scholarly journals A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis

Diabetes ◽  
2015 ◽  
Vol 64 (6) ◽  
pp. 2002-2014 ◽  
Author(s):  
Kristin I. Stanford ◽  
Roeland J.W. Middelbeek ◽  
Kristy L. Townsend ◽  
Min-Young Lee ◽  
Hirokazu Takahashi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Homeostasis ◽  
Subcutaneous Adipose Tissue ◽  
Exercise Induced ◽  
Subcutaneous Adipose

Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise

2007 ◽  
Vol 292 (1) ◽  
pp. E24-E31 ◽  
Author(s):  
Lone Frydelund-Larsen ◽  
Thorbjorn Akerstrom ◽  
Søren Nielsen ◽  
Pernille Keller ◽  
Charlotte Keller ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Mrna Expression ◽  
Subcutaneous Adipose Tissue ◽  
Recovery Period ◽  
Control Group ◽  
Time Points ◽  
Metabolic Role ◽  
Exercise Induced ◽  
Subcutaneous Adipose

Visfatin [pre-β-cell colony-enhancing factor (PBEF)] is a novel adipokine that is produced by adipose tissue, skeletal muscle, and liver and has insulin-mimetic actions. Regular exercise enhances insulin sensitivity. In the present study, we therefore examined visfatin mRNA expression in abdominal subcutaneous adipose tissue and skeletal muscle biopsies obtained from healthy young men at time points 0, 3, 4.5, 6, 9, and 24 h in relation to either 3 h of ergometer cycle exercise at 60% of V̇o2 max or rest. Adipose tissue visfatin mRNA expression increased threefold at the time points 3, 4.5, and 6 h in response to exercise ( n = 8) compared with preexercise samples and compared with the resting control group ( n = 7, P = 0.001). Visfatin mRNA expression in skeletal muscle was not influenced by exercise. The exercise-induced increase in adipose tissue visfatin was, however, not accompanied by elevated levels of plasma visfatin. Recombinant human IL-6 infusion to mimic the exercise-induced IL-6 response ( n = 6) had no effect on visfatin mRNA expression in adipose tissue compared with the effect of placebo infusion ( n = 6). The finding that exercise enhances subcutaneous adipose tissue visfatin mRNA expression suggests that visfatin has a local metabolic role in the recovery period following exercise.

Promoter methylation of TMEM18 in subcutaneous adipose tissue is related to glucose homeostasis

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
K Rohde ◽  
M Keller ◽  
M Klös ◽  
D Schleinitz ◽  
A Dietrich ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Homeostasis ◽  
Promoter Methylation ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides

2010 ◽  
Vol 299 (2) ◽  
pp. E258-E265 ◽  
Author(s):  
Katrien Koppo ◽  
Dominique Larrouy ◽  
Marie A. Marques ◽  
Michel Berlan ◽  
Magda Bajzova ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Exercise Bout ◽  
Saline Control ◽  
Microdialysis Probe ◽  
Lipid Mobilization ◽  
Obese Subjects ◽  
Exercise Induced ◽  
Subcutaneous Adipose ◽  
The Impact

The aim of this study was to evaluate the relative contributions of various hormones involved in the regulation of lipid mobilization in subcutaneous adipose tissue (SCAT) during exercise and to assess the impact of obesity on this regulation. Eight lean and eight obese men performed a 60-min cycle exercise bout at 50% of their peak oxygen uptake on two occasions: during intravenous infusion of octreotide (a somatostatin analog) or physiological saline (control condition). Lipolysis in SCAT was evaluated using in situ microdialysis. One microdialysis probe was perfused with the adrenergic blockers phentolamine and propranolol while another probe was perfused with the phosphodiesterase and adenosine receptor inhibitor aminophylline. Compared with the control condition, infusion of octreotide reduced plasma insulin levels in lean (from ∼3.5 to 0.5 μU/ml) and in obese (from ∼9 to 2 μU/ml), blunted the exercise-induced rise in plasma GH and epinephrine levels in both groups, and enhanced the exercise-induced natriuretic peptide (NP) levels in lean but not in obese subjects. In both groups, octreotide infusion resulted in higher exercise-induced increases in dialysate glycerol concentrations in the phentolamine-containing probe while no difference in lipolytic response was found in the aminophylline-containing probe. The results suggest that insulin antilipolytic action plays a role in the regulation of lipolysis during exercise in lean as well as in obese subjects. The octreotide-induced enhancement of exercise lipolysis in lean subjects was associated with an increased exercise-induced plasma NP response. Adenosine may contribute to the inhibition of basal lipolysis in both subject groups.

Adipocyte EGFL6 Expression from Subcutaneous Adipose Tissue Alters Glucose Homeostasis and Affects Human Obesity

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1751-P
Author(s):  
DAVID BRADLEY ◽  
ZHENG YIN ◽  
JOEY Z. LIU ◽  
ALECIA M. BLASZCZAK ◽  
STEPHEN T. WONG ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Homeostasis ◽  
Subcutaneous Adipose Tissue ◽  
Human Obesity ◽  
Subcutaneous Adipose

scholarly journals IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: local effects of IL-15 on adipose tissue lipolysis

2015 ◽  
Vol 308 (12) ◽  
pp. E1131-E1139 ◽  
Author(s):  
Joseph R. Pierce ◽  
Jill M. Maples ◽  
Robert C. Hickner
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Animal Cell ◽  
Glycerol Concentration ◽  
Tissue Mass ◽  
Obese Subjects ◽  
Adipose Tissue Lipolysis ◽  
Exercise Induced ◽  
Subcutaneous Adipose

Animal/cell investigations indicate that there is a decreased adipose tissue mass resulting from skeletal muscle (SkM) IL-15 secretion (e.g., SkM-blood-adipose tissue axis). IL-15 could regulate fat mass accumulation in obesity via lipolysis, although this has not been investigated in humans. Therefore, the purpose was to examine whether SkM and/or subcutaneous adipose tissue (SCAT) IL-15 concentrations were correlated with SCAT lipolysis in lean and obese humans and determine whether IL-15 perfusion could induce lipolysis in human SCAT. Local SkM and abdominal SCAT IL-15 (microdialysis) and circulating IL-15 (blood) were sampled in lean (BMI: 23.1 ± 1.9 kg/m2; n = 10) and obese (BMI: 34.7 ± 3.5 kg/m2; n = 10) subjects at rest/during 1-h cycling exercise. Lipolysis (SCAT interstitial glycerol concentration) was compared against local/systemic IL-15. An additional probe in SCAT was perfused with IL-15 to assess direct lipolytic responses. SkM IL-15 was not different between lean and obese subjects ( P = 0.45), whereas SCAT IL-15 was higher in obese vs. lean subjects ( P = 0.02) and was correlated with SCAT lipolysis ( r = 0.45, P = 0.05). Exercise increased SCAT lipolysis in lean and obese ( P < 0.01), but exercise-induced SCAT lipolysis changes were not correlated with exercise-induced SCAT IL-15 changes. Microdialysis perfusion resulting in physiological IL-15 concentrations in the adipose tissue interstitium increased lipolysis in lean ( P = 0.04) but suppressed lipolysis in obese ( P < 0.01). Although we found no support for a human IL-15 SkM-blood-adipose tissue axis, IL-15 may be produced in/act on the abdominal SCAT depot. The extent to which this autocrine/paracrine IL-15 action regulates human body composition remains unknown.

Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men

2008 ◽  
Vol 295 (2) ◽  
pp. E505-E513 ◽  
Author(s):  
Cedric Moro ◽  
Fabien Pillard ◽  
Isabelle de Glisezinski ◽  
Eva Klimcakova ◽  
Francois Crampes ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Natriuretic Peptides ◽  
Subcutaneous Adipose Tissue ◽  
Maximal Oxygen Consumption ◽  
Glycerol Concentration ◽  
Nonesterified Fatty Acids ◽  
Lipid Mobilization ◽  
Exercise Induced ◽  
Subcutaneous Adipose

Involvement of sympathetic nervous system and natriuretic peptides in the control of exercise-induced lipid mobilization was compared in overweight and lean men. Lipid mobilization was determined using local microdialysis during exercise. Subjects performed 35-min exercise bouts at 60% of their maximal oxygen consumption under placebo or after oral tertatolol [a β-adrenergic receptor (AR) antagonist]. Under placebo, exercise increased dialysate glycerol concentration (DGC) in both groups. Phentolamine (α-AR antagonist) potentiated exercise-induced lipolysis in overweight but not in lean subjects; the α2-antilipolytic effect was only functional in overweight men. After tertatolol administration, the DGC increased similarly during exercise no matter which was used probe in both groups. Compared with the control probe under placebo, lipolysis was reduced in lean but not in overweight men treated with the β-AR blocker. Tertatolol reduced plasma nonesterified fatty acids and insulin concentration in both groups at rest. Under placebo or tertatolol, the exercise-induced changes in plasma nonesterified fatty acids, glycerol, and insulin concentrations were similar in both groups. Exercise promoted a higher increase in catecholamine and ANP plasma levels after tertatolol administration. In conclusion, the major finding of our study is that in overweight men, in addition to an increased α2-antilipolytic effect, the lipid mobilization in subcutaneous adipose tissue that persists during exercise under β-blockade is not dependent on catecholamine action. On the basis of correlation findings, it seems to be related to a concomitant exercise-induced rise in plasma ANP when exercise is performed under tertatolol intake and a decrease in plasma insulin.

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