Role of Matrix Metalloproteinases in Extracellular Matrix Disintegration of Meckel’s Cartilage in Mice

2010 ◽  
Vol 52 (2) ◽  
pp. 143-149
Author(s):  
Yasunori Sakakura
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage

scholarly journals Immunolocalization of Proteoglycans in Meckel’s Cartilage of the Rat

2009 ◽  
Vol 3 (1) ◽  
pp. 177-183 ◽  
Author(s):  
Khansa Taha Ababneh ◽  
Taiseer Hussain Al-Khateeb
Keyword(s):  
Extracellular Matrix ◽  
Core Protein ◽  
Polyclonal Antibodies ◽  
Immunoperoxidase Technique ◽  
Paraffin Sections ◽  
Exact Role ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage ◽  
Indirect Immunoperoxidase

The aim of this study was to investigate the presence and distribution of proteoglycans within Meckel’s cartilage of rat embryos. A standard indirect immunoperoxidase technique was used on paraffin sections of rat heads. Sections were incubated with monoclonal antibodies recognising core protein epitopes in the proteoglycans versican and CD44. Polyclonal antibodies localized the proteoglycans decorin, biglycan and lumican. Versican was expressed by chondrocytes, but very weekly by the extracellular matrix. Decorin was strongly expressed by both of chondrocytes and the ECM. Both of biglycan and lumican were moderately expressed by chondrocytes, but weakly by the extracellular matrix. CD44 was weakly expressed by chondrocytes only, without staining of the ECM. It is concluded that Meckel’s cartilage chondrocytes express the proteoglycans versican, decorin, biglycan, lumican and CD44 at variable levels during development in the rat. Such data are important for a greater understanding of the changes that take place during mandibular development. Further studies are needed to elucidate the exact role of proteoglycans during Meckel’s cartilage and mandibular organogenesis.

Molecular regulation of cellular invasion— role of gelatinase A and TIMP-2

1996 ◽  
Vol 74 (6) ◽  
pp. 823-831 ◽  
Author(s):  
Anita E. Yu ◽  
Robert E. Hewitt ◽  
David E. Kleiner ◽  
William G. Stetler-Stevenson
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Gelatinase A ◽  
Cellular Mechanisms ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
The Matrix ◽  
Cell Matrix Interactions

Extracellular matrix (ECM) turnover is an event that is tightly regulated. Much of the coordinate (physiological) or discoordinate (pathological) degradation of the ECM is catalyzed by a class of proteases known as the matrix metalloproteinases (MMPs) or matrixins. Matrixins are a family of homologous Zn atom dependent endopeptidases that are usually secreted from cells as inactive zymogens. Net degradative activity in the extracellular environment is regulated by specific activators and inhibitors. One member of the matrixin family, gelatinase A, is regulated differently from other MMPs, suggesting that it may play a unique role in cell–matrix interactions, including cell invasion. The conversion from the 72 kDa progelatinase A to the active 62 kDa species may be a key event in the acquisition of invasive potential. This discussion reviews some recent findings on the cellular mechanisms involved in progelatinase A activation and, in particular, the role of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) and transmembrane containing metalloproteinases (MT-MMP) in this process.Key words: tissue inhibitors of metalloproteinases, metalloproteinase, gelatinases, extracellular matrix, activation.

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 ◽  
Vol 7 (15) ◽  
pp. 1434-1441 ◽  
Author(s):  
William G. Stetler‐Stevenson ◽  
Lance A. Liotta ◽  
David E. Kleiner
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Tumor Invasion ◽  
Invasion And Metastasis

scholarly journals The role of matrix metalloproteinases in glaucoma pathogenesis

2015 ◽  
Vol 8 (3) ◽  
pp. 28-43 ◽  
Author(s):  
Inessa Stanislavovna Beletskaya ◽  
Sergey Yurievich Astakhov
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Clinical Investigation ◽  
Experimental Studies ◽  
Glaucomatous Optic Neuropathy ◽  
Connective Tissues ◽  
Activity Impairment ◽  
Extracellular Matrix Components ◽  
The Impact

Matrix metalloproteinases belong to an enzyme family, which assure a proteolysis of practically all components of the extracellular matrix of connective tissues in normal and pathological conditions. At physiological conditions, there are evidences on the impact of this enzyme group in the embryogenesis, morphogenesis, angiogenesis, and tissue involution. The activity impairment of matrix metalloproteinases and of their specific inhibitors leads to the biosynthesis misbalance and to the degradation of extracellular matrix components; it plays a role in the development of such diseases as diabetes mellitus, rheumatoid arthritis, and arteriosclerosis. Laboratory tests and clinical investigation results confirm the role of these enzymes in tissue remodeling of different eyeball structures in glaucoma (in particular, of the trabecular meshwork and the optic disc); it leads to intraocular fluid outflow impairment and to the glaucomatous optic neuropathy development. In the review, the analysis of clinical and experimental studies is performed that are dedicated to the investigation of matrix metalloproteinases role in the pathogenesis of different glaucoma types, of the possibility to use them as biomarkers, as well as therapeutic action targets in this disease.

scholarly journals Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors

2005 ◽  
Vol 26 (13) ◽  
pp. 1333-1341 ◽  
Author(s):  
Olivier Fondard ◽  
Delphine Detaint ◽  
Bernard Iung ◽  
Christine Choqueux ◽  
Homa Adle-Biassette ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Aortic Valve ◽  
Matrix Metalloproteinases ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Tissue Inhibitors ◽  
Extracellular Matrix Remodelling ◽  
Human Aortic Valve

The role of matrix metalloproteinases in the mechanisms of organ damage in sepsis

2015 ◽  
Vol 51 (2) ◽  
pp. 131-138
Author(s):  
Jarosław Kuna ◽  
Anna Kuna ◽  
Marcin Dziedzic ◽  
Agnieszka Grafka ◽  
Marcin Łopucki ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Membrane Proteins ◽  
Matrix Metalloproteinases ◽  
Basement Membrane ◽  
Effective Treatment ◽  
Organ Damage ◽  
Cellular Damage ◽  
Main Subject ◽  
Cytokines And Chemokines

Understanding the mechanisms of the development of multi-organ damage constitutes the main subject of research in many renowned European centers. Until today, we failed to know neither all the mechanisms responsible for the development of sepsis nor to develop a fully effective treatment. A promising appears to be the inhibition of enzymes that are responsible for initiating the cascade of cellular damage. This applies mainly matrix metalloproteinases – enzymes involved in the degradation of basement membrane proteins and extracellular matrix and in regulating the activity of cytokines and chemokines.

scholarly journals The role of extracellular matrix metalloproteinases and their inhibitors in allergic diseases

2012 ◽  
Vol 5 ◽  
pp. 384-389 ◽  
Author(s):  
Andrzej Kuźmiński ◽  
Michał Przybyszewski ◽  
Małgorzata Graczyk ◽  
Zbigniew Bartuzi
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Allergic Diseases
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