Short-Term Hyperinsulinemia and Hyperglycemia Increase Myocardial Lipid Content in Normal Subjects

Nine normal, healthy male subjects had significantly elevated thyroid-stimulating hormone (TSH) concentrations while receiving oral lithium carbonate for two weeks. The mean minimum lithium serum concentration was 0.765 mEq/L. The TSH concentrations after 15 days on lithium were significantly correlated to the TSH concentration at baseline. No correlation was found between mean minimum lithium steady-state concentration and TSH concentration after 15 days on lithium. Further research is necessary to determine if a high baseline TSH concentration or an early rise in TSH will predict those patients who will eventually develop hypothyroidism after long-term lithium therapy.

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Short-term tissue decomposition alters stable isotope values and C:N ratio, but does not change relationships between lipid content, C:N ratio, and Δδ13C in marine animals

PLoS ONE ◽

10.1371/journal.pone.0199680 ◽

2018 ◽

Vol 13 (7) ◽

pp. e0199680 ◽

Cited By ~ 8

Author(s):

Matthew J. Perkins ◽

Yanny K. Y. Mak ◽

Lily S. R. Tao ◽

Archer T. L. Wong ◽

Jason K. C. Yau ◽

...

Keyword(s):

Stable Isotope ◽

Lipid Content ◽

C:N Ratio ◽

Short Term ◽

Marine Animals

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Effects of the cold pressor test on short-term fluctuations of finger arterial blood pressure and heart rate in normal subjects

Clinical Autonomic Research ◽

10.1007/bf01827331 ◽

1993 ◽

Vol 3 (5) ◽

pp. 303-310 ◽

Cited By ~ 39

Author(s):

Frank Weise ◽

Dominique Laude ◽

Arlette Girard ◽

Philippe Zitoun ◽

Jean-Philippe Siché ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Arterial Blood Pressure ◽

Cold Pressor Test ◽

Cold Pressor ◽

Normal Subjects ◽

Short Term ◽

Pressor Test ◽

Arterial Blood

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Inhibitory effect of an intellectual task on breathing after voluntary hyperventilation

Journal of Applied Physiology ◽

10.1152/jappl.1996.81.3.1379 ◽

1996 ◽

Vol 81 (3) ◽

pp. 1379-1387 ◽

Cited By ~ 12

Author(s):

K. Chin ◽

M. Ohi ◽

M. Fukui ◽

H. Kita ◽

T. Tsuboi ◽

...

Keyword(s):

Video Game ◽

Minute Ventilation ◽

Normal Subjects ◽

Inhibitory Effect ◽

Inspiratory Flow Rate ◽

Short Term ◽

Voluntary Hyperventilation ◽

Term Potentiation ◽

The Central Nervous System ◽

Increased Activity

We investigated the effects of an intellectual task on posthyperventilation (PHV) breathing by using a video game. Eight normal subjects were placed in a supine positions. The game task by itself led to increase ventilation compared with the control tasks via an increase in the average inspiratory flow rate (P < 0.01) and the respiratory frequency (P < 0.001). After hypocapnic voluntary hyperventilation (VHV), the task led to a decrease in the 1-min PHV breathing level compared with the control tasks after VHV [after VHV, first 60 s average minute ventilation while watching television and while playing a video game are 5.54 +/- 2.91 (SD) and 2.05 +/- 1.40 l/min, respectively; P < 0.01]. Only one subject showed PHV apnea for at least 10 s during the control protocol, whereas seven of the same eight subjects showed PHV apnea while performing the task. After isocapnic VHV, the task still led to a decrease in PHV breathing compared with the control tasks. However, this decrease was smaller than in the hypocapnic studies and was only significant during the first 15 s of recovery. These results suggest that increased activity in the higher centers of the central nervous system has an inhibitory effect on PHV breathing at a time when the effects of short-term potentiation after VHV, hypocapnia, and perhaps other mechanisms would be expected to be acting on breathing.

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Changes in Plaque Lipid Content After Short-Term Intensive Versus Standard Statin Therapy

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2013.03.058 ◽

2013 ◽

Vol 62 (1) ◽

pp. 21-29 ◽

Cited By ~ 124

Author(s):

Annapoorna S. Kini ◽

Usman Baber ◽

Jason C. Kovacic ◽

Atul Limaye ◽

Ziad A. Ali ◽

...

Keyword(s):

Statin Therapy ◽

Lipid Content ◽

Short Term

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Protein Metabolism in Acromegaly: Differential Effects of Short- and Long-Term Treatment

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-0664 ◽

2007 ◽

Vol 92 (4) ◽

pp. 1479-1484 ◽

Cited By ~ 17

Author(s):

James Gibney ◽

Troels Wolthers ◽

Morton G. Burt ◽

Kin-Chuen Leung ◽

A. Margot Umpleby ◽

...

Keyword(s):

Protein Oxidation ◽

Protein Metabolism ◽

Normal Subjects ◽

Term Treatment ◽

Protein Breakdown ◽

Short Term ◽

Leucine Oxidation ◽

Long Term Treatment ◽

Short And Long Term

Abstract Context: GH acutely increases body protein by stimulating protein synthesis and reducing protein oxidation. Objective: The objective of the study was to determine whether these changes in protein metabolism are sustained in long-term GH excess and reversed by correction. Design: We conducted a cross-sectional study in 16 acromegalic and 18 normal subjects and a longitudinal study in which acromegalic subjects were studied before and after short-term (n = 8) or long-term (n = 10) treatment. Setting: The study was conducted at a clinical research center. Main Outcome Measures: Whole-body rates of leucine appearance (leucine Ra; an index of protein breakdown), leucine oxidation, and nonoxidative leucine disposal (NOLD; an index of protein synthesis) estimated using infusion of 1-[13C] leucine were measured. Results: Leucine Ra and NOLD were greater (P < 0.01) in acromegalic compared with normal subjects, whereas leucine oxidation did not differ. Leucine oxidation increased significantly (P < 0.05) after short-term treatment but returned to baseline after long-term treatment. Both leucine Ra and NOLD decreased significantly (P < 0.05) after short- and long-term treatment. Adjustment for body composition did not affect results. Conclusions: In acromegalic subjects, protein breakdown and synthesis are increased, whereas protein oxidation does not differ from normal subjects. Protein oxidation increases transiently, whereas protein breakdown and synthesis are stably reduced after treatment. Because protein oxidation represents irreversible loss, we conclude that the normal state of protein oxidation found in acromegaly and after long-term treatment represents metabolic adaptation, which maintains protein mass at a steady state after stable changes in GH status.

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Studies of human zinc kinetics using the stable isotope 70Zn

Clinical Science ◽

10.1042/cs0840113 ◽

1993 ◽

Vol 84 (1) ◽

pp. 113-117 ◽

Cited By ~ 34

Author(s):

N. M. Lowe ◽

A. Green ◽

J. M. Rhodes ◽

M. Lombard ◽

R. Jalan ◽

...

Keyword(s):

Liver Disease ◽

Alcoholic Liver Disease ◽

Turnover Rate ◽

Kinetic Studies ◽

Normal Subjects ◽

Short Term ◽

Control Subjects ◽

Two Component ◽

Kinetics Of ◽

Fractional Turnover

1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70ZnCl2. 2. The 70Zn enrichment of plasma was found closely to obey two-compartment kinetics and the derived two-component decay equation has been used to calculate the size and turnover of the initial two rapidly exchanging pools of body Zn. 3. In normal subjects isotopic Zn appears initially to equilibrate with the whole of the plasma Zn which comprises the first metabolic compartment, pool a. This has a size of 0.72 ± 0.1 μmol/kg. 70Zn equilibration then occurs with a second compartment, pool b, consistent with a rapidly exchanging liver Zn pool of size 3.60 ± 0.93 μmol/kg. The fractional turnover rate of pool b was found to be fivefold slower than that of pool a. 4. In the alcoholic group an expansion of pool a was observed (1.63 ± 0.39 μmol/kg), but the size of the second pool was not significantly different from that of control subjects (5.55 ± 1.0 μmol/kg), although its fractional turnover was significantly increased (Kab: control subjects, 0.018 ± 0.002 min−1, alcoholic patients, 0.031 ± 0.006 min−1). 5. These data therefore demonstrate that kinetic studies using stable isotopes of Zn can provide novel information on exchangeable Zn pools in man, but provide no support for the possibility of an underlying Zn depletion in patients with alcoholic liver disease.

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The Effect of Short-Term Administration of CNS-Acting Drugs on the Circadian Variation of the Plasma 17-OHCS in Normal Subjects

Neuroendocrinology ◽

10.1159/000121552 ◽

1967 ◽

Vol 2 (4) ◽

pp. 232-246 ◽

Cited By ~ 13

Author(s):

Dorothy T. Krieger ◽

Howard P. Krieger

Keyword(s):

Circadian Variation ◽

Normal Subjects ◽

Short Term ◽

Term Administration

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Increased Glucose Disappearance Rate after Short-Term Clofibrate Administration in Normal Subjects and in Patients with Chemical Diabetes

Hormone and Metabolic Research ◽

10.1055/s-0028-1093469 ◽

1978 ◽

Vol 10 (01) ◽

pp. 4-6 ◽

Cited By ~ 6

Author(s):

C. Ferrari ◽

G. Testori ◽

Anna Bertazzoni ◽

M. Romussi ◽

R. Caldara ◽

...

Keyword(s):

Normal Subjects ◽

Disappearance Rate ◽

Short Term ◽

Chemical Diabetes ◽

Glucose Disappearance

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Acute Hyperglycemia Does Not Affect the Reactivity of Coronary Microcirculation in Humans

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-2207 ◽

2005 ◽

Vol 90 (7) ◽

pp. 3871-3876 ◽

Cited By ~ 7

Author(s):

Brunella Capaldo ◽

Maurizio Galderisi ◽

Anna Amelia Turco ◽

Arcangelo D’Errico ◽

Salvatore Turco ◽

...

Keyword(s):

Flow Velocity ◽

Healthy Subjects ◽

Coronary Flow ◽

Color Doppler ◽

Normal Subjects ◽

Coronary Microcirculation ◽

Short Term ◽

Acute Hyperglycemia ◽

Diastolic Flow ◽

Flow Reserve

Abstract Objective: There is some evidence that acute hyperglycemia (H) may cause vascular dysfunction in normal subjects. This study investigates whether acute, short-term H affects coronary vasodilatory function in healthy subjects. Design: Diastolic peak flow velocity in the left anterior descending coronary artery was measured at rest and after dipyridamole (0.56 mg/kg over 4 min) using transthoracic color Doppler echocardiography in 13 healthy men. Coronary flow reserve (CFR) was defined as the ratio of dipyridamole-induced coronary peak diastolic to resting peak diastolic flow velocity. CFR was measured both in euglycemia (E) and after 3 h H (∼14 mmol/liter) by a variable infusion of glucose and octreotide (0.4 mg/h) to prevent increase in insulin concentration. Results: Fasting plasma glucose increased to 14.3 ± 0.33 mmol/liter during the study and maintained variability within less than 10%. Plasma insulin remained nearly stable during H. Resting diastolic flow velocity was 18.5 ± 0.6 cm/sec in E and increased to 20.0 ± 0.7 cm/sec during H (P < 0.005). Dipyridamole infusion produced a marked increase in coronary flow velocity, which reached values of 50.8 ± 2.9 cm/sec in E and 51.8 ± 2.1 cm/sec in H (P = not significant). CFR was 2.78 ± 0.16 in E and 2.59 ± 0.12 in H (P = not significant). Conclusion: Our study indicates that short-term hyperglycemia does not affect the vasodilatory response of coronary microcirculation in healthy subjects.

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