IRAK-1/IRS-1 Signaling Cross Talk in Human Skeletal Muscle—Role in Insulin Resistance

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 159-OR
Author(s):  
THEODORE P. CIARALDI ◽  
SUNDER MUDALIAR ◽  
LIWU LI ◽  
ROSARIO SCALIA ◽  
XIAO JIAN SUN ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Cross Talk ◽  
Human Skeletal Muscle

1891-P: Palmitate-Enriched Lipid Ingestion Acutely Induces Insulin Resistance Associated with PKCγ Activation and Impaired Mitochondrial Function in Human Skeletal Muscle

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1891-P
Author(s):  
THERESIA SARABHAI ◽  
CHRYSI KOLIAKI ◽  
SABINE KAHL ◽  
DOMINIK PESTA ◽  
LUCIA MASTROTOTARO ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle

scholarly journals Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance

Diabetologia ◽  
2018 ◽  
Vol 61 (12) ◽  
pp. 2674-2674
Author(s):  
Laura Formentini ◽  
Alexander J. Ryan ◽  
Manuel Gálvez-Santisteban ◽  
Leslie Carter ◽  
Pam Taub ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Atp Synthase ◽  
Human Skeletal Muscle

scholarly journals The Mitochondrial Proteomic Signatures of Human Skeletal Muscle Linked to Insulin Resistance

2020 ◽  
Vol 21 (15) ◽  
pp. 5374 ◽  
Author(s):  
Rikke Kruse ◽  
Navid Sahebekhtiari ◽  
Kurt Højlund
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Human Skeletal Muscle ◽  
Metabolic Disorders ◽  
Muscle Protein ◽  
Protein Profiling ◽  
Muscle Mitochondria ◽  
Mitochondrial Proteome ◽  
Complex Disorders

Introduction: Mitochondria are essential in energy metabolism and cellular survival, and there is growing evidence that insulin resistance in chronic metabolic disorders, such as obesity, type 2 diabetes (T2D), and aging, is linked to mitochondrial dysfunction in skeletal muscle. Protein profiling by proteomics is a powerful tool to investigate mechanisms underlying complex disorders. However, despite significant advances in proteomics within the past two decades, the technologies have not yet been fully exploited in the field of skeletal muscle proteome. Area covered: Here, we review the currently available studies characterizing the mitochondrial proteome in human skeletal muscle in insulin-resistant conditions, such as obesity, T2D, and aging, as well as exercise-mediated changes in the mitochondrial proteome. Furthermore, we outline technical challenges and limitations and methodological aspects that should be considered when planning future large-scale proteomics studies of mitochondria from human skeletal muscle. Authors’ view: At present, most proteomic studies of skeletal muscle or isolated muscle mitochondria have demonstrated a reduced abundance of proteins in several mitochondrial biological processes in obesity, T2D, and aging, whereas the beneficial effects of exercise involve an increased content of muscle proteins involved in mitochondrial metabolism. Powerful mass-spectrometry-based proteomics now provides unprecedented opportunities to perform in-depth proteomics of muscle mitochondria, which in the near future is expected to increase our understanding of the complex molecular mechanisms underlying the link between mitochondrial dysfunction and insulin resistance in chronic metabolic disorders.

scholarly journals Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66628 ◽  
Author(s):  
Tipwadee Bunprajun ◽  
Tora Ida Henriksen ◽  
Camilla Scheele ◽  
Bente Klarlund Pedersen ◽  
Charlotte Jane Green
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Glucose Transporter ◽  
Transporter Expression

Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression

Metabolism ◽  
2000 ◽  
Vol 49 (8) ◽  
pp. 962-968 ◽  
Author(s):  
K.S. Park ◽  
T.P. Ciaraldi ◽  
L. Carter ◽  
S. Mudaliar ◽  
S.E. Nikoulina ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Protein Expression ◽  
Human Skeletal Muscle ◽  
Glycogen Synthase ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells
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