Evaluation of N-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein relationship with features of metabolic syndrome in high-risk subgroups for cardiovascular disease

Abstract Background: High-sensitivity C-reactive protein (hsCRP) testing is relatively inexpensive and has been shown to predict the risk of cardiovascular disease (CVD) and diabetes in multiple patient groups, including those treated with statin therapy. JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) is a recently completed large multicenter randomized clinical trial that tested whether statin therapy should be given to apparently healthy individuals with lower LDL cholesterol (LDL-C) concentrations but increased hsCRP concentrations. Content: This review discusses the literature on hsCRP in asymptomatic populations, analyzes it according to CVD and diabetes, and provides summary recommendations for the use of hsCRP in clinical practice. In this context, we highlight recent data from the landmark JUPITER trial, which demonstrated that hsCRP can be used to target high-risk patients who have typical LDL-C concentrations and no known vascular disease or diabetes and who would benefit from statin use. We also summarize evidence that among patients treated with statin therapy, achieving low hsCRP concentrations may be a clinically relevant therapeutic goal along with achieving very low LDL-C concentrations. Summary: JUPITER has demonstrated that combining hsCRP testing with traditional testing of lipids can reduce incident CVD in high-risk asymptomatic individuals by 44% and all-cause mortality by approximately 20%, extending the therapeutic use of statins for the primary prevention of CVD. Guidelines for practitioners could include testing asymptomatic individuals for increased concentrations of hsCRP in men ≥50 years and women ≥60 years when LDL-C concentrations are not increased and for whom the decision to treat with statin therapy is not otherwise clear.

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High-Sensitivity C-Reactive Protein: A Useful Marker for Cardiovascular Disease Risk Prediction and the Metabolic Syndrome

Clinical Chemistry ◽

10.1373/clinchem.2004.044990 ◽

2005 ◽

Vol 51 (3) ◽

pp. 504-505 ◽

Cited By ~ 22

Author(s):

Nader Rifai

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Risk Prediction ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Protein A ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome

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Correlation of Urine Albumin/Creatinine Ratio (UACR), High Sensitivity C-Reactive Protein (hsCRP) and N-Terminal Pro Brain Natriuretic Peptide (NT-proBNP) with Atherosclerosis (OxLDL) in Centrally Obese Men

The Indonesian Biomedical Journal ◽

10.18585/inabj.v3i1.132 ◽

2011 ◽

Vol 3 (1) ◽

pp. 37

Author(s):

Nancy Pakpahan ◽

Mansyur Arif ◽

Ilhamjaya Patellongi

Keyword(s):

Cardiovascular Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

High Sensitivity ◽

Creatinine Ratio ◽

C Reactive Protein ◽

Albumin Creatinine Ratio ◽

Reactive Protein ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio

BACKGROUND: Obesity is closely associated with atherosclerosis risk and cardiovascular disease. Novel cardiovascular risk biomarkers such as Urine Albumin/Creatinine Ratio (UACR), High Sensitivity C-Reactive Protein (hsCRP) and N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) have been observed to predict cardiovascular disease in the general population. The aim of this study was to observe the correlation of UACR, hsCRP and NT-proBNP with atherosclerosis (OxLDL) in centrally obese men.METHODS: The study was observational with a cross sectional design done on 76 male subjects aged 30–50 years with central obesity and mean of age of 37 years. Urine albumin was determined by PEG enhanced immunoturbidimetric assay, urine creatinine by Jaffe without deproteinase, hsCRP by chemiluminescent immunometric assay, NT-proBNP by electrochemiluminescence (ECLIA) and OxLDL by ELISA.RESULTS: There was significant correlation between hsCRP and OxLDL (r=0.230, p=0.046). There was no significant correlation between UACR and OxLDL (r=-0.138, p=0.236), neither between Log NT-proBNP and OxLDL (r=-0.173, p=0.136).CONCLUSIONS: Atherosclerosis was significantly correlated with hsCRP (low grade inflammation).KEYWORDS: NT-proBNP, UACR, hsCRP, OxLDL, atherosclerosis

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The prevalence of metabolic syndrome increases with serum high sensitivity C-reactive protein concentration in individuals without a history of cardiovascular disease: a report from a large Persian cohort

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563216676842 ◽

2017 ◽

Vol 54 (6) ◽

pp. 644-648 ◽

Cited By ~ 3

Author(s):

Seyyed MR Kazemi-Bajestani ◽

Maryam Tayefi ◽

Mahmoud Ebrahimi ◽

Ali R Heidari-Bakavoli ◽

Mohsen Moohebati ◽

...

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Protein Concentration ◽

International Diabetes Federation ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

History Of ◽

Fourth Quartile

Background Metabolic syndrome is defined by a clustering of cardiovascular risk factors and is associated with a heightened inflammatory state. A raised serum high-sensitivity C-reactive protein, a marker of inflammation, is also known to associate with cardiovascular risk. We have investigated the relationship between the presence of metabolic syndrome and serum high-sensitivity C-reactive protein concentration in a large representative Persian population cohort without a history of cardiovascular disease. Methods The MASHAD study population cohort comprised 9778 subjects, who were recruited from the city of Mashhad, Iran, between 2007 and 2008. Several cardiovascular risk factors were measured in this population without cardiovascular disease. Individuals were categorized into quartiles of serum high-sensitivity C-reactive protein concentration: first quartile – 0.72 (0.59–0.85) (median [range]) mg/L, second quartile – 1.30 (1.14–1.4) mg/L, third quartile – 2.29 (1.92–2.81) mg/L and fourth quartile – 6.63 (4.61–11.95) mg/L, respectively. The prevalence of metabolic syndrome in each quartile was determined using either International Diabetes Federation or Adult Treatment Panel III criteria. Results The prevalence of metabolic syndrome was highest in the fourth quartile for serum high-sensitivity C-reactive protein (1220 subjects [50.0%]), and significantly higher than that in the first quartile (reference group) (634 subjects [25.9%]) ( P < 0.001). A positive smoking habit (OR, 1.47 [1.26–1.70], P < 0.001) and the presence of either metabolic syndrome-International Diabetes Federation (OR, 1.35 [1.18–1.55], P < 0.001) or metabolic syndrome-ATPIII (OR, 1.40 [1.18–1.50], P < 0.001) were strong predictors of a fourth quartile for serum high-sensitivity C-reactive protein concentration. Conclusions There was a significant association between high concentrations of serum high-sensitivity C-reactive protein and the presence of metabolic syndrome among individuals without a history of cardiovascular disease in our Persian cohort.

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Abstract P059: Prevalence And Correlates Of Co-occurring Metabolic Syndrome And Chronic Kidney Disease: Findings From The Hispanic Community Health Study/study Of Latinos (hchs/sol)

Circulation ◽

10.1161/circ.143.suppl_1.p059 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Celestin Missikpode ◽

Sylvia E Rosas ◽

Ana Ricardo ◽

James Lash ◽

Unab I Khan ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Chronic Kidney Disease ◽

High Sensitivity ◽

Health Study ◽

C Reactive Protein ◽

Reactive Protein ◽

Hispanic Community

Introduction: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are highly prevalent among Hispanics/Latinos, yet data on co-occurring MetS and CKD are not available. Understanding the prevalence and correlates of MetS-CKD overlap may inform intervention programs for such subgroups. Methods: Data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Visit 1 (2008-2011) was used. MetS was defined as the presence of three or more of the following risk factors: abdominal obesity, high triglyceride, low high-density lipoprotein cholesterol level, elevated blood pressure, and elevated glucose level. CKD was defined as eGFR <60 mL/min per 1.73 m 2 or the presence of albuminuria (urine albumin-creatinine ratio ≥17 mg/g in men and ≥25 mg/g in women). Of 16,415 HCHS/SOL participants, data from 14,527 persons with complete information on kidney function measures and covariates were analyzed using logistic regression. Potential correlates included age, sex, Hispanic/Latino background, acculturation, education, income, physical activity, alcohol use, cigarette smoking, cardiovascular disease, hemoglobin, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance (HOMA-IR). Analyses accounted for complex sampling design. Results: Average age was 41 years, 52% were women, 33% had prevalent MetS, and 14% had prevalent CKD. MetS and CKD co-occurred in 7.8% of the study population, 8.5% in men and 7.2% in women. The prevalence of co-occurring MetS and CKD was 10.4% in Puerto Rican, 9.2% in Cuban, 7.2% in Central American, 7.2% in Mexican, 6.5% in Dominican, and 5.3% in South American. Factors independently related to those co-occurring conditions were age, sex, physical activity levels, cardiovascular disease, high-sensitivity C-reactive protein, and HOMA-IR ( Table ). Conclusions: Targeted prevention efforts that address key modifiable overlapping risk factors may be especially effective in reducing metabolic syndrome and improving kidney health.

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Association of high sensitivity C-reactive protein and metabolic syndrome components in middle-aged subjects without overt cardiovascular disease in LitHiR primary prevention programme

Seminars in Cardiovascular Medicine ◽

10.2478/semcard-2020-0003 ◽

2020 ◽

Vol 26 (1) ◽

pp. 14-19

Author(s):

Ieva Marija Saulė ◽

Jurgita Mikolaitytė ◽

Jolita Badarienė ◽

Jūratė Zupkauskienė ◽

Roma Puronaitė ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Fasting Blood Glucose ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Hs Crp ◽

Aged Subjects

Summary Objectives: Circulating levels of inflammatory markers such as high sensitivity C-reactive protein (hs-CRP) have been reported to be associated with increased risk of cardiovascular disease (CVD), as well as with metabolic syndrome (MetS). Therefore, our objectives were to investigate the associations between hs-CRP levels and individual MetS components as well as to analyse if hs-CRP levels are linked with the number of MetS components present in middle-aged subjects. Design and methods: A cross-sectional study included 4628 middle-aged MetS subjects from the Lithuanian High Cardiovascular Risk primary prevention programme (LitHiR) from 2011 to 2020. MetS was diagnosed according to the National Cholesterol Education Program ATP III modified criteria. CRP was measured by a validated high-sensitivity assay. A hs-CRP cutpoint of 5 mg/l was used to differentiate high and low hs-CRP groups. Results: The mean value of hs-CRP was 3.23 ± 4.04 mg/l, and significantly increased as the number of components of MetS increased (p < 0.001). The concentration of serum hs-CRP was significantly associated with waist circumference, systolic and diastolic blood pressure, and fasting blood glucose (all p < 0.001). However, no statistically significant associations were found between hs-CRP and serum triglycerides (p = 0.340) or serum high-density lipoprotein cholesterol (p = 0.148). Conclusions: Serum hs-CRP increased progressively with increased waist circumference, blood pressure, fasting blood glucose in middle-aged subjects with MetS. The higher values of hs-CRP were more often present in obese subjects and women. The incremental rise in mean serum hs-CRP level was found with an increasing number of MetS components.

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