Speech performance in adult patients undergoing Invisalign treatment:

ABSTRACT Objectives To assess speech performance of adult patients undergoing orthodontic treatment with Invisalign. Materials and Methods Twenty-four adult patients with Invisalign (Invisalign group: 6 men, 18 women; average age; 34.88 years) and 20 adult patients with fixed labial appliances (fixed group: 5 men, 15 women; average age; 38.85 years) were evaluated. Speech was recorded immediately before delivery of the first set of clear aligners or bonding of labial appliances (T0), immediately after delivery or bonding (T1), and 2 months after delivery or bonding (T2). Speech was evaluated via a combination of three auditory analyses: (1) objective acoustic analysis through digital sonography, (2) semiobjective assessment by six speech and language pathologists, and (3) subjective assessment patient questionnaire. Results The objective acoustic analysis showed a statistically significant difference over time from T0 to T1, T1 to T2, and T0 to T2 for Invisalign patients. The semiobjective analysis revealed a significant speech alteration from T0 to T1 and T1 to T2 for both groups, and from T0 to T2 in the Invisalign group. The subjective analysis showed a significant difference between means of Invisalign and fixed group patient perception at both T1 and T2. Conclusions Invisalign treatment significantly affected speech, and although patients experience some level of adaptation, speech does not return to normal after 2 months of treatment.

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The analysis of the subjective image quality of a dental radiogram obtained with a digital and film detector

Radiološke tehnologije ◽

10.48026/isnn.26373297.2020.11.1.5 ◽

2020 ◽

Vol 11 (1) ◽

pp. 30-34

Author(s):

Ermina Sadiković ◽

Adnan Beganović ◽

Fuad Julardžija ◽

Adnan Šehić ◽

Samir Tatarovac ◽

...

Keyword(s):

Image Quality ◽

New Technologies ◽

Subjective Assessment ◽

Dental Radiology ◽

Low Contrast ◽

Subjective Analysis ◽

Significant Difference ◽

Radiological Image ◽

Radiological Procedures

Introduction: Today film-based technologies are largely abandoned in dental radiology. New technologies based on digital detectors are being adopted. This change is part of the global digitalization of radiological procedures. A person operating the radiological device needs to be educated and well informed about radiological procedures and technologies, as well as to know how the system operates and to be sure about the dose required for the adequate image quality. The awareness of radiation doses received by patients is necessary for the estimation of risk from ionizing radiation.Material and methods: The aim of this study was to evaluate whether patient doses in intraoral dental radiology affect image quality. The study included subjective analysis of radiological image quality for an intraoral x-ray device with possibility to use both digital and film detector. Subjective assessment of image quality is performed according to criteria taken from the literature and is expressed using the Likert scale, grade 1–5. In order to improve the quality of inferential statistics related ratings to detector quality and image quality were collected, thus introducing two variables: the detector quality index and the technique quality index.Results: Z-test proportions column shows that the number of grades four given as a contrast score is significantly higher in the RVG detector (65%) compared to the film (40%). There is also a significant difference in the number of given grades five as a rating of the apex preview. The share of grades five in film is 19%, while in RVG it is 42%. It is similar in the evaluation of the preview of the dental canal, where there is also a significant difference in the number of given grades five, so that the share in the film is 11% and in RVG 35%.Conclusion: Analysis of the subjective quality of the radiological image in devices for intraoral radiography with the possibility of recording using digital and film detectors indicates that the digital detector is superior to film in low contrast resolution, apex and dental canal preview.

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Association of Health Insurance Status with Outcomes of Sepsis in Adult Patients: A Retrospective Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18115777 ◽

2021 ◽

Vol 18 (11) ◽

pp. 5777

Author(s):

Gaon-Sorae Wang ◽

Kyoung-Min You ◽

You-Hwan Jo ◽

Hui-Jai Lee ◽

Jong-Hwan Shin ◽

...

Keyword(s):

Health Insurance ◽

Propensity Score ◽

Hospital Mortality ◽

Cohort Analysis ◽

Adult Patients ◽

Multivariate Logistic Regression Model ◽

Insurance Status ◽

Matched Cohort ◽

Health Insurance Status ◽

Significant Difference

(1) Background: Sepsis is a life-threatening disease, and various demographic and socioeconomic factors affect outcomes in sepsis. However, little is known regarding the potential association between health insurance status and outcomes of sepsis in Korea. We evaluated the association of health insurance and clinical outcomes in patients with sepsis. (2) Methods: Prospective cohort data of adult patients with sepsis and septic shock from March 2016 to December 2018 in three hospitals were retrospectively analyzed. We categorized patients into two groups according to their health insurance status: National Health Insurance (NHI) and Medical Aid (MA). The primary end point was in-hospital mortality. The multivariate logistic regression model and propensity score matching were used. (3) Results: Of a total of 2526 eligible patients, 2329 (92.2%) were covered by NHI, and 197 (7.8%) were covered by MA. The MA group had fewer males, more chronic kidney disease, more multiple sources of infection, and more patients with initial lactate > 2 mmol/L. In-hospital, 28-day, and 90-day mortality were not significantly different between the two groups and in-hospital mortality was not different in the subgroup analysis. Furthermore, health insurance status was not independently associated with in-hospital mortality in multivariate analysis and was not associated with survival outcomes in the propensity score-matched cohort. (4) Conclusion: Our propensity score-matched cohort analysis demonstrated that there was no significant difference in in-hospital mortality by health insurance status in patients with sepsis.

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Association of Interatrial Septal Abnormalities with Cardiac Impulse Conduction Disorders in Adult Patients: Experience from a Tertiary Center in Kosovo

Heart International ◽

10.4081/hi.2011.e4 ◽

2011 ◽

Vol 6 (1) ◽

pp. hi.2011.e4 ◽

Cited By ~ 3

Author(s):

Aurora Bakalli ◽

Ejup Pllana ◽

Dardan Koçinaj ◽

Tefik Bekteshi ◽

Gani Dragusha ◽

...

Keyword(s):

Adult Patients ◽

Impulse Conduction ◽

Conduction Disorders ◽

Cardiac Impulse ◽

Tertiary Center ◽

Patients Experience

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Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities in Adults After Gemcitabine-Based Chemotherapies

Journal of Clinical Oncology ◽

10.1200/jco.2009.24.4491 ◽

2010 ◽

Vol 28 (1) ◽

pp. 160-165 ◽

Cited By ~ 86

Author(s):

Joseph Ciccolini ◽

Laetitia Dahan ◽

Nicolas André ◽

Alexandre Evrard ◽

Muriel Duluc ◽

...

Keyword(s):

Drug Exposure ◽

Cytidine Deaminase ◽

Residual Activity ◽

Predictive Marker ◽

Adult Patients ◽

Functional Testing ◽

Simple Test ◽

Increased Risk ◽

Significant Difference ◽

Patients At Risk

Purpose Anticipating toxicities with gemcitabine is an ongoing story, and deregulation in cytidine deaminase (CDA) could be associated with increased risk of developing early severe toxicities on drug exposure. Patients and Methods A simple test to evaluate CDA phenotypic status was first validated in an animal model investigating relationships between CDA activity and gemcitabine-related toxicities. Next, relevance of this test as a marker for toxicities was retrospectively tested in a first subset of 64 adult patients treated with gemcitabine alone, then it was tested in a larger group of 130 patients who received gemcitabine either alone or combined with other drugs and in 20 children. Additionally, search for the 435 T>C, 208 G>A and 79 A>C mutations on the CDA gene was performed. Results In mice, CDA deficiency impacted on gemcitabine pharmacokinetics and had subsequent lethal toxicities. In human, 12% of adult patients experienced early severe toxicities after gemcitabine administration. A significant difference in CDA activities was observed between patients with and without toxicities (1.2 ± 0.8 U/mg v 4 ± 2.6 U/mg; P < .01). Conversely, no genotype-to-phenotype relationships were found. Of note, the patients who displayed particularly reduced CDA activity all experienced strong toxicities. Gemcitabine was well tolerated in children, and no CDA deficiency was evidenced. Conclusion Our data suggest that CDA functional testing could be a simple and easy marker to discriminate adult patients at risk of developing severe toxicities with gemcitabine. Particularly, this study demonstrates that CDA deficiency, found in 7% of adult patients, is associated with a maximum risk of developing early severe toxicities with gemcitabine.

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In situ acoustic analysis of two twentieth-century heritage carillons

Heritage Science ◽

10.1186/s40494-021-00482-8 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Scott Allan Orr

Keyword(s):

Twentieth Century ◽

Acoustic Analysis ◽

Mechanical Action ◽

Ex Situ ◽

Physical Acoustics ◽

Acoustic Characteristics ◽

Dynamic Level ◽

Significant Difference ◽

And Function

AbstractCarillons are a diverse and global form of musical and civic heritage: musical instruments comprised of a series of 23 or more bells, typically hung in a tower-like structure, tuned chromatically and played from a touch-sensitive manual and pedal console using an elaborate mechanical action. Carillon bells have a distinct series of musical overtones which should be accurately tuned to one another and with other bells they sound alongside. Although these overtones have been previously studied ex situ, this study assesses the acoustic characteristics of two early-twentieth century carillons in Toronto, Canada as a combination of structure, bells, and mechanical action. Thus, the instrument and its context are considered holistically, more accurately reflecting the musical sensitivity of a carillonist. Spectral analysis of audio samples of each bell at different musical dynamic levels enabled the analysis of the acoustic qualities of the bells and the mechanical action of the instruments. The tuning of bells in the instruments varied; most importantly, there was a significant difference between the audial intensity of the bell tones produced by the instruments, demonstrating the importance of the mechanical action as part of the ‘carillon system’. This was represented with a resistive power-law model, that represents the sensitivity of intensity to carillonist musical dynamic level. A discussion of the implications for artistic and heritage practice follows. Understanding the in situ physical acoustics of the carillon as a holistic instrument in its context informs performers, arrangers, and composers of how they can best embrace the instrument’s unique qualities to improve artistic pursuits and support the appreciation of carillons as heritage instruments and function as civic voices.

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Determining the efficiency of the Imatinib mesylate and monitoring of relapse and emergence of IM resistance in Algerian adult patients with Chronic Myeloid Leukaemia

South Asian Journal of Experimental Biology ◽

10.38150/sajeb.8(3).p103-108 ◽

2019 ◽

Vol 8 (3) ◽

pp. 103-108

Author(s):

Amel Sebaa ◽

Mustapha Diaf ◽

Sakina Cherif Touil

Keyword(s):

Chronic Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Imatinib Mesylate ◽

Second Generation ◽

Adult Patients ◽

Second Line ◽

Second Line Therapy ◽

Molecular Responses ◽

Line Therapy ◽

Significant Difference

Imatinib mesylate (IM) shows remarkable clinical activity in patients with Chronic Myeloid Leukaemia (CML). Patients who fail to respond to IM or those who lose their response should be treated with second-generation tyrosine kinase inhibitors (TKIs). The aim of this study was to determine the efficiency of the Indian IM generic (Imatib*CIPLA), and to monitor relapse and emergence of IM resistance. Two hundred and seven adult patients from the Northwestern region of Algeria were diagnosed as CML in chronic phase (CP) and were treated with an Indian generic of IM at 400 mg/day. The IM 600 mg treatment and second-line therapy were prescribed after failure of treatment. Molecular Analysis was performed and BCR-ABL/ABL ratios were determined and standardised according to the international scale using 0.47 as conversion factor. Our findings showed a significant difference in major molecular response (MMR) for patients treated with IM 600 mg compared to IM 400 mg (51.7% vs. 37.6%, p<0.001). In the second line therapy group, there was a significant improvement of MR4.5 compared to the IM group (7.7% vs. 32.6%, p=0.039). Likewise, no significant relationship was found between the median duration of second-generation TKIs deep response and IM 400 mg/day regarding the MR4 (11 vs. 26.5 months, p=0.107) and MR4.5 (20 vs. 32.5 months, p=0.203). The Indian IM generic molecule (Imatib*CIPLA), has shown its efficiency in achieving major and deep molecular responses. Patients treated with the second-generation TKIs showed deep molecular responses with fewer relapses in a shorter median time than those treated with IM.

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Evaluation and Quantification of Cytomorphometry in Conjunction with Visual Examination and Exfoliative Cytology in Early Diagnosis of Oral Premalignant and Malignant Lesions

Acta Cytologica ◽

10.1159/000518582 ◽

2021 ◽

pp. 1-7

Author(s):

Vasudha Singh ◽

Mudita Bhargava ◽

Kachnar Varma ◽

Vatsala Misra ◽

Richa Singh

Keyword(s):

Tertiary Hospital ◽

Accurate Diagnosis ◽

Exfoliative Cytology ◽

Visual Examination ◽

Normal Cytology ◽

Subjective Analysis ◽

Oral Epithelial Dysplasia ◽

Significant Difference ◽

Potentially Malignant ◽

Malignant Lesions

Introduction: Incidence of oral epithelial dysplasia and oral squamous cell carcinoma (SCC) is very high in south Asian countries as compared to western population owing to a greater use of tobacco in these regions. While visual examination and exfoliative cytology are the most common screening and diagnostic modalities at present, it is a subjective analysis. Quantitative analyses such as nuclear size, cell size, and nuclear-to-cytoplasmic ratio may provide an accurate diagnosis and improve reproducibility. The aim of the study was to evaluate the role of morphometry as a diagnostic adjunct to exfoliative cytology and to derive a significant cutoff to identify the population at risk for development of SCC among chronic tobacco users. Material and Methods: This was an outpatient-based prospective study done in a tertiary hospital over a period of 2 years. Hundred and fifty cases with a history of chronic tobacco use for a minimum period of 5 years were evaluated. Visual inspection using acetic acid was done. Oral scrapes were taken for cytological and morphometric analysis followed by incision biopsy for histopathological evaluation, wherever possible. Results: On morphometrical analysis, mean nuclear area and nuclear:cytoplasmic (N:C) ratio increased, while the cytoplasmic area decreased from smears with normal cytology to oral dysplasia to SCC. Analysis of variance and post hoc Tukey’s honest significant difference test showed a statistically significant difference among the 3 groups (p value <0.05). A cutoff value for a significant N:C ratio was calculated as ≥0.08 using Youden’s index with a sensitivity and a specificity of 88% and 94%, respectively. Conclusion: In high-risk cases, morphometry can be a useful adjunct to exfoliative cytology and visual examination for an early and accurate diagnosis and timely intervention in oral potentially malignant and malignant lesions, thereby improving the prognosis.

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PREVALENCE OF MANDIBULAR ASYMMETRY IN SKELETAL CLASS I ADULT PATIENTS

Journal of Research in Dentistry ◽

10.19177/jrd.v2e22014189-97 ◽

2014 ◽

Vol 2 (2) ◽

pp. 189 ◽

Cited By ~ 6

Author(s):

Bruno Frazão Gribel ◽

Guilherme Thiesen ◽

Tássia Silvana Borges ◽

Maria Perpétua Mota Freitas

Keyword(s):

Computed Tomography ◽

Calculation Method ◽

Significant Error ◽

Adult Patients ◽

Class I ◽

Cone Beam ◽

Skeletal Class ◽

Mandibular Asymmetry ◽

Computed Tomography Images ◽

Significant Difference

AIM: The objective of this study was evaluating the prevalence of mandibular asymmetry in skeletal Class I adult patients. MATERIALS AND METHODS: The sample was composed by cone-beam computed tomography images of 250 skeletal Class I patients with age from 18 to 70 years old. The side deviation of mandibular asymmetry was evaluated (right and left), as well as the intensity of this asymmetry. People with gnathic deviation until 2mm were considered as patients with slight asymmetry; deviation between 2 and 5mm was considered moderate asymmetry and those higher than 5mm as severe asymmetries. The error calculation method was performed and there was not significant error in the measurements. To verify the association between the prevalence of mandibular asymmetry and the gender of individuals, the Χ2 was carried out and the significant level adopted was 5% (p<0.05). RESULTS: The results showed that mandibular deviation occurred more frequently to the left side in both genders (male 56.5% e female 58.2%), without statistically significant difference between them (p=0.792). Besides, the prevalence of slight, moderate and severe asymmetries were, respectively 61%, 27% and 12% for males and 54%, 28% and 18% for female; and there was not statistically significant difference (p=0.366) between the gender of the sample evaluated. CONCLUSION: In this study, both deviation and intensity of mandibular asymmetry did not present preference regarding to the gender.

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Pengaruh Substitusi Tepung Kedelai terhadap Kualitas Biskuit

Media Wisata ◽

10.36276/mws.v16i2.279 ◽

2021 ◽

Vol 16 (2) ◽

Author(s):

Heni Susilowati ◽

Adi Prabowo

Keyword(s):

Sampling Technique ◽

Subjective Assessment ◽

Soy Flour ◽

P Value ◽

Homogeneity Test ◽

Soybean Flour ◽

Normality Test ◽

Significant Difference ◽

Different Types ◽

Sensory Tests

The research entitled The Effect of Substitution of Soybean Flour on Biscuit Quality is a type of research using a quantitative approach with an experimental method. The purpose is to know the effect of quality biscuits with soybean flour substitution with a different percentage that is equal to 50%, 25% and 10% viewed from the aspect of colour, flavour, aroma and texture. The experiments used 3 different types of treatment on the percentage of soy flour used ie, biscuit A with 50% soy flour, biscuit B with 25% soy flour, and C biscuits with 10% soy flour. Methods of data collection using subjective assessment of sensory tests taken from the results of a panellist assessment that includes assessment of colour, aroma, taste and texture on biscuits. The panel of researchers was 30 people taken by random sampling technique with considerations that included panellist knowledge about the sensory properties of biscuits in general. Methods of data analysis to test the hypothesis using the analysis of single classification variables and Tukey test, previously conducted precariat test that is homogeneity test and normality test. The result of the research with Anova test seen from the color aspect shows that (significant value (p-value) <0,05 = 0,000 <0,05) shows that there is significant difference from three substitution biscuit substitution biscuit, while from aroma aspect shows significant (p-value) <0,05 = 0,008 <0,05) indicated that there were significant differences from the three soybean substitution biscuit samples. Seen from the texture aspect showed (significant value (p-value) <0,05 = 0,000 <0,05) indicated that there was significant difference from three sample of soybean substitution biscuit. In terms of taste taste (significant value (p-value) <0.05 = 0.005 <0.05) indicates that there are significant differences from the three soybean substitution biscuit samples.

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An Acoustic Study of Communication Apprehension during English Oral Presentations by Japanese University Students

English Language Teaching ◽

10.5539/elt.v13n8p178 ◽

2020 ◽

Vol 13 (8) ◽

pp. 178

Author(s):

Hiroko Nakamura ◽

Kazuhiro Nomura ◽

Namie Saeki

Keyword(s):

University Students ◽

Acoustic Analysis ◽

Communication Apprehension ◽

Oral Communication ◽

Oral Performance ◽

Speech Anxiety ◽

Actual Performance ◽

Japanese University ◽

Significant Difference ◽

English Major

This study investigated the influence of communication apprehension and anxiety in second-language (L2) learning on oral performance of Japanese university students in terms of F0 (fundamental frequency) analysis. The participants were English-major students (3 males and 6 females) who presented at an oral communication festival for university students. The F0 analysis consisted of a mean F0 and F0 range. The participants’ utterances were digitized and analysed with Praat. Participants also completed two structured closed-ended questionnaires: a Personal Report of Communication Apprehension (PRCA) and a Foreign Language Classroom Anxiety Scale (FLCAS). One subscale of PRCA is Speech Anxiety (SA) that measures apprehension in public speaking. Acoustic analysis of F0 was conducted of the utterances provided by the students and their F0 data during rehearsal and the actual performance settings. The results revealed a significant difference in mean F0 between the rehearsal and actual performance. Mean F0 was significantly correlated with SA. These results suggest that students tend to show higher speech anxiety during an actual performance setting that is also reflected by a higher speaking F0.

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