):  
Cenk Melikoglu ◽  
Fikret Eren ◽  
Barış Keklik ◽  
Cem Aslan ◽  
Mustafa Sutcu ◽  
...  
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Hair Follicles ◽  
Nodular Lesion ◽  
Case Presentation ◽  
The Third ◽  
Trichilemmal Cyst ◽  
Common Skin

Introduction: Trichilemmal cysts (TCs) are common skin lesions that occur in hairy areas. A TC involving a fingertip has not been previously described in the literature. We herein report a case of a TC occupying a fingertip region. Case presentation: A 43-year-old woman presented with a 1.5 × 1.5 cm nodular lesion on the third fingertip. The lesion was completely excised, and histopathological examination revealed a TC. Conclusion: TCs may involve atypical locations, such as fingertips, where there are no hair follicles. After surgical excision, a careful histopathological examination should be performed to differentiate TCs from proliferating pilar tumors.

scholarly journals Testicular Plasmablastic Lymphoma in an HIV-Negative Patient: A Rare Case Presentation

2021 ◽  
Vol 9 ◽  
pp. 232470962110174
Author(s):  
Kemnasom Nwanwene ◽  
Noman Ahmed Jang Khan ◽  
Mohamed Alsharedi
Keyword(s):  
Rare Case ◽  
B Cell Lymphoma ◽  
Plasmablastic Lymphoma ◽  
Case Presentation ◽  
Negative Patient ◽  
Left Testicle ◽  
Positron Emission ◽  
Immunodeficiency Virus ◽  
Tomography Scan ◽  
Hiv Negative

Plasmablastic lymphoma (PBL) is a very rare disease and it is usually considered a human immunodeficiency virus (HIV)–related B-cell lymphoma that carries a poor prognosis. It mostly involves the oral cavity, lungs, nasal cavity, gastrointestinal tract, lymph node, and skin. Therapeutic regimens like dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (DA-EPOCH) have shown better results in these aggressive lymphomas. We report a rare case of PBL in an HIV-negative patient who presented to the clinic with a complaint of left testicular swelling for 3 months. Ultrasound showed an enlarged left testicle. He underwent a left orchiectomy and the pathology showed PBL with involvement of the spermatic cord margin. Positron emission tomography scan showed hypermetabolic mediastinal and hilar lymph nodes. He was started on DA-EPOCH but showed no response. Accordingly, salvage therapy with bortezomib in addition to ifosfamide carboplatin and etoposide (B-ICE) chemotherapy was initiated with remarkable response. Several other regimens can be used in the refractory setting; however, the evidence is mostly based on retrospective analysis.

scholarly journals Congenital orbital teratoma: A case report

2020 ◽  
Vol 9 ◽  
pp. 9
Author(s):  
Ahmed Raza ◽  
Asma Mushtaq ◽  
Seema Qayyum ◽  
Fiza Azhar ◽  
Ahmad Imran ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Cystic Teratoma ◽  
Surgical Excision ◽  
Unusual Site ◽  
Case Presentation ◽  
Neonatal Life ◽  
Complete Surgical Excision ◽  
Sacrococcygeal Region ◽  
The Right ◽  
Unilateral Proptosis

Background: Teratoma originates from all three germinal layers and commonly found at the sacrococcygeal region. The orbit is an unusual site of occurrence, but they grow rapidly and cause massive proptosis. Case Presentation: A 9-day-old female neonate presented with marked unilateral proptosis of the right eye. Imaging workup gave a suspicion of a complex mass with internal hemorrhage or a teratoma. Modified exenteration was performed. Histopathological examination revealed mature cystic teratoma. Conclusion: Orbital teratoma presents with marked disfiguring proptosis in neonatal life. Prompt complete surgical excision is curative in the case of mature lesions.

scholarly journals Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

2021 ◽  
Author(s):  
Tomoyuki Otani ◽  
Kosuke Murakami ◽  
Masatomo Kimura ◽  
Mitsuru Matsuki ◽  
Takao Satou ◽  
...  
Keyword(s):  
Endometrial Biopsy ◽  
Plasmablastic Lymphoma ◽  
Mri Findings ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Negative Woman ◽  
Epstein Barr ◽  
Abnormal Vaginal Bleeding ◽  
Hiv Negative

Abstract Background Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma in the uterus is rare. Here we report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. Case presentation A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasms and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein–Barr virus was detected in a small number of cells. The histological picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. Conclusions This case underscores the sometimes blurry distinction between benign inflammation and lymphomas.

scholarly journals Concurrence of talaromycosis and Kaposi sarcoma in a HIV-infected Patient: A case report

2020 ◽  
Author(s):  
Feifei Su ◽  
Xingguo Miao ◽  
Hui Ye ◽  
Shoufeng Yang
Keyword(s):  
Fungal Pathogen ◽  
Histopathological Examination ◽  
Management Strategies ◽  
Kaposi Sarcoma ◽  
Vascular Tumor ◽  
Hiv Positive ◽  
Comorbid Conditions ◽  
Successful Management ◽  
Case Presentation ◽  
Immunodeficiency Virus

Abstract Background: Concurrence of talaromycosis, an opportunistic infection caused by the fungal pathogen Talaromyces marneffei and Kaposi sarcoma, a common vascular tumor in patients infected with human immunodeficiency virus (HIV) has only been rarely reported. Despite poor outcome, clinical characteristics and management strategies for HIV-infected patients with comorbid Kaposi sarcoma and talaromycosis has not been very well described.Case presentation: A 33-year-old, HIV-positive male patient presented to the Department of Infectious Diseases at Wenzhou Central Hospital with cough, sputum expectoration, hemoptysis, rashes on the feet and violaceous plaques in the oral cavity. Chest computed tomography (CT) showed bilateral nodular, patchy shadows and lymphadenectasis. Skin biopsy and histopathological examination indicated Kaposi sarcoma. T. marneffei was isolated from blood cultures and suggested talaromycosis. The patient’s conditions significantly improved following initiation of antiretroviral therapy and chemotherapy for Kaposi sarcoma in combination with antifungal treatment for talaromycosis.Conclusions: Severe medical conditions such as Kaposi sarcoma and talaromycosis may coexist in HIV-infected patients and pose a high mortality risk. Etiological diagnosis and treatment are the key to successful management of HIV-infected patients who has severe comorbid conditions.

scholarly journals Adult pancreatic cavernous hemangioma: case presentation of a benign tumor with a complex composition

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Lianyuan ◽  
Wang Yafeng ◽  
Yu Haibo ◽  
Dong Yadong ◽  
Ma Jiahao ◽  
...  
Keyword(s):  
Cavernous Hemangioma ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Complex Composition ◽  
Ki 67 ◽  
Case Presentation ◽  
Multilocular Cyst ◽  
Imaging Examination ◽  
Upper Abdominal

Abstract Background Pancreatic cavernous hemangioma is an extremely rare benign tumor that is difficult to diagnose on an imaging examination, and its histopathological examination has rarely been reported. Case presentation Herein, we present the case of a 63-year-old man who was admitted to the hospital due to left upper abdominal pain and defecation unformed for more than 2 years. None of the positive results obtained from the physical examination could explain his symptoms. The imaging examination indicated a multilocular cyst with septa in the head of the pancreas. The patient underwent a pancreaticoduodenectomy, and the pathologic diagnosis was pancreatic cavernous hemangioma. The histopathological examination showed that the lesion was positive for benign vascular markers, such as CD31, CD34 and F8, and negative for lymphocyte markers, such as D2–40. Moreover, it was also positive for ERG and cytokeratin markers, CAM5.2 and AE1/AE3, indicating the complexity of its components, and Ki-67 negativity revealed its benign nature. Conclusions Pancreatic cavernous hemangioma has a complex composition that may be reflected not only in the imaging examination but also in the immunohistochemical detection, and it may achieve a good outcome by surgical excision.

scholarly journals Schwannoma Located in Nasopharyngeal Region

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Fadlullah Aksoy ◽  
Alper Yenigun ◽  
Erol Senturk ◽  
Orhan Ozturan
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Neck Region ◽  
Case Presentation ◽  
Head And Neck Region ◽  
Nerve Sheath ◽  
Swallowing Difficulties ◽  
First Time ◽  
Slow Growing

Schwannoma is a tumor which has neuroectoderm origins, is hard, well-circumscribed, encapsulated, and slow growing benign cranial tumor, and may autonomously grow out of the nerve sheath of peripheral nerves. It is mostly seen in the head and neck region. In the paranasal sinus and nose areas, it is seen at a rate of 4%. The diagnosis is mostly made after histopathological examination. In this paper, a Schwannoma case observed in the nasopharyngeal region was presented in a 20-year-old female who had complaints of sleeping with open mouth, snoring, foreign body feeling in throat, and swallowing difficulties. The tumor was extracted via transoral approach. No recurrence was observed during follow-up over the next year. This case presentation is presented for the first time in the literature in English.

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