scholarly journals The role of extracellular matrix metalloproteinases and their inhibitors in allergic diseases

2012 ◽  
Vol 5 ◽  
pp. 384-389 ◽  
Author(s):  
Andrzej Kuźmiński ◽  
Michał Przybyszewski ◽  
Małgorzata Graczyk ◽  
Zbigniew Bartuzi
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Allergic Diseases

Molecular regulation of cellular invasion— role of gelatinase A and TIMP-2

1996 ◽  
Vol 74 (6) ◽  
pp. 823-831 ◽  
Author(s):  
Anita E. Yu ◽  
Robert E. Hewitt ◽  
David E. Kleiner ◽  
William G. Stetler-Stevenson
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Gelatinase A ◽  
Cellular Mechanisms ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
The Matrix ◽  
Cell Matrix Interactions

Extracellular matrix (ECM) turnover is an event that is tightly regulated. Much of the coordinate (physiological) or discoordinate (pathological) degradation of the ECM is catalyzed by a class of proteases known as the matrix metalloproteinases (MMPs) or matrixins. Matrixins are a family of homologous Zn atom dependent endopeptidases that are usually secreted from cells as inactive zymogens. Net degradative activity in the extracellular environment is regulated by specific activators and inhibitors. One member of the matrixin family, gelatinase A, is regulated differently from other MMPs, suggesting that it may play a unique role in cell–matrix interactions, including cell invasion. The conversion from the 72 kDa progelatinase A to the active 62 kDa species may be a key event in the acquisition of invasive potential. This discussion reviews some recent findings on the cellular mechanisms involved in progelatinase A activation and, in particular, the role of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) and transmembrane containing metalloproteinases (MT-MMP) in this process.Key words: tissue inhibitors of metalloproteinases, metalloproteinase, gelatinases, extracellular matrix, activation.

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 ◽  
Vol 7 (15) ◽  
pp. 1434-1441 ◽  
Author(s):  
William G. Stetler‐Stevenson ◽  
Lance A. Liotta ◽  
David E. Kleiner
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Tumor Invasion ◽  
Invasion And Metastasis

scholarly journals The role of matrix metalloproteinases in glaucoma pathogenesis

2015 ◽  
Vol 8 (3) ◽  
pp. 28-43 ◽  
Author(s):  
Inessa Stanislavovna Beletskaya ◽  
Sergey Yurievich Astakhov
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinases ◽  
Clinical Investigation ◽  
Experimental Studies ◽  
Glaucomatous Optic Neuropathy ◽  
Connective Tissues ◽  
Activity Impairment ◽  
Extracellular Matrix Components ◽  
The Impact

Matrix metalloproteinases belong to an enzyme family, which assure a proteolysis of practically all components of the extracellular matrix of connective tissues in normal and pathological conditions. At physiological conditions, there are evidences on the impact of this enzyme group in the embryogenesis, morphogenesis, angiogenesis, and tissue involution. The activity impairment of matrix metalloproteinases and of their specific inhibitors leads to the biosynthesis misbalance and to the degradation of extracellular matrix components; it plays a role in the development of such diseases as diabetes mellitus, rheumatoid arthritis, and arteriosclerosis. Laboratory tests and clinical investigation results confirm the role of these enzymes in tissue remodeling of different eyeball structures in glaucoma (in particular, of the trabecular meshwork and the optic disc); it leads to intraocular fluid outflow impairment and to the glaucomatous optic neuropathy development. In the review, the analysis of clinical and experimental studies is performed that are dedicated to the investigation of matrix metalloproteinases role in the pathogenesis of different glaucoma types, of the possibility to use them as biomarkers, as well as therapeutic action targets in this disease.

scholarly journals Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors

2005 ◽  
Vol 26 (13) ◽  
pp. 1333-1341 ◽  
Author(s):  
Olivier Fondard ◽  
Delphine Detaint ◽  
Bernard Iung ◽  
Christine Choqueux ◽  
Homa Adle-Biassette ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Aortic Valve ◽  
Matrix Metalloproteinases ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Tissue Inhibitors ◽  
Extracellular Matrix Remodelling ◽  
Human Aortic Valve

The role of matrix metalloproteinases in the mechanisms of organ damage in sepsis

2015 ◽  
Vol 51 (2) ◽  
pp. 131-138
Author(s):  
Jarosław Kuna ◽  
Anna Kuna ◽  
Marcin Dziedzic ◽  
Agnieszka Grafka ◽  
Marcin Łopucki ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Membrane Proteins ◽  
Matrix Metalloproteinases ◽  
Basement Membrane ◽  
Effective Treatment ◽  
Organ Damage ◽  
Cellular Damage ◽  
Main Subject ◽  
Cytokines And Chemokines

Understanding the mechanisms of the development of multi-organ damage constitutes the main subject of research in many renowned European centers. Until today, we failed to know neither all the mechanisms responsible for the development of sepsis nor to develop a fully effective treatment. A promising appears to be the inhibition of enzymes that are responsible for initiating the cascade of cellular damage. This applies mainly matrix metalloproteinases – enzymes involved in the degradation of basement membrane proteins and extracellular matrix and in regulating the activity of cytokines and chemokines.

scholarly journals THE ROLE OF MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORS IN THE DEVELOPMENT OF COMPLICATIONS OF KIDNEY DISEASE IN CHILDREN

2015 ◽  
Vol 14 (3) ◽  
pp. 35-39 ◽  
Author(s):  
G. A. Sukhanova ◽  
A. A. Terent’eva ◽  
N. N. Kuvshinov
Keyword(s):  
Extracellular Matrix ◽  
Renal Function ◽  
Kidney Disease ◽  
Matrix Metalloproteinases ◽  
Chronic Pyelonephritis ◽  
Chronic Glomerulonephritis ◽  
Acute Glomerulonephritis ◽  
Healthy Children ◽  
Tissue Inhibitors

The relevance of studying the role of matrix metalloproteinases (MMP) and tissue inhibitors (TIMP) in the pathology of the urinary system is determined, by the significant prevalence, prone to recurrent course of kidney disease in children. It is known that MMP-1 has pro-inflammatory action, MMP-2 and MMP-9 inhibits inflammation. TIMP-1 and TIMP-2 restricted cleavage of collagen. Disbalance between MMP and TIMP accompanied by the accumulation of extracellular matrix, increases the risk of chronic renal failure.The purpose of the study – to assess the role of MMP and TIMP involved in the processes of inflammation and resulting to renal dysfunction in glomerulonephritis and pyelonephritis in children.Material and methods. Surveyed of 15 children with a diagnosis of acute glomerulonephritis, 25 – chronic glomerulonephritis, 40 – chronic obstructive secondary pyelonephritis and 20 healthy children. In the group of patients with chronic glomerulonephritis renal function was impaired in 10 patients with chronic pyelonephritis – in 20 patients. The content of MMP-1, -2, -9 and TIMP-1, TIMP-2 in the serum of children was determined by ELISA.Results. It was found that in acute and chronic glomerulonephritis in children increases the content of MMP-1, MMP-2 is almost not changed, while the content of MMP-9 is reduced, which characterizes the presence of inflammation. In chronic pyelonephritis in a more pronounced reduction of MMP-9, antiinflammatory. The most significant changes were found in patients with impaired renal function. In all groups of patients experienced an increase in the level of TIMP-1 and TIMP-2.Conclusion. Thus, increasing the level of tissue inhibitors, elevated levels of MMP-1, decreased MMP-9, contributes to the progression of the disease and the development of inflammation and the accumulation of extracellular matrix proteins of interstitial kidney tissue, resulting in sclerotic and fibrotic changes.

scholarly journals Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology

2018 ◽  
Vol 219 (4) ◽  
pp. 633-636 ◽  
Author(s):  
Alvaro A Ordonez ◽  
Supriya Pokkali ◽  
Julian Sanchez-Bautista ◽  
Mariah H Klunk ◽  
Michael E Urbanowski ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mycobacterium Tuberculosis ◽  
Matrix Metalloproteinases ◽  
Pulmonary Tuberculosis ◽  
Matrix Metalloproteinase ◽  
Murine Model ◽  
Potent Inhibitor ◽  
Mmp Inhibitors

Abstract Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in tuberculosis pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis–infected C3HeB/FeJ mice. In this study, we evaluated whether administration of cipemastat, an orally available potent inhibitor of MMP-7, could reduce pulmonary cavitation in M. tuberculosis–infected C3HeB/FeJ mice. We demonstrate that, compared with untreated controls, cipemastat treatment paradoxically increases the frequency of cavitation (32% vs 7%; P = .029), immunopathology, and mortality. Further studies are needed to understand the role of MMP inhibitors as adjunctive treatments for pulmonary tuberculosis.

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