scholarly journals Role of Intrinsic Muscle Atrophy in the Etiology of Claw Toe Deformity in Diabetic Neuropathy May Not Be as Straightforward as Widely Believed

Diabetes Care ◽  
2009 ◽  
Vol 32 (6) ◽  
pp. 1063-1067 ◽  
Author(s):  
S. A. Bus ◽  
M. Maas ◽  
R. P.J. Michels ◽  
M. Levi
Keyword(s):  
Diabetic Neuropathy ◽  
Muscle Atrophy ◽  
Claw Toe ◽  
Intrinsic Muscle ◽  
Toe Deformity

scholarly journals Neuropathy, Claw Toes, Intrinsic Muscle Volume, and Plantar Aponeurosis Thickness in Diabetic Feet

2020 ◽  
Author(s):  
Tadashi Kimura ◽  
Eric D Thorhauer ◽  
Matthew W Kindig ◽  
Bruce J Sangeorzan ◽  
William R Ledoux
Keyword(s):  
Peripheral Neuropathy ◽  
Sagittal Plane ◽  
Ct Images ◽  
Muscle Volume ◽  
Plantar Aponeurosis ◽  
Claw Toe ◽  
Intrinsic Muscle ◽  
Claw Toes ◽  
Toe Deformity ◽  
Inferior Point

Abstract Background: The objective of this study was to explore the relationship between claw toe deformity, peripheral neuropathy, intrinsic muscle volume, and plantar aponeurosis thickness using computed tomography (CT) images of diabetic feet. Methods: Forty randomly-selected subjects with type 2 diabetes were selected for each of the following four groups (n = 10 per group): 1) peripheral neuropathy with claw toes, 2) peripheral neuropathy without claw toes, 3) non-neuropathic with claw toes, and 4) non-neuropathic without claw toes. The intrinsic muscles of the foot were segmented from processed CT images. Plantar aponeurosis thickness was measured in the reformatted sagittal plane at 20% of the distance from the most inferior point of calcaneus to the most inferior point of the second metatarsal. Five measurement sites in the medial-lateral direction were utilized to fully characterize the plantar aponeurosis thickness. A linear mixed effects analysis on the effect of peripheral neuropathy and claw toe deformity on plantar aponeurosis thickness and intrinsic muscle volume was performed. Results: Presence of claw toe deformity ( p = 0.008) and presence of neuropathy ( p = 0.039) were both associated with decreased intrinsic muscle volume. Subjects with both neuropathy and claw toe deformity had significantly thicker plantar aponeurosis tissue compared with the other three permutation subgroups ( p < 0.001). A negative correlation was observed between plantar aponeurosis thickness and intrinsic muscle volume ( R 2 = -0.3233, p < 0.001). Conclusions: In subjects with claw toe deformity, there were strong relationships between smaller intrinsic foot muscle volumes and thicker plantar aponeurosis tissue. Intrinsic muscle atrophy and plantar aponeurosis thickening may be related to the development of claw toes.

scholarly journals Intrinsic Muscle Atrophy and Toe Deformity in the Diabetic Neuropathic Foot: A magnetic resonance imaging study

Diabetes Care ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 1444-1450 ◽  
Author(s):  
S. A. Bus ◽  
Q. X. Yang ◽  
J. H. Wang ◽  
M. B. Smith ◽  
R. Wunderlich ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Muscle Atrophy ◽  
Imaging Study ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging ◽  
Intrinsic Muscle ◽  
Toe Deformity ◽  
Neuropathic Foot

The Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary Tract

2020 ◽  
Vol 16 (9) ◽  
pp. 931-948
Author(s):  
Benjamin Rahmani ◽  
Jason Gandhi ◽  
Gunjan Joshi ◽  
Noel L. Smith ◽  
Inefta Reid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Neuropathy ◽  
Gallbladder Cancer ◽  
Biliary Tract ◽  
Treatment Approach ◽  
Database Search ◽  
Heavy Burden ◽  
Prevalence Of Diabetes Mellitus

Background: The increasing prevalence of diabetes mellitus worldwide continues to pose a heavy burden. Though its gastrointestinal impact is appropriately recognized, the lesser known associations may be overlooked. Objective: We aim to review the negative implications of diabetes on the gallbladder and the biliary tract. Methods: A MEDLINE® database search of literature was conducted with emphasis on the previous five years, combining keywords such as "diabetes," "gallbladder," and "biliary". Results: The association of diabetes to the formation of gallstones, gallbladder cancer, and cancer of the biliary tract are discussed along with diagnosis and treatment. Conclusion: Though we uncover the role of diabetic neuropathy in gallbladder and biliary complications, the specific individual diabetic risk factors behind these developments is unclear. Also, in addition to diabetes control and surgical gallbladder management, the treatment approach also requires further focus.

Exploring the molecular role of endostatin in diabetic neuropathy

2021 ◽  
Vol 48 (2) ◽  
pp. 1819-1836
Author(s):  
Tuhin Mukherjee ◽  
Tapan Behl ◽  
Aayush Sehgal ◽  
Saurabh Bhatia ◽  
Harmanpreet Singh ◽  
...  
Keyword(s):  
Diabetic Neuropathy

PROTECTIVE ROLE OF FICUS RACEMOSA IN DIABETES INDUCED NEUROPATHY: STRUCTURAL AND FUNCTIONAL EVIDENCES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (11) ◽  
pp. 58-60
Author(s):  
N Solanki ◽  
◽  
S. K Bhavsar
Keyword(s):  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Ethanolic Extract ◽  
Protective Role ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Traditional System ◽  
Ficus Racemosa ◽  
Dose Dependent

Ficus racemosa is used in traditional system of medicine for various health problems and diseases, and is commonly known as Gular fig. The main objective was to study its effects against streptozotocin induced diabetic neuropathy by structural and functional marker. Investigation of diabetic neuropathy was carried out through functional and structural assessment in streptozotocin induced in diabetic rats. Diabetic rats were treated for 28 days in dose dependent manner of Ficus racemosa aqueous extract (250 mg/kg and 500 mg/kg) and ethanolic extract (200 mg/kg and 400 mg/kg). Study showed marked protection observed by Ficus racemosa in hippocampus region of brain and sciatic nerve tissues. Ficus racemosa treatment showed improvement in functional and structural markers, which strongly suggest its protective role in diabetic neuropathy.

High altitude mediated skeletal muscle atrophy: Protective role of curcumin

Biochimie ◽  
2019 ◽  
Vol 156 ◽  
pp. 138-147 ◽  
Author(s):  
Pooja Chaudhary ◽  
Yogendra Kumar Sharma ◽  
Shivani Sharma ◽  
Som Nath Singh ◽  
Geetha Suryakumar
Keyword(s):  
Skeletal Muscle ◽  
High Altitude ◽  
Muscle Atrophy ◽  
Protective Role ◽  
Skeletal Muscle Atrophy

scholarly journals Congenital Unilateral Hypertrophy of the Plantar Musculature with Multiple Toe Deformities: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Matthias Holzbauer ◽  
Stefan Rick ◽  
Marco Götze ◽  
Sébastien Hagmann
Keyword(s):  
Rare Case ◽  
Muscle Hypertrophy ◽  
Rare Condition ◽  
Abductor Hallucis ◽  
Claw Toe ◽  
Flexor Digitorum Brevis ◽  
Abductor Digiti Minimi ◽  
Fifth Toe ◽  
Flexor Digitorum ◽  
Toe Deformity

Congenital unilateral hypertrophy of the plantar musculature is a rare condition, and to our knowledge, reports of only 14 cases have been previously published. As only one describes a concomitant orthopedic toe deformity, we report our case of abductor hallucis, flexor digitorum brevis, and abductor digiti minimi muscle hypertrophy in combination with hallux valgus and claw toe deformity as well as a laterally abducted fifth toe. Thus, this report presents the rare case of congenital hypertrophy of the plantar musculature associated with complex toe deformities. Moreover, the present article contains a detailed description of our surgical technique as well as a review of the current literature.

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