5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome that attracted neutrophils and triggered the production of neutrophil extracellular traps (NETs). NETs ultimately cleared diseased endothelial cells and remodeled unhealthy vessels. Genetic or pharmacological inhibition of NETosis prevented the regression of senescent vessels and prolonged disease. Thus, clearance of senescent retinal blood vessels leads to reparative vascular remodeling.

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Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy

Scientific Reports ◽

10.1038/srep38445 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 9

Author(s):

Mitsuru Arima ◽

Dan Cui ◽

Tokuhiro Kimura ◽

Koh-Hei Sonoda ◽

Tatsuro Ishibashi ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Mouse Model ◽

Therapeutic Target ◽

Barrier Function

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Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy

Investigative Ophthalmology & Visual Science ◽

10.1167/iovs.14-15687 ◽

2015 ◽

Vol 56 (1) ◽

pp. 606-615 ◽

Cited By ~ 25

Author(s):

B. A. Berkowitz ◽

E. M. Grady ◽

N. Khetarpal ◽

A. Patel ◽

R. Roberts

Keyword(s):

Oxidative Stress ◽

Diabetic Retinopathy ◽

Mouse Model ◽

Posterior Segment ◽

Evoked Responses

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Role of Vasomotion in Control of Retina Edema in Diabetic Retinopathy: Quantification of Fluid Transport Through Retinal Capillaries

ASME 2008 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2008-189507 ◽

2008 ◽

Author(s):

Liang Zhu ◽

Robert Flower

Keyword(s):

Diabetic Retinopathy ◽

Fluid Transport ◽

Vision Loss ◽

Early Screening ◽

Retinal Tissue ◽

Visual Damage ◽

Prevention Of Diabetes ◽

Irreversible Nature ◽

Retinal Capillaries

Diabetic retinopathy refers to diabetes-related complications in the retina, It is a progressive disease and its symptoms in the eyes can vary from non-vision threatening to vision loss, and it can lead to permanent damage to the neuronal retinal tissue. The irreversible nature of the damage suggests that prevention of diabetes by eliminating risk factors and early screening are the cornerstone of relevant treatment to stop or limit visual damage in those patients.

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Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy

Redox Biology ◽

10.1016/j.redox.2020.101574 ◽

2020 ◽

Vol 34 ◽

pp. 101574 ◽

Cited By ~ 1

Author(s):

Rebekah Robinson ◽

Mukund Srinivasan ◽

Arul Shanmugam ◽

Alexander Ward ◽

Veena Ganapathy ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetic Retinopathy ◽

Mouse Model ◽

Interleukin 6

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Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas

International Journal of Molecular Sciences ◽

10.3390/ijms18122567 ◽

2017 ◽

Vol 18 (12) ◽

pp. 2567 ◽

Cited By ~ 8

Author(s):

Odunayo Mugisho ◽

Colin Green ◽

Jie Zhang ◽

Nicolette Binz ◽

Monica Acosta ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Mouse Model ◽

Human Donor

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Current Strategies and Future Perspective for the Effective Treatment of Diabetic Retinopathy

Current Drug Therapy ◽

10.2174/1574885514666191007101007 ◽

2020 ◽

Vol 15 (4) ◽

pp. 299-311

Author(s):

Deep Shikha Sharma ◽

Sachin Kumar Singh ◽

Divya Thakur ◽

Arya K.R ◽

Rubiya Khursheed ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Side Effects ◽

Combination Therapy ◽

Future Perspective ◽

Therapeutic Effects ◽

Herbal Drugs ◽

Laser Technology ◽

Treatment And Prevention ◽

Retinal Capillaries ◽

Main Strategy

: Diabetes Retinopathy (DR) is one of the main complications due to diabetes. DR will damage the retinal capillaries and block them, which causes the loss of vision. Different drugs and therapies are used for the treatment and prevention of the DR. The most commonly used treatment is laser technology and combination therapy, along with some drugs. But these drugs possess side effects in the form of cataract, glaucoma, and complete blindness of the eye. The main strategy to overcome In DR, medicines with minimum side effects or maximum therapeutic effects are used. This article emphasizes the current strategy used for the treatment of DR with allopathic as well as herbal drugs.

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