Cardiac Tissue Factor Regulates Inflammation, Hypertrophy and Heart Failure in Mouse Model of Type 1 Diabetes

Diabetes ◽  
2021 ◽  
pp. db200719
Author(s):  
Mary Cibi Dasan ◽  
Reddemma Sandireddy ◽  
Hanumakumar Bogireddy ◽  
Nicole Tee ◽  
Siti Aishah Binte Abdul Ghani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 1 Diabetes ◽  
Mouse Model ◽  
Tissue Factor ◽  
Cardiac Tissue

scholarly journals Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk

2016 ◽  
Vol 310 (7) ◽  
pp. E495-E504 ◽  
Author(s):  
Leni Vandekerckhove ◽  
Zarha Vermeulen ◽  
Zhi Zhao Liu ◽  
Sonia Boimvaser ◽  
Andreas Patzak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 1 Diabetes ◽  
Mouse Model ◽  
Contractile Function ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Glomerular Mesangial Cells ◽  
Neuregulin 1 ◽  
Diabetes Mouse

Neuregulin-1 (NRG-1) is an endothelium-derived growth factor with cardioprotective and antiatherosclerotic properties and is currently being tested in clinical trials as a treatment for systolic heart failure. In clinical practice, heart failure often coexists with renal failure, sharing an overlapping pathophysiological background. In this study, we hypothesized that NRG-1 might protect against cardiomyopathy, atherosclerosis, and nephropathy within one disease process. We tested this hypothesis in a hypercholesterolemic apolipoprotein E-deficient (apoE−/−) type 1 diabetes mouse model prone to the development of cardiomyopathy, atherosclerosis, and nephropathy and compared the effects of NRG-1 with insulin. Upon onset of hyperglycemia induced by streptozotocin, apoE−/− mice were treated with vehicle, insulin, or recombinant human (rh)NRG-1 for 14 wk and were compared with nondiabetic apoE−/− littermates. Vehicle-treated diabetic apoE−/− mice developed left ventricular (LV) dilatation and dysfunction, dense atherosclerotic plaques, and signs of nephropathy. Nephropathy was characterized by abnormalities including hyperfiltration, albuminuria, increased urinary neutrophil gelatinase-associated lipocalin (NGAL), upregulation of renal fibrotic markers, and glomerulosclerosis. rhNRG-1 treatment induced systemic activation of ErbB2 and ErbB4 receptors in both heart and kidneys and prevented LV dilatation, improved LV contractile function, and reduced atherosclerotic plaque size. rhNRG-1 also significantly reduced albuminuria, NGALuria, glomerular fibrosis, and expression of fibrotic markers. Regarding the renal effects of rhNRG-1, further analysis showed that rhNRG-1 inhibited collagen synthesis of glomerular mesangial cells in vitro but did not affect AngII-induced vasoconstriction of glomerular arterioles. In conclusion, systemic administration of rhNRG-1 in hypercholesterolemic type 1 diabetic mice simultaneously protects against complications in the heart, arteries and kidneys.

Absence of CXCL10 prolongs islet graft survival in an autoimmune mouse model for Type 1 Diabetes

2015 ◽  
Vol 10 (04) ◽  
Author(s):  
C Bender ◽  
S Christen ◽  
E Hintermann ◽  
U Christen
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Graft Survival ◽  
Islet Graft ◽  
Autoimmune Mouse

scholarly journals TLR9-Deficiency in B Cells Promotes Immune Tolerance via IL-10 in a Type 1 Diabetes Mouse Model

Diabetes ◽  
2020 ◽  
pp. db200373
Author(s):  
Sha Sha ◽  
James A Pearson ◽  
Jian Peng ◽  
Youjia Hu ◽  
Juan Huang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
B Cells ◽  
Mouse Model ◽  
Immune Tolerance ◽  
Diabetes Mouse

Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism

2021 ◽  
pp. 108710
Author(s):  
Huifeng Wang ◽  
Qingjun Zhou ◽  
Luqin Wan ◽  
Menglong Guo ◽  
Chen Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Potential Mechanism ◽  
Lipidomic Analysis ◽  
Meibomian Glands ◽  
Diabetes Mouse

scholarly journals Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

2016 ◽  
Vol 7 ◽  
Author(s):  
Elin Malek Abrahimians ◽  
Luc Vander Elst ◽  
Vincent A. Carlier ◽  
Jean-Marie Saint-Remy
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Nod Mouse

scholarly journals Hyperglycemia-Induced O-GlcNAcylation and Truncation of 4E-BP1 Protein in Liver of a Mouse Model of Type 1 Diabetes

2011 ◽  
Vol 286 (39) ◽  
pp. 34286-34297 ◽  
Author(s):  
Michael D. Dennis ◽  
Tabitha L. Schrufer ◽  
Sarah K. Bronson ◽  
Scot R. Kimball ◽  
Leonard S. Jefferson
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model

scholarly journals (D-Ser2)Oxm[Lys38- and #947;-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes

2016 ◽  
Vol 6 (1) ◽  
pp. 1 ◽  
Author(s):  
Nupur Pathak ◽  
Nigel Irwin ◽  
Varun Pathak ◽  
Victor Gault ◽  
Peter Flatt
Keyword(s):  
Gene Expression ◽  
Type 1 Diabetes ◽  
Mouse Model

scholarly journals Diabetes-induced Changes in Mannan-binding Lectin Levels and Complement Activation in a Mouse Model of Type 1 Diabetes

2013 ◽  
Vol 77 (3) ◽  
pp. 187-194 ◽  
Author(s):  
J. A. Østergaard ◽  
M. Bjerre ◽  
F. Dagnaes-Hansen ◽  
T. K. Hansen ◽  
S. Thiel ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Complement Activation ◽  
Induced Changes ◽  
Mannan Binding Lectin ◽  
Binding Lectin
Sign in / Sign up

Export Citation Format

Share Document