scholarly journals Paradoxical Elevation of High-Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies

Diabetes ◽  
2007 ◽  
Vol 56 (6) ◽  
pp. 1712-1717 ◽  
Author(s):  
R. K. Semple ◽  
N. H. Halberg ◽  
K. Burling ◽  
M. A. Soos ◽  
T. Schraw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Molecular Weight ◽  
Insulin Receptor ◽  
High Molecular Weight ◽  
High Molecular Weight Adiponectin ◽  
Extreme Insulin Resistance ◽  
Receptor Antibodies

scholarly journals Inflammatory Adipokines, High Molecular Weight Adiponectin, and Insulin Resistance: A Population-Based Survey in Prepubertal Schoolchildren

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17264 ◽  
Author(s):  
Giuseppe Murdolo ◽  
Bettina Nowotny ◽  
Federica Celi ◽  
Miranda Donati ◽  
Vittorio Bini ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Population Based ◽  
High Molecular Weight Adiponectin ◽  
Population Based Survey

scholarly journals Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Mathilde Sollier ◽  
Marine Halbron ◽  
Jean Donadieu ◽  
Ahmed Idbaih ◽  
Fleur Cohen Aubart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Receptor ◽  
Fasting Blood Glucose ◽  
Parallel Evolution ◽  
Growth Delay ◽  
Glucose Levels ◽  
First Case ◽  
Extreme Insulin Resistance ◽  
Receptor Antibodies

Background. Langerhans Cell Histiocytosis (LCH) is a rare inflammatory neoplasm characterized by an infiltration of organs by Langerin + (CD207+) and CD1a+ histiocytes. Diabetes insipidus is a frequent manifestation of the disease, while diabetes mellitus is very rare. We report the first case of a 20-year-old man suffering from hypothalamopituitary histiocytosis and diabetes mellitus with serum anti-insulin receptor antibodies. Case Presentation. A 20-year-old patient was admitted for the evaluation of growth delay and hyperphagia. HbA1c level and fasting blood glucose were in the normal range. The diagnosis of hypothalamopituitary histiocytosis was based on histological features after biopsy of a large suprachiasmatic lesion identified on magnetic resonance imaging (MRI). Association of vinblastine and purinethol was started followed by a second-line therapy by cladribine. During the follow-up, the patient was admitted for recurrence of hyperglycemic states and extreme insulin resistance. The screening for serum anti-insulin receptor antibodies was positive. Each episode of hyperglycemia appeared to be correlated with tumoral activity and increase in serum anti-insulin receptor antibodies and appeared to be improved when the disease was controlled by chemotherapy. Conclusion. We report the first description of a hypothalamopituitary histiocytosis associated with serum anti-insulin receptor antibodies, extreme insulin resistance, and diabetes. Parallel evolution of glucose levels and serum anti-insulin receptor antibodies seemed to be the consequence of immune suppressive properties of cladribine.

scholarly journals Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function

2010 ◽  
Vol 163 (2) ◽  
pp. 359
Author(s):  
Jessica L Fargnoli ◽  
Qi Sun ◽  
Deanna Olenczuk ◽  
Lu Qi ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Molecular Weight ◽  
Endothelial Function ◽  
High Molecular Weight ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
High Molecular Weight Adiponectin ◽  
Article Type ◽  
Postdoctoral Fellowship

The authors and the journal apologise for an error in the funding section of this article published in 2010, vol 162, pp 281–288. The grant number that is listed as DK081923 is actually DK081913. The Funding section with the correct grant numbers is published in full below:FundingThis work was supported by the National Institute of Health (grants HL65582, HL60712, HL34594, DK58785, DK081913, DK79929, and DK58845), a discretionary grant from BIDMC, and a grant-in-aid by Tanita Corporation. Dr Hu is a recipient of the American Heart Association Established Investigator Award. Dr Sun is supported by a Postdoctoral Fellowship from the Unilever Corporate Research.

scholarly journals Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Farnaz Kamali Haghighi Shirazi ◽  
Zohre Khodamoradi ◽  
Marjan Jeddi
Keyword(s):  
Insulin Resistance ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Polycystic Ovarian Syndrome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
High Molecular Weight Adiponectin ◽  
Cross Sectional ◽  
Free Androgen Index ◽  
Ovarian Syndrome

Abstract Background Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy among young women. Insulin resistance is a key feature in the pathogenesis of PCOS; also high molecular weight adiponectin is a marker of insulin resistance. The aim of this study was to evaluate the insulin resistance, metabolic and androgenic profiles and high molecular weight adiponectin in obese and non-obese PCOS patients. Methods In this cross-sectional study in outpatient endocrinology clinics of Shiraz University of Medical Sciences, 80 women aged 17–43 years old with PCOS were enrolled. Biochemical and hormonal assay was done on fasting blood sample on the third day of follicular phase. Results The individuals had a mean age of 28.39 ± 6.56 years, mean weight of 65.41 ± 12.59 Kg, mean BMI of 25.5 ± 4.9, and mean waist circumference of 88.0 ± 13.1 cm. Of all individuals 20% had frank insulin resistance with HOMA-IR > 3.8. Although the obese PCOS patients had lower levels of high molecular weight adiponectin (P = 0.03) than the normal weight PCOS individuals, the level of insulin and insulin resistance was not different in them (P = 0.13, 0.13). Patients with classic PCOS phenotype significantly had higher levels of insulin resistance and free androgen index (P < 0.001, 0.001). We found a significant correlation between the insulin level and free androgen index (correlation coefficient: 0.266 and P = 0.018) after adjusting for BMI. Conclusion This cross-sectional study showed a high incidence of insulin resistance in PCOS patients independent of obesity, and determined BMI related lower level of high molecular weight adiponectin in obese PCOS individuals. More detailed studies are warranted for evaluation of insulin resistance and its pathophysiologic role in PCOS.

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